8erz - Revision history

OCA at 21:26, 28 June 2023

2023-06-28T21:26:08Z

←Older revision		Revision as of 21:26, 28 June 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8erz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ERZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ERZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[8erz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ERZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ERZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8erz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8erz OCA], [https://pdbe.org/8erz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8erz RCSB], [https://www.ebi.ac.uk/pdbsum/8erz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8erz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8erz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8erz OCA], [https://pdbe.org/8erz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8erz RCSB], [https://www.ebi.ac.uk/pdbsum/8erz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8erz ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:29, 7 April 2023

2023-04-07T06:29:55Z

←Older revision		Revision as of 06:29, 7 April 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8erz is ~~ON HOLD until Paper~~ Publication	+	==Backbone modifications in the inter-helix loop of designed miniprotein oPPalpha: Aib10Gly11 turn==
		+	<StructureSection load='8erz' size='340' side='right'caption='[[8erz]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8erz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ERZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ERZ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8erz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8erz OCA], [https://pdbe.org/8erz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8erz RCSB], [https://www.ebi.ac.uk/pdbsum/8erz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8erz ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The importance of beta-turns to protein folding has motivated extensive efforts to stabilize the motif with non-canonical backbone connectivity. Prior work has focused almost exclusively on turns between strands in a beta-sheet (i. e., hairpins). Turns in other structural contexts are also common in nature and have distinct conformational preferences; however, design principles for their mimicry remain poorly understood. Here, we report strategies that stabilize non-hairpin beta-turns through systematic evaluation of the impacts of backbone alteration on the high-resolution folded structure and folded stability of a helix-loop-helix prototype protein. Several well-established hairpin turn mimetics are shown detrimental to folded stability and/or hydrophobic core packing, while less-explored modification schemes that reinforce alternate turn types lead to improved stability and more faithful structural mimicry. Collectively, these results have implications in control over protein folding through chemical modification as well as the design of protein mimetics.

-	~~Authors~~: Harmon, T.W.~~, Horne, W~~.S.	+	Protein Backbone Alteration in Non-Hairpin beta-Turns: Impacts on Tertiary Folded Structure and Folded Stability.,Harmon TW, Horne WS Chembiochem. 2023 Mar 15:e202300113. doi: 10.1002/cbic.202300113. PMID:36920327<ref>PMID:36920327</ref>

-	~~Description: Backbone modifications in~~ the ~~inter-helix loop~~ of ~~designed miniprotein oPPalpha~~: ~~Aib10Gly11 turn~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: ~~Horne, W.S~~]]	+	<div class="pdbe-citations 8erz" style="background-color:#fffaf0;"></div>
-	[[Category: Harmon~~, T.W~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Streptococcus mutans]]
		+	[[Category: Harmon TW]]
		+	[[Category: Horne WS]]

OCA at 05:03, 9 November 2022

2022-11-09T05:03:38Z

←Older revision		Revision as of 05:03, 9 November 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8erz is ON HOLD	+	The entry 8erz is ON HOLD until Paper Publication

	Authors: Harmon, T.W., Horne, W.S.		Authors: Harmon, T.W., Horne, W.S.

OCA: Protected "8erz" [edit=sysop:move=sysop]

2022-10-19T17:31:07Z

Protected "8erz" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:31, 19 October 2022

OCA: New page: '''Unreleased structure''' The entry 8erz is ON HOLD Authors: Harmon, T.W., Horne, W.S. Description: Backbone modifications in the inter-helix loop of designed miniprotein oPPalpha: Ai...

2022-10-19T17:31:06Z

New page: '''Unreleased structure''' The entry 8erz is ON HOLD Authors: Harmon, T.W., Horne, W.S. Description: Backbone modifications in the inter-helix loop of designed miniprotein oPPalpha: Ai...

New page

'''Unreleased structure'''

The entry 8erz is ON HOLD

Authors: Harmon, T.W., Horne, W.S.

Description: Backbone modifications in the inter-helix loop of designed miniprotein oPPalpha: Aib10Gly11 turn
[[Category: Unreleased Structures]]
[[Category: Horne, W.S]]
[[Category: Harmon, T.W]]