ATP-citrate synthase - Revision history

Michal Harel at 09:45, 21 January 2024

2024-01-21T09:45:37Z

←Older revision		Revision as of 09:45, 21 January 2024
Line 6:		Line 6:

	See also [[Citrate Synthase]]<br />		See also [[Citrate Synthase]]<br />
-	[[Citric acid cycle intermediates serve as substrates for biosynthetic processes]].	+	[[Citric acid cycle intermediates serve as substrates for biosynthetic processes]]<br />
		+	[[Reverse Krebs cycle]].
		+
	== Structural highlights ==		== Structural highlights ==

2023-01-08T10:41:33Z

←Older revision		Revision as of 10:41, 8 January 2023
Line 5:		Line 5:
	'''ATP-citrate synthase''' (ACS) or '''ATP citrate lyase''' or '''citryl-CoA synthetase''' is part of the citrate cycle. It catalyzes the transformation of ADP, acetyl-CoA and oxaloacetate to ATP, citrate and CoA. ACS is the link between energy metabolism from carbohydrates to the production of fatty acids.		'''ATP-citrate synthase''' (ACS) or '''ATP citrate lyase''' or '''citryl-CoA synthetase''' is part of the citrate cycle. It catalyzes the transformation of ADP, acetyl-CoA and oxaloacetate to ATP, citrate and CoA. ACS is the link between energy metabolism from carbohydrates to the production of fatty acids.

-	See also [[Citrate Synthase]]	+	See also [[Citrate Synthase]]<br />
		+	[[Citric acid cycle intermediates serve as substrates for biosynthetic processes]].
	== Structural highlights ==		== Structural highlights ==

2022-11-06T08:54:30Z

←Older revision		Revision as of 08:54, 6 November 2022
Line 3:		Line 3:
	== Function ==		== Function ==

-	'''ATP-citrate synthase''' (ACS) or '''ATP citrate lyase''' or '''citryl-CoA ~~synthesise~~''' is part of the citrate cycle. It catalyzes the transformation of ADP, acetyl-CoA and oxaloacetate to ATP, citrate and CoA. ACS is the link between energy metabolism from carbohydrates to the production of fatty acids.	+	'''ATP-citrate synthase''' (ACS) or '''ATP citrate lyase''' or '''citryl-CoA synthetase''' is part of the citrate cycle. It catalyzes the transformation of ADP, acetyl-CoA and oxaloacetate to ATP, citrate and CoA. ACS is the link between energy metabolism from carbohydrates to the production of fatty acids.

	See also [[Citrate Synthase]]		See also [[Citrate Synthase]]

2021-04-22T07:37:04Z

←Older revision		Revision as of 07:37, 22 April 2021
Line 3:		Line 3:
	== Function ==		== Function ==

-	'''ATP-citrate synthase''' (ACS) is part of the citrate cycle. It catalyzes the transformation of ADP, acetyl-CoA and oxaloacetate to ATP, citrate and CoA. ACS is the link between energy metabolism from carbohydrates to the production of fatty acids.	+	'''ATP-citrate synthase''' (ACS) or '''ATP citrate lyase''' or '''citryl-CoA synthesise''' is part of the citrate cycle. It catalyzes the transformation of ADP, acetyl-CoA and oxaloacetate to ATP, citrate and CoA. ACS is the link between energy metabolism from carbohydrates to the production of fatty acids.

	See also [[Citrate Synthase]]		See also [[Citrate Synthase]]

2019-03-25T09:02:55Z

←Older revision		Revision as of 09:02, 25 March 2019
Line 14:		Line 14:

	</StructureSection>		</StructureSection>
-
-	== 3D Structures of ATP-citrate synthase ==
-
-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-
-	[[3mwd]], [[5tde]] – hACS + citrate – human<br />
-	[[5tdf]], [[5tet]] – hACS + citrate derivative<br />
-	[[5teq]] – hACS N-terminal (mutant) + citrate <br />
-	[[5te1]] – hACS N-terminal (mutant) + citrate derivative<br />
-	[[5tes]] – hACS + citrate + ADP<br />
-	[[5tdm]] – hACS + citrate derivative + ADP<br />
-	[[3mwe]] – hACS + tartrate<br />
-	[[3pff]], [[5tdz]] - hACS + tartrate + ADP<br />

	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

2019-03-25T09:02:00Z

←Older revision		Revision as of 09:02, 25 March 2019
Line 9:		Line 9:

	Crystal structures have shown that tartrate and citrate bind to ACS in the same binding site. <scene name='47/477091/Cv/4'>Binding site of tartrate</scene> of ATP-citrate synthase. Water molecules are shown as red spheres. <scene name='47/477091/Cv/6'>Binding site of ADP and Mg+2 ions</scene>, [[3pff]]. <ref>PMID:22102020</ref>		Crystal structures have shown that tartrate and citrate bind to ACS in the same binding site. <scene name='47/477091/Cv/4'>Binding site of tartrate</scene> of ATP-citrate synthase. Water molecules are shown as red spheres. <scene name='47/477091/Cv/6'>Binding site of ADP and Mg+2 ions</scene>, [[3pff]]. <ref>PMID:22102020</ref>
		+
		+	== 3D Structures of ATP-citrate synthase ==
		+	[[ATP-citrate synthase 3D structures]]

	</StructureSection>		</StructureSection>

2018-05-14T13:32:34Z

←Older revision		Revision as of 13:32, 14 May 2018
Line 8:		Line 8:
	== Structural highlights ==		== Structural highlights ==

-	Crystal structures have shown that tartrate and citrate bind to ACS in the same binding site. <scene name='47/477091/Cv/2'>Binding site of tartrate</scene> of ATP-citrate synthase. <scene name='47/477091/Cv/3'>Binding site of ADP and Mg+2 ions</scene> , [[3pff]]. <ref>PMID:22102020</ref>	+	Crystal structures have shown that tartrate and citrate bind to ACS in the same binding site. <scene name='47/477091/Cv/4'>Binding site of tartrate</scene> of ATP-citrate synthase. Water molecules are shown as red spheres. <scene name='47/477091/Cv/6'>Binding site of ADP and Mg+2 ions</scene>, [[3pff]]. <ref>PMID:22102020</ref>

	</StructureSection>		</StructureSection>

2018-03-22T12:07:46Z

←Older revision		Revision as of 12:07, 22 March 2018
Line 16:		Line 16:
	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

-	[[3mwd]] – hACS + citrate – human<br />	+	[[3mwd]], [[5tde]] – hACS + citrate – human<br />
		+	[[5tdf]], [[5tet]] – hACS + citrate derivative<br />
		+	[[5teq]] – hACS N-terminal (mutant) + citrate <br />
		+	[[5te1]] – hACS N-terminal (mutant) + citrate derivative<br />
		+	[[5tes]] – hACS + citrate + ADP<br />
		+	[[5tdm]] – hACS + citrate derivative + ADP<br />
	[[3mwe]] – hACS + tartrate<br />		[[3mwe]] – hACS + tartrate<br />
-	[[3pff]] - hACS + tartrate + ADP	+	[[3pff]], [[5tdz]] - hACS + tartrate + ADP<br />

	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

2015-12-03T08:56:47Z

←Older revision		Revision as of 08:56, 3 December 2015
Line 8:		Line 8:
	== Structural highlights ==		== Structural highlights ==

-	Crystal structures have shown that tartrate and citrate bind to ACS in the same binding site. <scene name='47/477091/Cv/2'>Binding site ~~with~~ tartrate</scene> of ATP-citrate synthase ~~with~~ <scene name='47/477091/Cv/3'>ADP, Mg+2 ions</scene> , [[3pff]]. <ref>PMID:22102020</ref>	+	Crystal structures have shown that tartrate and citrate bind to ACS in the same binding site. <scene name='47/477091/Cv/2'>Binding site of tartrate</scene> of ATP-citrate synthase. <scene name='47/477091/Cv/3'>Binding site of ADP and Mg+2 ions</scene> , [[3pff]]. <ref>PMID:22102020</ref>

	</StructureSection>		</StructureSection>

2015-12-03T08:54:10Z

←Older revision		Revision as of 08:54, 3 December 2015
Line 1:		Line 1:
-	<StructureSection load='3pff' size='~~450~~' side='right' scene='47/477091/Cv/1' caption='ATP-citrate synthase complex with ADP (stick model), tartrate and Mg+2 ions (green), [[3pff]]'>	+	<StructureSection load='3pff' size='350' side='right' scene='47/477091/Cv/1' caption='ATP-citrate synthase complex with ADP (stick model), tartrate and Mg+2 ions (green), [[3pff]]'>

	== Function ==		== Function ==