Epithelial discoidin domain-containing receptor - Revision history

Michal Harel at 09:45, 19 January 2022

2022-01-19T09:45:52Z

←Older revision		Revision as of 09:45, 19 January 2022
Line 5:		Line 5:

	'''Epithelial discoidin domain-containing receptor''' (DDR1 and DDR2) are extracellular matrix-sensing [[Receptor tyrosine kinases]] which are activated by collagen and are expressed in bronchial epithelium. They are responsible for maintaining the normal structure of skin and kidney epithelia<ref>PMID:20884741</ref>. DDR1 and DDR2 function as sensors for extracellular matrix and to regulate a wide range of cell functions from migration and proliferation to cytokine secretion and extracellular matrix homeostasis/remodeling<ref name = "DDR1">PMID:24361528</ref>.		'''Epithelial discoidin domain-containing receptor''' (DDR1 and DDR2) are extracellular matrix-sensing [[Receptor tyrosine kinases]] which are activated by collagen and are expressed in bronchial epithelium. They are responsible for maintaining the normal structure of skin and kidney epithelia<ref>PMID:20884741</ref>. DDR1 and DDR2 function as sensors for extracellular matrix and to regulate a wide range of cell functions from migration and proliferation to cytokine secretion and extracellular matrix homeostasis/remodeling<ref name = "DDR1">PMID:24361528</ref>.
		+
		+	See also [[Kinase-linked, enzyme-linked and related receptors]].

	== Disease ==		== Disease ==

Michal Harel at 08:22, 18 July 2021

2021-07-18T08:22:19Z

Alexander Berchansky at 15:38, 18 February 2021

2021-02-18T15:38:42Z

←Older revision		Revision as of 15:38, 18 February 2021
Line 4:		Line 4:
	== Function ==		== Function ==

-	'''Epithelial discoidin domain-containing receptor''' (DDR1 and DDR2) are extracellular matrix-sensing ~~receptors~~ [[~~Tyrosine kinase~~]] which are activated by collagen and are expressed in bronchial epithelium. They are responsible for maintaining the normal structure of skin and kidney epithelia<ref>PMID:20884741</ref>. DDR1 and DDR2 function as sensors for extracellular matrix and to regulate a wide range of cell functions from migration and proliferation to cytokine secretion and extracellular matrix homeostasis/remodeling<ref name = "DDR1">PMID:24361528</ref>.	+	'''Epithelial discoidin domain-containing receptor''' (DDR1 and DDR2) are extracellular matrix-sensing [[Receptor tyrosine kinases]] which are activated by collagen and are expressed in bronchial epithelium. They are responsible for maintaining the normal structure of skin and kidney epithelia<ref>PMID:20884741</ref>. DDR1 and DDR2 function as sensors for extracellular matrix and to regulate a wide range of cell functions from migration and proliferation to cytokine secretion and extracellular matrix homeostasis/remodeling<ref name = "DDR1">PMID:24361528</ref>.

	== Disease ==		== Disease ==

Joel L. Sussman at 19:07, 21 August 2019

2019-08-21T19:07:32Z

←Older revision		Revision as of 19:07, 21 August 2019
Line 31:		Line 31:
	**[[3zos]], [[4bkj]], [[6bsd]] – hDDR1 kinase domain + cancer drug<br />		**[[3zos]], [[4bkj]], [[6bsd]] – hDDR1 kinase domain + cancer drug<br />
	**[[6few]] – hDDR1 kinase domain + alport syndrome drug<br />		**[[6few]] – hDDR1 kinase domain + alport syndrome drug<br />
-	**[[6fex]], [[6fil~~]], [[6fim~~]], [[6fin]], [[6fio]], [[6fiq]] – hDDR1 kinase domain (mutant) + alport syndrome drug<br />	+	**[[6fex]], [[6fil]],[[6fin]], [[6fio]], [[6fiq]] – hDDR1 kinase domain (mutant) + alport syndrome drug<br />
	**[[4ckr]], [[5bvn]], [[5bvo]], [[5bvw]], [[5fdp]], [[5fdx]], [[6brj]], [[6gwr]], [[6hp9]] – hDDR1 kinase domain + inhibitor<br />		**[[4ckr]], [[5bvn]], [[5bvo]], [[5bvw]], [[5fdp]], [[5fdx]], [[6brj]], [[6gwr]], [[6hp9]] – hDDR1 kinase domain + inhibitor<br />
	**[[4ag4]] – hDDR1 29-367 domain + antibody<br />		**[[4ag4]] – hDDR1 29-367 domain + antibody<br />

Michal Harel at 08:26, 23 June 2019

2019-06-23T08:26:20Z

←Older revision		Revision as of 08:26, 23 June 2019
Line 29:		Line 29:

	**[[5bvk]] – hDDR1 kinase domain 564-913 – human<br />		**[[5bvk]] – hDDR1 kinase domain 564-913 – human<br />
-	**[[3zos]], [[4bkj]] – hDDR1 kinase domain + cancer drug<br />	+	**[[3zos]], [[4bkj]], [[6bsd]] – hDDR1 kinase domain + cancer drug<br />
	**[[6few]] – hDDR1 kinase domain + alport syndrome drug<br />		**[[6few]] – hDDR1 kinase domain + alport syndrome drug<br />
	**[[6fex]], [[6fil]], [[6fim]], [[6fin]], [[6fio]], [[6fiq]] – hDDR1 kinase domain (mutant) + alport syndrome drug<br />		**[[6fex]], [[6fil]], [[6fim]], [[6fin]], [[6fio]], [[6fiq]] – hDDR1 kinase domain (mutant) + alport syndrome drug<br />
-	**[[4ckr]], [[5bvn]], [[5bvo]], [[5bvw]], [[5fdp]], [[5fdx]], [[6brj]], [[6gwr]] – hDDR1 kinase domain + inhibitor<br />	+	**[[4ckr]], [[5bvn]], [[5bvo]], [[5bvw]], [[5fdp]], [[5fdx]], [[6brj]], [[6gwr]], [[6hp9]] – hDDR1 kinase domain + inhibitor<br />
	**[[4ag4]] – hDDR1 29-367 domain + antibody<br />		**[[4ag4]] – hDDR1 29-367 domain + antibody<br />

Alexander Berchansky at 12:57, 31 December 2018

2018-12-31T12:57:05Z

←Older revision		Revision as of 12:57, 31 December 2018
Line 17:		Line 17:
	== Structural highlights ==		== Structural highlights ==

-	DDR1 contains a discoidin domain. This domain is about 150 amino acid long and is found in many blood coagulation factors. The structure of the complex between DDR1 and imatinib shows 6 hydrogen bonds interactions between the anti-cancer drug and the kinase domain including ~~two~~ bonds with the kinase allosteric site Asp-Phe-Gly (DFG motif)<ref>PMID:24768818</ref>.	+	DDR1 contains a discoidin domain. This domain is about 150 amino acid long and is found in many blood coagulation factors. The structure of the <scene name='80/805011/Cv/3'>complex between DDR1 and imatinib</scene> shows hydrogen bonds interactions between the anti-cancer drug and the kinase domain including bonds with the <scene name='80/805011/Cv/4'>kinase allosteric site Asp-Phe-Gly (DFG motif)</scene><ref>PMID:24768818</ref>. Water molecules are shown as red spheres.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 12:40, 31 December 2018

2018-12-31T12:40:06Z

←Older revision		Revision as of 12:40, 31 December 2018
Line 1:		Line 1:
-	<StructureSection load='4bkj' size='~~340~~' side='right' caption='Human DDR1 kinase domain complex with imatinib and ethylene glycol (PDB code [[4bkj]])' scene=''>	+	<StructureSection load='4bkj' size='400' side='right' caption='Human DDR1 kinase domain complex with imatinib and ethylene glycol (PDB code [[4bkj]])' scene='80/805011/Cv/1'>

Jaime Prilusky: Epithelial discoidin domain-containing receptor 1 moved to Epithelial discoidin domain-containing receptor: requested by Editor

2018-12-31T09:49:40Z

Epithelial discoidin domain-containing receptor 1 moved to Epithelial discoidin domain-containing receptor: requested by Editor

←Older revision

Revision as of 09:49, 31 December 2018

Michal Harel at 09:01, 31 December 2018

2018-12-31T09:01:30Z

←Older revision		Revision as of 09:01, 31 December 2018
Line 21:		Line 21:
	</StructureSection>		</StructureSection>

-	==3D structures of epithelial discoidin domain-containing receptor ~~1*Epithelial discoidin domain-containing receptor 1~~==	+	==3D structures of epithelial discoidin domain-containing receptor==

	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

Michal Harel at 09:00, 31 December 2018

2018-12-31T09:00:26Z

←Older revision		Revision as of 09:00, 31 December 2018
Line 4:		Line 4:
	== Function ==		== Function ==

-	'''Epithelial discoidin domain-containing receptor 1''' (DDR1) ~~is an~~ extracellular matrix-sensing ~~receptor~~ [[Tyrosine kinase]] which is activated by collagen and is expressed in bronchial epithelium. ~~It is~~ responsible for maintaining the normal structure of skin and kidney epithelia<ref>PMID:20884741</ref>. DDR1 and DDR2 function as sensors for extracellular matrix and to regulate a wide range of cell functions from migration and proliferation to cytokine secretion and extracellular matrix homeostasis/remodeling<ref name = "DDR1">PMID:24361528</ref>.	+	'''Epithelial discoidin domain-containing receptor''' (DDR1 and DDR2) are extracellular matrix-sensing receptors [[Tyrosine kinase]] which are activated by collagen and are expressed in bronchial epithelium. They are responsible for maintaining the normal structure of skin and kidney epithelia<ref>PMID:20884741</ref>. DDR1 and DDR2 function as sensors for extracellular matrix and to regulate a wide range of cell functions from migration and proliferation to cytokine secretion and extracellular matrix homeostasis/remodeling<ref name = "DDR1">PMID:24361528</ref>.

