Mur ligase - Revision history

Michal Harel at 11:28, 10 November 2021

2021-11-10T11:28:45Z

←Older revision		Revision as of 11:28, 10 November 2021
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	{{#tree:id=OrganizedByTopic\|openlevels=0\|		{{#tree:id=OrganizedByTopic\|openlevels=0\|

-	*'''MurD'''	+	*'''MurD''' or '''UDP-N-acetylmuramic acid L-alanyl-D-glutmate ligase'''

	**[[1e0d]], [[5a5e]] – EcMurD – ''Escherichia coli'' <br />		**[[1e0d]], [[5a5e]] – EcMurD – ''Escherichia coli'' <br />
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	**[[2x5o]], [[2y68]], [[2y66]], [[2y67]], [[2y1o]] – EcMurD + thiazolidine inhibitor <br />		**[[2x5o]], [[2y68]], [[2y66]], [[2y67]], [[2y1o]] – EcMurD + thiazolidine inhibitor <br />

-	*MurC	+	*MurC or UDP-N-acetylmuramic acid L-alanine ligase

	**[[1j6u]] – TmMurC <br />		**[[1j6u]] – TmMurC <br />
		+	**[[7bva]] – MtMurC – ''Mycobacterium tuberculosis''<br />
		+	**[[7bvb]] – MtMurC + UAG <br />
		+	**[[6cau]] – AbMurC + AMPPNP – ''Acinetobacter baumannii'' <br />
		+	**[[6x9f]], [[6x9n]] – MurC + inhibitor – ''Pseudomonas aeruginosa''<br />
		+	**[[6vr7]] – MfMurC – ''Methanothermus fervidus'' <br />

-	*MurE	+	*MurE or UDP-N-acetylmuramic acid L-alanyl-D-glutmate-2,6-diaminopimelate ligase

	**[[2xja]] – MtMurE + dipeptide + ADP – ''Mycobacterium tuberculosis'' <br />		**[[2xja]] – MtMurE + dipeptide + ADP – ''Mycobacterium tuberculosis'' <br />
	**[[2wtz]] – MtMurE + UAG <br />		**[[2wtz]] – MtMurE + UAG <br />
		+	**[[7b53]] – EcMurE <br />
		+	**[[7b6o]] – EcMurE (mutant)<br />
	**[[1e8c]] – EcMurE + UDP-tripeptide + UAG <br />		**[[1e8c]] – EcMurE + UDP-tripeptide + UAG <br />
		+	**[[7b60]], [[7b61]], [[7b68]], [[7b6g]], [[7b6i]], [[7b6j]], [[7b6l]], [[7b6k]], [[7b6m]], [[7b6n]], [[7b6q]], [[7b9e]], [[7b9w]] – EcMurE + inhibitor <br />
		+	**[[7b6p]] – EcMurE (mutant) + inhibitor <br />
	**[[4c12]] – SaMurE + UML + ADP – ''Staphylococcus aureus'' <br />		**[[4c12]] – SaMurE + UML + ADP – ''Staphylococcus aureus'' <br />
	**[[4c13]] – SaMurE + UML <br />		**[[4c13]] – SaMurE + UML <br />
		+	**[[7jt8]] – MfMurE <br />
		+	**[[6vr8]] – MfMurE + UDP <br />
		+	**[[7d27]], [[7sir]] – AbMurE <br />

	*MurF		*MurF
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	**[[6fqb]] – SpMurT + glutamine amidotransferase <br />		**[[6fqb]] – SpMurT + glutamine amidotransferase <br />
		+	**[[6gs2]] – SaMurT + glutamine amidotransferase <br />
		+	**[[6h5e]] – SaMurT + glutamine amidotransferase + AMPPNP<br />
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 08:32, 8 September 2020

2020-09-08T08:32:43Z

←Older revision		Revision as of 08:32, 8 September 2020
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	*MurF		*MurF

