http://52.214.119.220/wiki/index.php?action=history&feed=atom&title=EzetimibeEzetimibe - Revision history2026-04-12T17:08:06ZRevision history for this page on the wikiMediaWiki 1.11.2http://52.214.119.220/wiki/index.php?title=Ezetimibe&diff=4069359&oldid=prevAlexander Berchansky at 08:26, 28 February 20242024-02-28T08:26:39Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Ezetimibe is a medication used to treat high blood cholesterol and certain other lipid abnormalities.<ref name="a1">DailyMed. 26 January 2011. Archived from the original on 10 May 2021. Retrieved 13 August 2022</ref><ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref> Generally it is used together with dietary changes and a statin.<ref name="a3">British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 196. ISBN 9780857113382.</ref> It is also available in the fixed combinations ezetimibe/simvastatin ([[Vytorin]]),<ref name="a4">"Vytorin- ezetimibe and simvastatin tablet". DailyMed. 1 June 2022. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/atorvastatin,<ref name="a5">"Liptruzet (ezetimibe and atorvastatin) tablets for oral useInitial U.S. Approval: 2013". DailyMed. 30 September 2016. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/rosuvastatin,<ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref><ref name="a6">"Roszet- rosuvastatin and ezetimibe tablet Roszet (- rosuvastatin and ezetimibe tablet". DailyMed. 15 September 2021. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> and ezetimibe/bempedoic acid.<ref name="a7">"Nexlizet- bempedoic acid and ezetimibe tablet, film coated". DailyMed. 24 September 2021. Retrieved 13 August 2022.</ref> See also [https://en.wikipedia.org/wiki/Ezetimibe].</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Ezetimibe is a medication used to treat high blood cholesterol and certain other lipid abnormalities.<ref name="a1">DailyMed. 26 January 2011. Archived from the original on 10 May 2021. Retrieved 13 August 2022</ref><ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref> Generally it is used together with dietary changes and a statin.<ref name="a3">British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 196. ISBN 9780857113382.</ref> It is also available in the fixed combinations ezetimibe/simvastatin ([[Vytorin]]),<ref name="a4">"Vytorin- ezetimibe and simvastatin tablet". DailyMed. 1 June 2022. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/atorvastatin,<ref name="a5">"Liptruzet (ezetimibe and atorvastatin) tablets for oral useInitial U.S. Approval: 2013". DailyMed. 30 September 2016. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/rosuvastatin,<ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref><ref name="a6">"Roszet- rosuvastatin and ezetimibe tablet Roszet (- rosuvastatin and ezetimibe tablet". DailyMed. 15 September 2021. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> and ezetimibe/bempedoic acid.<ref name="a7">"Nexlizet- bempedoic acid and ezetimibe tablet, film coated". DailyMed. 24 September 2021. Retrieved 13 August 2022.</ref> See also [https://en.wikipedia.org/wiki/Ezetimibe].</div></td></tr>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>Ezetimibe inhibits the absorption of cholesterol from the small intestine and decreases the amount of cholesterol normally available to liver cells. The lower levels of cholesterol in the liver cells leads them to absorb more cholesterol from circulation and thus lowering the levels of circulating cholesterol. It blocks the critical mediator of cholesterol absorption, the Niemann-Pick C1-like 1 (NPC1L1) protein on the gastrointestinal tract epithelial cells, as well as in hepatocytes; it blocks aminopeptidase N and interrupts a caveolin 1–annexin A2 complex involved in trafficking cholesterol.<ref name="a12">PMID:22910633</ref></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Ezetimibe inhibits the absorption of cholesterol from the small intestine and decreases the amount of cholesterol normally available to liver cells. The lower levels of cholesterol in the liver cells leads them to absorb more cholesterol from circulation and thus lowering the levels of circulating cholesterol. It blocks the critical mediator of cholesterol absorption, the Niemann-Pick C1-like 1 (NPC1L1) protein on the gastrointestinal tract epithelial cells, as well as in hepatocytes; it blocks <ins style="color: red; font-weight: bold; text-decoration: none;">[[</ins>aminopeptidase N<ins style="color: red; font-weight: bold; text-decoration: none;">]] </ins>and interrupts a caveolin 1–annexin A2 complex involved in trafficking cholesterol.<ref name="a12">PMID:22910633</ref></div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><scene name='97/976769/Cv/2'>Niemann-Pick C1-like 1 bound with Ezetimibe</scene> ([[7dfz]]).</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><scene name='97/976769/Cv/2'>Niemann-Pick C1-like 1 bound with Ezetimibe</scene> ([[7dfz]]).</div></td></tr>
