OCA at 12:03, 8 November 2023

2023-11-08T12:03:04Z

←Older revision		Revision as of 12:03, 8 November 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8pdu is ~~ON HOLD until Paper~~ Publication	+	==cGMP-bound SpSLC9C1 in lipid nanodiscs, dimer==
		+	<StructureSection load='8pdu' size='340' side='right'caption='[[8pdu]], [[Resolution\|resolution]] 3.22Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8pdu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Strongylocentrotus_purpuratus Strongylocentrotus purpuratus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PDU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PDU FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.22Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCG:CYCLIC+GUANOSINE+MONOPHOSPHATE'>PCG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pdu OCA], [https://pdbe.org/8pdu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pdu RCSB], [https://www.ebi.ac.uk/pdbsum/8pdu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pdu ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A3RL54_STRPU A3RL54_STRPU]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The newly characterized sperm-specific Na(+)/H(+) exchanger stands out by its unique tripartite domain composition(1,2). It unites a classical solute carrier unit with regulatory domains usually found in ion channels, namely, a voltage-sensing domain and a cyclic-nucleotide binding domain(1,3), which makes it a mechanistic chimera and a secondary-active transporter activated strictly by membrane voltage. Our structures of the sea urchin SpSLC9C1 in the absence and presence of ligands reveal the overall domain arrangement and new structural coupling elements. They allow us to propose a gating model, where movements in the voltage sensor indirectly cause the release of the exchanging unit from a locked state through long-distance allosteric effects transmitted by the newly characterized coupling helices. We further propose that modulation by its ligand cyclic AMP occurs by means of disruption of the cytosolic dimer interface, which lowers the energy barrier for S4 movements in the voltage-sensing domain. As SLC9C1 members have been shown to be essential for male fertility, including in mammals(2,4,5), our structure represents a potential new platform for the development of new on-demand contraceptives.

-	~~Authors~~:	+	Structures of a sperm-specific solute carrier gated by voltage and cAMP.,Kalienkova V, Peter MF, Rheinberger J, Paulino C Nature. 2023 Nov;623(7985):202-209. doi: 10.1038/s41586-023-06629-w. Epub 2023 , Oct 25. PMID:37880361<ref>PMID:37880361</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8pdu" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Strongylocentrotus purpuratus]]
		+	[[Category: Kalienkova V]]
		+	[[Category: Paulino C]]
		+	[[Category: Peter M]]
		+	[[Category: Rheinberger J]]

OCA at 04:21, 6 September 2023

2023-09-06T04:21:50Z

←Older revision		Revision as of 04:21, 6 September 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8pdu is ON HOLD	+	The entry 8pdu is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 06:38, 16 August 2023

2023-08-16T06:38:58Z

←Older revision		Revision as of 06:38, 16 August 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8pdu is ON HOLD ~~until Paper Publication~~	+	The entry 8pdu is ON HOLD

	Authors:		Authors:

OCA at 04:49, 19 July 2023

2023-07-19T04:49:22Z

←Older revision		Revision as of 04:49, 19 July 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8pdu is ON HOLD	+	The entry 8pdu is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8pdu" [edit=sysop:move=sysop]

2023-06-21T08:24:28Z

Protected "8pdu" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:24, 21 June 2023

OCA: New page: '''Unreleased structure''' The entry 8pdu is ON HOLD Authors: Description: Category: Unreleased Structures

2023-06-21T08:24:27Z

New page: '''Unreleased structure''' The entry 8pdu is ON HOLD Authors: Description: Category: Unreleased Structures

New page