-	**[[2am1]], [[2am2]], [[3zm5]], [[3zm6]] – MurF + inhibitor – ''Streptococcus pneumoniae''<br />
-	**[[3zl8]] – TmMurF + ADP <br />
-	**[[1gg4]] – EcMurF <br />
	**[[3ddt]] – hMurF-1 ZF-B box + Zn – human <br />		**[[3ddt]] – hMurF-1 ZF-B box + Zn – human <br />
	**[[2d8u]] – hMurF-1 ZF-B box + Zn - NMR<br />		**[[2d8u]] – hMurF-1 ZF-B box + Zn - NMR<br />
	**[[3q1d]] – hMurF-3<br />		**[[3q1d]] – hMurF-3<br />
	**[[4m3l]] – hMurF-1 coiled coil domain<br />		**[[4m3l]] – hMurF-1 coiled coil domain<br />
		+	**[[2am1]], [[2am2]], [[3zm5]], [[3zm6]] – SpMurF + inhibitor – ''Streptococcus pneumoniae''<br />
		+	**[[3zl8]] – TmMurF + ADP <br />
		+	**[[1gg4]] – EcMurF <br />
	**[[4qdi]], [[4qf5]], [[4ziy]] – MurF - ''Acinetobacter baumannii'' <br />		**[[4qdi]], [[4qf5]], [[4ziy]] – MurF - ''Acinetobacter baumannii'' <br />
	**[[4cvl]] – PaMurF + AMPPNP - ''Pseudomonas aeruginosa''<br />		**[[4cvl]] – PaMurF + AMPPNP - ''Pseudomonas aeruginosa''<br />
	**[[4cvk]] – PaMurF + UDP-MurNac<br />		**[[4cvk]] – PaMurF + UDP-MurNac<br />
	**[[4cvm]] – PaMurF + UDP-MurNac + AMPPNP<br />		**[[4cvm]] – PaMurF + UDP-MurNac + AMPPNP<br />
		+
		+	*MurT
		+
		+	**[[6fqb]] – SpMurT + glutamine amidotransferase <br />
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Alexander Berchansky at 12:53, 17 July 2019

2019-07-17T12:53:19Z

←Older revision		Revision as of 12:53, 17 July 2019
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	== Structural highlights ==		== Structural highlights ==
-	<scene name='55/552206/Cv/2'>MurD contains three domains</scene>. <scene name='55/552206/Cv/5'>N-terminal domain ~~which~~ binds the substrate</scene> (<scene name='55/552206/Cv/~~6'>Mn coordination site</scene>), an <scene name='55/552206/Cv/7~~'>ATP-binding central domain</scene> ~~and a~~ C-terminal domain ~~which~~ binds the incorporated amino acid<ref>PMID:10356330</ref>. Water molecules shown as red spheres.	+	<scene name='55/552206/Cv/8'>MurD contains three domains</scene>.
-		+	*<scene name='55/552206/Cv/9'>N-terminal domain binds the substrate</scene>.
		+	*<scene name='55/552206/Cv/11'>ATP-binding central domain</scene>. C-terminal domain binds the incorporated amino acid<ref>PMID:10356330</ref>. Water molecules are shown as red spheres.
		+	*<scene name='55/552206/Cv/10'>Mn coordination site</scene>,
	</StructureSection>		</StructureSection>

Michal Harel at 22:57, 12 September 2018

2018-09-12T22:57:36Z

←Older revision		Revision as of 22:57, 12 September 2018
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	**[[3ddt]] – hMurF-1 ZF-B box + Zn – human <br />		**[[3ddt]] – hMurF-1 ZF-B box + Zn – human <br />
	**[[2d8u]] – hMurF-1 ZF-B box + Zn - NMR<br />		**[[2d8u]] – hMurF-1 ZF-B box + Zn - NMR<br />
		+	**[[3q1d]] – hMurF-3<br />
	**[[4m3l]] – hMurF-1 coiled coil domain<br />		**[[4m3l]] – hMurF-1 coiled coil domain<br />
		+	**[[4qdi]], [[4qf5]], [[4ziy]] – MurF - ''Acinetobacter baumannii'' <br />
		+	**[[4cvl]] – PaMurF + AMPPNP - ''Pseudomonas aeruginosa''<br />
		+	**[[4cvk]] – PaMurF + UDP-MurNac<br />
		+	**[[4cvm]] – PaMurF + UDP-MurNac + AMPPNP<br />
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Joel L. Sussman at 04:38, 31 July 2017

