Bacterioferritin comigratory protein - Revision history

Alexander Berchansky at 12:21, 16 April 2020

2020-04-16T12:21:46Z

←Older revision		Revision as of 12:21, 16 April 2020
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	== Structural highlights ==		== Structural highlights ==

-	The ~~active site of~~ BCP containing the cysteine-~~derivative~~ <scene name='84/842007/Cv/3'>3-sulfinoalanine</scene> and S-hydroxycysteine and contains 2 water molecules which mimic the oxygens of the peroxide substrate<ref>PMID:27594682</ref>.	+	The BCP containing the cysteine-derivatives <scene name='84/842007/Cv/3'>3-sulfinoalanine</scene> and <scene name='84/842007/Cv/4'>S-hydroxycysteine</scene> and contains 2 water molecules which mimic the oxygens of the peroxide substrate<ref>PMID:27594682</ref>.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 11:43, 16 April 2020

2020-04-16T11:43:01Z

←Older revision		Revision as of 11:43, 16 April 2020
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	== Structural highlights ==		== Structural highlights ==

-	The active site of BCP containing the cysteine-derivative <scene name='84/842007/Cv/2'>3-sulfinoalanine</scene> and S-hydroxycysteine and contains 2 water molecules which mimic the oxygens of the peroxide substrate<ref>PMID:27594682</ref>.	+	The active site of BCP containing the cysteine-derivative <scene name='84/842007/Cv/3'>3-sulfinoalanine</scene> and S-hydroxycysteine and contains 2 water molecules which mimic the oxygens of the peroxide substrate<ref>PMID:27594682</ref>.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 11:14, 16 April 2020

2020-04-16T11:14:41Z

←Older revision		Revision as of 11:14, 16 April 2020
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	== Structural highlights ==		== Structural highlights ==

-	The active site of BCP containing the cysteine-derivative 3-sulfinoalanine and S-hydroxycysteine ~~contain~~ 2 water molecules which mimic the oxygens of the peroxide substrate<ref>PMID:27594682</ref>.	+	The active site of BCP containing the cysteine-derivative <scene name='84/842007/Cv/2'>3-sulfinoalanine</scene> and S-hydroxycysteine and contains 2 water molecules which mimic the oxygens of the peroxide substrate<ref>PMID:27594682</ref>.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 11:05, 16 April 2020

2020-04-16T11:05:44Z

←Older revision		Revision as of 11:05, 16 April 2020
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-	<StructureSection load='5ipg' size='340' side='right' caption='Bacterioferritin comigratory protein containing 3-sulfinoaniline and S-hydroxycysteine complex with Na+ ions (purple) (PBD code [[5ipg]])' scene=''>	+	<StructureSection load='5ipg' size='340' side='right' caption='Bacterioferritin comigratory protein containing 3-sulfinoaniline and S-hydroxycysteine complex with Na+ ions (purple) (PBD code [[5ipg]])' scene='84/842007/Cv/1'>

	== Function ==		== Function ==

Alexander Berchansky at 11:03, 16 April 2020

2020-04-16T11:03:03Z

←Older revision		Revision as of 11:03, 16 April 2020
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	== Function ==		== Function ==

-	'''Bacterioferritin comigratory protein''' or '''Bacterioferritin comigratory protein peroxiredoxin''' or ~~'''thiol~~ peroxidase~~'''~~ or '''~~peroxiredoxin~~ Q'''(BCP) is part of the peroxiredoxin family of proteins. BCP is important in hydrogen peroxide resistance, nodulation and nitrogen fixation in bacteria<ref>PMID:30953092</ref>. BCP active site Cys is stabilized as a reactive cys-thiolate and attacks a bound hydrogen peroxide to form Cys-sulfenate and water<ref>PMID:27594682</ref>.	+	'''Bacterioferritin comigratory protein''' or '''Bacterioferritin comigratory protein peroxiredoxin''' or [[Thiol peroxidase]] or '''Peroxiredoxin Q'''. (BCP) is part of the peroxiredoxin family of proteins. BCP is important in hydrogen peroxide resistance, nodulation and nitrogen fixation in bacteria<ref>PMID:30953092</ref>. BCP active site Cys is stabilized as a reactive cys-thiolate and attacks a bound hydrogen peroxide to form Cys-sulfenate and water<ref>PMID:27594682</ref>.

