Fructose-1,6-bisphosphatase - Revision history

Alexander Berchansky at 13:22, 1 January 2023

2023-01-01T13:22:48Z

←Older revision		Revision as of 13:22, 1 January 2023
Line 2:		Line 2:
	== Function ==		== Function ==

-	'''Fructose-1,6-bisphosphatase''' (FBP) is an enzyme in the glucose generating pathway which converts fructose-1,6-bisphosphate to fructose 6-phosphate (F6P)<ref>PMID:8382485</ref>. FBP activity in hibernating animals is significantly reduced<ref>PMID:9505421</ref>. '''Fructose-2,6-bisphosphatase''' (F26BP) is the stimulator of phosphofructokinase which is a key enzyme in glycolysis<ref>PMID:8447185</ref>.	+	'''Fructose-1,6-bisphosphatase''' (FBP) is an enzyme in the glucose generating pathway which converts fructose-1,6-bisphosphate to fructose 6-phosphate (F6P)<ref>PMID:8382485</ref>. FBP activity in hibernating animals is significantly reduced<ref>PMID:9505421</ref>. '''Fructose-2,6-bisphosphatase''' (F26BP) is the stimulator of phosphofructokinase which is a key enzyme in [[glycolysis]]<ref>PMID:8447185</ref>.

	== Relevance ==		== Relevance ==

Michal Harel at 06:54, 4 July 2019

2019-07-04T06:54:48Z

←Older revision		Revision as of 06:54, 4 July 2019
Line 20:		Line 20:

	</StructureSection>		</StructureSection>
-	== 3D Structures of Fructose-1,6-bisphosphatase ==
-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|

