CREB-binding protein - Revision history

Michal Harel at 09:28, 30 November 2022

2022-11-30T09:28:06Z

←Older revision		Revision as of 09:28, 30 November 2022
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	== Function ==		== Function ==

-	'''CREB-binding protein''' (CBP) is a transcription activator. CREB is cAMP response element-binding protein which is a cellular transcription factor which binds to DNA and regulates transcription. CBP acetylates histones. It binds to phosphorylated CREB and enhances its activity. <ref>PMID:8413673</ref>	+	'''CREB-binding protein''' or '''CREBBP''' (CBP) is a transcription activator. CREB is cAMP response element-binding protein which is a cellular transcription factor which binds to DNA and regulates transcription. CBP acetylates histones. It binds to phosphorylated CREB and enhances its activity. <ref>PMID:8413673</ref>

	== Disease ==		== Disease ==

Michal Harel at 08:27, 19 May 2019

2019-05-19T08:27:47Z

←Older revision		Revision as of 08:27, 19 May 2019
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	</StructureSection>		</StructureSection>
-	== 3D Structures of CREB-binding protein ==

-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*CBP domains – BZIP 283-341; zinc finger 376-400; KIX 587-673; bromodomain 1081-1197; ZZ 1699-1751; TAZ2 1763-1854
-
-	**[[1wo3]], [[1wo4]], [[1wo5]], [[1wo6]], [[1wo7]] – hCBP zinc finger domain (mutant) – human - NMR <br />
-	**[[2d82]] – hCBP bromodomain - NMR<br />
-	**[[3dwy]], [[4ouf]], [[4whu]] – hCBP bromodomain <br />
-	**[[3p1c]], [[3p1d]], [[3p1e]], [[3p1f]], [[3svh]], [[4a9k]], [[4tqn]], [[4ts8]], [[4yk0]], [[5cgp]], [[5dbm]], [[5eic]], [[5eng]], [[5ep7]], [[5h85]], [[5i83]], [[5i86]], [[5i89]], [[5i8b]], [[5i8g]], [[5j0d]], [[5ktu]], [[5ktw]], [[5ktx]], [[5tb6]] – hCBP bromodomain + inhibitor<br />
-	[[2l84]], [[2l85]] – hCBP bromodomain + inhibitor - NMR<br />[[4i9o]] – mCBP GACKIX domain (mutant) - mouse <br />
-	**[[1f81]] – mCBP TAZ2 domain - NMR <br />
-	**[[1u2n]] – mCBP TAZ1 domain - NMR <br />
-	**[[1jjs]] – mCBP IBiD domain - NMR<br />
-	**[[1liq]] – mCBP CH1 domain - NMR<br />
-	**[[1tot]] – mCBP ZZ domain – NMR <br />
-	**[[2kkj]] – mCBP nuclear coactivator binding domain - NMR <br />
-
-	*CBP complex with protein
-
-	**[[1zoq]] – hCBP + interferon regulatory factor 3 <br />
-	**[[2n1a]] – hCBP + small ubiquitin-related modifier - NMR<br />
-	**[[5jem]] – hCBP residues 2065-2111 + interferon-3<br />
-	**[[2kje]] – hCBP TAZ2 domain + adenoviral E1A peptide - NMR<br />
-	**[[1jsp]] – hCBP bromodomain + p53 peptide - NMR<br />
-	**[[2kwf]] – hCBP KIX domain + transcription factor 4 – NMR <br />
-	**[[2lxs]], [[2lxt]] – hCBP KIX domain + histone methyltransferase MLL peptide – NMR <br />
-	**[[2rny]] – hCBP bromodomain + histone H3 peptide - NMR<br />
-	**[[4n3w]], [[4n4f]] - hCBP bromodomain + histone H4 peptide <br />
-	**[[4nr4]], [[4nr5]], [[4nr6]], [[4nr7]], [[4nyv]], [[4nyw]], [[4nyx]]- hCBP bromodomain + ligand<br />
-	**[[5zko]] – hCBP BZIP domain + CREB-regulated transcription coactivator + DNA <br />
-	**[[5zk1]] – hCBP BZIP domain (mutant) + CREB-regulated transcription coactivator + DNA <br />
-	**[[1kbh]] – mCBP + nuclear receptor coactivator - NMR <br />
-	**[[2c52]] – mCBP residues 2059-2117 + nuclear receptor coactivator - NMR<br />
-	**[[1r8u]] – mCBP TAZ1 domain + P300-interacting transactivator - NMR <br />
-	**[[1l8c]] – mCBP TAZ1 domain + hypoxia-inducible factor 1α - NMR<br />
-	**[[2lww]] - mCBP TAZ1 domain + nuclear transcription factor RELA – NMR <br />
-	**[[2ka6]] – mCBP TAZ2 domain + STAT1-TAD - NMR<br />
-	**[[2ka4]] – mCBP TAZ2 domain + STAT2-TAD - NMR<br />
-	**[[1kdx]] – mCBP KIX domain + CREB kinase inducible domain - NMR<br />
-	**[[2l14]] – mCBP nuclear coactivator binding domain + p53 peptide - NMR<br />
-	**[[1sb0]] – mCBP KIX domain + protein c-Myb – NMR <br />
-	**[[2agh]] – mCBP KIX domain + protein c-Myb + zinc finger protein HRX – NMR <br />
-	**[[2lqh]], [[2lqi]] – mCBP KIX domain + forkhead box O3 – NMR <br />
-
-	}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 08:17, 19 May 2019

2019-05-19T08:17:21Z

←Older revision		Revision as of 08:17, 19 May 2019
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	<scene name='54/541099/Cv/6'>Acetyllysine binding site</scene> with chain B ([[3p1c]]).<ref>PMID:22464331</ref>		<scene name='54/541099/Cv/6'>Acetyllysine binding site</scene> with chain B ([[3p1c]]).<ref>PMID:22464331</ref>
		+
		+	== 3D Structures of CREB-binding protein ==
		+	[[CREB-binding protein 3D structures]]
		+
	</StructureSection>		</StructureSection>
	== 3D Structures of CREB-binding protein ==		== 3D Structures of CREB-binding protein ==
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	{{#tree:id=OrganizedByTopic\|openlevels=0\|		{{#tree:id=OrganizedByTopic\|openlevels=0\|

-	*CBP	+	*CBP domains – BZIP 283-341; zinc finger 376-400; KIX 587-673; bromodomain 1081-1197; ZZ 1699-1751; TAZ2 1763-1854

-	**[[4i9o]] – mCBP GACKIX domain (mutant) - mouse <br />	+	**[[1wo3]], [[1wo4]], [[1wo5]], [[1wo6]], [[1wo7]] – hCBP zinc finger domain (mutant) – human - NMR <br />
		+	**[[2d82]] – hCBP bromodomain - NMR<br />
		+	**[[3dwy]], [[4ouf]], [[4whu]] – hCBP bromodomain <br />
		+	**[[3p1c]], [[3p1d]], [[3p1e]], [[3p1f]], [[3svh]], [[4a9k]], [[4tqn]], [[4ts8]], [[4yk0]], [[5cgp]], [[5dbm]], [[5eic]], [[5eng]], [[5ep7]], [[5h85]], [[5i83]], [[5i86]], [[5i89]], [[5i8b]], [[5i8g]], [[5j0d]], [[5ktu]], [[5ktw]], [[5ktx]], [[5tb6]] – hCBP bromodomain + inhibitor<br />
		+	[[2l84]], [[2l85]] – hCBP bromodomain + inhibitor - NMR<br />[[4i9o]] – mCBP GACKIX domain (mutant) - mouse <br />
	**[[1f81]] – mCBP TAZ2 domain - NMR <br />		**[[1f81]] – mCBP TAZ2 domain - NMR <br />
	**[[1u2n]] – mCBP TAZ1 domain - NMR <br />		**[[1u2n]] – mCBP TAZ1 domain - NMR <br />
Line 30:		Line 38:
	**[[1tot]] – mCBP ZZ domain – NMR <br />		**[[1tot]] – mCBP ZZ domain – NMR <br />
	**[[2kkj]] – mCBP nuclear coactivator binding domain - NMR <br />		**[[2kkj]] – mCBP nuclear coactivator binding domain - NMR <br />
-	**[[1wo3]], [[1wo4]], [[1wo5]], [[1wo6]], [[1wo7]] – hCBP zinc finger domain (mutant) – human - NMR <br />
-	**[[2d82]] – hCBP bromodomain - NMR<br />
-	**[[3dwy]], [[4ouf]], [[4whu]] – hCBP bromodomain <br />
-	**[[3p1c]], [[3p1d]], [[3p1e]], [[3p1f]], [[3svh]], [[4a9k]], [[4tqn]], [[4ts8]], [[4yk0]], [[5cgp]], [[5dbm]], [[5eic]], [[5eng]], [[5ep7]], [[5h85]], [[5i83]], [[5i86]], [[5i89]], [[5i8b]], [[5i8g]], [[5j0d]], [[5ktu]], [[5ktw]], [[5ktx]], [[5tb6]] – hCBP bromodomain + inhibitor<br />
-	**[[2l84]], [[2l85]] – hCBP bromodomain + inhibitor - NMR<br />

