OCA at 23:15, 27 December 2023

2023-12-27T23:15:50Z

←Older revision		Revision as of 23:15, 27 December 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8sry is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of BAK-BAX heterodimer with C12E8==
		+	<StructureSection load='8sry' size='340' side='right'caption='[[8sry]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8sry]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SRY FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N8E:3,6,9,12,15-PENTAOXATRICOSAN-1-OL'>N8E</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG0:2-(2-METHOXYETHOXY)ETHANOL'>PG0</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8sry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8sry OCA], [https://pdbe.org/8sry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8sry RCSB], [https://www.ebi.ac.uk/pdbsum/8sry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8sry ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/BAK_HUMAN BAK_HUMAN] In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.<ref>PMID:8521816</ref> <ref>PMID:17157251</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The B-cell lymphoma 2 (BCL2) family members, BCL2-associated protein X (BAX) and BCL2 homologous antagonist killer (BAK), are required for programmed cell death via the mitochondrial pathway. When cells are stressed, damaged or redundant, the balance of power between the BCL2 family of proteins shifts towards BAX and BAK, allowing their transition from an inactive, monomeric state to a membrane-active oligomeric form that releases cytochrome c from the mitochondrial intermembrane space. That oligomeric state has an essential intermediate, a symmetric homodimer of BAX or BAK. Here we describe crystal structures of dimers of the core domain of BAX, comprising its helices alpha2-alpha5. These structures provide an atomic resolution description of the interactions that drive BAX homo-dimerisation and insights into potential interaction between core domain dimers and membrane lipids. The previously identified BAK lipid-interacting sites are not conserved with BAX and are likely to determine the differences between them in their interactions with lipids. We also describe structures of heterodimers of BAK/BAX core domains, yielding further insight into the differences in lipid binding between BAX and BAK.

-	~~Authors~~:	+	Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.,Miller MS, Cowan AD, Brouwer JM, Smyth ST, Peng L, Wardak AZ, Uren RT, Luo C, Roy MJ, Shah S, Tan Z, Reid GE, Colman PM, Czabotar PE FEBS J. 2023 Dec 13. doi: 10.1111/febs.17031. PMID:38088212<ref>PMID:38088212</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8sry" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Brouwer JM]]
		+	[[Category: Colman PM]]
		+	[[Category: Czabotar PE]]
		+	[[Category: Miller MS]]

OCA: Protected "8sry" [edit=sysop:move=sysop]

2023-05-18T05:58:52Z

Protected "8sry" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:58, 18 May 2023

OCA: New page: '''Unreleased structure''' The entry 8sry is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2023-05-18T05:58:51Z

New page: '''Unreleased structure''' The entry 8sry is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8sry is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]

8sry - Revision history

OCA at 23:15, 27 December 2023

OCA: Protected "8sry" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8sry is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures