OCA at 05:30, 17 April 2024

2024-04-17T05:30:55Z

←Older revision		Revision as of 05:30, 17 April 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8v6o is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Inactivated-state cryo-EM structure of human TRPV3 in presence of 2-APB in cNW30 nanodiscs==
-		+	<StructureSection load='8v6o' size='340' side='right'caption='[[8v6o]], [[Resolution\|resolution]] 2.83Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8v6o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8V6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8V6O FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.83Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FZ4:2-aminoethyl+diphenylborinate'>FZ4</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8v6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8v6o OCA], [https://pdbe.org/8v6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8v6o RCSB], [https://www.ebi.ac.uk/pdbsum/8v6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8v6o ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/TRPV3_HUMAN TRPV3_HUMAN] Mutilating palmoplantar keratoderma with periorificial keratotic plaques. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TRPV3_HUMAN TRPV3_HUMAN] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).<ref>PMID:12077604</ref> <ref>PMID:12077606</ref> <ref>PMID:21593771</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Nadezhdin KD]]
		+	[[Category: Neuberger A]]
		+	[[Category: Sobolevsky AI]]

OCA at 08:10, 1 March 2024

2024-03-01T08:10:18Z

←Older revision		Revision as of 08:10, 1 March 2024
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8v6o is ON HOLD	+	The entry 8v6o is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 07:52, 21 February 2024

2024-02-21T07:52:28Z

←Older revision		Revision as of 07:52, 21 February 2024
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8v6o is ON HOLD ~~until Paper Publication~~	+	The entry 8v6o is ON HOLD

	Authors:		Authors:

OCA at 10:17, 24 January 2024

2024-01-24T10:17:01Z

←Older revision		Revision as of 10:17, 24 January 2024
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8v6o is ON HOLD	+	The entry 8v6o is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8v6o" [edit=sysop:move=sysop]

2023-12-13T10:09:41Z

Protected "8v6o" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:09, 13 December 2023

OCA: New page: '''Unreleased structure''' The entry 8v6o is ON HOLD Authors: Description: Category: Unreleased Structures

2023-12-13T10:09:40Z

New page: '''Unreleased structure''' The entry 8v6o is ON HOLD Authors: Description: Category: Unreleased Structures

New page