Disulfide Connectivity of Velaglucerase - Revision history

Michal Harel at 21:26, 10 January 2012

2012-01-10T21:26:06Z

←Older revision		Revision as of 21:26, 10 January 2012
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	==3D structures of beta-glucocerebrosidase==		==3D structures of beta-glucocerebrosidase==

-	[[Acid-beta glucosidase]]	+	[[Acid-beta-glucosidase]]

	==Additional Resources==		==Additional Resources==

Michal Harel at 21:25, 10 January 2012

2012-01-10T21:25:21Z

←Older revision		Revision as of 21:25, 10 January 2012
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	'''Disulfide Connectivity:''' ''C4-C16 & C18-C23''		'''Disulfide Connectivity:''' ''C4-C16 & C18-C23''
		+
		+	==3D structures of beta-glucocerebrosidase==
		+
		+	[[Acid-beta glucosidase]]

	==Additional Resources==		==Additional Resources==

Wayne Decatur: added links to PDB entry page

2010-12-19T01:05:26Z

added links to PDB entry page

←Older revision		Revision as of 01:05, 19 December 2010
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	{{Clear}}		{{Clear}}
	<applet load='1ogs' size='[450,338]' frame='true' align='right'		<applet load='1ogs' size='[450,338]' frame='true' align='right'
-	caption='Human beta-glucocerebrosidase (1ogs)' scene='User:Adriana_Kita/Sandbox_1/Gcase_whole/5'/>	+	caption='Human beta-glucocerebrosidase ([[1ogs]])' scene='User:Adriana_Kita/Sandbox_1/Gcase_whole/5'/>

	Human beta-glucocerebrosidase, also known as glucoceremidase, GCase, and velaglucerase, is an enzyme that is commonly found to be deficient in patients with Gaucher's disease. <ref group="xtra">PMID:12792654</ref><ref group="xtra">PMID:17524049</ref><ref group="xtra">PMID:19741058</ref>		Human beta-glucocerebrosidase, also known as glucoceremidase, GCase, and velaglucerase, is an enzyme that is commonly found to be deficient in patients with Gaucher's disease. <ref group="xtra">PMID:12792654</ref><ref group="xtra">PMID:17524049</ref><ref group="xtra">PMID:19741058</ref>
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	{{Clear}}		{{Clear}}
	<applet load='1ogs' size='[450,338]' frame='true' align='right'		<applet load='1ogs' size='[450,338]' frame='true' align='right'
-	caption='Disulfide Connectivity of GCase' scene='User:Adriana_Kita/Sandbox_1/Gcase_disulfide_1/2'/>	+	caption='Disulfide Connectivity of GCase ([[1ogs]])' scene='User:Adriana_Kita/Sandbox_1/Gcase_disulfide_1/2'/>
	=== Disulfide Structure ===		=== Disulfide Structure ===

David Canner at 08:03, 2 October 2010

2010-10-02T08:03:17Z

←Older revision		Revision as of 08:03, 2 October 2010
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	'''Disulfide Connectivity:''' ''C4-C16 & C18-C23''		'''Disulfide Connectivity:''' ''C4-C16 & C18-C23''
		+
		+	==Additional Resources==
		+	For additional information, see: [[Metabolic Disorders]]
		+	<br />

	==Reference==		==Reference==

Joel L. Sussman: /* Human beta-glucocerebrosidase */

2010-05-01T10:46:57Z

Human beta-glucocerebrosidase

←Older revision		Revision as of 10:46, 1 May 2010
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	caption='Human beta-glucocerebrosidase (1ogs)' scene='User:Adriana_Kita/Sandbox_1/Gcase_whole/5'/>		caption='Human beta-glucocerebrosidase (1ogs)' scene='User:Adriana_Kita/Sandbox_1/Gcase_whole/5'/>

-	Human beta-glucocerebrosidase, also known as glucoceremidase, GCase, and velaglucerase, is an enzyme that is commonly found to be deficient in patients with Gaucher's disease. <ref group="xtra">PMID:12792654</ref><ref group="xtra">PMID:17524049</ref>	+	Human beta-glucocerebrosidase, also known as glucoceremidase, GCase, and velaglucerase, is an enzyme that is commonly found to be deficient in patients with Gaucher's disease. <ref group="xtra">PMID:12792654</ref><ref group="xtra">PMID:17524049</ref><ref group="xtra">PMID:19741058</ref>
	Currently, there are three drugs on the market to treat this disease. One being Genzyme's Cerezyme, Protalix's Taliglucerase and SHIRE's VPRIV.		Currently, there are three drugs on the market to treat this disease. One being Genzyme's Cerezyme, Protalix's Taliglucerase and SHIRE's VPRIV.

Joel L. Sussman: /* Human beta-glucocerebrosidase */

2010-05-01T10:26:24Z

Human beta-glucocerebrosidase

←Older revision		Revision as of 10:26, 1 May 2010
Line 7:		Line 7:

	Human beta-glucocerebrosidase, also known as glucoceremidase, GCase, and velaglucerase, is an enzyme that is commonly found to be deficient in patients with Gaucher's disease. <ref group="xtra">PMID:12792654</ref><ref group="xtra">PMID:17524049</ref>		Human beta-glucocerebrosidase, also known as glucoceremidase, GCase, and velaglucerase, is an enzyme that is commonly found to be deficient in patients with Gaucher's disease. <ref group="xtra">PMID:12792654</ref><ref group="xtra">PMID:17524049</ref>
-	Currently, there are three drugs on the market to treat this disease. One being Genzyme's Cerezyme, by Protalix's Taliglucerase and SHIRE's VPRIV.	+	Currently, there are three drugs on the market to treat this disease. One being Genzyme's Cerezyme, Protalix's Taliglucerase and SHIRE's VPRIV.

