Metabotropic glutamate receptor - Revision history

Alexander Berchansky at 14:03, 3 June 2021

2021-06-03T14:03:25Z

←Older revision		Revision as of 14:03, 3 June 2021
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	[[Ionotropic Glutamate Receptors]]<br/>		[[Ionotropic Glutamate Receptors]]<br/>
	[[Alzheimer's Disease]]<br/>		[[Alzheimer's Disease]]<br/>
-		+	* [[G protein-coupled receptor]]
		+	*[[Receptor]]
		+	*[[Transmembrane (cell surface) receptors]]
	== References ==		== References ==
	<references/>		<references/>

	[[Category:Topic Page]]		[[Category:Topic Page]]

Alexander Berchansky at 14:56, 26 November 2019

2019-11-26T14:56:03Z

←Older revision		Revision as of 14:56, 26 November 2019
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	==See Also==		==See Also==
	[[Membrane Channels & Pumps]] <br/>		[[Membrane Channels & Pumps]] <br/>
-	[[~~Ionotropic_Glutamate_Receptors~~]]<br/>	+	[[Ionotropic Glutamate Receptors]]<br/>
	[[Alzheimer's Disease]]<br/>		[[Alzheimer's Disease]]<br/>

Michal Harel at 09:02, 30 October 2019

2019-10-30T09:02:06Z

←Older revision		Revision as of 09:02, 30 October 2019
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	</StructureSection>		</StructureSection>
-	==3D structures of metabotropic glutamate receptor ==

-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*Metabotropic glutamate receptor 1
-
-	**[[3ks9]] – hMGluR1 (mutant) + antagonist - human<br />
-	**[[4or2]] - hMGluR1/cytochrome b526<br />
-	**[[1ewt]], [[1ewv]] - rMGluR1 LBD - rat<br />
-	**[[1isr]], [[1ewk]] – rMGluR1 LBD + Glu<br />
-	**[[1iss]] - rMGluR1 LBD + antagonist<br />
-
-	*Metabotropic glutamate receptor 2
-
-	**[[4xas]], [[4xaq]] – hMGluR2 LBD + agonist<br />
-	**[[5kzq]], [[5kzn]] – hMGluR2 LBD + antagonist<br />
-	**[[5cni]] – hMGluR2 LBD + Glu <br />
-	**[[5cnj]] – hMGluR2 LBD + Glu analog<br />
-
-	*Metabotropic glutamate receptor 3
-
-	**[[5cnk]] – hMGluR3 LBD + Glu <br />
-	**[[3sm9]] - hMGluR3 + antagonist<br />
-	**[[4xar]], [[6b7h]] – hMGluR3 LBD + agonist<br />
-	**[[5cnm]] – hMGluR3 LBD + Glu analog<br />
-	**[[2e4u]] – rMGluR3 LBD (mutant) + Glu<br />
-	**[[2e4v]], [[2e4w]], [[2e4x]], [[2e4y]], [[2e4z]] - rMGluR3 LBD (mutant) + agonist<br />
-
-	*Metabotropic glutamate receptor 5
-
-	**[[6n52]] – hMGluR5 – Cryo EM<br />
-	**[[6n51]], [[6n50]], [[6n4y]] – hMGluR5 + nanobody – Cryo EM<br />
-	**[[6n4x]] – hMGluR5 LBD<br />
-	**[[6ffh]], [[6ffi]] - hMGluR5 LBD (mutant) + positive allosteric modulator<br />
-	**[[3lmk]] – hMGluR5 LBD (mutant) + positive allosteric modulator + Glu<br />
-	**[[5cgc]], [[5cgd]] - hMGluR5 transmembrane domain + negative allosteric modulator<br />
-
-	*Metabotropic glutamate receptor 7
-
-	**[[5c5c]] – hMGluR7 LBD (mutant)<br />
-	**[[3mq4]] – hMGluR7 LBD + antagonist<br />
-
-	*Metabotropic glutamate receptor 8
-
-	**[[6bsz]] – hMGluR8 LBD + Glu <br />
-	**[[6bt5]] – hMGluR8 LBD + phosphonobutanoic acid <br />
-	**[[6e5v]] – hMGluR8 N-terminal (mutant) + inhibitor <br />
-	}}
	==See Also==		==See Also==
	[[Membrane Channels & Pumps]] <br/>		[[Membrane Channels & Pumps]] <br/>

