Glycerol kinase - Revision history

Michal Harel at 08:35, 11 August 2021

2021-08-11T08:35:35Z

←Older revision		Revision as of 08:35, 11 August 2021
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	**[[2dpn]] - GK - ''Thermus thermophilus''<br />		**[[2dpn]] - GK - ''Thermus thermophilus''<br />
	**[[2d4w]] - GK - ''Cellulomonas''<br />		**[[2d4w]] - GK - ''Cellulomonas''<br />
-	**[[2zf5]] - GK - ''Thermococcus kodakarensis''<br />	+	**[[2zf5]] - TkGK - ''Thermococcus kodakarensis''<br />
	**[[3gg4]] – GK – ''Yersinia pseudotuberculosis''<br />		**[[3gg4]] – GK – ''Yersinia pseudotuberculosis''<br />
	**[[3wxi]] – TbGK – ''Trypanosoma brucei gambiense''<br />		**[[3wxi]] – TbGK – ''Trypanosoma brucei gambiense''<br />
		+	**[[6zq5]], [[6zq8]] – CtGK – ''Chaetonium thermophilum'' <br />

-	*Glycerol kinase binary complex ~~with glycerol~~	+	*Glycerol kinase binary complex

	**[[1xup]] - EncGK + glycerol<br />		**[[1xup]] - EncGK + glycerol<br />
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	**[[4e1j]] – GK + glycerol – ''Sinorhizobium meliloti''<br />		**[[4e1j]] – GK + glycerol – ''Sinorhizobium meliloti''<br />
	**[[1bu6]], [[3ezw]] - EcGK (mutant) + glycerol<br />		**[[1bu6]], [[3ezw]] - EcGK (mutant) + glycerol<br />
-	**[[3wxk]] – TbGK + glycerol <br />	+	**[[3wxk]], [[6j9x]], [[6jae]], [[6jaf]] – TbGK + glycerol <br />
		+	**[[6zq4]], [[6zq6]], [[6zq7]] – CtGK + glycerol <br />
		+	**[[6k76]] – TkGK + AMPPNP<br />
		+	**[[6k78]], [[6k79]] – TkGK + glycerol <br />

	*Glycerol kinase ternary complex		*Glycerol kinase ternary complex
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	**[[3h45]] - EncGK (mutant) + phosphate + ethylene glycol<br />		**[[3h45]] - EncGK (mutant) + phosphate + ethylene glycol<br />
	**[[3wxj]] – TbGK + glycerol + G3P<br />		**[[3wxj]] – TbGK + glycerol + G3P<br />
-	**[[3wxl]] – TbGK + glycerol + ADP<br />	+	**[[3wxl]], [[6j9v]] – TbGK + glycerol + ADP<br />
		+	**[[6j9q]] – TbGK + glycerol + AMPPNP<br />
	**[[5azi]], [[5azj]] – TbGK + glycerol + nitrophenyl-phosphate<br />		**[[5azi]], [[5azj]] – TbGK + glycerol + nitrophenyl-phosphate<br />
	**[[5gn5]], [[5gn6]] – TbGK + glycerol + coumarin derivative<br />		**[[5gn5]], [[5gn6]] – TbGK + glycerol + coumarin derivative<br />
		+	**[[6ude]] – GK + glycerol + ADP – ''Elizabethkingia anophelis''<br />
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Alexander Berchansky at 10:51, 2 April 2019

2019-04-02T10:51:04Z

←Older revision		Revision as of 10:51, 2 April 2019
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	== Structural highlights ==		== Structural highlights ==
-	<scene name='48/487479/Cv/2'>GK active site</scene> is located in a cleft between two domains<ref>PMID:14717590</ref>.	+	<scene name='48/487479/Cv/3'>GK active site</scene> is located in a cleft between two domains<ref>PMID:14717590</ref>.
	</StructureSection>		</StructureSection>
	==3D structures of glycerol kinase==		==3D structures of glycerol kinase==

