OCA at 07:36, 9 November 2022

2022-11-09T07:36:57Z

←Older revision		Revision as of 07:36, 9 November 2022
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-	'''Unreleased structure'''

-	The ~~entry~~ 8ep9 is ~~ON HOLD~~	+	==The capsid structure of Human Parvovirus 4==
		+	<StructureSection load='8ep9' size='340' side='right'caption='[[8ep9]], [[Resolution\|resolution]] 3.12Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8ep9]] is a 60 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_parvovirus_4 Human parvovirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EP9 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ep9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ep9 OCA], [https://pdbe.org/8ep9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ep9 RCSB], [https://www.ebi.ac.uk/pdbsum/8ep9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ep9 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A7J3Q7_9VIRU A7J3Q7_9VIRU]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Parvoviruses are small, single-stranded DNA viruses with non-enveloped capsids. Determining the capsid structures provides a framework for annotating regions important to the viral life cycle. Aleutian mink disease virus (AMDV), a pathogen in minks, and human parvovirus 4 (PARV4), infecting humans, are parvoviruses belonging to the genera Amdoparvovirus and Tetraparvovirus, respectively. While Aleutian mink disease caused by AMDV is a major threat to mink farming, no clear clinical manifestations have been established following infection with PARV4 in humans. Here, the capsid structures of AMDV and PARV4 were determined via cryo-electron microscopy at 2.37 and 3.12 A resolutions, respectively. Despite low amino acid sequence identities (10-30%) both viruses share the icosahedral nature of parvovirus capsids, with 60 viral proteins (VPs) assembling the capsid via two-, three-, and five-fold symmetry VP-related interactions, but display major structural variabilities in the surface loops when the capsid structures are superposed onto other parvoviruses. The capsid structures of AMDV and PARV4 will add to current knowledge of the structural platform for parvoviruses and permit future functional annotation of these viruses, which will help in understanding their infection mechanisms at a molecular level for the development of diagnostics and therapeutics.

-	~~Authors~~: Mietzsch, M., McKenna, R.	+	Capsid Structure of Aleutian Mink Disease Virus and Human Parvovirus 4: New Faces in the Parvovirus Family Portrait.,Lakshmanan R, Mietzsch M, Jimenez Ybargollin A, Chipman P, Fu X, Qiu J, Soderlund-Venermo M, McKenna R Viruses. 2022 Oct 9;14(10). pii: v14102219. doi: 10.3390/v14102219. PMID:36298773<ref>PMID:36298773</ref>

-	~~Description: The capsid structure~~ of Human ~~Parvovirus~~ 4	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: ~~Mckenna,~~ R]]	+	<div class="pdbe-citations 8ep9" style="background-color:#fffaf0;"></div>
-	[[Category: Mietzsch, M]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human parvovirus 4]]
		+	[[Category: Large Structures]]
		+	[[Category: McKenna R]]
		+	[[Category: Mietzsch M]]

OCA: Protected "8ep9" [edit=sysop:move=sysop]

2022-10-19T17:20:58Z

Protected "8ep9" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:20, 19 October 2022

OCA: New page: '''Unreleased structure''' The entry 8ep9 is ON HOLD Authors: Mietzsch, M., McKenna, R. Description: The capsid structure of Human Parvovirus 4 Category: Unreleased Structures [[Ca...

2022-10-19T17:20:57Z

New page: '''Unreleased structure''' The entry 8ep9 is ON HOLD Authors: Mietzsch, M., McKenna, R. Description: The capsid structure of Human Parvovirus 4 Category: Unreleased Structures [[Ca...

New page

'''Unreleased structure'''

The entry 8ep9 is ON HOLD

Authors: Mietzsch, M., McKenna, R.

Description: The capsid structure of Human Parvovirus 4
[[Category: Unreleased Structures]]
[[Category: Mckenna, R]]
[[Category: Mietzsch, M]]

8ep9 - Revision history

OCA at 07:36, 9 November 2022

OCA: Protected "8ep9" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8ep9 is ON HOLD Authors: Mietzsch, M., McKenna, R. Description: The capsid structure of Human Parvovirus 4 Category: Unreleased Structures [[Ca...