OCA at 11:25, 24 January 2024

2024-01-24T11:25:25Z

←Older revision		Revision as of 11:25, 24 January 2024
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-	'''Unreleased structure'''

-	~~The entry 8fta is ON HOLD until Paper Publication~~	+	==Crystal Structure of the second bromodomain of human Polybromo-1 (PB1) in complex with compound 16==
-		+	<StructureSection load='8fta' size='340' side='right'caption='[[8fta]], [[Resolution\|resolution]] 1.78Å' scene=''>
-	~~Authors: Nunez, R., Smith, B.C.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8fta]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FTA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FTA FirstGlance]. <br>
-	~~Description:~~ Crystal Structure of the second bromodomain of human Polybromo-1 (PB1) in complex with compound 16	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.78Å</td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Y8X:(2S)-5-chloro-2-(3-methylphenyl)-2,3-dihydroquinazolin-4(1H)-one'>Y8X</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[~~Category~~: ~~Smith~~, B.C]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fta OCA], [https://pdbe.org/8fta PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fta RCSB], [https://www.ebi.ac.uk/pdbsum/8fta PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fta ProSAT]</span></td></tr>
-	[[Category: Nunez, R]]	+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[https://omim.org/entry/144700 144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Nunez R]]
		+	[[Category: Smith BC]]

OCA at 08:43, 15 February 2023

2023-02-15T08:43:33Z

←Older revision		Revision as of 08:43, 15 February 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8fta is ON HOLD	+	The entry 8fta is ON HOLD until Paper Publication

	Authors: Nunez, R., Smith, B.C.		Authors: Nunez, R., Smith, B.C.

OCA: Protected "8fta" [edit=sysop:move=sysop]

2023-01-18T05:15:30Z

Protected "8fta" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:15, 18 January 2023

OCA: New page: '''Unreleased structure''' The entry 8fta is ON HOLD Authors: Nunez, R., Smith, B.C. Description: Crystal Structure of the second bromodomain of human Polybromo-1 (PB1) in complex with...

2023-01-18T05:15:29Z

New page: '''Unreleased structure''' The entry 8fta is ON HOLD Authors: Nunez, R., Smith, B.C. Description: Crystal Structure of the second bromodomain of human Polybromo-1 (PB1) in complex with...

New page

'''Unreleased structure'''

The entry 8fta is ON HOLD

Authors: Nunez, R., Smith, B.C.

Description: Crystal Structure of the second bromodomain of human Polybromo-1 (PB1) in complex with compound 16
[[Category: Unreleased Structures]]
[[Category: Smith, B.C]]
[[Category: Nunez, R]]

8fta - Revision history

OCA at 11:25, 24 January 2024

OCA at 08:43, 15 February 2023

OCA: Protected "8fta" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8fta is ON HOLD Authors: Nunez, R., Smith, B.C. Description: Crystal Structure of the second bromodomain of human Polybromo-1 (PB1) in complex with...