Michal Harel at 09:01, 30 October 2019

2019-10-30T09:01:01Z

←Older revision		Revision as of 09:01, 30 October 2019
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	== Structural highlights ==		== Structural highlights ==
	<scene name='46/464134/Cv/3'>Glutamate is bound to GluR1</scene> in the crevice between the N-terminal and C-terminal domains<ref>PMID:11069170</ref>. Water molecules are shown as red spheres.		<scene name='46/464134/Cv/3'>Glutamate is bound to GluR1</scene> in the crevice between the N-terminal and C-terminal domains<ref>PMID:11069170</ref>. Water molecules are shown as red spheres.
		+
		+	==3D structures of metabotropic glutamate receptor ==
		+	[[Metabotropic glutamate receptor 3D structures]]

	</StructureSection>		</StructureSection>
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	*Metabotropic glutamate receptor 1		*Metabotropic glutamate receptor 1
-		+
-	**[[1ewt]], [[1ewv]] - rMGluR1 LBD - rat<br />	+
	**[[3ks9]] – hMGluR1 (mutant) + antagonist - human<br />		**[[3ks9]] – hMGluR1 (mutant) + antagonist - human<br />
	**[[4or2]] - hMGluR1/cytochrome b526<br />		**[[4or2]] - hMGluR1/cytochrome b526<br />
		+	**[[1ewt]], [[1ewv]] - rMGluR1 LBD - rat<br />
	**[[1isr]], [[1ewk]] – rMGluR1 LBD + Glu<br />		**[[1isr]], [[1ewk]] – rMGluR1 LBD + Glu<br />
	**[[1iss]] - rMGluR1 LBD + antagonist<br />		**[[1iss]] - rMGluR1 LBD + antagonist<br />
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	**[[5cnk]] – hMGluR3 LBD + Glu <br />		**[[5cnk]] – hMGluR3 LBD + Glu <br />
-	**[[2e4u]] – rMGluR3 LBD (mutant) + Glu<br />
-	**[[2e4v]], [[2e4w]], [[2e4x]], [[2e4y]], [[2e4z]] - rMGluR3 LBD (mutant) + agonist<br />
	**[[3sm9]] - hMGluR3 + antagonist<br />		**[[3sm9]] - hMGluR3 + antagonist<br />
	**[[4xar]], [[6b7h]] – hMGluR3 LBD + agonist<br />		**[[4xar]], [[6b7h]] – hMGluR3 LBD + agonist<br />
	**[[5cnm]] – hMGluR3 LBD + Glu analog<br />		**[[5cnm]] – hMGluR3 LBD + Glu analog<br />
		+	**[[2e4u]] – rMGluR3 LBD (mutant) + Glu<br />
		+	**[[2e4v]], [[2e4w]], [[2e4x]], [[2e4y]], [[2e4z]] - rMGluR3 LBD (mutant) + agonist<br />

	*Metabotropic glutamate receptor 5		*Metabotropic glutamate receptor 5

		+	**[[6n52]] – hMGluR5 – Cryo EM<br />
		+	**[[6n51]], [[6n50]], [[6n4y]] – hMGluR5 + nanobody – Cryo EM<br />
		+	**[[6n4x]] – hMGluR5 LBD<br />
	**[[6ffh]], [[6ffi]] - hMGluR5 LBD (mutant) + positive allosteric modulator<br />		**[[6ffh]], [[6ffi]] - hMGluR5 LBD (mutant) + positive allosteric modulator<br />
	**[[3lmk]] – hMGluR5 LBD (mutant) + positive allosteric modulator + Glu<br />		**[[3lmk]] – hMGluR5 LBD (mutant) + positive allosteric modulator + Glu<br />
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	**[[6bsz]] – hMGluR8 LBD + Glu <br />		**[[6bsz]] – hMGluR8 LBD + Glu <br />
	**[[6bt5]] – hMGluR8 LBD + phosphonobutanoic acid <br />		**[[6bt5]] – hMGluR8 LBD + phosphonobutanoic acid <br />
		+	**[[6e5v]] – hMGluR8 N-terminal (mutant) + inhibitor <br />
	}}		}}
	==See Also==		==See Also==

