8g8d - Revision history

OCA at 19:49, 29 May 2024

2024-05-29T19:49:09Z

←Older revision		Revision as of 19:49, 29 May 2024
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g8d OCA], [https://pdbe.org/8g8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g8d RCSB], [https://www.ebi.ac.uk/pdbsum/8g8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g8d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g8d OCA], [https://pdbe.org/8g8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g8d RCSB], [https://www.ebi.ac.uk/pdbsum/8g8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g8d ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A critical roadblock to HIV vaccine development is the inability to induce B cell lineages of broadly neutralizing antibodies (bnAbs) in humans. In people living with HIV-1, bnAbs take years to develop. The HVTN 133 clinical trial studied a peptide/liposome immunogen targeting B cell lineages of HIV-1 envelope (Env) membrane-proximal external region (MPER) bnAbs (NCT03934541). Here, we report MPER peptide-liposome induction of polyclonal HIV-1 B cell lineages of mature bnAbs and their precursors, the most potent of which neutralized 15% of global tier 2 HIV-1 strains and 35% of clade B strains with lineage initiation after the second immunization. Neutralization was enhanced by vaccine selection of improbable mutations that increased antibody binding to gp41 and lipids. This study demonstrates proof of concept for rapid vaccine induction of human B cell lineages with heterologous neutralizing activity and selection of antibody improbable mutations and outlines a path for successful HIV-1 vaccine development.
		+
		+	Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans.,Williams WB, Alam SM, Ofek G, Erdmann N, Montefiori DC, Seaman MS, Wagh K, Korber B, Edwards RJ, Mansouri K, Eaton A, Cain DW, Martin M, Hwang J, Arus-Altuz A, Lu X, Cai F, Jamieson N, Parks R, Barr M, Foulger A, Anasti K, Patel P, Sammour S, Parsons RJ, Huang X, Lindenberger J, Fetics S, Janowska K, Niyongabo A, Janus BM, Astavans A, Fox CB, Mohanty I, Evangelous T, Chen Y, Berry M, Kirshner H, Van Itallie E, Saunders KO, Wiehe K, Cohen KW, McElrath MJ, Corey L, Acharya P, Walsh SR, Baden LR, Haynes BF Cell. 2024 May 14:S0092-8674(24)00459-8. doi: 10.1016/j.cell.2024.04.033. PMID:38761800<ref>PMID:38761800</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 8g8d" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:01, 22 May 2024

2024-05-22T08:01:33Z

←Older revision		Revision as of 08:01, 22 May 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8g8d is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of DH1346 Fab in complex with HIV proximal MPER peptide==
-		+	<StructureSection load='8g8d' size='340' side='right'caption='[[8g8d]], [[Resolution\|resolution]] 2.02Å' scene=''>
-	~~Authors~~: ~~Niyongabo~~, A., ~~Janus~~, B.M., ~~Ofek~~, G.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8g8d]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G8D FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of DH1346 Fab in complex with HIV proximal MPER peptide~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.02Å</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F:FLUORIDE+ION'>F</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	[[Category: ~~Ofek, G~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g8d OCA], [https://pdbe.org/8g8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g8d RCSB], [https://www.ebi.ac.uk/pdbsum/8g8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g8d ProSAT]</span></td></tr>
-	[[Category: Janus~~, B.M~~]]	+	</table>
-	[[Category: Niyongabo, A]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Human immunodeficiency virus 1]]
		+	[[Category: Large Structures]]
		+	[[Category: Janus BM]]
		+	[[Category: Niyongabo A]]
		+	[[Category: Ofek G]]

OCA at 18:36, 12 April 2023

2023-04-12T18:36:54Z

←Older revision		Revision as of 18:36, 12 April 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8g8d is ON HOLD	+	The entry 8g8d is ON HOLD until Paper Publication

	Authors: Niyongabo, A., Janus, B.M., Ofek, G.		Authors: Niyongabo, A., Janus, B.M., Ofek, G.

OCA at 05:45, 8 March 2023

2023-03-08T05:45:08Z

←Older revision		Revision as of 05:45, 8 March 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8g8d is ON HOLD ~~until sometime in the future~~	+	The entry 8g8d is ON HOLD

	Authors: Niyongabo, A., Janus, B.M., Ofek, G.		Authors: Niyongabo, A., Janus, B.M., Ofek, G.

OCA: Protected "8g8d" [edit=sysop:move=sysop]

2023-03-02T04:30:28Z

Protected "8g8d" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:30, 2 March 2023

OCA: New page: '''Unreleased structure''' The entry 8g8d is ON HOLD until sometime in the future Authors: Niyongabo, A., Janus, B.M., Ofek, G. Description: Crystal structure of DH1346 Fab in complex ...

2023-03-02T04:30:27Z

New page: '''Unreleased structure''' The entry 8g8d is ON HOLD until sometime in the future Authors: Niyongabo, A., Janus, B.M., Ofek, G. Description: Crystal structure of DH1346 Fab in complex ...

New page

'''Unreleased structure'''

The entry 8g8d is ON HOLD until sometime in the future

Authors: Niyongabo, A., Janus, B.M., Ofek, G.

Description: Crystal structure of DH1346 Fab in complex with HIV proximal MPER peptide
[[Category: Unreleased Structures]]
[[Category: Ofek, G]]
[[Category: Janus, B.M]]
[[Category: Niyongabo, A]]