8fa3 - Revision history

OCA at 06:21, 6 September 2023

2023-09-06T06:21:25Z

←Older revision		Revision as of 06:21, 6 September 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8fa3 is ~~ON HOLD until Paper~~ Publication	+	==Structure of N-terminal of Schistosoma japonicum asparaginyl-tRNA synthetase==
		+	<StructureSection load='8fa3' size='340' side='right'caption='[[8fa3]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8fa3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_japonicum Schistosoma japonicum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FA3 FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fa3 OCA], [https://pdbe.org/8fa3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fa3 RCSB], [https://www.ebi.ac.uk/pdbsum/8fa3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fa3 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/C1LGM4_SCHJA C1LGM4_SCHJA]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Several secreted proteins from helminths (parasitic worms) have been shown to have immunomodulatory activities. Asparaginyl-tRNA synthetases are abundantly secreted in the filarial nematode Brugia malayi (BmAsnRS) and the parasitic flatworm Schistosoma japonicum (SjAsnRS), indicating a possible immune function. The suggestion is supported by BmAsnRS alleviating disease symptoms in a T-cell transfer mouse model of colitis. This immunomodulatory function is potentially related to an N-terminal extension domain present in eukaryotic AsnRS proteins but few structure/function studies have been done on this domain. Here we have determined the three-dimensional solution structure of the N-terminal extension domain of SjAsnRS. A protein containing the 114 N-terminal amino acids of SjAsnRS was recombinantly expressed with isotopic labelling to allow structure determination using 3D NMR spectroscopy, and analysis of dynamics using NMR relaxation experiments. Structural comparisons of the N-terminal extension domain of SjAsnRS with filarial and human homologues highlight a high degree of variability in the beta-hairpin region of these eukaryotic N-AsnRS proteins, but similarities in the disorder of the C-terminal regions. Limitations in PrDOS-based intrinsically disordered region (IDR) model predictions were also evident in this comparison. Empirical structural data such as that presented in our study for N-SjAsnRS will enhance the prediction of sequence-homology based structure modelling and prediction of IDRs in the future.Communicated by Ramaswamy H. Sarma.

-	~~Authors: Peck~~, Y., ~~Daly, N.L.~~, Mobli, M.	+	Solution structure of the N-terminal extension domain of a Schistosoma japonicum asparaginyl-tRNA synthetase.,Peck Y, Pickering D, Mobli M, Liddell MJ, Wilson DT, Ruscher R, Ryan S, Buitrago G, McHugh C, Love NC, Pinlac T, Haertlein M, Kron MA, Loukas A, Daly NL J Biomol Struct Dyn. 2023 Aug 12:1-11. doi: 10.1080/07391102.2023.2241918. PMID:37572327<ref>PMID:37572327</ref>

-	~~Description: Structure~~ of ~~N-terminal~~ of ~~Schistosoma japonicum asparaginyl~~-~~tRNA synthetase~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: ~~Daly, N.L~~]]	+	<div class="pdbe-citations 8fa3" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Peck, Y~~]]	+	== References ==
-	[[Category: Mobli, M]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Schistosoma japonicum]]
		+	[[Category: Daly NL]]
		+	[[Category: Mobli M]]
		+	[[Category: Peck Y]]

OCA at 07:05, 30 August 2023

2023-08-30T07:05:42Z

←Older revision		Revision as of 07:05, 30 August 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8fa3 is ON HOLD	+	The entry 8fa3 is ON HOLD until Paper Publication

	Authors: Peck, Y., Daly, N.L., Mobli, M.		Authors: Peck, Y., Daly, N.L., Mobli, M.

OCA at 08:50, 2 August 2023

2023-08-02T08:50:04Z

←Older revision		Revision as of 08:50, 2 August 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8fa3 is ON HOLD ~~until Paper Publication~~	+	The entry 8fa3 is ON HOLD

	Authors: Peck, Y., Daly, N.L., Mobli, M.		Authors: Peck, Y., Daly, N.L., Mobli, M.
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	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Daly, N.L]]		[[Category: Daly, N.L]]
-	[[Category: Mobli, M]]
	[[Category: Peck, Y]]		[[Category: Peck, Y]]
		+	[[Category: Mobli, M]]

OCA at 05:07, 8 February 2023

2023-02-08T05:07:46Z

←Older revision		Revision as of 05:07, 8 February 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8fa3 is ON HOLD	+	The entry 8fa3 is ON HOLD until Paper Publication

	Authors: Peck, Y., Daly, N.L., Mobli, M.		Authors: Peck, Y., Daly, N.L., Mobli, M.

OCA: Protected "8fa3" [edit=sysop:move=sysop]

2022-11-30T08:44:02Z

Protected "8fa3" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:44, 30 November 2022

OCA: New page: '''Unreleased structure''' The entry 8fa3 is ON HOLD Authors: Peck, Y., Daly, N.L., Mobli, M. Description: Structure of N-terminal of Schistosoma japonicum asparaginyl-tRNA synthetase ...

2022-11-30T08:44:01Z

New page: '''Unreleased structure''' The entry 8fa3 is ON HOLD Authors: Peck, Y., Daly, N.L., Mobli, M. Description: Structure of N-terminal of Schistosoma japonicum asparaginyl-tRNA synthetase ...

New page

'''Unreleased structure'''

The entry 8fa3 is ON HOLD

Authors: Peck, Y., Daly, N.L., Mobli, M.

Description: Structure of N-terminal of Schistosoma japonicum asparaginyl-tRNA synthetase
[[Category: Unreleased Structures]]
[[Category: Daly, N.L]]
[[Category: Mobli, M]]
[[Category: Peck, Y]]