OCA: Protected "8ru2" [edit=sysop:move=sysop]

2024-04-10T08:02:36Z

Protected "8ru2" [edit=sysop:move=sysop]

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OCA: New page: ==Structure of the F-actin barbed end bound by formin mDia1== == S...

2024-04-10T08:02:35Z

New page: ==Structure of the F-actin barbed end bound by formin mDia1== <StructureSection load='8ru2' size='340' side='right'caption='8ru2, resolution 3.49Å' scene=''> == S...

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==Structure of the F-actin barbed end bound by formin mDia1==
<StructureSection load='8ru2' size='340' side='right'caption='[[8ru2]], [[Resolution|resolution]] 3.49Å' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ru2]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RU2 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8RU2 FirstGlance]. 
</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.49Å</td></tr>
<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8ru2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ru2 OCA], [https://pdbe.org/8ru2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ru2 RCSB], [https://www.ebi.ac.uk/pdbsum/8ru2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ru2 ProSAT]</td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ACTB_HUMAN ACTB_HUMAN] Defects in ACTB are a cause of dystonia juvenile-onset (DYTJ) [MIM:[https://omim.org/entry/607371 607371]. DYTJ is a form of dystonia with juvenile onset. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYTJ patients manifest progressive, generalized, dopa-unresponsive dystonia, developmental malformations and sensory hearing loss.<ref>PMID:16685646</ref> Defects in ACTB are the cause of Baraitser-Winter syndrome type 1 (BRWS1) [MIM:[https://omim.org/entry/243310 243310]. A rare developmental disorder characterized by the combination of congenital ptosis, high-arched eyebrows, hypertelorism, ocular colobomata, and a brain malformation consisting of anterior-predominant lissencephaly. Other typical features include postnatal short stature and microcephaly, intellectual disability, seizures, and hearing loss.<ref>PMID:22366783</ref>
== Function ==
[https://www.uniprot.org/uniprot/ACTB_HUMAN ACTB_HUMAN] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Bieling P]]
[[Category: Boiero Sanders M]]
[[Category: Funk J]]
[[Category: Oosterheert W]]
[[Category: Prumbaum D]]
[[Category: Raunser S]]

8ru2 - Revision history

OCA: Protected "8ru2" [edit=sysop:move=sysop]

OCA: New page: ==Structure of the F-actin barbed end bound by formin mDia1== == S...