</table>Alexander Berchanskyhttp://52.214.119.220/wiki/index.php?title=Ezetimibe&diff=4020333&oldid=prevMichal Harel at 07:50, 22 January 20242024-01-22T07:50:01Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Ezetimibe is a medication used to treat high blood cholesterol and certain other lipid abnormalities.<ref name="a1">DailyMed. 26 January 2011. Archived from the original on 10 May 2021. Retrieved 13 August 2022</ref><ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref> Generally it is used together with dietary changes and a statin.<ref name="a3">British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 196. ISBN 9780857113382.</ref> It is also available in the fixed combinations ezetimibe/simvastatin ([[Vytorin]]),<ref name="a4">"Vytorin- ezetimibe and simvastatin tablet". DailyMed. 1 June 2022. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/atorvastatin,<ref name="a5">"Liptruzet (ezetimibe and atorvastatin) tablets for oral useInitial U.S. Approval: 2013". DailyMed. 30 September 2016. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/rosuvastatin,<ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref><ref name="a6">"Roszet- rosuvastatin and ezetimibe tablet Roszet (- rosuvastatin and ezetimibe tablet". DailyMed. 15 September 2021. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> and ezetimibe/bempedoic acid.<ref name="a7">"Nexlizet- bempedoic acid and ezetimibe tablet, film coated". DailyMed. 24 September 2021. Retrieved 13 August 2022.</ref> See also [https://en.wikipedia.org/wiki/Ezetimibe].</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Ezetimibe is a medication used to treat high blood cholesterol and certain other lipid abnormalities.<ref name="a1">DailyMed. 26 January 2011. Archived from the original on 10 May 2021. Retrieved 13 August 2022</ref><ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref> Generally it is used together with dietary changes and a statin.<ref name="a3">British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 196. ISBN 9780857113382.</ref> It is also available in the fixed combinations ezetimibe/simvastatin ([[Vytorin]]),<ref name="a4">"Vytorin- ezetimibe and simvastatin tablet". DailyMed. 1 June 2022. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/atorvastatin,<ref name="a5">"Liptruzet (ezetimibe and atorvastatin) tablets for oral useInitial U.S. Approval: 2013". DailyMed. 30 September 2016. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/rosuvastatin,<ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref><ref name="a6">"Roszet- rosuvastatin and ezetimibe tablet Roszet (- rosuvastatin and ezetimibe tablet". DailyMed. 15 September 2021. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> and ezetimibe/bempedoic acid.<ref name="a7">"Nexlizet- bempedoic acid and ezetimibe tablet, film coated". DailyMed. 24 September 2021. Retrieved 13 August 2022.</ref> See also [https://en.wikipedia.org/wiki/Ezetimibe].</div></td></tr>
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</table>Michal Harelhttp://52.214.119.220/wiki/index.php?title=Ezetimibe&diff=3805353&oldid=prevAlexander Berchansky at 12:10, 16 July 20232023-07-16T12:10:53Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><scene name='97/976769/Cv/2'>Niemann-Pick C1-like 1 bound with Ezetimibe</scene> ([[7dfz]]).</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><scene name='97/976769/Cv/2'>Niemann-Pick C1-like 1 bound with Ezetimibe</scene> ([[7dfz]]).</div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td></tr>
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</table>Alexander Berchanskyhttp://52.214.119.220/wiki/index.php?title=Ezetimibe&diff=3805314&oldid=prevAlexander Berchansky at 14:15, 13 July 20232023-07-13T14:15:49Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Ezetimibe inhibits the absorption of cholesterol from the small intestine and decreases the amount of cholesterol normally available to liver cells. The lower levels of cholesterol in the liver cells leads them to absorb more cholesterol from circulation and thus lowering the levels of circulating cholesterol. It blocks the critical mediator of cholesterol absorption, the Niemann-Pick C1-like 1 (NPC1L1) protein on the gastrointestinal tract epithelial cells, as well as in hepatocytes; it blocks aminopeptidase N and interrupts a caveolin 1–annexin A2 complex involved in trafficking cholesterol.