	The typical method used to sequence current biologics, as well as map post translational modifications, is a combination of proteolytic digestion followed by LC/MS. Unfortunately, sometimes this method is not enough for complete identification of some post translational modifications. I am interested in the oxidation of Cys residues for the formation of disulfide bonds.		The typical method used to sequence current biologics, as well as map post translational modifications, is a combination of proteolytic digestion followed by LC/MS. Unfortunately, sometimes this method is not enough for complete identification of some post translational modifications. I am interested in the oxidation of Cys residues for the formation of disulfide bonds.

Joel L. Sussman: /* Human beta-glucocerebrosidase */

2010-05-01T10:25:58Z

Human beta-glucocerebrosidase

←Older revision		Revision as of 10:25, 1 May 2010
Line 7:		Line 7:

	Human beta-glucocerebrosidase, also known as glucoceremidase, GCase, and velaglucerase, is an enzyme that is commonly found to be deficient in patients with Gaucher's disease. <ref group="xtra">PMID:12792654</ref><ref group="xtra">PMID:17524049</ref>		Human beta-glucocerebrosidase, also known as glucoceremidase, GCase, and velaglucerase, is an enzyme that is commonly found to be deficient in patients with Gaucher's disease. <ref group="xtra">PMID:12792654</ref><ref group="xtra">PMID:17524049</ref>
-	Currently, there are ~~two~~ drugs on the market to treat this disease. One being Genzyme's Cerezyme and ~~the other~~ SHIRE's VPRIV.	+	Currently, there are three drugs on the market to treat this disease. One being Genzyme's Cerezyme, by Protalix's Taliglucerase and SHIRE's VPRIV.

	The typical method used to sequence current biologics, as well as map post translational modifications, is a combination of proteolytic digestion followed by LC/MS. Unfortunately, sometimes this method is not enough for complete identification of some post translational modifications. I am interested in the oxidation of Cys residues for the formation of disulfide bonds.		The typical method used to sequence current biologics, as well as map post translational modifications, is a combination of proteolytic digestion followed by LC/MS. Unfortunately, sometimes this method is not enough for complete identification of some post translational modifications. I am interested in the oxidation of Cys residues for the formation of disulfide bonds.
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	'''Disulfide Connectivity:''' ''C4-C16 & C18-C23''		'''Disulfide Connectivity:''' ''C4-C16 & C18-C23''
-

	==Reference==		==Reference==

Joel L. Sussman at 10:24, 1 May 2010

2010-05-01T10:24:57Z

←Older revision		Revision as of 10:24, 1 May 2010
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	caption='Human beta-glucocerebrosidase (1ogs)' scene='User:Adriana_Kita/Sandbox_1/Gcase_whole/5'/>		caption='Human beta-glucocerebrosidase (1ogs)' scene='User:Adriana_Kita/Sandbox_1/Gcase_whole/5'/>

-	Human beta-glucocerebrosidase~~, PDB ID 1ogs<ref>PMID: 12792654 </ref>~~, also known as glucoceremidase, GCase, and velaglucerase, is an enzyme that is commonly found to be deficient in patients with Gaucher's disease.	+	Human beta-glucocerebrosidase, also known as glucoceremidase, GCase, and velaglucerase, is an enzyme that is commonly found to be deficient in patients with Gaucher's disease. <ref group="xtra">PMID:12792654</ref><ref group="xtra">PMID:17524049</ref>
-		+
	Currently, there are two drugs on the market to treat this disease. One being Genzyme's Cerezyme and the other SHIRE's VPRIV.		Currently, there are two drugs on the market to treat this disease. One being Genzyme's Cerezyme and the other SHIRE's VPRIV.

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	==Reference==		==Reference==
-	<references />	+	<references group="xtra"/>
	[[Category: Glucosylceramidase]]		[[Category: Glucosylceramidase]]
	[[Category: Single protein]]		[[Category: Single protein]]

Joel L. Sussman at 09:16, 1 May 2010

2010-05-01T09:16:19Z

←Older revision		Revision as of 09:16, 1 May 2010
Line 6:		Line 6:
	caption='Human beta-glucocerebrosidase (1ogs)' scene='User:Adriana_Kita/Sandbox_1/Gcase_whole/5'/>		caption='Human beta-glucocerebrosidase (1ogs)' scene='User:Adriana_Kita/Sandbox_1/Gcase_whole/5'/>

-	Human beta-glucocerebrosidase, PDB ID 1ogs<ref>PMID: ~~14764885~~ </ref>, also known as glucoceremidase, GCase, and velaglucerase, is an enzyme that is commonly found to be deficient in patients with Gaucher's disease.	+	Human beta-glucocerebrosidase, PDB ID 1ogs<ref>PMID: 12792654 </ref>, also known as glucoceremidase, GCase, and velaglucerase, is an enzyme that is commonly found to be deficient in patients with Gaucher's disease.

	Currently, there are two drugs on the market to treat this disease. One being Genzyme's Cerezyme and the other SHIRE's VPRIV.		Currently, there are two drugs on the market to treat this disease. One being Genzyme's Cerezyme and the other SHIRE's VPRIV.

Joel L. Sussman: /* Reference */

2010-05-01T09:13:16Z

Reference

←Older revision		Revision as of 09:13, 1 May 2010
Line 27:		Line 27:

	==Reference==		==Reference==
		+	<references />
	[[Category: Glucosylceramidase]]		[[Category: Glucosylceramidase]]
	[[Category: Single protein]]		[[Category: Single protein]]