8f21 - Revision history

OCA at 05:54, 5 July 2023

2023-07-05T05:54:08Z

←Older revision		Revision as of 05:54, 5 July 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8f21]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F21 FirstGlance]. <br>		<table><tr><td colspan='2'>[[8f21]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F21 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f21 OCA], [https://pdbe.org/8f21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f21 RCSB], [https://www.ebi.ac.uk/pdbsum/8f21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f21 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 14.1Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f21 OCA], [https://pdbe.org/8f21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f21 RCSB], [https://www.ebi.ac.uk/pdbsum/8f21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f21 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 09:46, 21 June 2023

2023-06-21T09:46:34Z

←Older revision		Revision as of 09:46, 21 June 2023
Line 8:		Line 8:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/DEGP_ECOLI DEGP_ECOLI] DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. It degrades transiently denatured and unfolded proteins which accumulate in the periplasm following heat shock or other stress conditions. DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-specific proteolysis of folded proteins. Its proteolytic activity is essential for the survival of cells at elevated temperatures. It can degrade IciA, ada, casein, globin and PapA. DegP shares specificity with DegQ. DegP is also involved in the biogenesis of partially folded outer-membrane proteins (OMP).<ref>PMID:2180903</ref> <ref>PMID:8830688</ref> <ref>PMID:10319814</ref> <ref>PMID:18505836</ref> <ref>PMID:12730160</ref> <ref>PMID:18496527</ref>		[https://www.uniprot.org/uniprot/DEGP_ECOLI DEGP_ECOLI] DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. It degrades transiently denatured and unfolded proteins which accumulate in the periplasm following heat shock or other stress conditions. DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-specific proteolysis of folded proteins. Its proteolytic activity is essential for the survival of cells at elevated temperatures. It can degrade IciA, ada, casein, globin and PapA. DegP shares specificity with DegQ. DegP is also involved in the biogenesis of partially folded outer-membrane proteins (OMP).<ref>PMID:2180903</ref> <ref>PMID:8830688</ref> <ref>PMID:10319814</ref> <ref>PMID:18505836</ref> <ref>PMID:12730160</ref> <ref>PMID:18496527</ref>
		+
		+	==See Also==
		+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:16, 24 November 2022

2022-11-24T10:16:20Z

←Older revision		Revision as of 10:16, 24 November 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8f21 ~~is ON HOLD~~	+	==Structure of a 30mer DegP cage bound to the client protein hTRF1==
-		+	<StructureSection load='8f21' size='340' side='right'caption='[[8f21]], [[Resolution\|resolution]] 14.10Å' scene=''>
-	~~Authors~~: ~~Harkness~~, R.W., ~~Ripstein~~, Z.A., ~~Di Trani, J~~.M., ~~Kay, L~~.E.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8f21]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F21 FirstGlance]. <br>
-	~~Description~~: ~~Structure of a 30mer~~ DegP ~~cage bound~~ to ~~the client~~ protein ~~hTRF1~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f21 OCA], [https://pdbe.org/8f21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f21 RCSB], [https://www.ebi.ac.uk/pdbsum/8f21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f21 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: ~~Kay, L.E~~]]	+	== Function ==
-	[[Category: ~~Ripstein, Z.A~~]]	+	[https://www.uniprot.org/uniprot/DEGP_ECOLI DEGP_ECOLI] DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. It degrades transiently denatured and unfolded proteins which accumulate in the periplasm following heat shock or other stress conditions. DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-specific proteolysis of folded proteins. Its proteolytic activity is essential for the survival of cells at elevated temperatures. It can degrade IciA, ada, casein, globin and PapA. DegP shares specificity with DegQ. DegP is also involved in the biogenesis of partially folded outer-membrane proteins (OMP).<ref>PMID:2180903</ref> <ref>PMID:8830688</ref> <ref>PMID:10319814</ref> <ref>PMID:18505836</ref> <ref>PMID:12730160</ref> <ref>PMID:18496527</ref>
-	[[Category: Harkness~~, R.W~~]]	+	== References ==
-	[[Category: ~~Di Trani, J.M~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Escherichia coli K-12]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Di Trani JM]]
		+	[[Category: Harkness RW]]
		+	[[Category: Kay LE]]
		+	[[Category: Ripstein ZA]]

OCA: Protected "8f21" [edit=sysop:move=sysop]

2022-11-16T18:11:31Z

Protected "8f21" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:11, 16 November 2022

OCA: New page: '''Unreleased structure''' The entry 8f21 is ON HOLD Authors: Harkness, R.W., Ripstein, Z.A., Di Trani, J.M., Kay, L.E. Description: Structure of a 30mer DegP cage bound to the client ...

2022-11-16T18:11:29Z

New page: '''Unreleased structure''' The entry 8f21 is ON HOLD Authors: Harkness, R.W., Ripstein, Z.A., Di Trani, J.M., Kay, L.E. Description: Structure of a 30mer DegP cage bound to the client ...

New page

'''Unreleased structure'''

The entry 8f21 is ON HOLD

Authors: Harkness, R.W., Ripstein, Z.A., Di Trani, J.M., Kay, L.E.

Description: Structure of a 30mer DegP cage bound to the client protein hTRF1
[[Category: Unreleased Structures]]
[[Category: Kay, L.E]]
[[Category: Ripstein, Z.A]]
[[Category: Harkness, R.W]]
[[Category: Di Trani, J.M]]