OCA at 04:05, 25 May 2023

2023-05-25T04:05:01Z

←Older revision		Revision as of 04:05, 25 May 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8f2u is ~~ON HOLD until Paper~~ Publication	+	==Human CCC complex==
		+	<StructureSection load='8f2u' size='340' side='right'caption='[[8f2u]], [[Resolution\|resolution]] 3.53Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8f2u]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F2U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F2U FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f2u OCA], [https://pdbe.org/8f2u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f2u RCSB], [https://www.ebi.ac.uk/pdbsum/8f2u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f2u ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/COMD1_HUMAN COMD1_HUMAN] Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes.<ref>PMID:14685266</ref> <ref>PMID:15799966</ref> <ref>PMID:16573520</ref> <ref>PMID:17309234</ref> <ref>PMID:17183367</ref> <ref>PMID:20048074</ref> <ref>PMID:20595380</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Commander complex is required for endosomal recycling of diverse transmembrane cargos and is mutated in Ritscher-Schinzel syndrome. It comprises two sub-assemblies: Retriever composed of VPS35L, VPS26C, and VPS29; and the CCC complex which contains twelve subunits: COMMD1-COMMD10 and the coiled-coil domain-containing (CCDC) proteins CCDC22 and CCDC93. Combining X-ray crystallography, electron cryomicroscopy, and in silico predictions, we have assembled a complete structural model of Commander. Retriever is distantly related to the endosomal Retromer complex but has unique features preventing the shared VPS29 subunit from interacting with Retromer-associated factors. The COMMD proteins form a distinctive hetero-decameric ring stabilized by extensive interactions with CCDC22 and CCDC93. These adopt a coiled-coil structure that connects the CCC and Retriever assemblies and recruits a 16th subunit, DENND10, to form the complete Commander complex. The structure allows mapping of disease-causing mutations and reveals the molecular features required for the function of this evolutionarily conserved trafficking machinery.

-	~~Authors~~:	+	Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome.,Healy MD, McNally KE, Butkovic R, Chilton M, Kato K, Sacharz J, McConville C, Moody ERR, Shaw S, Planelles-Herrero VJ, Yadav SKN, Ross J, Borucu U, Palmer CS, Chen KE, Croll TI, Hall RJ, Caruana NJ, Ghai R, Nguyen THD, Heesom KJ, Saitoh S, Berger I, Schaffitzel C, Williams TA, Stroud DA, Derivery E, Collins BM, Cullen PJ Cell. 2023 May 11;186(10):2219-2237.e29. doi: 10.1016/j.cell.2023.04.003. PMID:37172566<ref>PMID:37172566</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8f2u" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Berger I]]
		+	[[Category: Berger-Schaffitzel C]]
		+	[[Category: Borucu U]]
		+	[[Category: Butkovic R]]
		+	[[Category: Caruana NJ]]
		+	[[Category: Chen K]]
		+	[[Category: Chilton M]]
		+	[[Category: Collins BM]]
		+	[[Category: Croll TI]]
		+	[[Category: Cullen PJ]]
		+	[[Category: Derivery E]]
		+	[[Category: Ghai R]]
		+	[[Category: Hall RJ]]
		+	[[Category: Healy MD]]
		+	[[Category: Heesom KJ]]
		+	[[Category: Kadapalakere SY]]
		+	[[Category: Kato K]]
		+	[[Category: McConville C]]
		+	[[Category: McNally KE]]
		+	[[Category: Moody ERR]]
		+	[[Category: Nguyen THD]]
		+	[[Category: Palmer CS]]
		+	[[Category: Planelles-Herrero VJ]]
		+	[[Category: Ross J]]
		+	[[Category: Sacharz J]]
		+	[[Category: Saitoh S]]
		+	[[Category: Shaw S]]
		+	[[Category: Stroud DA]]
		+	[[Category: Williams TA]]

OCA at 07:37, 14 December 2022

2022-12-14T07:37:06Z

←Older revision		Revision as of 07:37, 14 December 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8f2u is ON HOLD	+	The entry 8f2u is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8f2u" [edit=sysop:move=sysop]

2022-11-16T18:13:28Z

Protected "8f2u" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:13, 16 November 2022

OCA: New page: '''Unreleased structure''' The entry 8f2u is ON HOLD Authors: Description: Category: Unreleased Structures

2022-11-16T18:13:27Z

New page: '''Unreleased structure''' The entry 8f2u is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8f2u is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8f2u - Revision history

OCA at 04:05, 25 May 2023

OCA at 07:37, 14 December 2022

OCA: Protected "8f2u" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8f2u is ON HOLD Authors: Description: Category: Unreleased Structures