-	*FBP
-
-	**[[5et5]], [[5et7]], [[5ldz]] - hFBP - human<br />
-	**[[5k54]] – hFBP (mutant)<br />
-	**[[2fbp]] - pFBP - pig<br />
-	**[[1fj6]], [[1fj9]], [[1yxi]], [[2f3b]], [[2f3d]] - pFBP (mutant) <br />
-	**[[1bk4]] – FBP – rabbit<br />
-	**[[1d9q]] – peFBP – pea<br />
-	**[[1dbz]], [[1dcu]] – peFBP (mutant)<br />
-	**[[1spi]] - FBP - spinach<br />
-	**[[5iz1]] - FBP - moss<br />
-	**[[6ayy]], [[5djf]] - MtFBP – ''Mycobacterium tuberculosis''<br />
-	**[[3bih]] - EcFBP GlpX (mutant) - ''Escherichia coli''<br />
-
-	*FBP binary complexes with fructose-6-phosphate
-
-	**[[5et8]], [[5k56]] - hFBP + F6P<br />
-	**[[5k55]] - hFBP (mutant) + F6P<br />
-	**[[5l0a]] - hFBP 2 (mutant) + F6-di-P<br />
-	**[[5fbp]] - pFBP + F6P<br />
-	**[[1rdx]] - pFBP (mutant) + F6P<br />
-	**[[2qvu]], [[2qvv]], [[1fpb]], [[3fbp]] - pFBP + F6-di-P<br />
-	**[[4gwu]] - pFBP (mutant) + F6-di-P<br />
-	**[[2r8t]] - EcFBP GlpX + F6P<br />
-	**[[3d1r]] - EcFBP GlpX (mutant) + F6P<br />
-
-	*FBP other binary complexes
-
-	**[[1fta]] – hFBP + AMP <br />
-	**[[2fhy]], [[2fie]], [[2fix]], [[2jjk]], [[2vt5]], [[3a29]], [[2wbb]], [[2wbd]], [[3kbz]], [[3kc0]], [[3kc1]], [[2y5k]], [[2y5l]], [[4mjo]], [[5q00]], [[5q01]], [[5q02]], [[5q03]], [[5q04]], [[5q05]], [[5q06]], [[5q07]], [[5q08]], [[5q09]], [[5q0a]], [[5q0b]], [[5q0c]], [[5pzw]], [[5pzx]], [[5pzy]], [[5pzz]], [[5pzs]], [[5pzt]], [[5pzu]], [[5pzv]], [[5pzr]], [[5pzq]] - hFBP 1 + inhibitor<br />
-	**[[5et6]] - hFBP 2 + AMP<br />
-	**[[3ifa]] - hFBP 2 (mutant) + AMP<br />
-	**[[4he0]] - hFBP 2 + phosphate<br />
-	**[[1fpk]] – pFBP + Tl<br />
-	**[[4fbp]] - pFBP + AMP <br />
-	**[[1yyz]], [[1yz0]] - pFBP (mutant) + AMP<br />
-	**[[1kz8]], [[1lev]], [[1q9d]] – pFBP + inhibitor<br />
-	**[[1fbc]], [[1fbd]], [[1fbe]] – pFBP + anhydroglucitol-biphosphate <br />
-	**[[1fbf]], [[1fbg]] – pFBP + anhydromannitol-biphosphate <br />
-	**[[2gq1]] – EcFBP + sulfate <br />
-	**[[3big]] - EcFBP GlpX (mutant) + phosphate<br />
-	**[[5oey]] - FBP + phosphate – ''Leishmania major''<br />
-	**[[5djk]], [[5djj]] - MtFBP + phosphate<br />
-	**[[5djg]] - MtFBP + ADP derivative<br />
-
-	*FBP ternary complexes
-
-	**[[3ifc]] - hFBP 2 (mutant) + AMP + F6P<br />
-	**[[4he1]] - hFBP 2 (mutant) + phosphate + F6P<br />
-	**[[4he2]] - hFBP 2 (mutant) + phosphite + AMP<br />
-	**[[5zwk]] - hFBP 1 (mutant) + F6-di-P + AMP<br />
-	**[[1fpi]], [[1fpj]], [[1fpl]] – pFBP + AMP + glucitol bisphosphate<br />
-	**[[1cnq]] – pFBP + Zn + F6P<br />
-	**[[1eyi]], [[1nuw]], [[1nux]], [[1nuy]], [[1nuz]], [[1nv0]], [[1nv1]], [[1nv2]], [[1nv3]] - pFBP + phosphate + F6P<br />
-	**[[1fbp]] - pFBP + AMP + F6P<br />
-	**[[1rdy]], [[1rdz]] - pFBP (mutant) + AMP + F6P<br />
-	**[[4gx3]], [[4gww]], [[4gwx]], [[1fsa]] - pFBP (mutant) + phosphate + F6P<br />
-	**[[1frp]] - pFBP + AMP + F-2,6-di-P<br />
-	**[[1fpd]], [[1fpe]], [[1fpf]], [[1fpg]] – pFBP + anhydroglucitol-biphosphate + AMP<br />
-	**[[2owz]] – EcFBP + citrate + F6P<br />
-	**[[2qvr]] - EcFBP + citrate + F6-di-P<br />
-	**[[2ox3]] - EcFBP + PEP + F6P<br />
-	**[[6ayu]], [[6ayv]] - MtFBP (mutant) + malonate + F6P <br />
-	**[[5dji]], [[5djh]] - MtFBP + phosphate + AMP<br />
-
-	*FBP quaternary complexes
-
-	**[[1nv4]], [[1nv5]], [[1nv6]] - pFBP + phosphate + EDTA + F6P<br />
-	**[[1eyj]], [[1eyk]], [[1nv7]], [[4h46]] - pFBP + phosphate + AMP + F6P<br />
-	**[[4gbv]], [[4gbw]] - pFBP + phosphate + AMP + F6P<br />
-	**[[4gx4]], [[4gx6]], [[4gwy]], [[4gws]], [[4gwz]], [[4kxp]] - pFBP (mutant) + phosphate + AMP + F6P<br />
-	**[[4h45]] - pFBP (mutant) + phosphate + Zn + F6P<br />
-	**[[1fbh]] – pFBP + α F-1,6-P + β F-1,6-P + F-1,6-bisphosphate <br />
-	**[[2q8m]] – FBP + β glucose-6-P + β F-1,6-P + F-1,6-bisphosphate + AMP – ''Shigella boydii'' <br />
-
-	*F26BP
-
-	**[[1c7z]] – rF26BP + phosphate + G3P - rat<br />
-	**[[1c80]] – rF26BP + phosphate + GTP <br />
-	**[[1c81]] – rF26BP + gluco-anhydro-deoxy-phosphonohexitol-phosphate <br />
-	**[[1fbt]] – rF26BP (mutant) + phosphate <br />
-
-	}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 06:53, 4 July 2019

2019-07-04T06:53:34Z

←Older revision		Revision as of 06:53, 4 July 2019
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	A <scene name='46/468243/Cv/5'>tricyclic potent FBP inhibitor interacts with the enzyme in a hydrophobic pocket</scene> <ref>PMID:20045638</ref> ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}, water molecule shown as red sphere).		A <scene name='46/468243/Cv/5'>tricyclic potent FBP inhibitor interacts with the enzyme in a hydrophobic pocket</scene> <ref>PMID:20045638</ref> ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}, water molecule shown as red sphere).
		+
		+	== 3D Structures of Fructose-1,6-bisphosphatase ==
		+	[[Fructose-1,6-bisphosphatase 3D structures]]

