Adenosine A2A receptor - Revision history

Alexander Berchansky at 13:57, 3 June 2021

2021-06-03T13:57:40Z

←Older revision		Revision as of 13:57, 3 June 2021
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	== Relevance ==		== Relevance ==

-	A2AR is responsible for regulating myocardial blood flow. It is involved in cerebral and renal blood flow, immune function, pain regulation and sleep. For details see [[G protein-coupled receptor]]. A2AR is blocked by <scene name='54/540144/5mzp_caffeine/1'>caffeine</scene> producing the arousal effect.<ref>PMID:21734299</ref> For details see [[Caffeine]].	+	A2AR is responsible for regulating myocardial blood flow. It is involved in cerebral and renal blood flow, immune function, pain regulation and sleep. For details see [[G protein-coupled receptor]]. A2AR is blocked by <scene name='54/540144/5mzp_caffeine/1'>caffeine</scene> producing the arousal effect.<ref>PMID:21734299</ref> For details see [[Caffeine]].
		+
		+	See also:
		+	* [[G protein-coupled receptor]]
		+	*[[Receptor]]
		+	*[[Transmembrane (cell surface) receptors]]

	== Structural highlights ==		== Structural highlights ==

Alexander Berchansky at 07:13, 28 February 2021

2021-02-28T07:13:46Z

←Older revision		Revision as of 07:13, 28 February 2021
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	Like other G proteins, <scene name='54/540144/Cv/5'>A2AR has 7 transmembrane helices</scene>.		Like other G proteins, <scene name='54/540144/Cv/5'>A2AR has 7 transmembrane helices</scene>.
-	*<scene name='54/540144/Cv/8'>A2AR ~~posses~~ a ligand-binding cavity</scene>.	+	*<scene name='54/540144/Cv/8'>A2AR has a ligand-binding cavity</scene>.
	*<scene name='54/540144/Cv/7'>Adenosine binding site</scene>.		*<scene name='54/540144/Cv/7'>Adenosine binding site</scene>.

Michal Harel at 09:12, 28 February 2019

2019-02-28T09:12:29Z

←Older revision		Revision as of 09:12, 28 February 2019
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	== 3D Structures of adenosine A2A receptor ==		== 3D Structures of adenosine A2A receptor ==
-	[[Adenosine A2A receptor 3D structures==	+	[[Adenosine A2A receptor 3D structures]]

	</StructureSection>		</StructureSection>

-	== 3D Structures of adenosine A2A receptor ==
-
-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

-	[[3eml]] – hA2AR/lysozyme + antagonist – human<br />
-	[[5k2a]], [[5k2b]], [[5k2c]], [[5k2d]] – hA2AR/cytochrome b562 <br />
-	[[5iu4]], [[5iu7]], [[5iu8]], [[5iua]], [[5iub]] – hA2AR/cytochrome b562 (mutant) + inhibitor<br />
-	[[4ug2]], [[4uhr]] – hA2AR (mutant) + inhibitor<br />
-	[[5g53]] – hA2AR + G protein <br />
-	[[3qak]] – hA2AR/lysozyme + agonist <br />
-	[[2ydo]] – hA2AR (mutant) + adenosine<br />
-	[[2ydv]], [[5wf5]], [[5wf6]] – hA2AR (mutant) + agonist<br />
-	[[3pwh]], [[3rey]], [[3rfm]], [[3uza]], [[3uzc]] – hA2AR (mutant) + antagonist<br />
-	[[3rfm]] – hA2AR (mutant) + caffeine<br />
-	[[3vg9]], [[3vga]] – hA2AR (mutant) + antibody<br />
-	[[5jtb]], [[5nlx]], [[5nm2]], [[5nm4]], [[5uvi]], [[5vra]] – hA2AR/cytochrome b562 <br />
-	[[5olg]], [[5olh]], [[5olo]], [[5olv]], [[5olz]], [[5om1]], [[5om4]] – hA2AR/cytochrome b562 (mutant) <br />
-	[[4eiy]] – hA2AR/cytochrome b562 + antagonist <br />
-	[[5uig]], [[6aqf]] – hA2AR/cytochrome b562 (mutant) + antagonist <br />
-	[[5mzj]] – hA2AR/cytochrome b562 (mutant) + theophylline <br />
-	[[5mzp]] – hA2AR/cytochrome b562 (mutant) + caffeine <br />
-	[[5n2r]] – hA2AR/cytochrome b562 (mutant) + xanthine derivative <br />
-	[[6gdg]] – hA2AR/TrxA + transducing β + G γ-I + adenylate cyclase-stimulating G α + antibody – Cryo EM<br />

	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 09:10, 28 February 2019

2019-02-28T09:10:59Z

←Older revision		Revision as of 09:10, 28 February 2019
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	*<scene name='54/540144/Cv/8'>A2AR posses a ligand-binding cavity</scene>.		*<scene name='54/540144/Cv/8'>A2AR posses a ligand-binding cavity</scene>.
	*<scene name='54/540144/Cv/7'>Adenosine binding site</scene>.		*<scene name='54/540144/Cv/7'>Adenosine binding site</scene>.
		+
		+	== 3D Structures of adenosine A2A receptor ==
		+	[[Adenosine A2A receptor 3D structures==
		+
	</StructureSection>		</StructureSection>

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	[[5mzp]] – hA2AR/cytochrome b562 (mutant) + caffeine <br />		[[5mzp]] – hA2AR/cytochrome b562 (mutant) + caffeine <br />
	[[5n2r]] – hA2AR/cytochrome b562 (mutant) + xanthine derivative <br />		[[5n2r]] – hA2AR/cytochrome b562 (mutant) + xanthine derivative <br />
		+	[[6gdg]] – hA2AR/TrxA + transducing β + G γ-I + adenylate cyclase-stimulating G α + antibody – Cryo EM<br />

