OCA at 09:12, 30 August 2023

2023-08-30T09:12:16Z

←Older revision		Revision as of 09:12, 30 August 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8ihh is ~~ON HOLD until Paper Publication~~	+	==Cryo-EM structure of HCA2-Gi complex with LUF6283==
-		+	<StructureSection load='8ihh' size='340' side='right'caption='[[8ihh]], [[Resolution\|resolution]] 3.06Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8ihh]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IHH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IHH FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.06Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P8A:5-butyl-1~{H}-pyrazole-3-carboxylic+acid'>P8A</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ihh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ihh OCA], [https://pdbe.org/8ihh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ihh RCSB], [https://www.ebi.ac.uk/pdbsum/8ihh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ihh ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/HCAR2_HUMAN HCAR2_HUMAN] Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.<ref>PMID:17932499</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Escherichia coli]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Synthetic construct]]
		+	[[Category: Fujiyoshi Y]]
		+	[[Category: Nishikawa K]]
		+	[[Category: Suzuki H]]
		+	[[Category: Suzuki S]]

OCA at 19:37, 28 June 2023

2023-06-28T19:37:33Z

←Older revision		Revision as of 19:37, 28 June 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8ihh is ON HOLD	+	The entry 8ihh is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 04:11, 7 June 2023

2023-06-07T04:11:46Z

←Older revision		Revision as of 04:11, 7 June 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8ihh is ON HOLD ~~until Paper Publication~~	+	The entry 8ihh is ON HOLD

	Authors:		Authors:

OCA at 08:04, 15 March 2023

2023-03-15T08:04:26Z

←Older revision		Revision as of 08:04, 15 March 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8ihh is ON HOLD	+	The entry 8ihh is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8ihh" [edit=sysop:move=sysop]

2023-03-02T04:43:32Z

Protected "8ihh" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:43, 2 March 2023

OCA: New page: '''Unreleased structure''' The entry 8ihh is ON HOLD Authors: Description: Category: Unreleased Structures

2023-03-02T04:43:31Z

New page: '''Unreleased structure''' The entry 8ihh is ON HOLD Authors: Description: Category: Unreleased Structures

New page