<ref name="a12">PMID:22910633</ref></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Ezetimibe inhibits the absorption of cholesterol from the small intestine and decreases the amount of cholesterol normally available to liver cells. The lower levels of cholesterol in the liver cells leads them to absorb more cholesterol from circulation and thus lowering the levels of circulating cholesterol. It blocks the critical mediator of cholesterol absorption, the Niemann-Pick C1-like 1 (NPC1L1) protein on the gastrointestinal tract epithelial cells, as well as in hepatocytes; it blocks aminopeptidase N and interrupts a caveolin 1–annexin A2 complex involved in trafficking cholesterol.<ref name="a12">PMID:22910633</ref></div></td></tr>
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<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><scene name='97/976769/Cv/2'>Niemann-Pick C1-like 1 bound with Ezetimibe</scene> ([[7dfz]]).</div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td></tr>
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</table>Alexander Berchanskyhttp://52.214.119.220/wiki/index.php?title=Ezetimibe&diff=3805313&oldid=prevAlexander Berchansky at 13:57, 13 July 20232023-07-13T13:57:58Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Ezetimibe is a medication used to treat high blood cholesterol and certain other lipid abnormalities.<ref name="a1">DailyMed. 26 January 2011. Archived from the original on 10 May 2021. Retrieved 13 August 2022</ref><ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref> Generally it is used together with dietary changes and a statin.<ref name="a3">British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 196. ISBN 9780857113382.</ref> It is also available in the fixed combinations ezetimibe/simvastatin ([[Vytorin]]),<ref name="a4">"Vytorin- ezetimibe and simvastatin tablet". DailyMed. 1 June 2022. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/atorvastatin,<ref name="a5">"Liptruzet (ezetimibe and atorvastatin) tablets for oral useInitial U.S. Approval: 2013". DailyMed. 30 September 2016. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/rosuvastatin,<ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref><ref name="a6">"Roszet- rosuvastatin and ezetimibe tablet Roszet (- rosuvastatin and ezetimibe tablet". DailyMed. 15 September 2021. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> and ezetimibe/bempedoic acid.<ref name="a7">"Nexlizet- bempedoic acid and ezetimibe tablet, film coated". DailyMed. 24 September 2021. Retrieved 13 August 2022.</ref> See also [https://en.wikipedia.org/wiki/Ezetimibe].</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Ezetimibe is a medication used to treat high blood cholesterol and certain other lipid abnormalities.<ref name="a1">DailyMed. 26 January 2011. Archived from the original on 10 May 2021. Retrieved 13 August 2022</ref><ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref> Generally it is used together with dietary changes and a statin.<ref name="a3">British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 196. ISBN 9780857113382.</ref> It is also available in the fixed combinations ezetimibe/simvastatin ([[Vytorin]]),<ref name="a4">"Vytorin- ezetimibe and simvastatin tablet". DailyMed. 1 June 2022. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/atorvastatin,<ref name="a5">"Liptruzet (ezetimibe and atorvastatin) tablets for oral useInitial U.S. Approval: 2013". DailyMed. 30 September 2016. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/rosuvastatin,<ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref><ref name="a6">"Roszet- rosuvastatin and ezetimibe tablet Roszet (- rosuvastatin and ezetimibe tablet". DailyMed. 15 September 2021. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> and ezetimibe/bempedoic acid.<ref name="a7">"Nexlizet- bempedoic acid and ezetimibe tablet, film coated". DailyMed. 24 September 2021. Retrieved 13 August 2022.</ref> See also [https://en.wikipedia.org/wiki/Ezetimibe].</div></td></tr>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>Ezetimibe inhibits the absorption of cholesterol from the small intestine and decreases the amount of cholesterol normally available to liver cells. The lower levels of cholesterol in the liver cells leads them to absorb more cholesterol from circulation and thus lowering the levels of circulating cholesterol. It blocks the critical mediator of cholesterol absorption, the Niemann-Pick C1-like 1 (NPC1L1) protein on the gastrointestinal tract epithelial cells, as well as in hepatocytes; it blocks aminopeptidase N and interrupts a caveolin 1–annexin A2 complex involved in trafficking cholesterol.