	</StructureSection>		</StructureSection>
Line 23:		Line 26:
	*FBP		*FBP

		+	**[[5et5]], [[5et7]], [[5ldz]] - hFBP - human<br />
		+	**[[5k54]] – hFBP (mutant)<br />
		+	**[[2fbp]] - pFBP - pig<br />
		+	**[[1fj6]], [[1fj9]], [[1yxi]], [[2f3b]], [[2f3d]] - pFBP (mutant) <br />
	**[[1bk4]] – FBP – rabbit<br />		**[[1bk4]] – FBP – rabbit<br />
	**[[1d9q]] – peFBP – pea<br />		**[[1d9q]] – peFBP – pea<br />
	**[[1dbz]], [[1dcu]] – peFBP (mutant)<br />		**[[1dbz]], [[1dcu]] – peFBP (mutant)<br />
-	**[[2fbp]] - pFBP - pig<br />
-	**[[1fj6]], [[1fj9]], [[1yxi]], [[2f3b]], [[2f3d]] - pFBP (mutant) <br />
-	**[[3bih]] - EcFBP GlpX (mutant) - ''Escherichia coli''<br />
	**[[1spi]] - FBP - spinach<br />		**[[1spi]] - FBP - spinach<br />
-	**[[5et5]], [[5et7]], [[5ldz]] - hFBP - human<br />
-	**[[5k54]] – hFBP (mutant)<br />
	**[[5iz1]] - FBP - moss<br />		**[[5iz1]] - FBP - moss<br />
	**[[6ayy]], [[5djf]] - MtFBP – ''Mycobacterium tuberculosis''<br />		**[[6ayy]], [[5djf]] - MtFBP – ''Mycobacterium tuberculosis''<br />
		+	**[[3bih]] - EcFBP GlpX (mutant) - ''Escherichia coli''<br />

	*FBP binary complexes with fructose-6-phosphate		*FBP binary complexes with fructose-6-phosphate
Line 39:		Line 42:
	**[[5et8]], [[5k56]] - hFBP + F6P<br />		**[[5et8]], [[5k56]] - hFBP + F6P<br />
	**[[5k55]] - hFBP (mutant) + F6P<br />		**[[5k55]] - hFBP (mutant) + F6P<br />
		+	**[[5l0a]] - hFBP 2 (mutant) + F6-di-P<br />
	**[[5fbp]] - pFBP + F6P<br />		**[[5fbp]] - pFBP + F6P<br />
	**[[1rdx]] - pFBP (mutant) + F6P<br />		**[[1rdx]] - pFBP (mutant) + F6P<br />
		+	**[[2qvu]], [[2qvv]], [[1fpb]], [[3fbp]] - pFBP + F6-di-P<br />
		+	**[[4gwu]] - pFBP (mutant) + F6-di-P<br />
	**[[2r8t]] - EcFBP GlpX + F6P<br />		**[[2r8t]] - EcFBP GlpX + F6P<br />
	**[[3d1r]] - EcFBP GlpX (mutant) + F6P<br />		**[[3d1r]] - EcFBP GlpX (mutant) + F6P<br />
Line 47:		Line 53:

	**[[1fta]] – hFBP + AMP <br />		**[[1fta]] – hFBP + AMP <br />
-	**[[2fhy]], [[2fie]], [[2fix]], [[2jjk]], [[2vt5]], [[3a29]], [[2wbb]], [[2wbd]], [[3kbz]], [[3kc0]], [[3kc1]], [[2y5k]], [[2y5l]], [[4mjo]] - hFBP + inhibitor<br />	+	**[[2fhy]], [[2fie]], [[2fix]], [[2jjk]], [[2vt5]], [[3a29]], [[2wbb]], [[2wbd]], [[3kbz]], [[3kc0]], [[3kc1]], [[2y5k]], [[2y5l]], [[4mjo]], [[5q00]], [[5q01]], [[5q02]], [[5q03]], [[5q04]], [[5q05]], [[5q06]], [[5q07]], [[5q08]], [[5q09]], [[5q0a]], [[5q0b]], [[5q0c]], [[5pzw]], [[5pzx]], [[5pzy]], [[5pzz]], [[5pzs]], [[5pzt]], [[5pzu]], [[5pzv]], [[5pzr]], [[5pzq]] - hFBP 1 + inhibitor<br />
-	**[[5et6]] - hFBP + AMP<br />	+	**[[5et6]] - hFBP 2 + AMP<br />
-	**[[3ifa]] - hFBP (mutant) + AMP<br />	+	**[[3ifa]] - hFBP 2 (mutant) + AMP<br />
-	**[[4he0]] - hFBP + phosphate~~<br />~~	+	**[[4he0]] - hFBP 2 + phosphate<br />
-	**[[5djk]], [[5djj]] - MtFBP + phosphate<br />	+
-	**[[5djg]] - MtFBP + ADP derivative<br />	+
	**[[1fpk]] – pFBP + Tl<br />		**[[1fpk]] – pFBP + Tl<br />
	**[[4fbp]] - pFBP + AMP <br />		**[[4fbp]] - pFBP + AMP <br />
	**[[1yyz]], [[1yz0]] - pFBP (mutant) + AMP<br />		**[[1yyz]], [[1yz0]] - pFBP (mutant) + AMP<br />
	**[[1kz8]], [[1lev]], [[1q9d]] – pFBP + inhibitor<br />		**[[1kz8]], [[1lev]], [[1q9d]] – pFBP + inhibitor<br />
-	**[[2qvu]], [[2qvv]], [[1fpb]], [[3fbp]] - pFBP + F6-di-P<br />
-	**[[4gwu]] - pFBP (mutant) + F6-di-P<br />
	**[[1fbc]], [[1fbd]], [[1fbe]] – pFBP + anhydroglucitol-biphosphate <br />		**[[1fbc]], [[1fbd]], [[1fbe]] – pFBP + anhydroglucitol-biphosphate <br />
	**[[1fbf]], [[1fbg]] – pFBP + anhydromannitol-biphosphate <br />		**[[1fbf]], [[1fbg]] – pFBP + anhydromannitol-biphosphate <br />
Line 64:		Line 66:
	**[[3big]] - EcFBP GlpX (mutant) + phosphate<br />		**[[3big]] - EcFBP GlpX (mutant) + phosphate<br />
	**[[5oey]] - FBP + phosphate – ''Leishmania major''<br />		**[[5oey]] - FBP + phosphate – ''Leishmania major''<br />
		+	**[[5djk]], [[5djj]] - MtFBP + phosphate<br />
		+	**[[5djg]] - MtFBP + ADP derivative<br />

	*FBP ternary complexes		*FBP ternary complexes

-	**[[3ifc]] - hFBP (mutant) + AMP + F6P<br />	+	**[[3ifc]] - hFBP 2 (mutant) + AMP + F6P<br />
-	**[[4he1]] - hFBP (mutant) + phosphate + F6P<br />	+	**[[4he1]] - hFBP 2 (mutant) + phosphate + F6P<br />
-	**[[4he2]] - hFBP (mutant) + phosphite + AMP<br />	+	**[[4he2]] - hFBP 2 (mutant) + phosphite + AMP<br />
		+	**[[5zwk]] - hFBP 1 (mutant) + F6-di-P + AMP<br />
	**[[1fpi]], [[1fpj]], [[1fpl]] – pFBP + AMP + glucitol bisphosphate<br />		**[[1fpi]], [[1fpj]], [[1fpl]] – pFBP + AMP + glucitol bisphosphate<br />
	**[[1cnq]] – pFBP + Zn + F6P<br />		**[[1cnq]] – pFBP + Zn + F6P<br />
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	**[[4h45]] - pFBP (mutant) + phosphate + Zn + F6P<br />		**[[4h45]] - pFBP (mutant) + phosphate + Zn + F6P<br />
	**[[1fbh]] – pFBP + α F-1,6-P + β F-1,6-P + F-1,6-bisphosphate <br />		**[[1fbh]] – pFBP + α F-1,6-P + β F-1,6-P + F-1,6-bisphosphate <br />
-	**[[2q8m]] – FBP + β glucose-6-P + β F-1,6-P + F-1,6-bisphosphate + AMP <br />	+	**[[2q8m]] – FBP + β glucose-6-P + β F-1,6-P + F-1,6-bisphosphate + AMP – ''Shigella boydii'' <br />

	*F26BP		*F26BP

Alexander Berchansky at 13:47, 29 May 2018

2018-05-29T13:47:16Z

←Older revision		Revision as of 13:47, 29 May 2018
Line 14:		Line 14:
	== Structural highlights ==		== Structural highlights ==

-	A <scene name='46/468243/Cv/4'>tricyclic potent FBP inhibitor interacts with the enzyme in a hydrophobic pocket</scene> <ref>PMID:20045638</ref> ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}, water molecule shown as red sphere).	+	A <scene name='46/468243/Cv/5'>tricyclic potent FBP inhibitor interacts with the enzyme in a hydrophobic pocket</scene> <ref>PMID:20045638</ref> ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}, water molecule shown as red sphere).

