OCA at 21:19, 28 June 2023

2023-06-28T21:19:03Z

←Older revision		Revision as of 21:19, 28 June 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8fql is ~~ON HOLD until Paper~~ Publication	+	==Portal vertex of HK97 phage==
		+	<StructureSection load='8fql' size='340' side='right'caption='[[8fql]], [[Resolution\|resolution]] 3.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8fql]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_HK97 Escherichia phage HK97]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FQL FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.6Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fql OCA], [https://pdbe.org/8fql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fql RCSB], [https://www.ebi.ac.uk/pdbsum/8fql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fql ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PORTL_BPHK7 PORTL_BPHK7] Forms the portal vertex of the capsid. This portal plays critical roles in head assembly, genome packaging, neck/tail attachment, and genome ejection. The portal protein multimerizes as a single ring-shaped homododecamer arranged around a central channel. Binds to the terminase subunits to form the packaging machine.[UniProtKB:P25480]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tailed bacteriophages and herpesviruses use a transient scaffold to assemble icosahedral capsids with hexameric capsomers on the faces and pentameric capsomers at all but one vertex where a 12-fold portal is thought to nucleate the assembly. How does the scaffold orchestrate this step? We have determined the portal vertex structure of the bacteriophage HK97 procapsid, where the scaffold is a domain of the major capsid protein. The scaffold forms rigid helix-turn-strand structures on the interior surfaces of all capsomers and is further stabilized around the portal, forming trimeric coiled-coil towers, two per surrounding capsomer. These 10 towers bind identically to 10 of 12 portal subunits, adopting a pseudo-12-fold organization that explains how the symmetry mismatch is managed at this early step.

-	~~Authors~~: ~~Huet~~, A., Oh, B., Maurer, J., Duda, R.L.~~, Conway, J~~.F.	+	A symmetry mismatch unraveled: How phage HK97 scaffold flexibly accommodates a 12-fold pore at a 5-fold viral capsid vertex.,Huet A, Oh B, Maurer J, Duda RL, Conway JF Sci Adv. 2023 Jun 16;9(24):eadg8868. doi: 10.1126/sciadv.adg8868. Epub 2023 Jun , 16. PMID:37327331<ref>PMID:37327331</ref>

-	~~Description: Portal vertex~~ of ~~HK97 phage~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Maurer, J~~]]	+	<div class="pdbe-citations 8fql" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Oh, B~~]]	+	== References ==
-	[[Category: Duda~~, R.L~~]]	+	<references/>
-	[[Category: Huet, A]]	+	__TOC__
-	[[Category: ~~Conway,~~ J.F]]	+	</StructureSection>
		+	[[Category: Escherichia phage HK97]]
		+	[[Category: Large Structures]]
		+	[[Category: Conway JF]]
		+	[[Category: Duda RL]]
		+	[[Category: Huet A]]
		+	[[Category: Maurer J]]
		+	[[Category: Oh B]]

OCA at 08:42, 15 February 2023

2023-02-15T08:42:36Z

←Older revision		Revision as of 08:42, 15 February 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8fql is ON HOLD	+	The entry 8fql is ON HOLD until Paper Publication

	Authors: Huet, A., Oh, B., Maurer, J., Duda, R.L., Conway, J.F.		Authors: Huet, A., Oh, B., Maurer, J., Duda, R.L., Conway, J.F.
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	Description: Portal vertex of HK97 phage		Description: Portal vertex of HK97 phage
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Maurer, J]]
	[[Category: Oh, B]]		[[Category: Oh, B]]
	[[Category: Duda, R.L]]		[[Category: Duda, R.L]]
	[[Category: Huet, A]]		[[Category: Huet, A]]
	[[Category: Conway, J.F]]		[[Category: Conway, J.F]]
-	[[Category: Maurer, J]]

OCA: Protected "8fql" [edit=sysop:move=sysop]

2023-01-18T05:08:47Z

Protected "8fql" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:08, 18 January 2023

OCA: New page: '''Unreleased structure''' The entry 8fql is ON HOLD Authors: Huet, A., Oh, B., Maurer, J., Duda, R.L., Conway, J.F. Description: Portal vertex of HK97 phage [[Category: Unreleased Str...

2023-01-18T05:08:45Z

New page: '''Unreleased structure''' The entry 8fql is ON HOLD Authors: Huet, A., Oh, B., Maurer, J., Duda, R.L., Conway, J.F. Description: Portal vertex of HK97 phage [[Category: Unreleased Str...

New page

'''Unreleased structure'''

The entry 8fql is ON HOLD

Authors: Huet, A., Oh, B., Maurer, J., Duda, R.L., Conway, J.F.

Description: Portal vertex of HK97 phage
[[Category: Unreleased Structures]]
[[Category: Oh, B]]
[[Category: Duda, R.L]]
[[Category: Huet, A]]
[[Category: Conway, J.F]]
[[Category: Maurer, J]]

8fql - Revision history

OCA at 21:19, 28 June 2023

OCA at 08:42, 15 February 2023

OCA: Protected "8fql" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8fql is ON HOLD Authors: Huet, A., Oh, B., Maurer, J., Duda, R.L., Conway, J.F. Description: Portal vertex of HK97 phage [[Category: Unreleased Str...