OCA at 17:06, 26 April 2023

2023-04-26T17:06:39Z

←Older revision		Revision as of 17:06, 26 April 2023
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-	'''Unreleased structure'''

-	The entry ~~8flq~~ is ~~ON HOLD~~ ~~until 2024~~-12-22	+	==Human PTH1R in complex with PTH(1-34) and Gs==
-		+	<StructureSection load='8flq' size='340' side='right'caption='[[8flq]], [[Resolution\|resolution]] 2.55Å' scene=''>
-	~~Authors:~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8flq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FLQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FLQ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8flq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8flq OCA], [https://pdbe.org/8flq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8flq RCSB], [https://www.ebi.ac.uk/pdbsum/8flq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8flq ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/GNAS2_HUMAN GNAS2_HUMAN] Pseudopseudohypoparathyroidism;Pseudohypoparathyroidism type 1A;Progressive osseous heteroplasia;Polyostotic fibrous dysplasia;Monostotic fibrous dysplasia;Pseudohypoparathyroidism type 1C;Pseudohypoparathyroidism type 1B;McCune-Albright syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Most affected individuals have defects in methylation of the gene. In some cases microdeletions involving the STX16 appear to cause loss of methylation at exon A/B of GNAS, resulting in PHP1B. Paternal uniparental isodisomy have also been observed. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GNAS2_HUMAN GNAS2_HUMAN] Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161).<ref>PMID:12391161</ref> <ref>PMID:17110384</ref> <ref>PMID:21488135</ref> <ref>PMID:26206488</ref> <ref>PMID:8702665</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Lama glama]]
		+	[[Category: Large Structures]]
		+	[[Category: Belousoff MJ]]
		+	[[Category: Cary BP]]
		+	[[Category: Piper SJ]]
		+	[[Category: Sexton PM]]
		+	[[Category: Wootten D]]

OCA at 09:21, 1 February 2023

2023-02-01T09:21:46Z

←Older revision		Revision as of 09:21, 1 February 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8flq is ON HOLD	+	The entry 8flq is ON HOLD until 2024-12-22

	Authors:		Authors:

OCA: Protected "8flq" [edit=sysop:move=sysop]

2022-12-28T06:12:38Z

Protected "8flq" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:12, 28 December 2022

OCA: New page: '''Unreleased structure''' The entry 8flq is ON HOLD Authors: Description: Category: Unreleased Structures

2022-12-28T06:12:35Z

New page: '''Unreleased structure''' The entry 8flq is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8flq is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8flq - Revision history

OCA at 17:06, 26 April 2023

OCA at 09:21, 1 February 2023

OCA: Protected "8flq" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8flq is ON HOLD Authors: Description: Category: Unreleased Structures