Krebs cycle step 2 - Revision history

Alexander Berchansky at 09:20, 18 December 2019

2019-12-18T09:20:11Z

←Older revision		Revision as of 09:20, 18 December 2019
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-	<h2>Second Step of the ~~krebs~~ Cycle: [[Aconitase]]</h2>	+	<h2>Second Step of the Krebs Cycle: [[Aconitase]]</h2>

	[[Image:aconitase.jpg]]		[[Image:aconitase.jpg]]

Alexander Berchansky at 09:19, 18 December 2019

2019-12-18T09:19:55Z

←Older revision		Revision as of 09:19, 18 December 2019
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-	<h2>Second Step of the krebs Cycle: Aconitase</h2>	+	<h2>Second Step of the krebs Cycle: [[Aconitase]]</h2>

	[[Image:aconitase.jpg]]		[[Image:aconitase.jpg]]
	<p>Figure: Reaction of the isomerisation of citrate to isocitrate</p>		<p>Figure: Reaction of the isomerisation of citrate to isocitrate</p>

-	<p>In the second reaction of the Krebs cycle, the isomerisation of citrate to	+	<p>In the second reaction of the [[Citric Acid Cycle\|Krebs cycle]], the isomerisation of citrate to
	isocitrate takes place. As an intermediate, <i>cis</i>-aconitate is formed. Therefore, it is a two-step reaction sequence. In the first step, H<sub>2</sub>O is removed from the cireate molecule (see Figure). Thie dehydration ledas to the intermediate, <i>cis</i>-aconitate which is bound to the enzyme. In the		isocitrate takes place. As an intermediate, <i>cis</i>-aconitate is formed. Therefore, it is a two-step reaction sequence. In the first step, H<sub>2</sub>O is removed from the cireate molecule (see Figure). Thie dehydration ledas to the intermediate, <i>cis</i>-aconitate which is bound to the enzyme. In the
	second step, <i>cis</i>-aconitate is hydrated again. Therefore, the proton (from C2 to C3) and the OH group		second step, <i>cis</i>-aconitate is hydrated again. Therefore, the proton (from C2 to C3) and the OH group

Jaime Prilusky: Sandbox Oldenburg05 moved to Krebs cycle step 2

2014-08-03T21:33:11Z

Sandbox Oldenburg05 moved to Krebs cycle step 2

←Older revision

Revision as of 21:33, 3 August 2014

Verena Pietzner: New page:

Second Step of the krebs Cycle: Aconitase

Image:aconitase.jpg

Figure: Reaction of the isomerisation of citrate to isocitrate

In the second reaction of the Krebs cy...

2014-07-28T07:30:14Z

New page: <h2>Second Step of the krebs Cycle: Aconitase</h2> Image:aconitase.jpg <p>Figure: Reaction of the isomerisation of citrate to isocitrate</p> <p>In the second reaction of the Krebs cy...

New page

<h2>Second Step of the krebs Cycle: Aconitase</h2>

[[Image:aconitase.jpg]]
<p>Figure: Reaction of the isomerisation of citrate to isocitrate</p>

<p>In the second reaction of the Krebs cycle, the isomerisation of citrate to
isocitrate takes place. As an intermediate, <i>cis</i>-aconitate is formed. Therefore, it is a two-step reaction sequence. In the first step, H<sub>2</sub>O is removed from the cireate molecule (see Figure). Thie dehydration ledas to the intermediate, <i>cis</i>-aconitate which is bound to the enzyme. In the
second step, <i>cis</i>-aconitate is hydrated again. Therefore, the proton (from C2 to C3) and the OH group
(from C3 to C2) swap places. A tretiary aclohol is transformed into a secondary alcohol.</p>
<p>This conversion is of utmost importance for the subsequent decarboxylation, because a tertiary alcohol (the citrate) can not be directly oxidized to a keto
carboxylic acid.</p>