OCA at 10:13, 27 March 2024

2024-03-27T10:13:30Z

←Older revision		Revision as of 10:13, 27 March 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 8u4w is ~~ON HOLD until Paper Publication~~	+	==The crystal structure of a helical domain deleted PARP1 in complex with isoindolinone based inhibitor.==
-		+	<StructureSection load='8u4w' size='340' side='right'caption='[[8u4w]], [[Resolution\|resolution]] 3.02Å' scene=''>
-	~~Authors~~: ~~Marcotte~~, D.J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8u4w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8U4W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8U4W FirstGlance]. <br>
-	~~Description~~: ~~The crystal structure~~ of a ~~helical domain deleted PARP1~~ in complex ~~with isoindolinone based inhibitor~~.	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.02Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VHU:(4M)-4-(2-{4-[(3S)-1-acetylpiperidine-3-carbonyl]piperazine-1-carbonyl}-1-benzofuran-7-yl)-1H-isoindol-1-one'>VHU</scene></td></tr>
-	[[Category: Marcotte~~, D.J~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8u4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8u4w OCA], [https://pdbe.org/8u4w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8u4w RCSB], [https://www.ebi.ac.uk/pdbsum/8u4w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8u4w ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Marcotte DJ]]

OCA at 07:51, 21 February 2024

2024-02-21T07:51:59Z

←Older revision		Revision as of 07:51, 21 February 2024
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	Authors: Marcotte, D.J.		Authors: Marcotte, D.J.

-	Description: The crystal structure of a helical domain deleted PARP1 in complex with ~~indole~~ based inhibitor	+	Description: The crystal structure of a helical domain deleted PARP1 in complex with isoindolinone based inhibitor.
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Marcotte, D.J]]		[[Category: Marcotte, D.J]]

OCA: Protected "8u4w" [edit=sysop:move=sysop]

2023-09-20T12:42:19Z

Protected "8u4w" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:42, 20 September 2023

OCA: New page: '''Unreleased structure''' The entry 8u4w is ON HOLD until Paper Publication Authors: Marcotte, D.J. Description: The crystal structure of a helical domain deleted PARP1 in complex wit...

2023-09-20T12:42:18Z

New page: '''Unreleased structure''' The entry 8u4w is ON HOLD until Paper Publication Authors: Marcotte, D.J. Description: The crystal structure of a helical domain deleted PARP1 in complex wit...

New page

'''Unreleased structure'''

The entry 8u4w is ON HOLD until Paper Publication

Authors: Marcotte, D.J.

Description: The crystal structure of a helical domain deleted PARP1 in complex with indole based inhibitor
[[Category: Unreleased Structures]]
[[Category: Marcotte, D.J]]

8u4w - Revision history

OCA at 10:13, 27 March 2024

OCA at 07:51, 21 February 2024

OCA: Protected "8u4w" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8u4w is ON HOLD until Paper Publication Authors: Marcotte, D.J. Description: The crystal structure of a helical domain deleted PARP1 in complex wit...