Arrestin - Revision history

Michal Harel at 09:31, 28 May 2024

2024-05-28T09:31:06Z

←Older revision		Revision as of 09:31, 28 May 2024
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	*'''Arrestin-3''' assists in activation of JNK3 <ref>PMID:37371033</ref>.		*'''Arrestin-3''' assists in activation of JNK3 <ref>PMID:37371033</ref>.
	*'''Arrestin-4''' or '''cone arrestin''' binds in a cone cell th G protein kinase to desensitise opsin.		*'''Arrestin-4''' or '''cone arrestin''' binds in a cone cell th G protein kinase to desensitise opsin.
		+	*'''S-arrestin''' binds to photo activated Rho and terminates its signaling.

	== Structural highlights ==		== Structural highlights ==

Michal Harel at 09:25, 28 May 2024

2024-05-28T09:25:26Z

←Older revision		Revision as of 09:25, 28 May 2024
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	*'''Arrestin-2''' is regulator of B-cell function<ref>PMID:28145434</ref>.		*'''Arrestin-2''' is regulator of B-cell function<ref>PMID:28145434</ref>.
	*'''Arrestin-3''' assists in activation of JNK3 <ref>PMID:37371033</ref>.		*'''Arrestin-3''' assists in activation of JNK3 <ref>PMID:37371033</ref>.
-	*'''Arrestin-3''' or '''cone arrestin''' binds in a cone cell th G protein kinase to desensitise opsin.	+	*'''Arrestin-4''' or '''cone arrestin''' binds in a cone cell th G protein kinase to desensitise opsin.

	== Structural highlights ==		== Structural highlights ==

Michal Harel at 09:25, 28 May 2024

2024-05-28T09:25:12Z

←Older revision		Revision as of 09:25, 28 May 2024
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	*'''Arrestin-2''' is regulator of B-cell function<ref>PMID:28145434</ref>.		*'''Arrestin-2''' is regulator of B-cell function<ref>PMID:28145434</ref>.
	*'''Arrestin-3''' assists in activation of JNK3 <ref>PMID:37371033</ref>.		*'''Arrestin-3''' assists in activation of JNK3 <ref>PMID:37371033</ref>.
-	*'''Arrestin-3''' or '''cone arrestin'''	+	*'''Arrestin-3''' or '''cone arrestin''' binds in a cone cell th G protein kinase to desensitise opsin.

	== Structural highlights ==		== Structural highlights ==

Michal Harel at 09:22, 28 May 2024

2024-05-28T09:22:46Z

←Older revision		Revision as of 09:22, 28 May 2024
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	*'''Arrestin-2''' is regulator of B-cell function<ref>PMID:28145434</ref>.		*'''Arrestin-2''' is regulator of B-cell function<ref>PMID:28145434</ref>.
	*'''Arrestin-3''' assists in activation of JNK3 <ref>PMID:37371033</ref>.		*'''Arrestin-3''' assists in activation of JNK3 <ref>PMID:37371033</ref>.
		+	*'''Arrestin-3''' or '''cone arrestin'''

	== Structural highlights ==		== Structural highlights ==

Michal Harel at 08:55, 28 May 2024

2024-05-28T08:55:10Z

←Older revision		Revision as of 08:55, 28 May 2024
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	'''Arrestin''' (ARR) is a ubiquitous protein which binds to the G protein-coupled receptor after its phosphorylation. ARR binding blocks further G protein-mediated signaling and redirects signaling to alternative non-G protein-independent pathways. Hence, ARR are versatile adaptor molecules which can also activate signaling cascades and are involved in nuclear functions.<ref>PMID:10219246</ref>		'''Arrestin''' (ARR) is a ubiquitous protein which binds to the G protein-coupled receptor after its phosphorylation. ARR binding blocks further G protein-mediated signaling and redirects signaling to alternative non-G protein-independent pathways. Hence, ARR are versatile adaptor molecules which can also activate signaling cascades and are involved in nuclear functions.<ref>PMID:10219246</ref>
-	*'''Arrestin-2''' is ~~regulayor~~ of B-cell function<ref>PMID:28145434</ref>.	+	*'''Arrestin-2''' is regulator of B-cell function<ref>PMID:28145434</ref>.
		+	*'''Arrestin-3''' assists in activation of JNK3 <ref>PMID:37371033</ref>.

	== Structural highlights ==		== Structural highlights ==

Michal Harel at 08:47, 28 May 2024

2024-05-28T08:47:37Z

←Older revision		Revision as of 08:47, 28 May 2024
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	'''Arrestin''' (ARR) is a ubiquitous protein which binds to the G protein-coupled receptor after its phosphorylation. ARR binding blocks further G protein-mediated signaling and redirects signaling to alternative non-G protein-independent pathways. Hence, ARR are versatile adaptor molecules which can also activate signaling cascades and are involved in nuclear functions.<ref>PMID:10219246</ref>		'''Arrestin''' (ARR) is a ubiquitous protein which binds to the G protein-coupled receptor after its phosphorylation. ARR binding blocks further G protein-mediated signaling and redirects signaling to alternative non-G protein-independent pathways. Hence, ARR are versatile adaptor molecules which can also activate signaling cascades and are involved in nuclear functions.<ref>PMID:10219246</ref>
		+	*'''Arrestin-2''' is regulayor of B-cell function<ref>PMID:28145434</ref>.