2017-07-31T04:38:23Z

←Older revision		Revision as of 04:38, 31 July 2017
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-	<StructureSection load='~~3uag~~' size='350' side='right' caption='Structure of MurD ligase complex with UMA, ADP and Mn+2 ion (purple) (PDB entry [[3uag]])' scene='55/552206/Cv/1'>	+	<StructureSection load='' size='350' side='right' caption='Structure of MurD ligase complex with UMA, ADP and Mn+2 ion (purple) (PDB entry [[3uag]])' scene='55/552206/Cv/1'>
	== Function ==		== Function ==
	'''Mur ligase''' are a set of four Mur ubiquitin ligase enzymes: MurC, MurD, MurE, MurF which catalyze the addition of a short polypeptide to UDP-D-acetylmuramic acid in the process of bacterial cell wall buildup from peptidoglycans<ref>PMID:23555903</ref>. All four enzymes are topologically similar.		'''Mur ligase''' are a set of four Mur ubiquitin ligase enzymes: MurC, MurD, MurE, MurF which catalyze the addition of a short polypeptide to UDP-D-acetylmuramic acid in the process of bacterial cell wall buildup from peptidoglycans<ref>PMID:23555903</ref>. All four enzymes are topologically similar.

Michal Harel at 08:53, 30 July 2017

2017-07-30T08:53:47Z

←Older revision		Revision as of 08:53, 30 July 2017
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	*'''MurD'''		*'''MurD'''

-	**[[1e0d]] – EcMurD – ''Escherichia coli'' <br />	+	**[[1e0d]], [[5a5e]] – EcMurD – ''Escherichia coli'' <br />
	**[[3lk7]] – MurD – ''Streptococcus agalactiae''<br />		**[[3lk7]] – MurD – ''Streptococcus agalactiae''<br />
	**[[4buc]] – TmMurD – ''Thermotoga maritima''<br />		**[[4buc]] – TmMurD – ''Thermotoga maritima''<br />
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	**[[2uag]] – EcMurD + UMA + ADP + Mg<br />		**[[2uag]] – EcMurD + UMA + ADP + Mg<br />
	**[[3uag]] – EcMurD + UMA + ADP + Mn<br />		**[[3uag]] – EcMurD + UMA + ADP + Mn<br />
		+	**[[5a5f]] – EcMurD + UMA + ADP + malonate<br />
	**[[4uag]] – EcMurD + UAG<br />		**[[4uag]] – EcMurD + UAG<br />
	**[[4bub]] – TmMurD + ADP <br />		**[[4bub]] – TmMurD + ADP <br />
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	*MurE		*MurE

-	**[[2xja]] – ~~MurE~~ + dipeptide + ADP – ''Mycobacterium tuberculosis'' <br />	+	**[[2xja]] – MtMurE + dipeptide + ADP – ''Mycobacterium tuberculosis'' <br />
		+	**[[2wtz]] – MtMurE + UAG <br />
		+	**[[1e8c]] – EcMurE + UDP-tripeptide + UAG <br />
		+	**[[4c12]] – SaMurE + UML + ADP – ''Staphylococcus aureus'' <br />
		+	**[[4c13]] – SaMurE + UML <br />

	*MurF		*MurF
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	**[[2am1]], [[2am2]], [[3zm5]], [[3zm6]] – MurF + inhibitor – ''Streptococcus pneumoniae''<br />		**[[2am1]], [[2am2]], [[3zm5]], [[3zm6]] – MurF + inhibitor – ''Streptococcus pneumoniae''<br />
	**[[3zl8]] – TmMurF + ADP <br />		**[[3zl8]] – TmMurF + ADP <br />
-		+	**[[1gg4]] – EcMurF <br />
		+	**[[3ddt]] – hMurF-1 ZF-B box + Zn – human <br />
		+	**[[2d8u]] – hMurF-1 ZF-B box + Zn - NMR<br />
		+	**[[4m3l]] – hMurF-1 coiled coil domain<br />
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Jaime Prilusky: MurD ligase moved to Mur ligase over redirect: requested by Editor

