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8p82 - Revision history
2026-04-13T11:10:32Z
Revision history for this page on the wiki
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OCA at 08:22, 14 June 2023
2023-06-14T08:22:16Z
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<td colspan='2' style="background-color: white; color:black;">Revision as of 08:22, 14 June 2023</td>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>'''Unreleased structure'''</div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">The entry </del>8p82 is <del style="color: red; font-weight: bold; text-decoration: none;">ON HOLD </del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">==Cryo-EM structure of dimeric UBR5==</ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><StructureSection load='</ins>8p82<ins style="color: red; font-weight: bold; text-decoration: none;">' size='340' side='right'caption='[[8p82]], [[Resolution|resolution]] 3.36&Aring;' scene=''></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">Authors</del>: <del style="color: red; font-weight: bold; text-decoration: none;">Aguirre</del>, <del style="color: red; font-weight: bold; text-decoration: none;">J</del>.<del style="color: red; font-weight: bold; text-decoration: none;">D</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Kater, L</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Kempf, G</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Cavadini, S</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Thoma, N</del>.<del style="color: red; font-weight: bold; text-decoration: none;">H</del>.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">== Structural highlights ==</ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><table><tr><td colspan='2'>[[8p82]] </ins>is <ins style="color: red; font-weight: bold; text-decoration: none;">a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P82 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P82 FirstGlance]. <br></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">Description</del>: <del style="color: red; font-weight: bold; text-decoration: none;">Cryo</del>-<del style="color: red; font-weight: bold; text-decoration: none;">EM structure </del>of <del style="color: red; font-weight: bold; text-decoration: none;">dimeric UBR5</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Unreleased Structures</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><tr id='resources'><td class="sblockLbl"><b>Resources</ins>:<ins style="color: red; font-weight: bold; text-decoration: none;"></b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p82 FirstGlance]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[http://oca</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">weizmann</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">ac.il/oca-bin/ocaids?id=8p82 OCA]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[https://pdbe</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">org/8p82 PDBe]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[https://www</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">rcsb.org/pdb/explore.do?structureId=8p82 RCSB]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[https://www</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">ebi.ac.uk/pdbsum/8p82 PDBsum]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[https://prosat</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">h-its</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">org/prosat/prosatexe?pdbcode=8p82 ProSAT]</span></td></tr></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Cavadini, S</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></table></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Kempf, G</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">== Function ==</ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Aguirre, J.D</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[https</ins>:<ins style="color: red; font-weight: bold; text-decoration: none;">//www.uniprot.org/uniprot/UBR5_HUMAN UBR5_HUMAN] E3 ubiquitin</ins>-<ins style="color: red; font-weight: bold; text-decoration: none;">protein ligase which is a component </ins>of <ins style="color: red; font-weight: bold; text-decoration: none;">the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.<ref>PMID:21127351</ref> <ref>PMID:21726808</ref> <ref>PMID:22884692</ref> </ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Kater<del style="color: red; font-weight: bold; text-decoration: none;">, </del>L]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">== References ==</ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Thoma<del style="color: red; font-weight: bold; text-decoration: none;">, N.H</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><references/></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">__TOC__</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></StructureSection></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Homo sapiens</ins>]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Large Structures</ins>]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Aguirre JD</ins>]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Cavadini S</ins>]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Kater L<ins style="color: red; font-weight: bold; text-decoration: none;">]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[Category: Kempf G</ins>]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Thoma <ins style="color: red; font-weight: bold; text-decoration: none;">NH</ins>]]</div></td></tr>
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OCA
http://52.214.119.220/wiki/index.php?title=8p82&diff=3777279&oldid=prev
OCA: Protected "8p82" [edit=sysop:move=sysop]
2023-06-07T04:23:55Z
<p>Protected "<a href="/wiki/index.php/8p82" title="8p82">8p82</a>" [edit=sysop:move=sysop]</p>
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<td colspan='2' style="background-color: white; color:black;">←Older revision</td>
<td colspan='2' style="background-color: white; color:black;">Revision as of 04:23, 7 June 2023</td>
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OCA
http://52.214.119.220/wiki/index.php?title=8p82&diff=3777278&oldid=prev
OCA: New page: '''Unreleased structure''' The entry 8p82 is ON HOLD Authors: Aguirre, J.D., Kater, L., Kempf, G., Cavadini, S., Thoma, N.H. Description: Cryo-EM structure of dimeric UBR5 [[Category: ...
2023-06-07T04:23:54Z
<p>New page: '''Unreleased structure''' The entry 8p82 is ON HOLD Authors: Aguirre, J.D., Kater, L., Kempf, G., Cavadini, S., Thoma, N.H. Description: Cryo-EM structure of dimeric UBR5 [[Category: ...</p>
<p><b>New page</b></p><div>'''Unreleased structure'''<br />
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The entry 8p82 is ON HOLD <br />
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Authors: Aguirre, J.D., Kater, L., Kempf, G., Cavadini, S., Thoma, N.H.<br />
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Description: Cryo-EM structure of dimeric UBR5<br />
[[Category: Unreleased Structures]]<br />
[[Category: Cavadini, S]]<br />
[[Category: Kempf, G]]<br />
[[Category: Aguirre, J.D]]<br />
[[Category: Kater, L]]<br />
[[Category: Thoma, N.H]]</div>
OCA