<del style="color: red; font-weight: bold; text-decoration: none;"></ref></del><ref name="a12">PMID:22910633</ref></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Ezetimibe inhibits the absorption of cholesterol from the small intestine and decreases the amount of cholesterol normally available to liver cells. The lower levels of cholesterol in the liver cells leads them to absorb more cholesterol from circulation and thus lowering the levels of circulating cholesterol. It blocks the critical mediator of cholesterol absorption, the Niemann-Pick C1-like 1 (NPC1L1) protein on the gastrointestinal tract epithelial cells, as well as in hepatocytes; it blocks aminopeptidase N and interrupts a caveolin 1–annexin A2 complex involved in trafficking cholesterol.<ref name="a12">PMID:22910633</ref></div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td></tr>
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</table>Alexander Berchanskyhttp://52.214.119.220/wiki/index.php?title=Ezetimibe&diff=3805312&oldid=prevAlexander Berchansky at 13:57, 13 July 20232023-07-13T13:57:30Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Ezetimibe is a medication used to treat high blood cholesterol and certain other lipid abnormalities.<ref name="a1">DailyMed. 26 January 2011. Archived from the original on 10 May 2021. Retrieved 13 August 2022</ref><ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref> Generally it is used together with dietary changes and a statin.<ref name="a3">British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 196. ISBN 9780857113382.</ref> It is also available in the fixed combinations ezetimibe/simvastatin ([[Vytorin]]),<ref name="a4">"Vytorin- ezetimibe and simvastatin tablet". DailyMed. 1 June 2022. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/atorvastatin,<ref name="a5">"Liptruzet (ezetimibe and atorvastatin) tablets for oral useInitial U.S. Approval: 2013". DailyMed. 30 September 2016. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/rosuvastatin,<ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref><ref name="a6">"Roszet- rosuvastatin and ezetimibe tablet Roszet (- rosuvastatin and ezetimibe tablet". DailyMed. 15 September 2021. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> and ezetimibe/bempedoic acid.<ref name="a7">"Nexlizet- bempedoic acid and ezetimibe tablet, film coated". DailyMed. 24 September 2021. Retrieved 13 August 2022.</ref> See also [https://en.wikipedia.org/wiki/Ezetimibe].</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Ezetimibe is a medication used to treat high blood cholesterol and certain other lipid abnormalities.<ref name="a1">DailyMed. 26 January 2011. Archived from the original on 10 May 2021. Retrieved 13 August 2022</ref><ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref> Generally it is used together with dietary changes and a statin.<ref name="a3">British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 196. ISBN 9780857113382.</ref> It is also available in the fixed combinations ezetimibe/simvastatin ([[Vytorin]]),<ref name="a4">"Vytorin- ezetimibe and simvastatin tablet". DailyMed. 1 June 2022. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/atorvastatin,<ref name="a5">"Liptruzet (ezetimibe and atorvastatin) tablets for oral useInitial U.S. Approval: 2013". DailyMed. 30 September 2016. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/rosuvastatin,<ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref><ref name="a6">"Roszet- rosuvastatin and ezetimibe tablet Roszet (- rosuvastatin and ezetimibe tablet". DailyMed. 15 September 2021. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> and ezetimibe/bempedoic acid.<ref name="a7">"Nexlizet- bempedoic acid and ezetimibe tablet, film coated". DailyMed. 24 September 2021. Retrieved 13 August 2022.</ref> See also [https://en.wikipedia.org/wiki/Ezetimibe].</div></td></tr>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>Ezetimibe inhibits the absorption of cholesterol from the small intestine and decreases the amount of cholesterol normally available to liver cells. The lower levels of cholesterol in the liver cells leads them to absorb more cholesterol from circulation and thus lowering the levels of circulating cholesterol. It blocks the critical mediator of cholesterol absorption, the Niemann-Pick C1-like 1 (NPC1L1) protein on the gastrointestinal tract epithelial cells, as well as in hepatocytes; it blocks aminopeptidase N and interrupts a caveolin 1–annexin A2 complex involved in trafficking cholesterol.