Krebs cycle overview - Revision history

Alexander Berchansky at 12:42, 29 September 2022

2022-09-29T12:42:34Z

←Older revision		Revision as of 12:42, 29 September 2022
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	* [[Krebs_cycle_carbons\|The way of the carbon atoms in the Krebs cycle]]		* [[Krebs_cycle_carbons\|The way of the carbon atoms in the Krebs cycle]]
	* [[Krebs_cycle_reactions\|Reactions related with the Krebs cycle]]		* [[Krebs_cycle_reactions\|Reactions related with the Krebs cycle]]
		+	*[[Major metabolic pathways converging on the citric acid cycle]]
		+	*[[Citric acid cycle intermediates serve as substrates for biosynthetic processes]]

Karsten Theis at 01:33, 21 July 2019

2019-07-21T01:33:21Z

←Older revision		Revision as of 01:33, 21 July 2019
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	<div style='mso-element:para-border-div;border:solid windowtext 1.0pt;mso-border-alt:solid windowtext .5pt;padding:1.0pt 4.0pt 1.0pt 4.0pt'>		<div style='mso-element:para-border-div;border:solid windowtext 1.0pt;mso-border-alt:solid windowtext .5pt;padding:1.0pt 4.0pt 1.0pt 4.0pt'>
-	Acetyl-CoA + 3 NAD<sup>+</sup> + FAD + GDP (~~bzw.~~ ADP) + P<sub>i</sub> + 2 H<sub>2</sub>O →	+	Acetyl-CoA + 3 NAD<sup>+</sup> + FAD + GDP (or ADP) + P<sub>i</sub> + 2 H<sub>2</sub>O →
-	HS-CoA + 3 NADH + FADH<sub>2</sub> + GTP (~~bzw.~~ ATP) + 2 CO<sub>2</sub> + 2 H<sup>+</sup>	+	HS-CoA + 3 NADH + FADH<sub>2</sub> + GTP (or ATP) + 2 CO<sub>2</sub> + 2 H<sup>+</sup>
	</div>		</div>

Karsten Theis at 01:32, 21 July 2019

2019-07-21T01:32:26Z

←Older revision		Revision as of 01:32, 21 July 2019
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	<h2>The Krebs cycle - an overview</h2>		<h2>The Krebs cycle - an overview</h2>
-	<span style="margin: 10px; ">[[Image:~~Krebs_overview~~.jpg\|400px\|left]]</span>	+	<span style="margin: 10px; ">[[Image:Krebs_Overview.jpg\|400px\|left]]</span>

	<p>The entire citric acid cycle (see figure) as a final common pathway of degradation of the nutrients		<p>The entire citric acid cycle (see figure) as a final common pathway of degradation of the nutrients

Karsten Theis at 01:32, 21 July 2019

2019-07-21T01:32:01Z

←Older revision		Revision as of 01:32, 21 July 2019
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	<h2>The Krebs cycle - an overview</h2>		<h2>The Krebs cycle - an overview</h2>
-	<span style="margin: 10px; ">[[Image:~~overview~~.jpg\|400px\|left]]</span>	+	<span style="margin: 10px; ">[[Image:Krebs_overview.jpg\|400px\|left]]</span>

	<p>The entire citric acid cycle (see figure) as a final common pathway of degradation of the nutrients		<p>The entire citric acid cycle (see figure) as a final common pathway of degradation of the nutrients

Jaime Prilusky at 22:13, 3 August 2014

2014-08-03T22:13:06Z

←Older revision		Revision as of 22:13, 3 August 2014
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	<h2>The Krebs cycle - an overview</h2>		<h2>The Krebs cycle - an overview</h2>
-	[[Image:overview.jpg\|400px\|left]]	+	<span style="margin: 10px; ">[[Image:overview.jpg\|400px\|left]]</span>

	<p>The entire citric acid cycle (see figure) as a final common pathway of degradation of the nutrients		<p>The entire citric acid cycle (see figure) as a final common pathway of degradation of the nutrients
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	HS-CoA + 3 NADH + FADH<sub>2</sub> + GTP (bzw. ATP) + 2 CO<sub>2</sub> + 2 H<sup>+</sup>		HS-CoA + 3 NADH + FADH<sub>2</sub> + GTP (bzw. ATP) + 2 CO<sub>2</sub> + 2 H<sup>+</sup>
	</div>		</div>
		+
		+	* [[Krebs_cycle_discovery\|The discovery of the Krebs cycle]]
		+	* [[Krebs_cycle_importance\|The importance of the Krebs Cycle in the metabolism]]
		+	* [[Krebs_cycle_step_1\|First step: Citrate Synthase]]
		+	* [[Krebs_cycle_step_2\|Second Step of the krebs Cycle: Aconitase]]
		+	* [[Krebs_cycle_step_3\|Step three of the Krebs Cycle: Isocitrate Dehydrogenase]]
		+	* [[Krebs_cycle_step_4\|Step four of the Krebs Cycle: α-Ketoglutarat Dehydrogenase]]
		+	* [[Krebs_cycle_step_5\|Step 5 of the Krebs cycle: Succinyl-CoA Synthetase]]
		+	* [[Krebs_cycle_step_6\|Step 6 of the Krebs cycle: Succinate Dehydrogenase]]
		+	* [[Krebs_cycle_step_7\|Step 7 of the Krebs cycle: Fumarase]]
		+	* [[Krebs_cycle_step_8\|Step 8 of the Krebs cycle: Malat-Dehydrogenase]]
		+	* [[Krebs_cycle_carbons\|The way of the carbon atoms in the Krebs cycle]]
		+	* [[Krebs_cycle_reactions\|Reactions related with the Krebs cycle]]

