OCA at 07:00, 27 September 2023

2023-09-27T07:00:58Z

←Older revision		Revision as of 07:00, 27 September 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8oxp is ~~ON HOLD~~ ~~until Paper Publication~~	+	==ATM(Q2971A) in complex with Mg AMP-PNP==
-		+	<StructureSection load='8oxp' size='340' side='right'caption='[[8oxp]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8oxp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OXP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OXP FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8oxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8oxp OCA], [https://pdbe.org/8oxp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8oxp RCSB], [https://www.ebi.ac.uk/pdbsum/8oxp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8oxp ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/ATM_HUMAN ATM_HUMAN] Mantle cell lymphoma;B-cell chronic lymphocytic leukemia;Combined cervical dystonia;Ataxia-telangiectasia;Ataxia-telangiectasia variant. The disease is caused by mutations affecting the gene represented in this entry. Defects in ATM contribute to T-cell acute lymphoblastic leukemia (TALL) and T-prolymphocytic leukemia (TPLL). TPLL is characterized by a high white blood cell count, with a predominance of prolymphocytes, marked splenomegaly, lymphadenopathy, skin lesions and serous effusion. The clinical course is highly aggressive, with poor response to chemotherapy and short survival time. TPLL occurs both in adults as a sporadic disease and in younger AT patients.<ref>PMID:9288106</ref> <ref>PMID:9334731</ref> <ref>PMID:9463314</ref> <ref>PMID:9488043</ref> <ref>PMID:9573030</ref> Defects in ATM contribute to B-cell non-Hodgkin lymphomas (BNHL), including mantle cell lymphoma (MCL).<ref>PMID:10397742</ref> <ref>PMID:10706620</ref> <ref>PMID:9288106</ref> Defects in ATM contribute to B-cell chronic lymphocytic leukemia (BCLL). BCLL is the commonest form of leukemia in the elderly. It is characterized by the accumulation of mature CD5+ B-lymphocytes, lymphadenopathy, immunodeficiency and bone marrow failure.<ref>PMID:10023947</ref> <ref>PMID:10397742</ref> <ref>PMID:9892178</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ATM_HUMAN ATM_HUMAN] Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.<ref>PMID:10973490</ref> <ref>PMID:12556884</ref> <ref>PMID:14871926</ref> <ref>PMID:15916964</ref> <ref>PMID:16086026</ref> <ref>PMID:16858402</ref> <ref>PMID:17923702</ref> <ref>PMID:19965871</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Howes AC]]
		+	[[Category: Perisic O]]
		+	[[Category: Williams RL]]

OCA at 08:13, 21 June 2023

2023-06-21T08:13:22Z

←Older revision		Revision as of 08:13, 21 June 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8oxp is ON HOLD	+	The entry 8oxp is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8oxp" [edit=sysop:move=sysop]

2023-05-10T05:16:37Z

Protected "8oxp" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:16, 10 May 2023

OCA: New page: '''Unreleased structure''' The entry 8oxp is ON HOLD Authors: Description: Category: Unreleased Structures

2023-05-10T05:16:36Z

New page: '''Unreleased structure''' The entry 8oxp is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8oxp is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8oxp - Revision history

OCA at 07:00, 27 September 2023

OCA at 08:13, 21 June 2023

OCA: Protected "8oxp" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8oxp is ON HOLD Authors: Description: Category: Unreleased Structures