8hz2 - Revision history

OCA at 19:52, 29 May 2024

2024-05-29T19:52:16Z

←Older revision		Revision as of 19:52, 29 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8hz2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HZ2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[8hz2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HZ2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hz2 OCA], [https://pdbe.org/8hz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hz2 RCSB], [https://www.ebi.ac.uk/pdbsum/8hz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hz2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hz2 OCA], [https://pdbe.org/8hz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hz2 RCSB], [https://www.ebi.ac.uk/pdbsum/8hz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hz2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/TRAF6_HUMAN TRAF6_HUMAN] E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation.<ref>PMID:8837778</ref> <ref>PMID:11057907</ref> <ref>PMID:16378096</ref> <ref>PMID:17135271</ref> <ref>PMID:18093978</ref> <ref>PMID:18758450</ref> <ref>PMID:19675569</ref> <ref>PMID:19713527</ref> <ref>PMID:12140561</ref> <ref>PMID:19465916</ref>		[https://www.uniprot.org/uniprot/TRAF6_HUMAN TRAF6_HUMAN] E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation.<ref>PMID:8837778</ref> <ref>PMID:11057907</ref> <ref>PMID:16378096</ref> <ref>PMID:17135271</ref> <ref>PMID:18093978</ref> <ref>PMID:18758450</ref> <ref>PMID:19675569</ref> <ref>PMID:19713527</ref> <ref>PMID:12140561</ref> <ref>PMID:19465916</ref>
		+
		+	==See Also==
		+	*[[TNF receptor-associated factor 3D structures\|TNF receptor-associated factor 3D structures]]
		+	*[[Tumor necrosis factor receptor 3D structures\|Tumor necrosis factor receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:38, 25 January 2023

2023-01-25T06:38:57Z

←Older revision		Revision as of 06:38, 25 January 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8hz2 is ~~ON HOLD~~	+	==Tumor Necrosis Factor Receptor Associated Factor 6 (TRAF6) N-terminal Domain==
-		+	<StructureSection load='8hz2' size='340' side='right'caption='[[8hz2]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~Authors~~: ~~Guven~~, O., ~~Ciftci~~, H., ~~DeMirci~~, H.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8hz2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HZ2 FirstGlance]. <br>
-	~~Description~~: ~~Tumor Necrosis Factor Receptor Associated Factor 6~~ (~~TRAF6~~) N-~~terminal Domain~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hz2 OCA], [https://pdbe.org/8hz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hz2 RCSB], [https://www.ebi.ac.uk/pdbsum/8hz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hz2 ProSAT]</span></td></tr>
-	[[Category: ~~Guven, O~~]]	+	</table>
-	[[Category: Ciftci, H]]	+	== Function ==
-	[[Category: ~~Demirci,~~ H]]	+	[https://www.uniprot.org/uniprot/TRAF6_HUMAN TRAF6_HUMAN] E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation.<ref>PMID:8837778</ref> <ref>PMID:11057907</ref> <ref>PMID:16378096</ref> <ref>PMID:17135271</ref> <ref>PMID:18093978</ref> <ref>PMID:18758450</ref> <ref>PMID:19675569</ref> <ref>PMID:19713527</ref> <ref>PMID:12140561</ref> <ref>PMID:19465916</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Ciftci H]]
		+	[[Category: DeMirci H]]
		+	[[Category: Guven O]]

OCA: Protected "8hz2" [edit=sysop:move=sysop]

2023-01-18T05:23:25Z

Protected "8hz2" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:23, 18 January 2023

OCA: New page: '''Unreleased structure''' The entry 8hz2 is ON HOLD Authors: Guven, O., Ciftci, H., DeMirci, H. Description: Tumor Necrosis Factor Receptor Associated Factor 6 (TRAF6) N-terminal Doma...

2023-01-18T05:23:22Z

New page: '''Unreleased structure''' The entry 8hz2 is ON HOLD Authors: Guven, O., Ciftci, H., DeMirci, H. Description: Tumor Necrosis Factor Receptor Associated Factor 6 (TRAF6) N-terminal Doma...

New page

'''Unreleased structure'''

The entry 8hz2 is ON HOLD

Authors: Guven, O., Ciftci, H., DeMirci, H.

Description: Tumor Necrosis Factor Receptor Associated Factor 6 (TRAF6) N-terminal Domain
[[Category: Unreleased Structures]]
[[Category: Guven, O]]
[[Category: Ciftci, H]]
[[Category: Demirci, H]]