	== Structural highlights ==		== Structural highlights ==

Michal Harel at 08:32, 20 March 2019

2019-03-20T08:32:57Z

←Older revision		Revision as of 08:32, 20 March 2019
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	</StructureSection>		</StructureSection>
-
-	== 3D Structures of arrestin ==
-
-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*Arrestin-2 (β-arrestin-1)
-
-	**[[1g4m]], [[1g4r]], [[1jsy]], [[2wtr]] – bARR2 - bovine<br />
-	**[[1zsh]], [[5tv1]] – bARR2 + inositol hexakisphosphate<br />
-	**[[3gc3]], [[3gd1]] – bARR2 + clathrin heavy chain<br />
-	**[[4jqi]] – rARR2 + antibody + vasopressin V2 receptor peptide - rat<br />
-
-	*Arrestin-3 (β-arrestin-2)
-
-	**[[3p2d]] – bARR3 <br />
-
-	*S-arrestin (P44)
-
-	**[[1ayr]], [[1cf1]], [[3ugu]], [[3ugx]], [[4j2q]] – bS-ARR <br />
-	**[[4zrg]] – bS-ARR (mutant)<br />
-	**[[4pxf]] – bS-ARR + rhodopsin<br />
-	**[[4zwj]], [[5dgy]], [[5w0p]] – S-ARR/rhodopsin/endolysin - mouse<br />
-
-	*Arrestin-4 or Cone arrestin
-
-	**[[1suj]] – ARRC – tiger salamander <br />
-
-	*Visual arrestin
-
-	**[[6bk9]] – ARR – longfin inshore squid <br />
-	}}

	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 08:31, 20 March 2019

2019-03-20T08:31:46Z

←Older revision		Revision as of 08:31, 20 March 2019
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	ARR consist of 2 domains. The N terminal domain structure is immunoglobulin-like. The binding site of phosphorylated light-activated rhodopsin is located at the N terminal of ARR.		ARR consist of 2 domains. The N terminal domain structure is immunoglobulin-like. The binding site of phosphorylated light-activated rhodopsin is located at the N terminal of ARR.
	*<scene name='70/706269/Cv/3'>Ba+2 ion binding sites</scene>.		*<scene name='70/706269/Cv/3'>Ba+2 ion binding sites</scene>.
		+
		+	== 3D Structures of arrestin ==
		+	[[Arrestin 3D structures]]

	</StructureSection>		</StructureSection>
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	**[[1suj]] – ARRC – tiger salamander <br />		**[[1suj]] – ARRC – tiger salamander <br />
		+
		+	*Visual arrestin
		+
		+	**[[6bk9]] – ARR – longfin inshore squid <br />
	}}		}}

Alexander Berchansky at 11:14, 6 January 2019

2019-01-06T11:14:31Z

←Older revision		Revision as of 11:14, 6 January 2019
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	ARR consist of 2 domains. The N terminal domain structure is immunoglobulin-like. The binding site of phosphorylated light-activated rhodopsin is located at the N terminal of ARR.		ARR consist of 2 domains. The N terminal domain structure is immunoglobulin-like. The binding site of phosphorylated light-activated rhodopsin is located at the N terminal of ARR.
-	*<scene name='70/706269/Cv/2'>Ba+2 ion binding sites</scene>.	+	*<scene name='70/706269/Cv/3'>Ba+2 ion binding sites</scene>.

	</StructureSection>		</StructureSection>

Michal Harel at 09:19, 22 March 2018

2018-03-22T09:19:54Z

←Older revision		Revision as of 09:19, 22 March 2018
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	**[[1g4m]], [[1g4r]], [[1jsy]], [[2wtr]] – bARR2 - bovine<br />		**[[1g4m]], [[1g4r]], [[1jsy]], [[2wtr]] – bARR2 - bovine<br />
-	**[[1zsh]] – bARR2 + inositol hexakisphosphate<br />	+	**[[1zsh]], [[5tv1]] – bARR2 + inositol hexakisphosphate<br />
	**[[3gc3]], [[3gd1]] – bARR2 + clathrin heavy chain<br />		**[[3gc3]], [[3gd1]] – bARR2 + clathrin heavy chain<br />
	**[[4jqi]] – rARR2 + antibody + vasopressin V2 receptor peptide - rat<br />		**[[4jqi]] – rARR2 + antibody + vasopressin V2 receptor peptide - rat<br />
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	**[[4zrg]] – bS-ARR (mutant)<br />		**[[4zrg]] – bS-ARR (mutant)<br />
	**[[4pxf]] – bS-ARR + rhodopsin<br />		**[[4pxf]] – bS-ARR + rhodopsin<br />
-	**[[4zwj]], [[5dgy]] – S-ARR/rhodopsin/endolysin - mouse<br />	+	**[[4zwj]], [[5dgy]], [[5w0p]] – S-ARR/rhodopsin/endolysin - mouse<br />

	*Arrestin-4 or Cone arrestin		*Arrestin-4 or Cone arrestin