OCA at 05:29, 15 May 2024

2024-05-15T05:29:03Z

←Older revision		Revision as of 05:29, 15 May 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 9emc is ~~ON HOLD until Paper Publication~~	+	==RUVBL1/2 in complex with ATP==
-		+	<StructureSection load='9emc' size='340' side='right'caption='[[9emc]], [[Resolution\|resolution]] 3.26Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[9emc]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EMC FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.26Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9emc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9emc OCA], [https://pdbe.org/9emc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9emc RCSB], [https://www.ebi.ac.uk/pdbsum/9emc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9emc ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/RUVB1_HUMAN RUVB1_HUMAN] Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.<ref>PMID:11027681</ref> <ref>PMID:14506706</ref> <ref>PMID:11080158</ref> <ref>PMID:14695187</ref> <ref>PMID:14966270</ref> Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.<ref>PMID:11027681</ref> <ref>PMID:14506706</ref> <ref>PMID:11080158</ref> <ref>PMID:14695187</ref> <ref>PMID:14966270</ref> Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.<ref>PMID:11027681</ref> <ref>PMID:14506706</ref> <ref>PMID:11080158</ref> <ref>PMID:14695187</ref> <ref>PMID:14966270</ref> Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. Essential for cell proliferation.<ref>PMID:11027681</ref> <ref>PMID:14506706</ref> <ref>PMID:11080158</ref> <ref>PMID:14695187</ref> <ref>PMID:14966270</ref> May be able to bind plasminogen at cell surface and enhance plasminogen activation.<ref>PMID:11027681</ref> <ref>PMID:14506706</ref> <ref>PMID:11080158</ref> <ref>PMID:14695187</ref> <ref>PMID:14966270</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Garcia-Martin C]]
		+	[[Category: Llorca O]]
		+	[[Category: Lopez-Perrote A]]

OCA at 06:52, 10 April 2024

2024-04-10T06:52:45Z

←Older revision		Revision as of 06:52, 10 April 2024
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 9emc is ON HOLD	+	The entry 9emc is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "9emc" [edit=sysop:move=sysop]

2024-03-20T07:26:56Z

Protected "9emc" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:26, 20 March 2024

OCA: New page: '''Unreleased structure''' The entry 9emc is ON HOLD Authors: Description: Category: Unreleased Structures

2024-03-20T07:26:55Z

New page: '''Unreleased structure''' The entry 9emc is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 9emc is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

9emc - Revision history

OCA at 05:29, 15 May 2024

OCA at 06:52, 10 April 2024

OCA: Protected "9emc" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 9emc is ON HOLD Authors: Description: Category: Unreleased Structures