<del style="color: red; font-weight: bold; text-decoration: none;">[12]</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Ezetimibe inhibits the absorption of cholesterol from the small intestine and decreases the amount of cholesterol normally available to liver cells. The lower levels of cholesterol in the liver cells leads them to absorb more cholesterol from circulation and thus lowering the levels of circulating cholesterol. It blocks the critical mediator of cholesterol absorption, the Niemann-Pick C1-like 1 (NPC1L1) protein on the gastrointestinal tract epithelial cells, as well as in hepatocytes; it blocks aminopeptidase N and interrupts a caveolin 1–annexin A2 complex involved in trafficking cholesterol.<ins style="color: red; font-weight: bold; text-decoration: none;"></ref><ref name="a12">PMID:22910633</ref></ins></div></td></tr>
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</table>Alexander Berchanskyhttp://52.214.119.220/wiki/index.php?title=Ezetimibe&diff=3805311&oldid=prevAlexander Berchansky at 13:56, 13 July 20232023-07-13T13:56:27Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Ezetimibe is a medication used to treat high blood cholesterol and certain other lipid abnormalities.<ref name="a1">DailyMed. 26 January 2011. Archived from the original on 10 May 2021. Retrieved 13 August 2022</ref><ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref> Generally it is used together with dietary changes and a statin.<ref name="a3">British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 196. ISBN 9780857113382.</ref> It is also available in the fixed combinations ezetimibe/simvastatin ([[Vytorin]]),<ref name="a4">"Vytorin- ezetimibe and simvastatin tablet". DailyMed. 1 June 2022. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/atorvastatin,<ref name="a5">"Liptruzet (ezetimibe and atorvastatin) tablets for oral useInitial U.S. Approval: 2013". DailyMed. 30 September 2016. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/rosuvastatin,<ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref><ref name="a6">"Roszet- rosuvastatin and ezetimibe tablet Roszet (- rosuvastatin and ezetimibe tablet". DailyMed. 15 September 2021. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> and ezetimibe/bempedoic acid.<ref name="a7">"Nexlizet- bempedoic acid and ezetimibe tablet, film coated". DailyMed. 24 September 2021. Retrieved 13 August 2022.</ref> See also [https://en.wikipedia.org/wiki/Ezetimibe].</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Ezetimibe is a medication used to treat high blood cholesterol and certain other lipid abnormalities.<ref name="a1">DailyMed. 26 January 2011. Archived from the original on 10 May 2021. Retrieved 13 August 2022</ref><ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref> Generally it is used together with dietary changes and a statin.<ref name="a3">British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 196. ISBN 9780857113382.</ref> It is also available in the fixed combinations ezetimibe/simvastatin ([[Vytorin]]),<ref name="a4">"Vytorin- ezetimibe and simvastatin tablet". DailyMed. 1 June 2022. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/atorvastatin,<ref name="a5">"Liptruzet (ezetimibe and atorvastatin) tablets for oral useInitial U.S. Approval: 2013". DailyMed. 30 September 2016. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/rosuvastatin,<ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref><ref name="a6">"Roszet- rosuvastatin and ezetimibe tablet Roszet (- rosuvastatin and ezetimibe tablet". DailyMed. 15 September 2021. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> and ezetimibe/bempedoic acid.<ref name="a7">"Nexlizet- bempedoic acid and ezetimibe tablet, film coated". DailyMed. 24 September 2021. Retrieved 13 August 2022.</ref> See also [https://en.wikipedia.org/wiki/Ezetimibe].</div></td></tr>
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<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Ezetimibe inhibits the absorption of cholesterol from the small intestine and decreases the amount of cholesterol normally available to liver cells. The lower levels of cholesterol in the liver cells leads them to absorb more cholesterol from circulation and thus lowering the levels of circulating cholesterol. It blocks the critical mediator of cholesterol absorption, the Niemann-Pick C1-like 1 (NPC1L1) protein on the gastrointestinal tract epithelial cells, as well as in hepatocytes; it blocks aminopeptidase N and interrupts a caveolin 1–annexin A2 complex involved in trafficking cholesterol.[12]</div></td></tr>
