OCA at 10:11, 14 December 2022

2022-12-14T10:11:58Z

←Older revision		Revision as of 10:11, 14 December 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8f7w ~~is ON HOLD~~	+	==Gi bound kappa-opioid receptor in complex with dynorphin==
-		+	<StructureSection load='8f7w' size='340' side='right'caption='[[8f7w]], [[Resolution\|resolution]] 3.19Å' scene=''>
-	~~Authors~~: ~~Wang, Y~~.~~, Zhuang, Y~~., ~~DiBerto, J~~.F., ~~Zhou, X~~.E.~~, Schmitz, G~~.P.~~, Yuan, Q~~., ~~Jain, M~~.K., ~~Liu, W~~., ~~Melcher, K~~., ~~Jiang, Y~~., ~~Roth, B~~.L., ~~Xu, H~~.E.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8f7w]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F7W FirstGlance]. <br>
-	~~Description~~: ~~Gi bound kappa~~-opioid receptor in ~~complex~~ with ~~dynorphin~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f7w OCA], [https://pdbe.org/8f7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f7w RCSB], [https://www.ebi.ac.uk/pdbsum/8f7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f7w ProSAT]</span></td></tr>
-	[[Category: ~~Zhou, X.E~~]]	+	</table>
-	[[Category: ~~Xu, H.E~~]]	+	== Function ==
-	[[Category: Jain~~, M.K~~]]	+	[https://www.uniprot.org/uniprot/OPRK_HUMAN OPRK_HUMAN] G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.<ref>PMID:12004055</ref> <ref>PMID:22437504</ref> <ref>PMID:7624359</ref> <ref>PMID:8060324</ref>
-	[[Category: ~~Melcher, K~~]]	+	== References ==
-	[[Category: Liu, W]]	+	<references/>
-	[[Category: ~~Diberto, J.F~~]]	+	__TOC__
-	[[Category: ~~Jiang, Y~~]]	+	</StructureSection>
-	[[Category: ~~Wang, Y~~]]	+	[[Category: Bos taurus]]
-	[[Category: ~~Zhuang,~~ Y]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Roth, B.L~~]]	+	[[Category: Large Structures]]
-	[[Category: Yuan, Q]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Schmitz, G.P~~]]	+	[[Category: Synthetic construct]]
		+	[[Category: DiBerto JF]]
		+	[[Category: Jain MK]]
		+	[[Category: Jiang Y]]
		+	[[Category: Liu W]]
		+	[[Category: Melcher K]]
		+	[[Category: Roth BL]]
		+	[[Category: Schmitz GP]]
		+	[[Category: Wang Y]]
		+	[[Category: Xu HE]]
		+	[[Category: Yuan Q]]
		+	[[Category: Zhou XE]]
		+	[[Category: Zhuang Y]]

OCA: Protected "8f7w" [edit=sysop:move=sysop]

2022-11-30T08:40:24Z

Protected "8f7w" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:40, 30 November 2022

OCA: New page: '''Unreleased structure''' The entry 8f7w is ON HOLD Authors: Wang, Y., Zhuang, Y., DiBerto, J.F., Zhou, X.E., Schmitz, G.P., Yuan, Q., Jain, M.K., Liu, W., Melcher, K., Jiang, Y., Roth...

2022-11-30T08:40:23Z

New page: '''Unreleased structure''' The entry 8f7w is ON HOLD Authors: Wang, Y., Zhuang, Y., DiBerto, J.F., Zhou, X.E., Schmitz, G.P., Yuan, Q., Jain, M.K., Liu, W., Melcher, K., Jiang, Y., Roth...

New page

'''Unreleased structure'''

The entry 8f7w is ON HOLD

Authors: Wang, Y., Zhuang, Y., DiBerto, J.F., Zhou, X.E., Schmitz, G.P., Yuan, Q., Jain, M.K., Liu, W., Melcher, K., Jiang, Y., Roth, B.L., Xu, H.E.

Description: Gi bound kappa-opioid receptor in complex with dynorphin
[[Category: Unreleased Structures]]
[[Category: Zhou, X.E]]
[[Category: Xu, H.E]]
[[Category: Jain, M.K]]
[[Category: Melcher, K]]
[[Category: Liu, W]]
[[Category: Diberto, J.F]]
[[Category: Jiang, Y]]
[[Category: Wang, Y]]
[[Category: Zhuang, Y]]
[[Category: Roth, B.L]]
[[Category: Yuan, Q]]
[[Category: Schmitz, G.P]]

8f7w - Revision history

OCA at 10:11, 14 December 2022

OCA: Protected "8f7w" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8f7w is ON HOLD Authors: Wang, Y., Zhuang, Y., DiBerto, J.F., Zhou, X.E., Schmitz, G.P., Yuan, Q., Jain, M.K., Liu, W., Melcher, K., Jiang, Y., Roth...