	== Relevance ==		== Relevance ==

Michal Harel at 10:14, 16 April 2020

2020-04-16T10:14:51Z

←Older revision		Revision as of 10:14, 16 April 2020
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-	<StructureSection load='5ipg' size='340' side='right' caption='~~Caption for this structure~~' scene=''>	+	<StructureSection load='5ipg' size='340' side='right' caption='Bacterioferritin comigratory protein containing 3-sulfinoaniline and S-hydroxycysteine complex with Na+ ions (purple) (PBD code [[5ipg]])' scene=''>

	== Function ==		== Function ==

	'''Bacterioferritin comigratory protein''' or '''Bacterioferritin comigratory protein peroxiredoxin''' or '''thiol peroxidase''' or '''peroxiredoxin Q'''(BCP) is part of the peroxiredoxin family of proteins. BCP is important in hydrogen peroxide resistance, nodulation and nitrogen fixation in bacteria<ref>PMID:30953092</ref>. BCP active site Cys is stabilized as a reactive cys-thiolate and attacks a bound hydrogen peroxide to form Cys-sulfenate and water<ref>PMID:27594682</ref>.		'''Bacterioferritin comigratory protein''' or '''Bacterioferritin comigratory protein peroxiredoxin''' or '''thiol peroxidase''' or '''peroxiredoxin Q'''(BCP) is part of the peroxiredoxin family of proteins. BCP is important in hydrogen peroxide resistance, nodulation and nitrogen fixation in bacteria<ref>PMID:30953092</ref>. BCP active site Cys is stabilized as a reactive cys-thiolate and attacks a bound hydrogen peroxide to form Cys-sulfenate and water<ref>PMID:27594682</ref>.
-
-	== Disease ==

	== Relevance ==		== Relevance ==
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	== Structural highlights ==		== Structural highlights ==

		+	The active site of BCP containing the cysteine-derivative 3-sulfinoalanine and S-hydroxycysteine contain 2 water molecules which mimic the oxygens of the peroxide substrate<ref>PMID:27594682</ref>.

	</StructureSection>		</StructureSection>

Michal Harel at 09:25, 16 April 2020

2020-04-16T09:25:32Z

←Older revision		Revision as of 09:25, 16 April 2020
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-		+	<StructureSection load='5ipg' size='340' side='right' caption='Caption for this structure' scene=''>
-	<StructureSection load='~~1stp~~' size='340' side='right' caption='Caption for this structure' scene=''>	+

	== Function ==		== Function ==

Michal Harel: New page: == Function == '''Bacterioferritin comigratory protein''' or '''Bacterioferritin com...

2020-04-16T09:08:21Z

New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Bacterioferritin comigratory protein''' or '''Bacterioferritin com...

New page

<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>

== Function ==

'''Bacterioferritin comigratory protein''' or '''Bacterioferritin comigratory protein peroxiredoxin''' or '''thiol peroxidase''' or '''peroxiredoxin Q'''(BCP) is part of the peroxiredoxin family of proteins. BCP is important in hydrogen peroxide resistance, nodulation and nitrogen fixation in bacteria<ref>PMID:30953092</ref>. BCP active site Cys is stabilized as a reactive cys-thiolate and attacks a bound hydrogen peroxide to form Cys-sulfenate and water<ref>PMID:27594682</ref>.

== Disease ==

== Relevance ==

BCP has defensive role against peroxide-mediated cell killing and protects supercoiled DNA against oxidative damage<ref>PMID:27987036</ref>.

== Structural highlights ==

</StructureSection>

==3D structures of bacterioferritin comigratory protein==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

[[2cx4]], [[2cx3]], [[4gqf]] - BCP - ''Aeropyrum pernix'' 
[[3gkk]], [[5iiz]], [[5iox]] - XcBCP- ''Xanthomonas campestris'' 
[[5io2]], [[5iph]] - XcBCP (mutant) 
[[3gkn]] - XcBCP (mutant) + naphthalenedisulfonic acid 
[[5im9]] - XcBCP + S-hydroxycysteine 
[[5imv]], [[5imd]] - XcBCP + formate + cysteinesulfonic acid 
[[5ima]], [[5imc]] - XcBCP + formate + S-hydroxycysteine 
[[3gkm]] - XcBCP (mutant) + formate 
[[5ipg]], [[5iow]], [[5io0]] - XcBCP + sulfinoalanine + S-hydroxycysteine 
[[5imf]], [[5iny]], [[5imz]] - XcBCP + formate + sulfinoalanine + S-hydroxycysteine 
[[3drn]] - SsBCP1 (mutant) - ''Sulfolobus solfataricus'' 
[[3hjp]] - SsBCP4 (mutant) 
[[3ixr]] - BCP (mutant) - ''Xylella fastidiosas'' 

== References ==
<references/>

[[Category:Topic Page]]