OCA at 08:02, 22 May 2024

2024-05-22T08:02:36Z

←Older revision		Revision as of 08:02, 22 May 2024
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-	'''Unreleased structure'''

-	The entry ~~8jpp~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Cryo-EM structure of succinate receptor bound to succinate acid coupling MiniGsq==
-		+	<StructureSection load='8jpp' size='340' side='right'caption='[[8jpp]], [[Resolution\|resolution]] 3.20Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8jpp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Oplophorus_gracilirostris Oplophorus gracilirostris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JPP FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.2Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jpp OCA], [https://pdbe.org/8jpp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jpp RCSB], [https://www.ebi.ac.uk/pdbsum/8jpp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jpp ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/GNAS2_HUMAN GNAS2_HUMAN] Pseudopseudohypoparathyroidism;Pseudohypoparathyroidism type 1A;Progressive osseous heteroplasia;Polyostotic fibrous dysplasia;Monostotic fibrous dysplasia;Pseudohypoparathyroidism type 1C;Pseudohypoparathyroidism type 1B;McCune-Albright syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Most affected individuals have defects in methylation of the gene. In some cases microdeletions involving the STX16 appear to cause loss of methylation at exon A/B of GNAS, resulting in PHP1B. Paternal uniparental isodisomy have also been observed. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GNAS2_HUMAN GNAS2_HUMAN] Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161).<ref>PMID:12391161</ref> <ref>PMID:17110384</ref> <ref>PMID:21488135</ref> <ref>PMID:26206488</ref> <ref>PMID:8702665</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Escherichia coli]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Oplophorus gracilirostris]]
		+	[[Category: Li FH]]
		+	[[Category: Tang WQ]]
		+	[[Category: Wang JY]]
		+	[[Category: Wang TX]]

OCA at 06:23, 10 April 2024

2024-04-10T06:23:59Z

←Older revision		Revision as of 06:23, 10 April 2024
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8jpp is ON HOLD	+	The entry 8jpp is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 09:00, 27 March 2024

2024-03-27T09:00:26Z

←Older revision		Revision as of 09:00, 27 March 2024
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8jpp is ON HOLD ~~until Paper Publication~~	+	The entry 8jpp is ON HOLD

	Authors:		Authors:

OCA at 10:31, 1 February 2024

2024-02-01T10:31:32Z

←Older revision		Revision as of 10:31, 1 February 2024
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8jpp is ON HOLD	+	The entry 8jpp is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 10:07, 24 January 2024

2024-01-24T10:07:48Z

←Older revision		Revision as of 10:07, 24 January 2024
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8jpp is ON HOLD ~~until Paper Publication~~	+	The entry 8jpp is ON HOLD

	Authors:		Authors:

OCA at 04:39, 19 July 2023

2023-07-19T04:39:07Z

←Older revision		Revision as of 04:39, 19 July 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8jpp is ON HOLD	+	The entry 8jpp is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8jpp" [edit=sysop:move=sysop]

2023-06-21T08:06:19Z

Protected "8jpp" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:06, 21 June 2023

OCA: New page: '''Unreleased structure''' The entry 8jpp is ON HOLD Authors: Description: Category: Unreleased Structures

2023-06-21T08:06:18Z

New page: '''Unreleased structure''' The entry 8jpp is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8jpp is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8jpp - Revision history