OCA at 09:38, 1 March 2024

2024-03-01T09:38:17Z

←Older revision		Revision as of 09:38, 1 March 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8jt8 is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of 5-HT2AR in complex with (R)-IHCH-7179==
-		+	<StructureSection load='8jt8' size='340' side='right'caption='[[8jt8]], [[Resolution\|resolution]] 2.70Å' scene=''>
-	~~Authors~~: ~~Chen~~, Z., ~~Fan~~, L., ~~Wang~~, S.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8jt8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JT8 FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of 5-~~HT2AR in complex with~~ (R)-~~IHCH~~-~~7179~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=EZX:1-(4-fluorophenyl)-4-[(7R)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one'>EZX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	[[Category: Chen, Z]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jt8 OCA], [https://pdbe.org/8jt8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jt8 RCSB], [https://www.ebi.ac.uk/pdbsum/8jt8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jt8 ProSAT]</span></td></tr>
-	[[Category: ~~Wang, S~~]]	+	</table>
-	[[Category: ~~Fan, L~~]]	+	== Function ==
		+	[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/5HT2A_HUMAN 5HT2A_HUMAN] G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:28129538). Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores (PubMed:18703043, PubMed:28129538). Affects neural activity, perception, cognition and mood (PubMed:18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.<ref>PMID:1330647</ref> <ref>PMID:18297054</ref> <ref>PMID:18703043</ref> <ref>PMID:19057895</ref> <ref>PMID:21645528</ref> <ref>PMID:22300836</ref> <ref>PMID:28129538</ref> (Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV.<ref>PMID:24089568</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Escherichia coli]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Chen Z]]
		+	[[Category: Fan L]]
		+	[[Category: Wang S]]

OCA at 08:53, 2 August 2023

2023-08-02T08:53:07Z

←Older revision		Revision as of 08:53, 2 August 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8jt8 is ON HOLD	+	The entry 8jt8 is ON HOLD until Paper Publication

	Authors: Chen, Z., Fan, L., Wang, S.		Authors: Chen, Z., Fan, L., Wang, S.

OCA: Protected "8jt8" [edit=sysop:move=sysop]

2023-06-28T19:45:28Z

Protected "8jt8" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:45, 28 June 2023

OCA: New page: '''Unreleased structure''' The entry 8jt8 is ON HOLD Authors: Chen, Z., Fan, L., Wang, S. Description: Crystal structure of 5-HT2AR in complex with (R)-IHCH-7179 [[Category: Unreleased...

2023-06-28T19:45:27Z

New page: '''Unreleased structure''' The entry 8jt8 is ON HOLD Authors: Chen, Z., Fan, L., Wang, S. Description: Crystal structure of 5-HT2AR in complex with (R)-IHCH-7179 [[Category: Unreleased...

New page

'''Unreleased structure'''

The entry 8jt8 is ON HOLD

Authors: Chen, Z., Fan, L., Wang, S.

Description: Crystal structure of 5-HT2AR in complex with (R)-IHCH-7179
[[Category: Unreleased Structures]]
[[Category: Chen, Z]]
[[Category: Wang, S]]
[[Category: Fan, L]]

8jt8 - Revision history

OCA at 09:38, 1 March 2024

OCA at 08:53, 2 August 2023

OCA: Protected "8jt8" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8jt8 is ON HOLD Authors: Chen, Z., Fan, L., Wang, S. Description: Crystal structure of 5-HT2AR in complex with (R)-IHCH-7179 [[Category: Unreleased...