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8f5f - Revision history
2026-04-04T11:29:20Z
Revision history for this page on the wiki
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http://52.214.119.220/wiki/index.php?title=8f5f&diff=3799882&oldid=prev
OCA at 05:44, 5 July 2023
2023-07-05T05:44:22Z
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<td colspan='2' style="background-color: white; color:black;">Revision as of 05:44, 5 July 2023</td>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>'''Unreleased structure'''</div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">The entry </del>8f5f <del style="color: red; font-weight: bold; text-decoration: none;">is ON HOLD until Paper Publication</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">==human branched chain ketoacid dehydrogenase kinase in complex with inhibitors==</ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><StructureSection load='</ins>8f5f<ins style="color: red; font-weight: bold; text-decoration: none;">' size='340' side='right'caption='[[8f5f]], [[Resolution|resolution]] 3.15&Aring;' scene=''></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">Authors</del>: <del style="color: red; font-weight: bold; text-decoration: none;">Liu</del>, <del style="color: red; font-weight: bold; text-decoration: none;">S</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Roth Flach</del>, <del style="color: red; font-weight: bold; text-decoration: none;">R</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Bollinger</del>, <del style="color: red; font-weight: bold; text-decoration: none;">E</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Filikpski</del>, <del style="color: red; font-weight: bold; text-decoration: none;">F</del>.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">== Structural highlights ==</ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><table><tr><td colspan='2'>[[8f5f]] is a 2 chain structure with sequence from [https</ins>:<ins style="color: red; font-weight: bold; text-decoration: none;">//en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F5F FirstGlance]. <br></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">Description</del>: <del style="color: red; font-weight: bold; text-decoration: none;">human </del>branched chain ketoacid dehydrogenase kinase in <del style="color: red; font-weight: bold; text-decoration: none;">complex </del>with <del style="color: red; font-weight: bold; text-decoration: none;">inhibitors</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[[Resolution|Resolution]] 3</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">149&#8491;</td></tr></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Unreleased </del>Structures]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></ins>, <ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></ins>, <ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XGG:(2P)-2-[(4P)-4-{6-[(1-ethylcyclopropyl)methoxy]pyridin-3-yl}-1,3-thiazol-2-yl]benzoic+acid'>XGG</scene></td></tr></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Liu, S</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">org/fgij/fg.htm?mol=8f5f FirstGlance]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f5f OCA]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[https://pdbe</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">org/8f5f PDBe]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[https://www.rcsb.org/pdb/explore.do?structureId=8f5f RCSB]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[https://www</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">ebi.ac.uk/pdbsum/8f5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f5f ProSAT]</span></td></tr></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Roth Flach, R</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></table></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Filikpski, F</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">== Disease ==</ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Bollinger, E</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[https</ins>:<ins style="color: red; font-weight: bold; text-decoration: none;">//www.uniprot.org/uniprot/BCKD_HUMAN BCKD_HUMAN] Autism-epilepsy syndrome due to </ins>branched chain ketoacid dehydrogenase kinase <ins style="color: red; font-weight: bold; text-decoration: none;">deficiency. The disease is caused by variants affecting the gene represented </ins>in <ins style="color: red; font-weight: bold; text-decoration: none;">this entry. A diet enriched in branched amino acids (BCAAs) allows to normalize plasma BCAA levels. This suggests that it may be possible to treat patients </ins>with <ins style="color: red; font-weight: bold; text-decoration: none;">mutations in BCKDK with BCAA supplementation.</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">== Function ==</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[https://www.uniprot.org/uniprot/BCKD_HUMAN BCKD_HUMAN] Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.<ref>PMID:24449431</ref> </ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">== References ==</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><references/></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">__TOC__</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></StructureSection></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Homo sapiens]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[Category: Large </ins>Structures]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Bollinger E</ins>]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Filipski K</ins>]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Liu S</ins>]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Roth Flach R</ins>]]</div></td></tr>
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OCA
http://52.214.119.220/wiki/index.php?title=8f5f&diff=3689945&oldid=prev
OCA at 05:47, 28 December 2022
2022-12-28T05:47:01Z
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<td colspan='2' style="background-color: white; color:black;">Revision as of 05:47, 28 December 2022</td>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Unreleased structure'''</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Unreleased structure'''</div></td></tr>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>The entry 8f5f is ON HOLD </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The entry 8f5f is ON HOLD <ins style="color: red; font-weight: bold; text-decoration: none;"> until Paper Publication</ins></div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Authors: Liu, S., Roth Flach, R., Bollinger, E., Filikpski, F.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Authors: Liu, S., Roth Flach, R., Bollinger, E., Filikpski, F.</div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Description: human branched chain ketoacid dehydrogenase kinase in complex with inhibitors</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Description: human branched chain ketoacid dehydrogenase kinase in complex with inhibitors</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Unreleased Structures]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Unreleased Structures]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Filikpski, F]]</div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Liu, S]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Liu, S]]</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Roth Flach, R]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Roth Flach, R]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Filikpski, F]]</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Bollinger, E]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Bollinger, E]]</div></td></tr>
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OCA
http://52.214.119.220/wiki/index.php?title=8f5f&diff=3668165&oldid=prev
OCA: Protected "8f5f" [edit=sysop:move=sysop]
2022-11-24T08:13:25Z
<p>Protected "<a href="/wiki/index.php/8f5f" title="8f5f">8f5f</a>" [edit=sysop:move=sysop]</p>
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<td colspan='2' style="background-color: white; color:black;">Revision as of 08:13, 24 November 2022</td>
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OCA
http://52.214.119.220/wiki/index.php?title=8f5f&diff=3668164&oldid=prev
OCA: New page: '''Unreleased structure''' The entry 8f5f is ON HOLD Authors: Liu, S., Roth Flach, R., Bollinger, E., Filikpski, F. Description: human branched chain ketoacid dehydrogenase kinase in c...
2022-11-24T08:13:24Z
<p>New page: '''Unreleased structure''' The entry 8f5f is ON HOLD Authors: Liu, S., Roth Flach, R., Bollinger, E., Filikpski, F. Description: human branched chain ketoacid dehydrogenase kinase in c...</p>
<p><b>New page</b></p><div>'''Unreleased structure'''<br />
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The entry 8f5f is ON HOLD <br />
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Authors: Liu, S., Roth Flach, R., Bollinger, E., Filikpski, F.<br />
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Description: human branched chain ketoacid dehydrogenase kinase in complex with inhibitors<br />
[[Category: Unreleased Structures]]<br />
[[Category: Filikpski, F]]<br />
[[Category: Liu, S]]<br />
[[Category: Roth Flach, R]]<br />
[[Category: Bollinger, E]]</div>
OCA