OCA at 06:27, 6 September 2023

2023-09-06T06:27:45Z

←Older revision		Revision as of 06:27, 6 September 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8ss3 is ~~ON HOLD~~	+	==Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK and channel blocker spermidine (closed state)==
-		+	<StructureSection load='8ss3' size='340' side='right'caption='[[8ss3]], [[Resolution\|resolution]] 3.21Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8ss3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SS3 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.21Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AJP:Digitonin'>AJP</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=PCW:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PCW</scene>, <scene name='pdbligand=SPD:SPERMIDINE'>SPD</scene>, <scene name='pdbligand=ZK1:{[7-MORPHOLIN-4-YL-2,3-DIOXO-6-(TRIFLUOROMETHYL)-3,4-DIHYDROQUINOXALIN-1(2H)-YL]METHYL}PHOSPHONIC+ACID'>ZK1</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ss3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ss3 OCA], [https://pdbe.org/8ss3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ss3 RCSB], [https://www.ebi.ac.uk/pdbsum/8ss3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ss3 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref> [https://www.uniprot.org/uniprot/CCG5_RAT CCG5_RAT] Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. According to PubMed:18817736, shows only specificity for GRIA2 and specifically to the form of GRIA2 for which a single amino acid in the pore region has been edited from a glutamine to an arginine residue. Thought to stabilize the calcium channel in an inactivated (closed) state.<ref>PMID:18817736</ref> <ref>PMID:19234459</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Rattus norvegicus]]
		+	[[Category: Gangwar SP]]
		+	[[Category: Sobolevsky AI]]
		+	[[Category: Yelshanskaya MV]]
		+	[[Category: Yen LY]]

OCA: Protected "8ss3" [edit=sysop:move=sysop]

2023-05-18T05:59:06Z

Protected "8ss3" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:59, 18 May 2023

OCA: New page: '''Unreleased structure''' The entry 8ss3 is ON HOLD Authors: Description: Category: Unreleased Structures

2023-05-18T05:59:05Z

New page: '''Unreleased structure''' The entry 8ss3 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8ss3 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8ss3 - Revision history

OCA at 06:27, 6 September 2023

OCA: Protected "8ss3" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8ss3 is ON HOLD Authors: Description: Category: Unreleased Structures