Alexander Berchansky at 13:41, 11 July 2019

2019-07-11T13:41:40Z

←Older revision		Revision as of 13:41, 11 July 2019
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	== Structural highlights ==		== Structural highlights ==
-	<scene name='46/464134/Cv/2'>Glutamate is bound to GluR1</scene> in the crevice between the N-terminal and C-terminal domains<ref>PMID:11069170</ref>. Water molecules shown as red spheres.	+	<scene name='46/464134/Cv/3'>Glutamate is bound to GluR1</scene> in the crevice between the N-terminal and C-terminal domains<ref>PMID:11069170</ref>. Water molecules are shown as red spheres.

	</StructureSection>		</StructureSection>

Michal Harel at 09:54, 6 August 2018

2018-08-06T09:54:41Z

←Older revision		Revision as of 09:54, 6 August 2018
Line 6:		Line 6:
	*'''Metabotropic glutamate receptor 1''' and '''metabotropic glutamate receptor 5''' belong to group I and activate phospholipase C. For details see [[Metabotropic glutamate receptor 5]].<br />		*'''Metabotropic glutamate receptor 1''' and '''metabotropic glutamate receptor 5''' belong to group I and activate phospholipase C. For details see [[Metabotropic glutamate receptor 5]].<br />
	*'''Metabotropic glutamate receptor 2''' and '''metabotropic glutamate receptor 3''' belong to group II and inhibit the cyclic AMP cascade.<br />		*'''Metabotropic glutamate receptor 2''' and '''metabotropic glutamate receptor 3''' belong to group II and inhibit the cyclic AMP cascade.<br />
-	*'''Metabotropic glutamate receptor 7''' and '''metabotropic glutamate receptor 8'''belong to group III and inhibits adenylate cyclase activity.<br />	+	*'''Metabotropic glutamate receptor 7''' and '''metabotropic glutamate receptor 8''' belong to group III and inhibits adenylate cyclase activity.<br />

	Articles in Proteopedia concerning Toll-like Receptors include:		Articles in Proteopedia concerning Toll-like Receptors include:

Michal Harel at 09:54, 6 August 2018

2018-08-06T09:54:14Z

←Older revision		Revision as of 09:54, 6 August 2018
Line 6:		Line 6:
	*'''Metabotropic glutamate receptor 1''' and '''metabotropic glutamate receptor 5''' belong to group I and activate phospholipase C. For details see [[Metabotropic glutamate receptor 5]].<br />		*'''Metabotropic glutamate receptor 1''' and '''metabotropic glutamate receptor 5''' belong to group I and activate phospholipase C. For details see [[Metabotropic glutamate receptor 5]].<br />
	*'''Metabotropic glutamate receptor 2''' and '''metabotropic glutamate receptor 3''' belong to group II and inhibit the cyclic AMP cascade.<br />		*'''Metabotropic glutamate receptor 2''' and '''metabotropic glutamate receptor 3''' belong to group II and inhibit the cyclic AMP cascade.<br />
-	*'''Metabotropic glutamate receptor 7''' ~~belongs~~ to group III and inhibits adenylate cyclase activity.<br />	+	*'''Metabotropic glutamate receptor 7''' and '''metabotropic glutamate receptor 8'''belong to group III and inhibits adenylate cyclase activity.<br />

	Articles in Proteopedia concerning Toll-like Receptors include:		Articles in Proteopedia concerning Toll-like Receptors include:

Michal Harel at 09:51, 6 August 2018

2018-08-06T09:51:56Z

←Older revision		Revision as of 09:51, 6 August 2018
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	**[[2e4v]], [[2e4w]], [[2e4x]], [[2e4y]], [[2e4z]] - rMGluR3 LBD (mutant) + agonist<br />		**[[2e4v]], [[2e4w]], [[2e4x]], [[2e4y]], [[2e4z]] - rMGluR3 LBD (mutant) + agonist<br />
	**[[3sm9]] - hMGluR3 + antagonist<br />		**[[3sm9]] - hMGluR3 + antagonist<br />
-	**[[4xar]] – hMGluR3 LBD + agonist<br />	+	**[[4xar]], [[6b7h]] – hMGluR3 LBD + agonist<br />
	**[[5cnm]] – hMGluR3 LBD + Glu analog<br />		**[[5cnm]] – hMGluR3 LBD + Glu analog<br />

