M2 protein - Revision history

Michal Harel at 10:22, 20 June 2023

2023-06-20T10:22:53Z

←Older revision		Revision as of 10:22, 20 June 2023
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	[[6g0y]] – hrsvM2 + phosphoprotein<br />		[[6g0y]] – hrsvM2 + phosphoprotein<br />
	[[6pzq]] – hrsvM2 + RNA<br />		[[6pzq]] – hrsvM2 + RNA<br />
		+	[[5hyu]] – M2 residues 42-142 + C4B-binding protein alpha chain – ''Steptococcus pyogenes''<br />
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 06:50, 3 September 2020

2020-09-03T06:50:11Z

←Older revision		Revision as of 06:50, 3 September 2020
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	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

-	[[~~3lbw~~]], [[~~5c02~~]], [[~~4rwc~~]], [[~~4rwb~~]] ~~– IavM2 TM (mutant) – Influenza A virus<br />~~	+	[[3bkd]], [[5um1]], [[5ttc]], [[5joo]], [[4qkm]], [[4qkl]], [[4qkc]], [[4qk7]], [[6mpl]], [[6mpm]], [[6mpn]] - IavM2 TM – Influenza A virus<br />
-	[[~~3bkd~~]], [[~~5um1~~]], [[~~5ttc~~]], [[~~5joo~~]], [[~~4qkm~~]], [[~~4qkl~~]], [[~~4qkc~~]], [[~~4qk7~~]], [[~~6mpl~~]], [[~~6mpm~~]], [[~~6mpn~~]] - IavM2 TM<br />	+	[[3lbw]], [[5c02]], [[4rwc]], [[4rwb]] – IavM2 TM (mutant) <br />
	[[3c9j]], [[6bkk]], [[6bmz]] - IavM2 TM + amantadine derivative<br />		[[3c9j]], [[6bkk]], [[6bmz]] - IavM2 TM + amantadine derivative<br />
		+	[[6oug]] - IavM2 TM (mutant) + amantadine derivative<br />
	[[6bkl]], [[6boc]] - IavM2 TM + rimantadine<br />		[[6bkl]], [[6boc]] - IavM2 TM + rimantadine<br />
	[[2rlf]] - IavM2 TM +rimantadine - NMR<br />		[[2rlf]] - IavM2 TM +rimantadine - NMR<br />
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	[[4c3b]], [[4c3d]] – hrsvM2 – Human respiratory syncytial virus<br />		[[4c3b]], [[4c3d]] – hrsvM2 – Human respiratory syncytial virus<br />
	[[4c3e]] – hrsvM2 (mutant)<br />		[[4c3e]] – hrsvM2 (mutant)<br />
-	[[5nkx]] – hrsvM2 core domain <br />	+	[[5nkx]] – hrsvM2 core domain 73-185<br />
	[[2l9j]] – hrsvM2 core domain (mutant) - NMR<br />		[[2l9j]] – hrsvM2 core domain (mutant) - NMR<br />
		+	[[6g0y]] – hrsvM2 + phosphoprotein<br />
		+	[[6pzq]] – hrsvM2 + RNA<br />
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 08:48, 24 October 2019

2019-10-24T08:48:34Z

←Older revision		Revision as of 08:48, 24 October 2019
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	[[3lbw]], [[5c02]], [[4rwc]], [[4rwb]] – IavM2 TM (mutant) – Influenza A virus<br />		[[3lbw]], [[5c02]], [[4rwc]], [[4rwb]] – IavM2 TM (mutant) – Influenza A virus<br />
-	[[3bkd]], [[5um1]], [[5ttc]], [[5joo]], [[4qkm]], [[4qkl]], [[4qkc]], [[4qk7]] - IavM2 TM<br />	+	[[3bkd]], [[5um1]], [[5ttc]], [[5joo]], [[4qkm]], [[4qkl]], [[4qkc]], [[4qk7]], [[6mpl]], [[6mpm]], [[6mpn]] - IavM2 TM<br />
-	[[3c9j]] - IavM2 TM + amantadine<br />	+	[[3c9j]], [[6bkk]], [[6bmz]] - IavM2 TM + amantadine derivative<br />
		+	[[6bkl]], [[6boc]] - IavM2 TM + rimantadine<br />
	[[2rlf]] - IavM2 TM +rimantadine - NMR<br />		[[2rlf]] - IavM2 TM +rimantadine - NMR<br />
	[[2kqt]], [[1mp6]], [[1nyj]], [[2h95]] - IavM2 TM – NMR<br />		[[2kqt]], [[1mp6]], [[1nyj]], [[2h95]] - IavM2 TM – NMR<br />

Michal Harel at 08:35, 24 October 2019

2019-10-24T08:35:56Z

←Older revision		Revision as of 08:35, 24 October 2019
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	__TOC__		__TOC__
	== Function ==		== Function ==
-	The '''M2 protein''' (M2) is a proton selective ion channel of the influenza virus<ref>PMID:18045172</ref>. It is activated by low pH. M2 has 3 domains: an ectodomain, transmembrane domain (TM) and a C terminal cytoplasmic domain. See more in:<br />	+	The '''M2 protein''' or '''Matrix protein 2''' (M2) is a proton selective ion channel of the influenza virus<ref>PMID:18045172</ref>. It is activated by low pH. M2 has 3 domains: an ectodomain, transmembrane domain (TM) and a C terminal cytoplasmic domain. See more in:<br />
	[[M2 Proton Channel]]<br />		[[M2 Proton Channel]]<br />
	[[Molecular Playground/Influenza A M2 transmembrane domain]]<br />		[[Molecular Playground/Influenza A M2 transmembrane domain]]<br />

