OCA at 11:24, 14 March 2024

2024-03-14T11:24:13Z

←Older revision		Revision as of 11:24, 14 March 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8ty1 is ~~ON HOLD~~	+	==Cryo-EM structure of coagulation factor VIII bound to NB2E9==
-		+	<StructureSection load='8ty1' size='340' side='right'caption='[[8ty1]], [[Resolution\|resolution]] 3.46Å' scene=''>
-	~~Authors~~: ~~Childers~~, K.C., ~~Spiegel~~, P.C.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8ty1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TY1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TY1 FirstGlance]. <br>
-	~~Description~~: ~~Cryo-EM structure~~ of coagulation factor VIII ~~bound~~ to ~~NB2E9~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.46Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: Childers~~, K.C~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ty1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ty1 OCA], [https://pdbe.org/8ty1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ty1 RCSB], [https://www.ebi.ac.uk/pdbsum/8ty1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ty1 ProSAT]</span></td></tr>
-	[[Category: Spiegel~~, P.C~~]]	+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/FA8_HUMAN FA8_HUMAN] Defects in F8 are the cause of hemophilia A (HEMA) [MIM:[https://omim.org/entry/306700 306700]. A disorder of blood coagulation characterized by a permanent tendency to hemorrhage. About 50% of patients have severe hemophilia resulting in frequent spontaneous bleeding into joints, muscles and internal organs. Less severe forms are characterized by bleeding after trauma or surgery. Note=Of particular interest for the understanding of the function of F8 is the category of CRM (cross-reacting material) positive patients (approximately 5%) that have considerable amount of F8 in their plasma (at least 30% of normal), but the protein is non-functional; i.e. the F8 activity is much less than the plasma protein level. CRM-reduced is another category of patients in which the F8C antigen and activity are reduced to approximately the same level. Most mutations are CRM negative, and probably affect the folding and stability of the protein.<ref>PMID:3012775</ref> <ref>PMID:3122181</ref> <ref>PMID:2833855</ref> <ref>PMID:2835904</ref> <ref>PMID:2499363</ref> <ref>PMID:2506948</ref> <ref>PMID:2510835</ref> <ref>PMID:2495245</ref> <ref>PMID:2498882</ref> <ref>PMID:2104766</ref> <ref>PMID:2105106</ref> <ref>PMID:1973901</ref> <ref>PMID:2105906</ref> <ref>PMID:2106480</ref> <ref>PMID:2107542</ref> <ref>PMID:1908817</ref> <ref>PMID:1908096</ref> <ref>PMID:1851341</ref> <ref>PMID:1356412</ref> <ref>PMID:1639429</ref> <ref>PMID:1349567</ref> <ref>PMID:1301194</ref> <ref>PMID:1301932</ref> <ref>PMID:1301960</ref> <ref>PMID:8449505</ref> <ref>PMID:8322269</ref> <ref>PMID:7579394</ref> <ref>PMID:7794769</ref> <ref>PMID:7759074</ref> <ref>PMID:8644728</ref> <ref>PMID:8639447</ref> <ref>PMID:8759905</ref> <ref>PMID:9029040</ref> <ref>PMID:9326186</ref> <ref>PMID:9341862</ref> <ref>PMID:9886318</ref> <ref>PMID:9450898</ref> <ref>PMID:10215414</ref> <ref>PMID:9603440</ref> <ref>PMID:9452104</ref> <ref>PMID:9792405</ref> <ref>PMID:9829908</ref> <ref>PMID:9569180</ref> <ref>PMID:9569189</ref> <ref>PMID:10554831</ref> <ref>PMID:10338101</ref> <ref>PMID:10408784</ref> <ref>PMID:10404764</ref> <ref>PMID:10910910</ref> <ref>PMID:10910913</ref> <ref>PMID:10691849</ref> <ref>PMID:10886198</ref> <ref>PMID:10800171</ref> <ref>PMID:10896236</ref> <ref>PMID:10612839</ref> <ref>PMID:11410838</ref> <ref>PMID:11298607</ref> <ref>PMID:11442643</ref> <ref>PMID:11442647</ref> <ref>PMID:11554935</ref> <ref>PMID:11748850</ref> <ref>PMID:11341489</ref> <ref>PMID:12351418</ref> <ref>PMID:12406074</ref> <ref>PMID:12199686</ref> <ref>PMID:11857744</ref> <ref>PMID:12203998</ref> <ref>PMID:12325022</ref> <ref>PMID:11858487</ref> <ref>PMID:12195713</ref> <ref>PMID:12930394</ref> <ref>PMID:12871415</ref> <ref>PMID:12614369</ref> <ref>PMID:15682412</ref> <ref>PMID:15810915</ref> <ref>PMID:16805874</ref> <ref>PMID:18184865</ref> <ref>PMID:21371196</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FA8_HUMAN FA8_HUMAN] Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.[https://www.uniprot.org/uniprot/FA8_PIG FA8_PIG] Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Sus scrofa]]
		+	[[Category: Childers KC]]
		+	[[Category: Spiegel PC]]

OCA: Protected "8ty1" [edit=sysop:move=sysop]

2023-08-30T07:49:03Z

Protected "8ty1" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:49, 30 August 2023

OCA: New page: '''Unreleased structure''' The entry 8ty1 is ON HOLD Authors: Childers, K.C., Spiegel, P.C. Description: Cryo-EM structure of coagulation factor VIII bound to NB2E9 [[Category: Unrelea...

2023-08-30T07:49:02Z

New page: '''Unreleased structure''' The entry 8ty1 is ON HOLD Authors: Childers, K.C., Spiegel, P.C. Description: Cryo-EM structure of coagulation factor VIII bound to NB2E9 [[Category: Unrelea...

New page

'''Unreleased structure'''

The entry 8ty1 is ON HOLD

Authors: Childers, K.C., Spiegel, P.C.

Description: Cryo-EM structure of coagulation factor VIII bound to NB2E9
[[Category: Unreleased Structures]]
[[Category: Childers, K.C]]
[[Category: Spiegel, P.C]]

8ty1 - Revision history

OCA at 11:24, 14 March 2024

OCA: Protected "8ty1" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8ty1 is ON HOLD Authors: Childers, K.C., Spiegel, P.C. Description: Cryo-EM structure of coagulation factor VIII bound to NB2E9 [[Category: Unrelea...