	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Nina Clavio at 07:47, 5 June 2018

2018-06-05T07:47:42Z

←Older revision		Revision as of 07:47, 5 June 2018
Line 11:		Line 11:
	== Relevance ==		== Relevance ==

-	A2AR is responsible for regulating myocardial blood flow. It is involved in cerebral and renal blood flow, immune function, pain regulation and sleep. For details see [[G protein-coupled receptor]]. A2AR is blocked by caffeine producing the arousal effect.<ref>PMID:21734299</ref> For details see [[Caffeine]].	+	A2AR is responsible for regulating myocardial blood flow. It is involved in cerebral and renal blood flow, immune function, pain regulation and sleep. For details see [[G protein-coupled receptor]]. A2AR is blocked by <scene name='54/540144/5mzp_caffeine/1'>caffeine</scene> producing the arousal effect.<ref>PMID:21734299</ref> For details see [[Caffeine]].

	== Structural highlights ==		== Structural highlights ==

Alexander Berchansky at 14:45, 23 April 2018

2018-04-23T14:45:43Z

←Older revision		Revision as of 14:45, 23 April 2018
Line 15:		Line 15:
	== Structural highlights ==		== Structural highlights ==

-	Like other G proteins, <scene name='54/540144/Cv/4'>A2AR has 7 transmembrane helices</scene>. <scene name='54/540144/Cv/3'>A2AR posses a ligand-binding cavity</scene>.	+	Like other G proteins, <scene name='54/540144/Cv/5'>A2AR has 7 transmembrane helices</scene>.
		+	*<scene name='54/540144/Cv/8'>A2AR posses a ligand-binding cavity</scene>.
		+	*<scene name='54/540144/Cv/7'>Adenosine binding site</scene>.
	</StructureSection>		</StructureSection>

Michal Harel at 09:15, 6 March 2018

2018-03-06T09:15:12Z

←Older revision		Revision as of 09:15, 6 March 2018
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	[[3qak]] – hA2AR/lysozyme + agonist <br />		[[3qak]] – hA2AR/lysozyme + agonist <br />
	[[2ydo]] – hA2AR (mutant) + adenosine<br />		[[2ydo]] – hA2AR (mutant) + adenosine<br />
-	[[2ydv]] – hA2AR (mutant) + agonist<br />	+	[[2ydv]], [[5wf5]], [[5wf6]] – hA2AR (mutant) + agonist<br />
	[[3pwh]], [[3rey]], [[3rfm]], [[3uza]], [[3uzc]] – hA2AR (mutant) + antagonist<br />		[[3pwh]], [[3rey]], [[3rfm]], [[3uza]], [[3uzc]] – hA2AR (mutant) + antagonist<br />
	[[3rfm]] – hA2AR (mutant) + caffeine<br />		[[3rfm]] – hA2AR (mutant) + caffeine<br />
	[[3vg9]], [[3vga]] – hA2AR (mutant) + antibody<br />		[[3vg9]], [[3vga]] – hA2AR (mutant) + antibody<br />
		+	[[5jtb]], [[5nlx]], [[5nm2]], [[5nm4]], [[5uvi]], [[5vra]] – hA2AR/cytochrome b562 <br />
		+	[[5olg]], [[5olh]], [[5olo]], [[5olv]], [[5olz]], [[5om1]], [[5om4]] – hA2AR/cytochrome b562 (mutant) <br />
	[[4eiy]] – hA2AR/cytochrome b562 + antagonist <br />		[[4eiy]] – hA2AR/cytochrome b562 + antagonist <br />
-	[[5uig]] – hA2AR/cytochrome b562 (mutant) + antagonist <br />	+	[[5uig]], [[6aqf]] – hA2AR/cytochrome b562 (mutant) + antagonist <br />
		+	[[5mzj]] – hA2AR/cytochrome b562 (mutant) + theophylline <br />
		+	[[5mzp]] – hA2AR/cytochrome b562 (mutant) + caffeine <br />
		+	[[5n2r]] – hA2AR/cytochrome b562 (mutant) + xanthine derivative <br />

	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Joel L. Sussman at 20:29, 18 October 2017

2017-10-18T20:29:03Z

←Older revision		Revision as of 20:29, 18 October 2017
Line 1:		Line 1:
-	<StructureSection load='~~2ydo~~' size='350' side='right' scene='54/540144/Cv/1' caption='Human A2AR (mutant) complex with adenosine [[2ydo]]'>	+	<StructureSection load='' size='350' side='right' scene='54/540144/Cv/1' caption='Human A2AR (mutant) complex with adenosine [[2ydo]]'>

	== Function ==		== Function ==

Michal Harel at 17:19, 18 October 2017

2017-10-18T17:19:25Z

←Older revision		Revision as of 17:19, 18 October 2017
Line 38:		Line 38:
	== References ==		== References ==
	<references/>		<references/>
		+	[[Category:Topic Page]]

Michal Harel at 10:47, 21 February 2017

2017-02-21T10:47:54Z

←Older revision		Revision as of 10:47, 21 February 2017
Line 34:		Line 34:
	[[3vg9]], [[3vga]] – hA2AR (mutant) + antibody<br />		[[3vg9]], [[3vga]] – hA2AR (mutant) + antibody<br />
	[[4eiy]] – hA2AR/cytochrome b562 + antagonist <br />		[[4eiy]] – hA2AR/cytochrome b562 + antagonist <br />
		+	[[5uig]] – hA2AR/cytochrome b562 (mutant) + antagonist <br />

	== References ==		== References ==
	<references/>		<references/>