	== Disease ==		== Disease ==
Line 21:		Line 21:
	</StructureSection>		</StructureSection>

-	==3D structures of epithelial discoidin domain-containing receptor 1==	+	==3D structures of epithelial discoidin domain-containing receptor 1*Epithelial discoidin domain-containing receptor 1==

	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
		+	{{#tree:id=OrganizedByTopic\|openlevels=0\|

-	[[5bvk]] – hDDR1 kinase domain 564-913 – human<br />	+	*Epithelial discoidin domain-containing receptor 1; Domains – discoidin 26-186; ligand-binding 283-385; kinase 543-838
-	[[3zos]], [[4bkj]] – hDDR1 kinase domain + cancer drug<br />	+
-	[[6few]] – hDDR1 kinase domain + alport syndrome drug<br />	+	**[[5bvk]] – hDDR1 kinase domain 564-913 – human<br />
-	[[6fex]], [[6fil]], [[6fim]], [[6fin]], [[6fio]], [[6fiq]] – hDDR1 kinase domain (mutant) + alport syndrome drug<br />	+	**[[3zos]], [[4bkj]] – hDDR1 kinase domain + cancer drug<br />
-	[[4ckr]], [[5bvn]], [[5bvo]], [[5bvw]], [[5fdp]], [[5fdx]], [[6brj]], [[6gwr]] – hDDR1 kinase domain + inhibitor<br />	+	**[[6few]] – hDDR1 kinase domain + alport syndrome drug<br />
-	[[4ag4]] – hDDR1 29-367 domain + antibody<br />	+	**[[6fex]], [[6fil]], [[6fim]], [[6fin]], [[6fio]], [[6fiq]] – hDDR1 kinase domain (mutant) + alport syndrome drug<br />
		+	**[[4ckr]], [[5bvn]], [[5bvo]], [[5bvw]], [[5fdp]], [[5fdx]], [[6brj]], [[6gwr]] – hDDR1 kinase domain + inhibitor<br />
		+	**[[4ag4]] – hDDR1 29-367 domain + antibody<br />
		+
		+	*Epithelial discoidin domain-containing receptor 2
		+
		+	**[[2z4f]] – hDDR2 discoidin domain – NMR<br />
		+	**[[2wuh]] – hDDR2 discoidin domain + collagen<br />
		+	**[[6fer]] – hDDR2 kinase domain + inhibitor<br />
		+	}}
	== References ==		== References ==
	<references/>		<references/>

	[[Category:Topic Page]]		[[Category:Topic Page]]

←Older revision		Revision as of 08:22, 18 July 2021
Line 26:		Line 26:
	{{#tree:id=OrganizedByTopic\|openlevels=0\|		{{#tree:id=OrganizedByTopic\|openlevels=0\|

-	*Epithelial discoidin domain-containing receptor 1; Domains – discoidin 26-186; ligand-binding 283-385; kinase 543-~~838~~	+	*Epithelial discoidin domain-containing receptor 1; Domains – discoidin 26-186; ligand-binding 283-385; kinase 543-913

-	**[[5bvk]] – hDDR1 kinase domain ~~564-913~~ – human<br />	+	**[[5bvk]], [[6y23]] – hDDR1 kinase domain – human<br />
	**[[3zos]], [[4bkj]], [[6bsd]] – hDDR1 kinase domain + cancer drug<br />		**[[3zos]], [[4bkj]], [[6bsd]] – hDDR1 kinase domain + cancer drug<br />
	**[[6few]] – hDDR1 kinase domain + alport syndrome drug<br />		**[[6few]] – hDDR1 kinase domain + alport syndrome drug<br />
	**[[6fex]], [[6fil]],[[6fin]], [[6fio]], [[6fiq]] – hDDR1 kinase domain (mutant) + alport syndrome drug<br />		**[[6fex]], [[6fil]],[[6fin]], [[6fio]], [[6fiq]] – hDDR1 kinase domain (mutant) + alport syndrome drug<br />
-	**[[4ckr]], [[5bvn]], [[5bvo]], [[5bvw]], [[5fdp]], [[5fdx]], [[6brj]], [[6gwr]], [[6hp9]] – hDDR1 kinase domain + inhibitor<br />	+	**[[4ckr]], [[5bvn]], [[5bvo]], [[5bvw]], [[5fdp]], [[5fdx]], [[6brj]], [[6gwr]], [[6hp9]], [[7bcm]], [[7be6]] – hDDR1 kinase domain + inhibitor<br />
	**[[4ag4]] – hDDR1 29-367 domain + antibody<br />		**[[4ag4]] – hDDR1 29-367 domain + antibody<br />

Line 39:		Line 39:
	**[[2z4f]] – hDDR2 discoidin domain – NMR<br />		**[[2z4f]] – hDDR2 discoidin domain – NMR<br />
	**[[2wuh]] – hDDR2 discoidin domain + collagen<br />		**[[2wuh]] – hDDR2 discoidin domain + collagen<br />
-	**[[6fer]] – hDDR2 kinase domain + inhibitor<br />	+	**[[6fer]], [[7aym]] – hDDR2 kinase domain + inhibitor<br />
	}}		}}
	== References ==		== References ==