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</table>Alexander Berchanskyhttp://52.214.119.220/wiki/index.php?title=Ezetimibe&diff=3805310&oldid=prevAlexander Berchansky at 13:08, 13 July 20232023-07-13T13:08:06Z<p></p>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>Ezetimibe is a medication used to treat high blood cholesterol and certain other lipid abnormalities.<ref name="a1">DailyMed. 26 January 2011. Archived from the original on 10 May 2021. Retrieved 13 August 2022</ref><ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref> Generally it is used together with dietary changes and a statin.<ref name="a3">British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 196. ISBN 9780857113382.</ref> It is also available in the fixed combinations ezetimibe/simvastatin,<ref name="a4">"Vytorin- ezetimibe and simvastatin tablet". DailyMed. 1 June 2022. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/atorvastatin,<ref name="a5">"Liptruzet (ezetimibe and atorvastatin) tablets for oral useInitial U.S. Approval: 2013". DailyMed. 30 September 2016. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/rosuvastatin,<ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref><ref name="a6">"Roszet- rosuvastatin and ezetimibe tablet Roszet (- rosuvastatin and ezetimibe tablet". DailyMed. 15 September 2021. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> and ezetimibe/bempedoic acid.<ref name="a7">"Nexlizet- bempedoic acid and ezetimibe tablet, film coated". DailyMed. 24 September 2021. Retrieved 13 August 2022.</ref> See also [https://en.wikipedia.org/wiki/Ezetimibe].</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Ezetimibe is a medication used to treat high blood cholesterol and certain other lipid abnormalities.<ref name="a1">DailyMed. 26 January 2011. Archived from the original on 10 May 2021. Retrieved 13 August 2022</ref><ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref> Generally it is used together with dietary changes and a statin.<ref name="a3">British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 196. ISBN 9780857113382.</ref> It is also available in the fixed combinations ezetimibe/simvastatin <ins style="color: red; font-weight: bold; text-decoration: none;">([[Vytorin]])</ins>,<ref name="a4">"Vytorin- ezetimibe and simvastatin tablet". DailyMed. 1 June 2022. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/atorvastatin,<ref name="a5">"Liptruzet (ezetimibe and atorvastatin) tablets for oral useInitial U.S. Approval: 2013". DailyMed. 30 September 2016. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/rosuvastatin,<ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref><ref name="a6">"Roszet- rosuvastatin and ezetimibe tablet Roszet (- rosuvastatin and ezetimibe tablet". DailyMed. 15 September 2021. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> and ezetimibe/bempedoic acid.<ref name="a7">"Nexlizet- bempedoic acid and ezetimibe tablet, film coated". DailyMed. 24 September 2021. Retrieved 13 August 2022.</ref> See also [https://en.wikipedia.org/wiki/Ezetimibe].</div></td></tr>
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</table>Alexander Berchanskyhttp://52.214.119.220/wiki/index.php?title=Ezetimibe&diff=3805309&oldid=prevAlexander Berchansky at 13:06, 13 July 20232023-07-13T13:06:12Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Ezetimibe is a medication used to treat high blood cholesterol and certain other lipid abnormalities.<ref name="a1">DailyMed. 26 January 2011. Archived from the original on 10 May 2021. Retrieved 13 August 2022</ref><ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref> Generally it is used together with dietary changes and a statin.<ref name="a3">British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 196. ISBN 9780857113382.</ref> It is also available in the fixed combinations ezetimibe/simvastatin,<ref name="a4">"Vytorin- ezetimibe and simvastatin tablet". DailyMed. 1 June 2022. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/atorvastatin,<ref name="a5">"Liptruzet (ezetimibe and atorvastatin) tablets for oral useInitial U.S. Approval: 2013". DailyMed. 30 September 2016. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/rosuvastatin,<ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref><ref name="a6">"Roszet- rosuvastatin and ezetimibe tablet Roszet (- rosuvastatin and ezetimibe tablet". DailyMed. 15 September 2021. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> and ezetimibe/bempedoic acid.<ref name="a7">"Nexlizet- bempedoic acid and ezetimibe tablet, film coated". DailyMed. 24 September 2021. Retrieved 13 August 2022.</ref> See also [https://en.wikipedia.org/wiki/Ezetimibe].