Joel L. Sussman at 10:42, 4 June 2018

2018-06-04T10:42:39Z

←Older revision		Revision as of 10:42, 4 June 2018
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-	<StructureSection load='~~1xup~~' size='350' side='right' caption='Glycerol kinase complex with glycerol (PDB entry [[1xup]])' scene='48/487479/Cv/1'>	+	<StructureSection load='' size='350' side='right' caption='Glycerol kinase complex with glycerol (PDB entry [[1xup]])' scene='48/487479/Cv/1'>
	== Function ==		== Function ==
	'''Glycerol kinase''' (GK) phosphorylates glycerol forming glycerol 3-phosphate (G3P) using Mg-ATP as phosphate source. GK is a key enzyme in glycerol uptake and metabolism. Mutations of GK gene cause GK deficiency syndrome. PK is a multi-subunit allosteric enzyme. Its activity can be inhibited by fructose 1,6-bisphosphate (FBP) and by the glucose-specific phosphocarrier IIA(Glc). PK cofactor is a Zn atom which binds to the dimer<ref>PMID:10759857</ref>.		'''Glycerol kinase''' (GK) phosphorylates glycerol forming glycerol 3-phosphate (G3P) using Mg-ATP as phosphate source. GK is a key enzyme in glycerol uptake and metabolism. Mutations of GK gene cause GK deficiency syndrome. PK is a multi-subunit allosteric enzyme. Its activity can be inhibited by fructose 1,6-bisphosphate (FBP) and by the glucose-specific phosphocarrier IIA(Glc). PK cofactor is a Zn atom which binds to the dimer<ref>PMID:10759857</ref>.

Michal Harel at 09:15, 3 June 2018

2018-06-03T09:15:09Z

←Older revision		Revision as of 09:15, 3 June 2018
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	**[[3wxl]] – TbGK + glycerol + ADP<br />		**[[3wxl]] – TbGK + glycerol + ADP<br />
	**[[5azi]], [[5azj]] – TbGK + glycerol + nitrophenyl-phosphate<br />		**[[5azi]], [[5azj]] – TbGK + glycerol + nitrophenyl-phosphate<br />
		+	**[[5gn5]], [[5gn6]] – TbGK + glycerol + coumarin derivative<br />
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 09:11, 1 June 2017

2017-06-01T09:11:37Z

←Older revision		Revision as of 09:11, 1 June 2017
Line 46:		Line 46:
	**[[3wxj]] – TbGK + glycerol + G3P<br />		**[[3wxj]] – TbGK + glycerol + G3P<br />
	**[[3wxl]] – TbGK + glycerol + ADP<br />		**[[3wxl]] – TbGK + glycerol + ADP<br />
		+	**[[5azi]], [[5azj]] – TbGK + glycerol + nitrophenyl-phosphate<br />
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Alexander Berchansky at 13:30, 16 March 2016

2016-03-16T13:30:01Z

←Older revision		Revision as of 13:30, 16 March 2016
Line 7:		Line 7:

	== Structural highlights ==		== Structural highlights ==
-	GK active site is located in a cleft between two domains<ref>PMID:14717590</ref>.	+	<scene name='48/487479/Cv/2'>GK active site</scene> is located in a cleft between two domains<ref>PMID:14717590</ref>.
	</StructureSection>		</StructureSection>
	==3D structures of glycerol kinase==		==3D structures of glycerol kinase==

