OCA at 09:19, 30 August 2023

2023-08-30T09:19:44Z

←Older revision		Revision as of 09:19, 30 August 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8sbd is ~~ON HOLD until Paper Publication~~	+	==Cryo-EM structure of insulin amyloid-like fibril that is composed of two antiparallel protofilaments==
-		+	<StructureSection load='8sbd' size='340' side='right'caption='[[8sbd]], [[Resolution\|resolution]] 3.20Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8sbd]] is a 32 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SBD FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.2Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8sbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8sbd OCA], [https://pdbe.org/8sbd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8sbd RCSB], [https://www.ebi.ac.uk/pdbsum/8sbd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8sbd ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN] Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:[https://omim.org/entry/176730 176730].<ref>PMID:3470784</ref> <ref>PMID:2196279</ref> <ref>PMID:4019786</ref> <ref>PMID:1601997</ref> Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:[https://omim.org/entry/125852 125852]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:18192540</ref> Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:[https://omim.org/entry/606176 606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.<ref>PMID:17855560</ref> <ref>PMID:18162506</ref> Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [MIM:[https://omim.org/entry/613370 613370]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.<ref>PMID:18192540</ref> <ref>PMID:18162506</ref> <ref>PMID:20226046</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Bai XC]]
		+	[[Category: Chen DL]]
		+	[[Category: Choi E]]
		+	[[Category: Hall C]]
		+	[[Category: Uchikawa E]]
		+	[[Category: Wang LW]]
		+	[[Category: Zhang XW]]

OCA at 04:59, 19 July 2023

2023-07-19T04:59:14Z

←Older revision		Revision as of 04:59, 19 July 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8sbd is ON HOLD	+	The entry 8sbd is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 04:25, 7 June 2023

2023-06-07T04:25:03Z

←Older revision		Revision as of 04:25, 7 June 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8sbd is ON HOLD ~~until Paper Publication~~	+	The entry 8sbd is ON HOLD

	Authors:		Authors:

OCA at 05:19, 10 May 2023

2023-05-10T05:19:16Z

←Older revision		Revision as of 05:19, 10 May 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8sbd is ON HOLD	+	The entry 8sbd is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8sbd" [edit=sysop:move=sysop]

2023-04-12T19:05:18Z

Protected "8sbd" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:05, 12 April 2023

OCA: New page: '''Unreleased structure''' The entry 8sbd is ON HOLD Authors: Description: Category: Unreleased Structures

2023-04-12T19:05:17Z

New page: '''Unreleased structure''' The entry 8sbd is ON HOLD Authors: Description: Category: Unreleased Structures

New page