2017-07-30T08:21:59Z

MurD ligase moved to Mur ligase over redirect: requested by Editor

←Older revision

Revision as of 08:21, 30 July 2017

Michal Harel at 10:28, 25 December 2016

2016-12-25T10:28:42Z

←Older revision		Revision as of 10:28, 25 December 2016
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-	<StructureSection load='3uag' size='~~450~~' side='right' caption='Structure of MurD ligase complex with UMA, ADP and Mn+2 ion (purple) (PDB entry [[3uag]])' scene='55/552206/Cv/1'>	+	<StructureSection load='3uag' size='350' side='right' caption='Structure of MurD ligase complex with UMA, ADP and Mn+2 ion (purple) (PDB entry [[3uag]])' scene='55/552206/Cv/1'>
	== Function ==		== Function ==
	'''Mur ligase''' are a set of four Mur ubiquitin ligase enzymes: MurC, MurD, MurE, MurF which catalyze the addition of a short polypeptide to UDP-D-acetylmuramic acid in the process of bacterial cell wall buildup from peptidoglycans<ref>PMID:23555903</ref>. All four enzymes are topologically similar.		'''Mur ligase''' are a set of four Mur ubiquitin ligase enzymes: MurC, MurD, MurE, MurF which catalyze the addition of a short polypeptide to UDP-D-acetylmuramic acid in the process of bacterial cell wall buildup from peptidoglycans<ref>PMID:23555903</ref>. All four enzymes are topologically similar.

Alexander Berchansky at 11:06, 24 May 2016

2016-05-24T11:06:26Z

←Older revision		Revision as of 11:06, 24 May 2016
Line 1:		Line 1:
-	<StructureSection load='3uag' size='~~350~~' side='right' caption='Structure of MurD ligase complex with UMA, ADP and Mn+2 ion (purple) (PDB entry [[3uag]])' scene='55/552206/Cv/1'>	+	<StructureSection load='3uag' size='450' side='right' caption='Structure of MurD ligase complex with UMA, ADP and Mn+2 ion (purple) (PDB entry [[3uag]])' scene='55/552206/Cv/1'>
	== Function ==		== Function ==
	'''Mur ligase''' are a set of four Mur ubiquitin ligase enzymes: MurC, MurD, MurE, MurF which catalyze the addition of a short polypeptide to UDP-D-acetylmuramic acid in the process of bacterial cell wall buildup from peptidoglycans<ref>PMID:23555903</ref>. All four enzymes are topologically similar.		'''Mur ligase''' are a set of four Mur ubiquitin ligase enzymes: MurC, MurD, MurE, MurF which catalyze the addition of a short polypeptide to UDP-D-acetylmuramic acid in the process of bacterial cell wall buildup from peptidoglycans<ref>PMID:23555903</ref>. All four enzymes are topologically similar.
Line 12:		Line 12:

	== Structural highlights ==		== Structural highlights ==
-	<scene name='55/552206/Cv/2'>MurD contains three domains</scene>. N-terminal domain which binds the substrate, an ATP-binding central domain and a C-terminal domain which binds the incorporated amino acid<ref>PMID:10356330</ref>.	+	<scene name='55/552206/Cv/2'>MurD contains three domains</scene>. <scene name='55/552206/Cv/5'>N-terminal domain which binds the substrate</scene> (<scene name='55/552206/Cv/6'>Mn coordination site</scene>), an <scene name='55/552206/Cv/7'>ATP-binding central domain</scene> and a C-terminal domain which binds the incorporated amino acid<ref>PMID:10356330</ref>. Water molecules shown as red spheres.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 09:48, 24 May 2016

2016-05-24T09:48:33Z

←Older revision		Revision as of 09:48, 24 May 2016
Line 12:		Line 12:

	== Structural highlights ==		== Structural highlights ==
-	MurD contains three domains. N-terminal domain which binds the substrate, an ATP-binding central domain and a C-terminal domain which binds the incorporated amino acid<ref>PMID:10356330</ref>.	+	<scene name='55/552206/Cv/2'>MurD contains three domains</scene>. N-terminal domain which binds the substrate, an ATP-binding central domain and a C-terminal domain which binds the incorporated amino acid<ref>PMID:10356330</ref>.

	</StructureSection>		</StructureSection>