	</StructureSection>		</StructureSection>

Michal Harel at 09:38, 28 May 2018

2018-05-28T09:38:19Z

←Older revision		Revision as of 09:38, 28 May 2018
Line 31:		Line 31:
	**[[1spi]] - FBP - spinach<br />		**[[1spi]] - FBP - spinach<br />
	**[[5et5]], [[5et7]], [[5ldz]] - hFBP - human<br />		**[[5et5]], [[5et7]], [[5ldz]] - hFBP - human<br />
		+	**[[5k54]] – hFBP (mutant)<br />
	**[[5iz1]] - FBP - moss<br />		**[[5iz1]] - FBP - moss<br />
		+	**[[6ayy]], [[5djf]] - MtFBP – ''Mycobacterium tuberculosis''<br />

-	*FBP binary complexes	+	*FBP binary complexes with fructose-6-phosphate
		+
		+	**[[5et8]], [[5k56]] - hFBP + F6P<br />
		+	**[[5k55]] - hFBP (mutant) + F6P<br />
		+	**[[5fbp]] - pFBP + F6P<br />
		+	**[[1rdx]] - pFBP (mutant) + F6P<br />
		+	**[[2r8t]] - EcFBP GlpX + F6P<br />
		+	**[[3d1r]] - EcFBP GlpX (mutant) + F6P<br />
		+
		+	*FBP other binary complexes

	**[[1fta]] – hFBP + AMP <br />		**[[1fta]] – hFBP + AMP <br />
Line 40:		Line 51:
	**[[3ifa]] - hFBP (mutant) + AMP<br />		**[[3ifa]] - hFBP (mutant) + AMP<br />
	**[[4he0]] - hFBP + phosphate<br />		**[[4he0]] - hFBP + phosphate<br />
-	**[[~~5et8~~]] - ~~hFBP~~ + ~~F6P~~<br />	+	**[[5djk]], [[5djj]] - MtFBP + phosphate<br />
		+	**[[5djg]] - MtFBP + ADP derivative<br />
	**[[1fpk]] – pFBP + Tl<br />		**[[1fpk]] – pFBP + Tl<br />
	**[[4fbp]] - pFBP + AMP <br />		**[[4fbp]] - pFBP + AMP <br />
	**[[1yyz]], [[1yz0]] - pFBP (mutant) + AMP<br />		**[[1yyz]], [[1yz0]] - pFBP (mutant) + AMP<br />
-	**[[5fbp]] - pFBP + F6P<br />
-	**[[1rdx]] - pFBP (mutant) + F6P<br />
	**[[1kz8]], [[1lev]], [[1q9d]] – pFBP + inhibitor<br />		**[[1kz8]], [[1lev]], [[1q9d]] – pFBP + inhibitor<br />
	**[[2qvu]], [[2qvv]], [[1fpb]], [[3fbp]] - pFBP + F6-di-P<br />		**[[2qvu]], [[2qvv]], [[1fpb]], [[3fbp]] - pFBP + F6-di-P<br />
Line 52:		Line 62:
	**[[1fbf]], [[1fbg]] – pFBP + anhydromannitol-biphosphate <br />		**[[1fbf]], [[1fbg]] – pFBP + anhydromannitol-biphosphate <br />
	**[[2gq1]] – EcFBP + sulfate <br />		**[[2gq1]] – EcFBP + sulfate <br />
-	**[[2r8t]] - EcFBP GlpX + F6P<br />
	**[[3big]] - EcFBP GlpX (mutant) + phosphate<br />		**[[3big]] - EcFBP GlpX (mutant) + phosphate<br />
-	**[[~~3d1r~~]] - ~~EcFBP GlpX (mutant)~~ + ~~F6P~~<br />	+	**[[5oey]] - FBP + phosphate – ''Leishmania major''<br />