	*CBP complex with protein		*CBP complex with protein

-	**[[1kbh]] – hCBP + nuclear receptor coactivator - NMR <br />
	**[[1zoq]] – hCBP + interferon regulatory factor 3 <br />		**[[1zoq]] – hCBP + interferon regulatory factor 3 <br />
		+	**[[2n1a]] – hCBP + small ubiquitin-related modifier - NMR<br />
		+	**[[5jem]] – hCBP residues 2065-2111 + interferon-3<br />
		+	**[[2kje]] – hCBP TAZ2 domain + adenoviral E1A peptide - NMR<br />
		+	**[[1jsp]] – hCBP bromodomain + p53 peptide - NMR<br />
		+	**[[2kwf]] – hCBP KIX domain + transcription factor 4 – NMR <br />
		+	**[[2lxs]], [[2lxt]] – hCBP KIX domain + histone methyltransferase MLL peptide – NMR <br />
		+	**[[2rny]] – hCBP bromodomain + histone H3 peptide - NMR<br />
		+	**[[4n3w]], [[4n4f]] - hCBP bromodomain + histone H4 peptide <br />
		+	**[[4nr4]], [[4nr5]], [[4nr6]], [[4nr7]], [[4nyv]], [[4nyw]], [[4nyx]]- hCBP bromodomain + ligand<br />
		+	**[[5zko]] – hCBP BZIP domain + CREB-regulated transcription coactivator + DNA <br />
		+	**[[5zk1]] – hCBP BZIP domain (mutant) + CREB-regulated transcription coactivator + DNA <br />
		+	**[[1kbh]] – mCBP + nuclear receptor coactivator - NMR <br />
	**[[2c52]] – mCBP residues 2059-2117 + nuclear receptor coactivator - NMR<br />		**[[2c52]] – mCBP residues 2059-2117 + nuclear receptor coactivator - NMR<br />
	**[[1r8u]] – mCBP TAZ1 domain + P300-interacting transactivator - NMR <br />		**[[1r8u]] – mCBP TAZ1 domain + P300-interacting transactivator - NMR <br />
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	**[[2ka6]] – mCBP TAZ2 domain + STAT1-TAD - NMR<br />		**[[2ka6]] – mCBP TAZ2 domain + STAT1-TAD - NMR<br />
	**[[2ka4]] – mCBP TAZ2 domain + STAT2-TAD - NMR<br />		**[[2ka4]] – mCBP TAZ2 domain + STAT2-TAD - NMR<br />
-	**[[2n1a]] – hCBP + small ubiquitin-related modifier - NMR<br />
-	**[[5jem]] – hCBP residues 2065-2111 + interferon-3<br />
	**[[1kdx]] – mCBP KIX domain + CREB kinase inducible domain - NMR<br />		**[[1kdx]] – mCBP KIX domain + CREB kinase inducible domain - NMR<br />
-	**[[2kje]] – hCBP TAZ2 domain + adenoviral E1A peptide - NMR<br />
-	**[[1jsp]] – hCBP bromodomain + p53 peptide - NMR<br />
	**[[2l14]] – mCBP nuclear coactivator binding domain + p53 peptide - NMR<br />		**[[2l14]] – mCBP nuclear coactivator binding domain + p53 peptide - NMR<br />
	**[[1sb0]] – mCBP KIX domain + protein c-Myb – NMR <br />		**[[1sb0]] – mCBP KIX domain + protein c-Myb – NMR <br />
	**[[2agh]] – mCBP KIX domain + protein c-Myb + zinc finger protein HRX – NMR <br />		**[[2agh]] – mCBP KIX domain + protein c-Myb + zinc finger protein HRX – NMR <br />
	**[[2lqh]], [[2lqi]] – mCBP KIX domain + forkhead box O3 – NMR <br />		**[[2lqh]], [[2lqi]] – mCBP KIX domain + forkhead box O3 – NMR <br />
-	**[[2kwf]] – hCBP KIX domain + transcription factor 4 – NMR <br />	+
-	**[[2lxs]], [[2lxt]] – hCBP KIX domain + histone methyltransferase MLL peptide – NMR <br />	+
-	**[[2rny]] – hCBP bromodomain + histone H3 peptide - NMR<br />	+
-	**[[4n3w]], [[4n4f]] - hCBP bromodomain + histone H4 peptide <br />	+
-	**[[4nr4]], [[4nr5]], [[4nr6]], [[4nr7]], [[4nyv]], [[4nyw]], [[4nyx]]- hCBP bromodomain + ligand<br />	+
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Alexander Berchansky at 06:56, 18 February 2019

2019-02-18T06:56:57Z

←Older revision		Revision as of 06:56, 18 February 2019
Line 12:		Line 12:
	CBP contains several domains. Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53; IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 (Cys- and His-rich region 1) interacts with the N-terminal of p73.		CBP contains several domains. Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53; IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 (Cys- and His-rich region 1) interacts with the N-terminal of p73.