Jaime Prilusky at 22:06, 3 August 2014

2014-08-03T22:06:24Z

←Older revision		Revision as of 22:06, 3 August 2014
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	<h2>The Krebs cycle - an overview</h2>		<h2>The Krebs cycle - an overview</h2>
-	[[Image:overview.jpg\|left]]	+	[[Image:overview.jpg\|400px\|left]]
-		+

	<p>The entire citric acid cycle (see figure) as a final common pathway of degradation of the nutrients		<p>The entire citric acid cycle (see figure) as a final common pathway of degradation of the nutrients
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	<p>Overall, the entire Krebs cycle can be summarised by the following equation:</p>		<p>Overall, the entire Krebs cycle can be summarised by the following equation:</p>

-	<div style='mso-element:para-border-div;border:solid windowtext 1.0pt;	+	<div style='mso-element:para-border-div;border:solid windowtext 1.0pt;mso-border-alt:solid windowtext .5pt;padding:1.0pt 4.0pt 1.0pt 4.0pt'>
-	mso-border-alt:solid windowtext .5pt;padding:1.0pt 4.0pt 1.0pt 4.0pt'>	+	Acetyl-CoA + 3 NAD<sup>+</sup> + FAD + GDP (bzw. ADP) + P<sub>i</sub> + 2 H<sub>2</sub>O →
-		+	HS-CoA + 3 NADH + FADH<sub>2</sub> + GTP (bzw. ATP) + 2 CO<sub>2</sub> + 2 H<sup>+</sup>
-	~~<p>~~Acetyl-CoA + 3 NAD<sup>+</sup> + FAD + GDP (bzw. ADP) + P<sub>i</sub> + 2 H<sub>2</sub>O →	+	</div>
-	HS-CoA + 3 NADH + FADH<sub>2</sub> + GTP (bzw. ATP) + 2 CO<sub>2</sub> + 2 H<sup>+</sup></p>	+

Jaime Prilusky: Sandbox Oldenburg01 moved to Krebs cycle overview

2014-08-03T21:28:37Z

Sandbox Oldenburg01 moved to Krebs cycle overview

←Older revision

Revision as of 21:28, 3 August 2014

Verena Pietzner at 08:02, 28 July 2014

2014-07-28T08:02:33Z

←Older revision		Revision as of 08:02, 28 July 2014
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	<h2>The Krebs cycle - an overview</h2>		<h2>The Krebs cycle - an overview</h2>
-	[[Image:overview.jpg]]	+	[[Image:overview.jpg\|left]]

Verena Pietzner: New page:

The Krebs cycle - an overview

Image:overview.jpg

The entire citric acid cycle (see figure) as a final common pathway of degradation of the nutrients is introduced into c...

2014-07-28T06:48:53Z

New page: <h2>The Krebs cycle - an overview</h2> Image:overview.jpg The entire citric acid cycle (see figure) as a final common pathway of degradation of the nutrients is introduced into c...

New page

<h2>The Krebs cycle - an overview</h2>
[[Image:overview.jpg]]

The entire citric acid cycle (see figure) as a final common pathway of degradation of the nutrients
is introduced into citrate by the condensation reaction of oxaloacetate (C4 ) and acetyl -CoA. Here,
acetyl-CoA releases its acetyl group (C2) that froms the C6-body citrate by reacting with oxal acetate. This reaction is
catalyzed by the enzyme citrate synthase. In the second step, catalysed
by the enzyme aconitase, citrate is transformed into isocitrate. The subsequent reaction, catalysed by isocitrate
dehydrogenase, is an oxidative decarboxylation, wherein the first CO2 molecule is released and accordingly, the C5-body α-ketoglutarate is formed. The second oxidative decarboxylation reaction takes place in the next step, in which the product succinyl-CoA is formed.
Since this reaction also releases a molecule of CO2, succinyl-CoA is a C4-body. 
After the first half of the Kreby cycle, two molecules of CO2 are released out of citrate. the second half of the Krebs cycle serves as preparation: Succinyl-CoA is transformed via four steps into oxal acetate that can react again with acetyl-CoA to start the cycle again: In the fifth
reaction, succinyl-CoA transformed to succinat. Afterwards, succinate looses two protons to form fumarate, a molecule with a double bond. The reaction of fumarate to L-malate (step 6) is a
hydration reaction: Therefore, a hydrogen atom is replaced by an OH group within two steps (from succinate to L-malate). In the last reaction , oxal acetate is regenerated.
Overall, the entire Krebs cycle can be summarised by the following equation:

<div style='mso-element:para-border-div;border:solid windowtext 1.0pt;
mso-border-alt:solid windowtext .5pt;padding:1.0pt 4.0pt 1.0pt 4.0pt'>

Acetyl-CoA + 3 NAD+ + FAD + GDP (bzw. ADP) + Pi + 2 H2O →
HS-CoA + 3 NADH + FADH2 + GTP (bzw. ATP) + 2 CO2 + 2 H+