	*FBP ternary complexes		*FBP ternary complexes
Line 72:		Line 81:
	**[[2qvr]] - EcFBP + citrate + F6-di-P<br />		**[[2qvr]] - EcFBP + citrate + F6-di-P<br />
	**[[2ox3]] - EcFBP + PEP + F6P<br />		**[[2ox3]] - EcFBP + PEP + F6P<br />
		+	**[[6ayu]], [[6ayv]] - MtFBP (mutant) + malonate + F6P <br />
		+	**[[5dji]], [[5djh]] - MtFBP + phosphate + AMP<br />

	*FBP quaternary complexes		*FBP quaternary complexes

Michal Harel at 10:12, 22 May 2017

2017-05-22T10:12:10Z

←Older revision		Revision as of 10:12, 22 May 2017
Line 2:		Line 2:
	== Function ==		== Function ==

-	'''Fructose-1,6-bisphosphatase''' (FBP) is an enzyme in the glucose generating pathway which converts fructose-1,6-bisphosphate to fructose 6-phosphate (F6P)<ref>PMID:8382485</ref>. FBP activity in hibernating animals is significantly reduced<ref>PMID:9505421</ref>. Fructose-2,6-bisphosphatase (F26BP) is the stimulator of phosphofructokinase which is a key enzyme in glycolysis<ref>PMID:8447185</ref>.	+	'''Fructose-1,6-bisphosphatase''' (FBP) is an enzyme in the glucose generating pathway which converts fructose-1,6-bisphosphate to fructose 6-phosphate (F6P)<ref>PMID:8382485</ref>. FBP activity in hibernating animals is significantly reduced<ref>PMID:9505421</ref>. '''Fructose-2,6-bisphosphatase''' (F26BP) is the stimulator of phosphofructokinase which is a key enzyme in glycolysis<ref>PMID:8447185</ref>.

	== Relevance ==		== Relevance ==
Line 80:		Line 80:
	**[[4gx4]], [[4gx6]], [[4gwy]], [[4gws]], [[4gwz]], [[4kxp]] - pFBP (mutant) + phosphate + AMP + F6P<br />		**[[4gx4]], [[4gx6]], [[4gwy]], [[4gws]], [[4gwz]], [[4kxp]] - pFBP (mutant) + phosphate + AMP + F6P<br />
	**[[4h45]] - pFBP (mutant) + phosphate + Zn + F6P<br />		**[[4h45]] - pFBP (mutant) + phosphate + Zn + F6P<br />
-	**[[1fbh]] – pFBP + a F-1,6-P + b F-1,6-P + F-1,6-bisphosphate <br />	+	**[[1fbh]] – pFBP + α F-1,6-P + β F-1,6-P + F-1,6-bisphosphate <br />
-	**[[2q8m]] – FBP + b glucose-6-P + b F-1,6-P + F-1,6-bisphosphate + AMP <br />	+	**[[2q8m]] – FBP + β glucose-6-P + β F-1,6-P + F-1,6-bisphosphate + AMP <br />

	*F26BP		*F26BP

Michal Harel at 10:10, 22 May 2017

2017-05-22T10:10:13Z

←Older revision		Revision as of 10:10, 22 May 2017
Line 2:		Line 2:
	== Function ==		== Function ==

-	'''Fructose-1,6-bisphosphatase''' (FBP) is an enzyme in the glucose generating pathway which converts fructose-1,6-bisphosphate to fructose 6-phosphate (F6P)<ref>PMID:8382485</ref>. FBP activity in hibernating animals is significantly reduced<ref>PMID:9505421</ref>.	+	'''Fructose-1,6-bisphosphatase''' (FBP) is an enzyme in the glucose generating pathway which converts fructose-1,6-bisphosphate to fructose 6-phosphate (F6P)<ref>PMID:8382485</ref>. FBP activity in hibernating animals is significantly reduced<ref>PMID:9505421</ref>. Fructose-2,6-bisphosphatase (F26BP) is the stimulator of phosphofructokinase which is a key enzyme in glycolysis<ref>PMID:8447185</ref>.