-	<scene name='54/541099/Cv/4'>Acetyllysine binding site</scene> with chain A. Water molecules are shown as red spheres.	+	<scene name='54/541099/Cv/5'>Acetyllysine binding site</scene> with chain A. Water molecules are shown as red spheres.

-	<scene name='54/541099/Cv/2'>Acetyllysine binding site</scene> with chain B ([[3p1c]]).<ref>PMID:22464331</ref>	+	<scene name='54/541099/Cv/6'>Acetyllysine binding site</scene> with chain B ([[3p1c]]).<ref>PMID:22464331</ref>
	</StructureSection>		</StructureSection>
	== 3D Structures of CREB-binding protein ==		== 3D Structures of CREB-binding protein ==

Michal Harel at 07:26, 5 April 2017

2017-04-05T07:26:05Z

←Older revision		Revision as of 07:26, 5 April 2017
Line 32:		Line 32:
	**[[1wo3]], [[1wo4]], [[1wo5]], [[1wo6]], [[1wo7]] – hCBP zinc finger domain (mutant) – human - NMR <br />		**[[1wo3]], [[1wo4]], [[1wo5]], [[1wo6]], [[1wo7]] – hCBP zinc finger domain (mutant) – human - NMR <br />
	**[[2d82]] – hCBP bromodomain - NMR<br />		**[[2d82]] – hCBP bromodomain - NMR<br />
-	**[[3dwy]] – hCBP bromodomain <br />	+	**[[3dwy]], [[4ouf]], [[4whu]] – hCBP bromodomain <br />
-	**[[3p1c]], [[3p1d]], [[3p1e]], [[3p1f]], [[3svh]], [[4a9k]] – hCBP bromodomain + ~~small molecule~~<br />	+	**[[3p1c]], [[3p1d]], [[3p1e]], [[3p1f]], [[3svh]], [[4a9k]], [[4tqn]], [[4ts8]], [[4yk0]], [[5cgp]], [[5dbm]], [[5eic]], [[5eng]], [[5ep7]], [[5h85]], [[5i83]], [[5i86]], [[5i89]], [[5i8b]], [[5i8g]], [[5j0d]], [[5ktu]], [[5ktw]], [[5ktx]], [[5tb6]] – hCBP bromodomain + inhibitor<br />
-	**[[2l84]], [[2l85]] – hCBP bromodomain + ~~small molecule~~ - NMR<br />	+	**[[2l84]], [[2l85]] – hCBP bromodomain + inhibitor - NMR<br />

	*CBP complex with protein		*CBP complex with protein
Line 46:		Line 46:
	**[[2ka6]] – mCBP TAZ2 domain + STAT1-TAD - NMR<br />		**[[2ka6]] – mCBP TAZ2 domain + STAT1-TAD - NMR<br />
	**[[2ka4]] – mCBP TAZ2 domain + STAT2-TAD - NMR<br />		**[[2ka4]] – mCBP TAZ2 domain + STAT2-TAD - NMR<br />
		+	**[[2n1a]] – hCBP + small ubiquitin-related modifier - NMR<br />
		+	**[[5jem]] – hCBP residues 2065-2111 + interferon-3<br />
	**[[1kdx]] – mCBP KIX domain + CREB kinase inducible domain - NMR<br />		**[[1kdx]] – mCBP KIX domain + CREB kinase inducible domain - NMR<br />
	**[[2kje]] – hCBP TAZ2 domain + adenoviral E1A peptide - NMR<br />		**[[2kje]] – hCBP TAZ2 domain + adenoviral E1A peptide - NMR<br />

Alexander Berchansky at 14:05, 31 January 2016

2016-01-31T14:05:56Z

←Older revision		Revision as of 14:05, 31 January 2016
Line 12:		Line 12:
	CBP contains several domains. Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53; IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 (Cys- and His-rich region 1) interacts with the N-terminal of p73.		CBP contains several domains. Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53; IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 (Cys- and His-rich region 1) interacts with the N-terminal of p73.

