OCA at 05:48, 3 April 2024

2024-04-03T05:48:58Z

←Older revision		Revision as of 05:48, 3 April 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8p6i is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of the 139H2 Fab fragment bound to Muc1 peptide epitope==
-		+	<StructureSection load='8p6i' size='340' side='right'caption='[[8p6i]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8p6i]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P6I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P6I FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p6i OCA], [https://pdbe.org/8p6i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p6i RCSB], [https://www.ebi.ac.uk/pdbsum/8p6i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p6i ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/MUC1_HUMAN MUC1_HUMAN] Note=MUC1/CA 15-3 is used as a serological clinical marker of breast cancer to monitor response to breast cancer treatment and disease recurrence (PubMed:20816948). Decreased levels over time may be indicative of a positive response to treatment. Conversely, increased levels may indicate disease progression. At an early stage disease, only 21% of patients exhibit high MUC1/CA 15-3 levels, that is why CA 15-3 is not a useful screening test. Most antibodies target the highly immunodominant core peptide domain of 20 amino acid (APDTRPAPGSTAPPAHGVTS) tandem repeats. Some antibodies recognize glycosylated epitopes.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MUC1_HUMAN MUC1_HUMAN] The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.<ref>PMID:9139698</ref> <ref>PMID:11877440</ref> <ref>PMID:14688481</ref> <ref>PMID:15710329</ref> <ref>PMID:16288032</ref> <ref>PMID:15513966</ref> <ref>PMID:17524503</ref> <ref>PMID:17308127</ref> <ref>PMID:16983337</ref> The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.<ref>PMID:9139698</ref> <ref>PMID:11877440</ref> <ref>PMID:14688481</ref> <ref>PMID:15710329</ref> <ref>PMID:16288032</ref> <ref>PMID:15513966</ref> <ref>PMID:17524503</ref> <ref>PMID:17308127</ref> <ref>PMID:16983337</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Beugelink JW]]
		+	[[Category: Janssen BJC]]
		+	[[Category: Peng W]]
		+	[[Category: Pronker MF]]
		+	[[Category: Siborova M]]
		+	[[Category: Snijder J]]

OCA at 06:33, 14 June 2023

2023-06-14T06:33:16Z

←Older revision		Revision as of 06:33, 14 June 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8p6i is ON HOLD	+	The entry 8p6i is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8p6i" [edit=sysop:move=sysop]

2023-06-07T04:21:38Z

Protected "8p6i" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:21, 7 June 2023

OCA: New page: '''Unreleased structure''' The entry 8p6i is ON HOLD Authors: Description: Category: Unreleased Structures

2023-06-07T04:21:37Z

New page: '''Unreleased structure''' The entry 8p6i is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8p6i is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8p6i - Revision history

OCA at 05:48, 3 April 2024

OCA at 06:33, 14 June 2023

OCA: Protected "8p6i" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8p6i is ON HOLD Authors: Description: Category: Unreleased Structures