8hrj - Revision history

OCA at 10:02, 20 December 2023

2023-12-20T10:02:01Z

←Older revision		Revision as of 10:02, 20 December 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8hrj is ~~ON HOLD until Paper Publication~~	+	==SARS-CoV-2 Delta variant spike protein==
-		+	<StructureSection load='8hrj' size='340' side='right'caption='[[8hrj]], [[Resolution\|resolution]] 3.10Å' scene=''>
-	~~Authors~~: Xu, J., ~~Cheng~~, H., ~~Liu, N~~., ~~Wang, H~~.W.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8hrj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HRJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HRJ FirstGlance]. <br>
-	~~Description~~: ~~SARS~~-~~CoV-2 Delta variant spike~~ protein	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.1Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hrj OCA], [https://pdbe.org/8hrj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hrj RCSB], [https://www.ebi.ac.uk/pdbsum/8hrj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hrj ProSAT]</span></td></tr>
-	[[Category: ~~Liu, N~~]]	+	</table>
-	[[Category: ~~Wang,~~ H.W]]	+	== Function ==
-	[[Category: ~~Xu, J~~]]	+	[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
-	[[Category: ~~Cheng, H~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Cheng H]]
		+	[[Category: Liu N]]
		+	[[Category: Wang HW]]
		+	[[Category: Xu J]]

OCA at 04:44, 27 September 2023

2023-09-27T04:44:51Z

←Older revision		Revision as of 04:44, 27 September 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8hrj is ON HOLD	+	The entry 8hrj is ON HOLD until Paper Publication

	Authors: Xu, J., Cheng, H., Liu, N., Wang, H.W.		Authors: Xu, J., Cheng, H., Liu, N., Wang, H.W.
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	Description: SARS-CoV-2 Delta variant spike protein		Description: SARS-CoV-2 Delta variant spike protein
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Liu, N]]
	[[Category: Wang, H.W]]		[[Category: Wang, H.W]]
	[[Category: Xu, J]]		[[Category: Xu, J]]
-	[[Category: Liu, N]]
	[[Category: Cheng, H]]		[[Category: Cheng, H]]

OCA at 05:23, 3 May 2023

2023-05-03T05:23:35Z

←Older revision		Revision as of 05:23, 3 May 2023
Line 3:		Line 3:
	The entry 8hrj is ON HOLD		The entry 8hrj is ON HOLD

-	Authors: Xu, J., Cheng, H., Liu, N., Wang, H.-W.	+	Authors: Xu, J., Cheng, H., Liu, N., Wang, H.W.

	Description: SARS-CoV-2 Delta variant spike protein		Description: SARS-CoV-2 Delta variant spike protein
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Wang, H.W]]
	[[Category: Xu, J]]		[[Category: Xu, J]]
-	[[Category: Wang, H.-W]]
	[[Category: Liu, N]]		[[Category: Liu, N]]
	[[Category: Cheng, H]]		[[Category: Cheng, H]]

OCA: Protected "8hrj" [edit=sysop:move=sysop]

2022-12-21T07:17:28Z

Protected "8hrj" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:17, 21 December 2022

OCA: New page: '''Unreleased structure''' The entry 8hrj is ON HOLD Authors: Xu, J., Cheng, H., Liu, N., Wang, H.-W. Description: SARS-CoV-2 Delta variant spike protein [[Category: Unreleased Structu...

2022-12-21T07:17:23Z

New page: '''Unreleased structure''' The entry 8hrj is ON HOLD Authors: Xu, J., Cheng, H., Liu, N., Wang, H.-W. Description: SARS-CoV-2 Delta variant spike protein [[Category: Unreleased Structu...

New page

'''Unreleased structure'''

The entry 8hrj is ON HOLD

Authors: Xu, J., Cheng, H., Liu, N., Wang, H.-W.

Description: SARS-CoV-2 Delta variant spike protein
[[Category: Unreleased Structures]]
[[Category: Xu, J]]
[[Category: Wang, H.-W]]
[[Category: Liu, N]]
[[Category: Cheng, H]]