-	<scene name='54/541099/Cv/4'>Acetyllysine binding site</scene> with chain A.	+	<scene name='54/541099/Cv/4'>Acetyllysine binding site</scene> with chain A. Water molecules are shown as red spheres.

-	<scene name='54/541099/Cv/2'>Acetyllysine binding site</scene> with chain B.	+	<scene name='54/541099/Cv/2'>Acetyllysine binding site</scene> with chain B ([[3p1c]]).<ref>PMID:22464331</ref>
	</StructureSection>		</StructureSection>
	== 3D Structures of CREB-binding protein ==		== 3D Structures of CREB-binding protein ==

Alexander Berchansky at 14:03, 31 January 2016

2016-01-31T14:03:51Z

←Older revision		Revision as of 14:03, 31 January 2016
Line 11:		Line 11:

	CBP contains several domains. Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53; IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 (Cys- and His-rich region 1) interacts with the N-terminal of p73.		CBP contains several domains. Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53; IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 (Cys- and His-rich region 1) interacts with the N-terminal of p73.
		+
		+	<scene name='54/541099/Cv/4'>Acetyllysine binding site</scene> with chain A.
		+
		+	<scene name='54/541099/Cv/2'>Acetyllysine binding site</scene> with chain B.
	</StructureSection>		</StructureSection>
	== 3D Structures of CREB-binding protein ==		== 3D Structures of CREB-binding protein ==

Alexander Berchansky at 13:36, 31 January 2016

2016-01-31T13:36:31Z

←Older revision		Revision as of 13:36, 31 January 2016
Line 1:		Line 1:
-	<StructureSection load='' size='350' side='right' scene='' caption='Human CREB-binding protein with acetyllysine complex with SCN- and K+ (purple) ions [[3p1c]]'>	+	<StructureSection load='3p1c' size='350' side='right' scene='54/541099/Cv/1' caption='Human CREB-binding protein with acetyllysine complex with SCN- and K+ (purple) ions [[3p1c]]'>
-	~~[[Image:1kbh.png\|left\|200px\|thumb\|Crystal structure of CREB-binding protein bromodomain (green) complex with nuclear receptor coactivator (grey) [[1kbh]]]]~~	+
	== Function ==		== Function ==

Alexander Berchansky at 13:33, 31 January 2016

2016-01-31T13:33:02Z

←Older revision		Revision as of 13:33, 31 January 2016
Line 1:		Line 1:
-		+	<StructureSection load='' size='350' side='right' scene='' caption='Human CREB-binding protein with acetyllysine complex with SCN- and K+ (purple) ions [[3p1c]]'>
	[[Image:1kbh.png\|left\|200px\|thumb\|Crystal structure of CREB-binding protein bromodomain (green) complex with nuclear receptor coactivator (grey) [[1kbh]]]]		[[Image:1kbh.png\|left\|200px\|thumb\|Crystal structure of CREB-binding protein bromodomain (green) complex with nuclear receptor coactivator (grey) [[1kbh]]]]
-	{{STRUCTURE_3p1c\| PDB=3p1c \| SIZE=350\| SCENE= \|right\|CAPTION=Human CREB-binding protein with acetyllysine complex with SCN- and K+ (purple) ions [[3p1c]] }}
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
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	== Function ==		== Function ==

Line 34:		Line 12:

	CBP contains several domains. Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53; IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 (Cys- and His-rich region 1) interacts with the N-terminal of p73.		CBP contains several domains. Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53; IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 (Cys- and His-rich region 1) interacts with the N-terminal of p73.
-		+	</StructureSection>
	== 3D Structures of CREB-binding protein ==		== 3D Structures of CREB-binding protein ==

Michal Harel at 09:51, 15 December 2015

2015-12-15T09:51:55Z

←Older revision		Revision as of 09:51, 15 December 2015
Line 1:		Line 1:

-	[[Image:1kbh.png\|left\|200px\|thumb\|Crystal structure of CREB-binding protein (green) complex with nuclear receptor coactivator (grey) [[1kbh]]]]	+	[[Image:1kbh.png\|left\|200px\|thumb\|Crystal structure of CREB-binding protein bromodomain (green) complex with nuclear receptor coactivator (grey) [[1kbh]]]]
	{{STRUCTURE_3p1c\| PDB=3p1c \| SIZE=350\| SCENE= \|right\|CAPTION=Human CREB-binding protein with acetyllysine complex with SCN- and K+ (purple) ions [[3p1c]] }}		{{STRUCTURE_3p1c\| PDB=3p1c \| SIZE=350\| SCENE= \|right\|CAPTION=Human CREB-binding protein with acetyllysine complex with SCN- and K+ (purple) ions [[3p1c]] }}