	== Relevance ==		== Relevance ==
Line 26:		Line 26:
	**[[1d9q]] – peFBP – pea<br />		**[[1d9q]] – peFBP – pea<br />
	**[[1dbz]], [[1dcu]] – peFBP (mutant)<br />		**[[1dbz]], [[1dcu]] – peFBP (mutant)<br />
-	**[[1fj6]], [[1fj9]], [[1yxi]], [[2f3b]], [[2f3d]] - pFBP (mutant) ~~– pig~~<br />	+	**[[2fbp]] - pFBP - pig<br />
		+	**[[1fj6]], [[1fj9]], [[1yxi]], [[2f3b]], [[2f3d]] - pFBP (mutant) <br />
	**[[3bih]] - EcFBP GlpX (mutant) - ''Escherichia coli''<br />		**[[3bih]] - EcFBP GlpX (mutant) - ''Escherichia coli''<br />
		+	**[[1spi]] - FBP - spinach<br />
		+	**[[5et5]], [[5et7]], [[5ldz]] - hFBP - human<br />
		+	**[[5iz1]] - FBP - moss<br />

	*FBP binary complexes		*FBP binary complexes

-	**[[1fta]] – hFBP + AMP ~~– human~~<br />	+	**[[1fta]] – hFBP + AMP <br />
	**[[2fhy]], [[2fie]], [[2fix]], [[2jjk]], [[2vt5]], [[3a29]], [[2wbb]], [[2wbd]], [[3kbz]], [[3kc0]], [[3kc1]], [[2y5k]], [[2y5l]], [[4mjo]] - hFBP + inhibitor<br />		**[[2fhy]], [[2fie]], [[2fix]], [[2jjk]], [[2vt5]], [[3a29]], [[2wbb]], [[2wbd]], [[3kbz]], [[3kc0]], [[3kc1]], [[2y5k]], [[2y5l]], [[4mjo]] - hFBP + inhibitor<br />
		+	**[[5et6]] - hFBP + AMP<br />
	**[[3ifa]] - hFBP (mutant) + AMP<br />		**[[3ifa]] - hFBP (mutant) + AMP<br />
		+	**[[4he0]] - hFBP + phosphate<br />
		+	**[[5et8]] - hFBP + F6P<br />
	**[[1fpk]] – pFBP + Tl<br />		**[[1fpk]] – pFBP + Tl<br />
		+	**[[4fbp]] - pFBP + AMP <br />
	**[[1yyz]], [[1yz0]] - pFBP (mutant) + AMP<br />		**[[1yyz]], [[1yz0]] - pFBP (mutant) + AMP<br />
		+	**[[5fbp]] - pFBP + F6P<br />
		+	**[[1rdx]] - pFBP (mutant) + F6P<br />
	**[[1kz8]], [[1lev]], [[1q9d]] – pFBP + inhibitor<br />		**[[1kz8]], [[1lev]], [[1q9d]] – pFBP + inhibitor<br />
-	**[[2qvu]], [[2qvv]] - pFBP + F6-di-P<br />	+	**[[2qvu]], [[2qvv]], [[1fpb]], [[3fbp]] - pFBP + F6-di-P<br />
	**[[4gwu]] - pFBP (mutant) + F6-di-P<br />		**[[4gwu]] - pFBP (mutant) + F6-di-P<br />
		+	**[[1fbc]], [[1fbd]], [[1fbe]] – pFBP + anhydroglucitol-biphosphate <br />
		+	**[[1fbf]], [[1fbg]] – pFBP + anhydromannitol-biphosphate <br />
	**[[2gq1]] – EcFBP + sulfate <br />		**[[2gq1]] – EcFBP + sulfate <br />
	**[[2r8t]] - EcFBP GlpX + F6P<br />		**[[2r8t]] - EcFBP GlpX + F6P<br />
Line 47:		Line 59:

	**[[3ifc]] - hFBP (mutant) + AMP + F6P<br />		**[[3ifc]] - hFBP (mutant) + AMP + F6P<br />
		+	**[[4he1]] - hFBP (mutant) + phosphate + F6P<br />
		+	**[[4he2]] - hFBP (mutant) + phosphite + AMP<br />
	**[[1fpi]], [[1fpj]], [[1fpl]] – pFBP + AMP + glucitol bisphosphate<br />		**[[1fpi]], [[1fpj]], [[1fpl]] – pFBP + AMP + glucitol bisphosphate<br />
	**[[1cnq]] – pFBP + Zn + F6P<br />		**[[1cnq]] – pFBP + Zn + F6P<br />
	**[[1eyi]], [[1nuw]], [[1nux]], [[1nuy]], [[1nuz]], [[1nv0]], [[1nv1]], [[1nv2]], [[1nv3]] - pFBP + phosphate + F6P<br />		**[[1eyi]], [[1nuw]], [[1nux]], [[1nuy]], [[1nuz]], [[1nv0]], [[1nv1]], [[1nv2]], [[1nv3]] - pFBP + phosphate + F6P<br />
-	**[[4gx3]], [[4gww]], [[4gwx]] - pFBP (mutant) + phosphate + F6P<br />	+	**[[1fbp]] - pFBP + AMP + F6P<br />
		+	**[[1rdy]], [[1rdz]] - pFBP (mutant) + AMP + F6P<br />
		+	**[[4gx3]], [[4gww]], [[4gwx]], [[1fsa]] - pFBP (mutant) + phosphate + F6P<br />
		+	**[[1frp]] - pFBP + AMP + F-2,6-di-P<br />
		+	**[[1fpd]], [[1fpe]], [[1fpf]], [[1fpg]] – pFBP + anhydroglucitol-biphosphate + AMP<br />
	**[[2owz]] – EcFBP + citrate + F6P<br />		**[[2owz]] – EcFBP + citrate + F6P<br />
	**[[2qvr]] - EcFBP + citrate + F6-di-P<br />		**[[2qvr]] - EcFBP + citrate + F6-di-P<br />
Line 62:		Line 80:
	**[[4gx4]], [[4gx6]], [[4gwy]], [[4gws]], [[4gwz]], [[4kxp]] - pFBP (mutant) + phosphate + AMP + F6P<br />		**[[4gx4]], [[4gx6]], [[4gwy]], [[4gws]], [[4gwz]], [[4kxp]] - pFBP (mutant) + phosphate + AMP + F6P<br />
	**[[4h45]] - pFBP (mutant) + phosphate + Zn + F6P<br />		**[[4h45]] - pFBP (mutant) + phosphate + Zn + F6P<br />
		+	**[[1fbh]] – pFBP + a F-1,6-P + b F-1,6-P + F-1,6-bisphosphate <br />
		+	**[[2q8m]] – FBP + b glucose-6-P + b F-1,6-P + F-1,6-bisphosphate + AMP <br />
		+
		+	*F26BP
		+
		+	**[[1c7z]] – rF26BP + phosphate + G3P - rat<br />
		+	**[[1c80]] – rF26BP + phosphate + GTP <br />
		+	**[[1c81]] – rF26BP + gluco-anhydro-deoxy-phosphonohexitol-phosphate <br />
		+	**[[1fbt]] – rF26BP (mutant) + phosphate <br />

	}}		}}

Michal Harel at 08:49, 17 November 2016

2016-11-17T08:49:54Z

←Older revision		Revision as of 08:49, 17 November 2016
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	**[[1d9q]] – peFBP – pea<br />		**[[1d9q]] – peFBP – pea<br />
	**[[1dbz]], [[1dcu]] – peFBP (mutant)<br />		**[[1dbz]], [[1dcu]] – peFBP (mutant)<br />
-	**[[1fj6]], [[1fj9]], [[1yxi]], [[2f3b]], [[2f3d~~]], [[2f3h~~]] - pFBP (mutant) – pig<br />	+	**[[1fj6]], [[1fj9]], [[1yxi]], [[2f3b]], [[2f3d]] - pFBP (mutant) – pig<br />
	**[[3bih]] - EcFBP GlpX (mutant) - ''Escherichia coli''<br />		**[[3bih]] - EcFBP GlpX (mutant) - ''Escherichia coli''<br />

Alexander Berchansky at 14:37, 3 March 2016

2016-03-03T14:37:45Z

←Older revision		Revision as of 14:37, 3 March 2016
Line 14:		Line 14:
	== Structural highlights ==		== Structural highlights ==

-	A <scene name='46/468243/Cv/4'>tricyclic potent FBP inhibitor interacts with the enzyme in a hydrophobic pocket</scene> <ref>PMID:20045638</ref> ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}).	+	A <scene name='46/468243/Cv/4'>tricyclic potent FBP inhibitor interacts with the enzyme in a hydrophobic pocket</scene> <ref>PMID:20045638</ref> ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}, water molecule shown as red sphere).

	</StructureSection>		</StructureSection>

Alexander Berchansky at 14:36, 3 March 2016

2016-03-03T14:36:48Z

←Older revision		Revision as of 14:36, 3 March 2016
Line 14:		Line 14:
	== Structural highlights ==		== Structural highlights ==

-	A tricyclic potent FBP inhibitor interacts with the enzyme in a hydrophobic pocket <ref>PMID:20045638</ref>.	+	A <scene name='46/468243/Cv/4'>tricyclic potent FBP inhibitor interacts with the enzyme in a hydrophobic pocket</scene> <ref>PMID:20045638</ref> ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}).

	</StructureSection>		</StructureSection>