Alexander Berchansky at 12:36, 16 March 2016

2016-03-16T12:36:08Z

←Older revision		Revision as of 12:36, 16 March 2016
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-	<StructureSection load='1xup' size='350' side='right' caption='Glycerol kinase complex with glycerol (PDB entry [[1xup]])' scene=''>	+	<StructureSection load='1xup' size='350' side='right' caption='Glycerol kinase complex with glycerol (PDB entry [[1xup]])' scene='48/487479/Cv/1'>
	== Function ==		== Function ==
	'''Glycerol kinase''' (GK) phosphorylates glycerol forming glycerol 3-phosphate (G3P) using Mg-ATP as phosphate source. GK is a key enzyme in glycerol uptake and metabolism. Mutations of GK gene cause GK deficiency syndrome. PK is a multi-subunit allosteric enzyme. Its activity can be inhibited by fructose 1,6-bisphosphate (FBP) and by the glucose-specific phosphocarrier IIA(Glc). PK cofactor is a Zn atom which binds to the dimer<ref>PMID:10759857</ref>.		'''Glycerol kinase''' (GK) phosphorylates glycerol forming glycerol 3-phosphate (G3P) using Mg-ATP as phosphate source. GK is a key enzyme in glycerol uptake and metabolism. Mutations of GK gene cause GK deficiency syndrome. PK is a multi-subunit allosteric enzyme. Its activity can be inhibited by fructose 1,6-bisphosphate (FBP) and by the glucose-specific phosphocarrier IIA(Glc). PK cofactor is a Zn atom which binds to the dimer<ref>PMID:10759857</ref>.

Michal Harel at 08:42, 13 March 2016

2016-03-13T08:42:26Z

←Older revision		Revision as of 08:42, 13 March 2016
Line 8:		Line 8:
	== Structural highlights ==		== Structural highlights ==
	GK active site is located in a cleft between two domains<ref>PMID:14717590</ref>.		GK active site is located in a cleft between two domains<ref>PMID:14717590</ref>.
-		+	</StructureSection>
	==3D structures of glycerol kinase==		==3D structures of glycerol kinase==

Michal Harel at 08:41, 13 March 2016

2016-03-13T08:41:31Z

←Older revision		Revision as of 08:41, 13 March 2016
Line 5:		Line 5:
	== Disease ==		== Disease ==
	GK Deficiency is an X-linked disease which has 3 forms: infantile, juvenile and adult<ref>PMID:15684452</ref>		GK Deficiency is an X-linked disease which has 3 forms: infantile, juvenile and adult<ref>PMID:15684452</ref>
		+
		+	== Structural highlights ==
		+	GK active site is located in a cleft between two domains<ref>PMID:14717590</ref>.

	==3D structures of glycerol kinase==		==3D structures of glycerol kinase==

Michal Harel at 07:56, 13 March 2016

2016-03-13T07:56:14Z

←Older revision		Revision as of 07:56, 13 March 2016
Line 1:		Line 1:
	<StructureSection load='1xup' size='350' side='right' caption='Glycerol kinase complex with glycerol (PDB entry [[1xup]])' scene=''>		<StructureSection load='1xup' size='350' side='right' caption='Glycerol kinase complex with glycerol (PDB entry [[1xup]])' scene=''>
	== Function ==		== Function ==
-	'''Glycerol kinase''' (GK) phosphorylates glycerol forming glycerol 3-phosphate (G3P) using Mg-ATP as phosphate source. GK is a key enzyme in glycerol uptake and metabolism. Mutations of GK gene cause GK deficiency syndrome. PK is a multi-subunit allosteric enzyme. Its activity can be inhibited by fructose 1,6-bisphosphate (FBP) and by the glucose-specific phosphocarrier IIA(Glc). PK cofactor is a Zn atom which binds to the dimer<ref>PMID:~~8528769~~</ref>.	+	'''Glycerol kinase''' (GK) phosphorylates glycerol forming glycerol 3-phosphate (G3P) using Mg-ATP as phosphate source. GK is a key enzyme in glycerol uptake and metabolism. Mutations of GK gene cause GK deficiency syndrome. PK is a multi-subunit allosteric enzyme. Its activity can be inhibited by fructose 1,6-bisphosphate (FBP) and by the glucose-specific phosphocarrier IIA(Glc). PK cofactor is a Zn atom which binds to the dimer<ref>PMID:10759857</ref>.
		+
		+	== Disease ==
		+	GK Deficiency is an X-linked disease which has 3 forms: infantile, juvenile and adult<ref>PMID:15684452</ref>

	==3D structures of glycerol kinase==		==3D structures of glycerol kinase==