Alexander Berchansky at 10:44, 8 July 2019

2019-07-08T10:44:15Z

←Older revision		Revision as of 10:44, 8 July 2019
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	== Structural highlights ==		== Structural highlights ==
-	M2 protein from Human respiratory syncytial virus contains 4 domains: Zn-binding, transmembrane (TM), core which binds RNA and a C terminal domain<ref>PMID:24434552</ref>. <scene name='45/458472/Cv/2'>Zn binding site</scene>.	+	M2 protein from Human respiratory syncytial virus contains 4 domains: Zn-binding, transmembrane (TM), core which binds RNA and a C terminal domain<ref>PMID:24434552</ref>. <scene name='45/458472/Cv/3'>Zn binding site</scene>.

	==3D structures of M2 protein==		==3D structures of M2 protein==

Michal Harel at 10:01, 1 August 2018

2018-08-01T10:01:20Z

←Older revision		Revision as of 10:01, 1 August 2018
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	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

-	[[3lbw]] – IavM2 TM (mutant) – Influenza A virus<br />	+	[[3lbw]], [[5c02]], [[4rwc]], [[4rwb]] – IavM2 TM (mutant) – Influenza A virus<br />
-	[[3bkd]] - IavM2 TM<br />	+	[[3bkd]], [[5um1]], [[5ttc]], [[5joo]], [[4qkm]], [[4qkl]], [[4qkc]], [[4qk7]] - IavM2 TM<br />
	[[3c9j]] - IavM2 TM + amantadine<br />		[[3c9j]] - IavM2 TM + amantadine<br />
	[[2rlf]] - IavM2 TM +rimantadine - NMR<br />		[[2rlf]] - IavM2 TM +rimantadine - NMR<br />
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	[[4c3b]], [[4c3d]] – hrsvM2 – Human respiratory syncytial virus<br />		[[4c3b]], [[4c3d]] – hrsvM2 – Human respiratory syncytial virus<br />
	[[4c3e]] – hrsvM2 (mutant)<br />		[[4c3e]] – hrsvM2 (mutant)<br />
		+	[[5nkx]] – hrsvM2 core domain <br />
	[[2l9j]] – hrsvM2 core domain (mutant) - NMR<br />		[[2l9j]] – hrsvM2 core domain (mutant) - NMR<br />
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 09:58, 1 August 2018

2018-08-01T09:58:16Z

←Older revision		Revision as of 09:58, 1 August 2018
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-	<StructureSection load='4c3e' size='~~450~~' side='right' caption='Human respiratory syncytial virus M2 protein complex with Zn+2 ions (grey) (PDB entry [[4c3e]])' scene='45/458472/Cv/1'>	+	<StructureSection load='4c3e' size='350' side='right' caption='Human respiratory syncytial virus M2 protein complex with Zn+2 ions (grey) (PDB entry [[4c3e]])' scene='45/458472/Cv/1'>
	__TOC__		__TOC__
	== Function ==		== Function ==

Michal Harel at 09:23, 5 July 2017

2017-07-05T09:23:15Z

←Older revision		Revision as of 09:23, 5 July 2017
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-	<StructureSection load='4c3e' size='450' side='right' caption='Human respiratory syncytial virus M2 protein (PDB entry [[4c3e]])' scene='45/458472/Cv/1'>	+	<StructureSection load='4c3e' size='450' side='right' caption='Human respiratory syncytial virus M2 protein complex with Zn+2 ions (grey) (PDB entry [[4c3e]])' scene='45/458472/Cv/1'>
	__TOC__		__TOC__
	== Function ==		== Function ==

Alexander Berchansky at 08:46, 18 April 2016

2016-04-18T08:46:27Z

←Older revision		Revision as of 08:46, 18 April 2016
Line 8:		Line 8:

	== Structural highlights ==		== Structural highlights ==
-	M2 protein from Human respiratory syncytial virus contains 4 domains: Zn-binding, transmembrane (TM), core which binds RNA and a C terminal domain<ref>PMID:24434552</ref>.	+	M2 protein from Human respiratory syncytial virus contains 4 domains: Zn-binding, transmembrane (TM), core which binds RNA and a C terminal domain<ref>PMID:24434552</ref>. <scene name='45/458472/Cv/2'>Zn binding site</scene>.

	==3D structures of M2 protein==		==3D structures of M2 protein==

Alexander Berchansky at 08:33, 18 April 2016

2016-04-18T08:33:53Z

←Older revision		Revision as of 08:33, 18 April 2016
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-	<StructureSection load='4c3e' size='450' side='right' caption='Human respiratory syncytial virus M2 protein (PDB entry [[4c3e]])' scene=''>	+	<StructureSection load='4c3e' size='450' side='right' caption='Human respiratory syncytial virus M2 protein (PDB entry [[4c3e]])' scene='45/458472/Cv/1'>
	__TOC__		__TOC__
	== Function ==		== Function ==