</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Ezetimibe is a medication used to treat high blood cholesterol and certain other lipid abnormalities.<ref name="a1">DailyMed. 26 January 2011. Archived from the original on 10 May 2021. Retrieved 13 August 2022</ref><ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref> Generally it is used together with dietary changes and a statin.<ref name="a3">British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 196. ISBN 9780857113382.</ref> It is also available in the fixed combinations ezetimibe/simvastatin,<ref name="a4">"Vytorin- ezetimibe and simvastatin tablet". DailyMed. 1 June 2022. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/atorvastatin,<ref name="a5">"Liptruzet (ezetimibe and atorvastatin) tablets for oral useInitial U.S. Approval: 2013". DailyMed. 30 September 2016. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/rosuvastatin,<ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref><ref name="a6">"Roszet- rosuvastatin and ezetimibe tablet Roszet (- rosuvastatin and ezetimibe tablet". DailyMed. 15 September 2021. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> and ezetimibe/bempedoic acid.<ref name="a7">"Nexlizet- bempedoic acid and ezetimibe tablet, film coated". DailyMed. 24 September 2021. Retrieved 13 August 2022.</ref> See also [https://en.wikipedia.org/wiki/Ezetimibe].</div></td></tr>
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</table>Alexander Berchanskyhttp://52.214.119.220/wiki/index.php?title=Ezetimibe&diff=3805307&oldid=prevAlexander Berchansky at 13:02, 13 July 20232023-07-13T13:02:06Z<p></p>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>Ezetimibe is a medication used to treat high blood cholesterol and certain other lipid abnormalities.<ref name="a1">DailyMed. 26 January 2011. Archived from the original on 10 May 2021. Retrieved 13 August 2022</ref><ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref> Generally it is used together with dietary changes and a statin.<ref name="a3">British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 196. ISBN 9780857113382.</ref> It is also available in the fixed combinations ezetimibe/simvastatin,<ref name="a4">"Vytorin- ezetimibe and simvastatin tablet". DailyMed. 1 June 2022. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/atorvastatin,<ref name="a5">"Liptruzet (ezetimibe and atorvastatin) tablets for oral useInitial U.S. Approval: 2013". DailyMed. 30 September 2016. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/rosuvastatin,<del style="color: red; font-weight: bold; text-decoration: none;"><</del><ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref><ref name="a6">"Roszet- rosuvastatin and ezetimibe tablet Roszet (- rosuvastatin and ezetimibe tablet". DailyMed. 15 September 2021. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> and ezetimibe/bempedoic acid.<ref name="a7">"Nexlizet- bempedoic acid and ezetimibe tablet, film coated". DailyMed. 24 September 2021. Retrieved 13 August 2022.</ref> See also [https://en.wikipedia.org/wiki/Ezetimibe].</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Ezetimibe is a medication used to treat high blood cholesterol and certain other lipid abnormalities.<ref name="a1">DailyMed. 26 January 2011. Archived from the original on 10 May 2021. Retrieved 13 August 2022</ref><ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref> Generally it is used together with dietary changes and a statin.<ref name="a3">British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 196. ISBN 9780857113382.</ref> It is also available in the fixed combinations ezetimibe/simvastatin,<ref name="a4">"Vytorin- ezetimibe and simvastatin tablet". DailyMed. 1 June 2022. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/atorvastatin,<ref name="a5">"Liptruzet (ezetimibe and atorvastatin) tablets for oral useInitial U.S. Approval: 2013". DailyMed. 30 September 2016. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> ezetimibe/rosuvastatin,<ref name="a2">"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.</ref><ref name="a6">"Roszet- rosuvastatin and ezetimibe tablet Roszet (- rosuvastatin and ezetimibe tablet". DailyMed. 15 September 2021. Archived from the original on 14 August 2022. Retrieved 13 August 2022.</ref> and ezetimibe/bempedoic acid.<ref name="a7">"Nexlizet- bempedoic acid and ezetimibe tablet, film coated". DailyMed. 24 September 2021. Retrieved 13 August 2022.</ref> See also [https://en.wikipedia.org/wiki/Ezetimibe].</div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td></tr>
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</table>Alexander Berchansky