8ewp - Revision history

OCA at 10:24, 25 October 2023

2023-10-25T10:24:40Z

←Older revision		Revision as of 10:24, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8ewp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EWP FirstGlance]. <br>		<table><tr><td colspan='2'>[[8ewp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EWP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=X2Q:{N-[([2,2-bipyridin]-5-yl-kappa~2~N~1~,N~1~)methyl]-3-(pyridin-4-yl)propanamide}bis[2-(quinolin-2-yl-kappaN)-1-benzothiophen-3-yl-kappaC~3~]iridium(1+)'>X2Q</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=X2Q:{N-[([2,2-bipyridin]-5-yl-kappa~2~N~1~,N~1~)methyl]-3-(pyridin-4-yl)propanamide}bis[2-(quinolin-2-yl-kappaN)-1-benzothiophen-3-yl-kappaC~3~]iridium(1+)'>X2Q</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ewp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ewp OCA], [https://pdbe.org/8ewp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ewp RCSB], [https://www.ebi.ac.uk/pdbsum/8ewp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ewp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ewp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ewp OCA], [https://pdbe.org/8ewp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ewp RCSB], [https://www.ebi.ac.uk/pdbsum/8ewp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ewp ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:23, 1 February 2023

2023-02-01T11:23:35Z

←Older revision		Revision as of 11:23, 1 February 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8ewp is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of CYP3A4 bound to an inhibitor==
-		+	<StructureSection load='8ewp' size='340' side='right'caption='[[8ewp]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8ewp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EWP FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=X2Q:{N-[([2,2-bipyridin]-5-yl-kappa~2~N~1~,N~1~)methyl]-3-(pyridin-4-yl)propanamide}bis[2-(quinolin-2-yl-kappaN)-1-benzothiophen-3-yl-kappaC~3~]iridium(1+)'>X2Q</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ewp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ewp OCA], [https://pdbe.org/8ewp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ewp RCSB], [https://www.ebi.ac.uk/pdbsum/8ewp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ewp ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CP3A4_HUMAN CP3A4_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.<ref>PMID:11159812</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Sevrioukova IF]]

OCA at 05:04, 9 November 2022

2022-11-09T05:04:37Z

←Older revision		Revision as of 05:04, 9 November 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8ewp is ON HOLD	+	The entry 8ewp is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8ewp" [edit=sysop:move=sysop]

2022-11-03T05:24:37Z

Protected "8ewp" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:24, 3 November 2022

OCA: New page: '''Unreleased structure''' The entry 8ewp is ON HOLD Authors: Description: Category: Unreleased Structures

2022-11-03T05:24:36Z

New page: '''Unreleased structure''' The entry 8ewp is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8ewp is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]