	*Metabotropic glutamate receptor 5		*Metabotropic glutamate receptor 5

		+	**[[6ffh]], [[6ffi]] - hMGluR5 LBD (mutant) + positive allosteric modulator<br />
	**[[3lmk]] – hMGluR5 LBD (mutant) + positive allosteric modulator + Glu<br />		**[[3lmk]] – hMGluR5 LBD (mutant) + positive allosteric modulator + Glu<br />
	**[[5cgc]], [[5cgd]] - hMGluR5 transmembrane domain + negative allosteric modulator<br />		**[[5cgc]], [[5cgd]] - hMGluR5 transmembrane domain + negative allosteric modulator<br />
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	**[[5c5c]] – hMGluR7 LBD (mutant)<br />		**[[5c5c]] – hMGluR7 LBD (mutant)<br />
	**[[3mq4]] – hMGluR7 LBD + antagonist<br />		**[[3mq4]] – hMGluR7 LBD + antagonist<br />
		+
		+	*Metabotropic glutamate receptor 8
		+
		+	**[[6bsz]] – hMGluR8 LBD + Glu <br />
		+	**[[6bt5]] – hMGluR8 LBD + phosphonobutanoic acid <br />
	}}		}}
	==See Also==		==See Also==

Michal Harel at 07:28, 20 July 2017

2017-07-20T07:28:32Z

←Older revision		Revision as of 07:28, 20 July 2017
Line 51:		Line 51:

	**[[3lmk]] – hMGluR5 LBD (mutant) + positive allosteric modulator + Glu<br />		**[[3lmk]] – hMGluR5 LBD (mutant) + positive allosteric modulator + Glu<br />
		+	**[[5cgc]], [[5cgd]] - hMGluR5 transmembrane domain + negative allosteric modulator<br />

	*Metabotropic glutamate receptor 7		*Metabotropic glutamate receptor 7

Michal Harel at 06:42, 26 June 2017

2017-06-26T06:42:49Z

←Older revision		Revision as of 06:42, 26 June 2017
Line 35:		Line 35:

	**[[4xas]], [[4xaq]] – hMGluR2 LBD + agonist<br />		**[[4xas]], [[4xaq]] – hMGluR2 LBD + agonist<br />
		+	**[[5kzq]], [[5kzn]] – hMGluR2 LBD + antagonist<br />
		+	**[[5cni]] – hMGluR2 LBD + Glu <br />
		+	**[[5cnj]] – hMGluR2 LBD + Glu analog<br />

	*Metabotropic glutamate receptor 3		*Metabotropic glutamate receptor 3

		+	**[[5cnk]] – hMGluR3 LBD + Glu <br />
	**[[2e4u]] – rMGluR3 LBD (mutant) + Glu<br />		**[[2e4u]] – rMGluR3 LBD (mutant) + Glu<br />
	**[[2e4v]], [[2e4w]], [[2e4x]], [[2e4y]], [[2e4z]] - rMGluR3 LBD (mutant) + agonist<br />		**[[2e4v]], [[2e4w]], [[2e4x]], [[2e4y]], [[2e4z]] - rMGluR3 LBD (mutant) + agonist<br />
	**[[3sm9]] - hMGluR3 + antagonist<br />		**[[3sm9]] - hMGluR3 + antagonist<br />
	**[[4xar]] – hMGluR3 LBD + agonist<br />		**[[4xar]] – hMGluR3 LBD + agonist<br />
		+	**[[5cnm]] – hMGluR3 LBD + Glu analog<br />

	*Metabotropic glutamate receptor 5		*Metabotropic glutamate receptor 5
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	*Metabotropic glutamate receptor 7		*Metabotropic glutamate receptor 7

		+	**[[5c5c]] – hMGluR7 LBD (mutant)<br />
	**[[3mq4]] – hMGluR7 LBD + antagonist<br />		**[[3mq4]] – hMGluR7 LBD + antagonist<br />
	}}		}}