NAD(P) transhydrogenase - Revision history

Michal Harel at 10:52, 5 November 2019

2019-11-05T10:52:39Z

←Older revision		Revision as of 10:52, 5 November 2019
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	</StructureSection>		</StructureSection>

-	==3D structures of NAD(P) transhydrogenase==
-
-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*PTH
-
-	**[[6s59]] – sPTH – sheep – Cryo EM<br />
-	**[[6qti]], [[6que]] – sPTH + NAD + NADP – Cryo EM<br />
-	**[[5uni]] – TtPTH - ''Thermus thermophilus'' <br />
-
-	*NAD(P) transhydrogenase domain I
-
-	**[[1l7d]] – RrPTH domain I – ''Rhodospirillum rubrum'' <br />
-	**[[1l7e]] – RrPTH domain I + NAD <br />
-	**[[1x13]] – EcPTH domain I – ''Escherichia coli'' <br />
-	**[[1x14]], [[1x15]] – EcPTH domain I + NAD <br />
-	**[[4dio]] – PTH domain I – ''Sinorhizobium meliloti''<br />
-
-	*PTH domain II
-
-	**[[4o93]], [[4o9p]], [[4o9t]], [[4o9u]] – TtPTH domain II <br />
-
-	*NAD(P) transhydrogenase domain III
-
-	**[[1djl]], [[1u31]] – hPTH domain III + NADP - human<br />
-	**[[1pt9]] – hPTH domain III + NADP analog<br />
-	**[[1e3t]] – RrPTH domain III + NADP - NMR<br />
-	**[[1pno]] – RrPTH domain III + NADP <br />
-	**[[1pnq]] – RrPTH domain III + NADPH <br />
-	**[[1d4o]] – bPTH domain III + NADP - bovine<br />
-
-	*NAD(P) transhydrogenase domain I+III
-
-	**[[1hzz]], [[1u28]], [[1u2d]], [[1xlt]] – RrPTH domain I+III + NADP + NAD<br />
-	**[[1f8g]] – RrPTH domain I+III + NAD<br />
-	**[[1nm5]], [[2fr8]], [[2fsv]] – RrPTH domain I+III (mutant) + NADP + NAD<br />
-	**[[1ptj]], [[1u2g]], [[2frd]], [[2oo5]] – RrPTH domain I+III + NADP + NAD derivative<br />
-	**[[2oor]] – RrPTH domain I+III + NADP derivative + NAD<br />
-	**[[2bru]] – EcPTH domain I+III + NADP + NAD - NMR<br />
-	**[[4j16]], [[4j1t]] – TtPTH domain I+III + NADP + NAD <br />
-
-	}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 10:51, 5 November 2019

2019-11-05T10:51:41Z

←Older revision		Revision as of 10:51, 5 November 2019
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	* Domain III binds NADP(+)/NADPH.<br />		* Domain III binds NADP(+)/NADPH.<br />
	PTH is composed of 2 subunits. Subunit β contains domain III and part of II. The active site of PTH contains <scene name='57/571286/Cv/6'>NAD in domain I</scene> and <scene name='57/571286/Cv/7'>NADP in domain III</scene><ref>PMID:15323555</ref>. Water molecules are shown as red spheres.		PTH is composed of 2 subunits. Subunit β contains domain III and part of II. The active site of PTH contains <scene name='57/571286/Cv/6'>NAD in domain I</scene> and <scene name='57/571286/Cv/7'>NADP in domain III</scene><ref>PMID:15323555</ref>. Water molecules are shown as red spheres.
		+
		+	==3D structures of NAD(P) transhydrogenase==
		+	[[NAD(P) transhydrogenase 3D structures]]
		+
	</StructureSection>		</StructureSection>

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	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
	{{#tree:id=OrganizedByTopic\|openlevels=0\|		{{#tree:id=OrganizedByTopic\|openlevels=0\|
		+
		+	*PTH
		+
		+	**[[6s59]] – sPTH – sheep – Cryo EM<br />
		+	**[[6qti]], [[6que]] – sPTH + NAD + NADP – Cryo EM<br />
		+	**[[5uni]] – TtPTH - ''Thermus thermophilus'' <br />

	*NAD(P) transhydrogenase domain I		*NAD(P) transhydrogenase domain I
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	*PTH domain II		*PTH domain II

-	**[[4o93]], [[4o9p]], [[4o9t]], [[4o9u]] – TtPTH domain II ~~– ''Thermus thermophilus''~~<br />	+	**[[4o93]], [[4o9p]], [[4o9t]], [[4o9u]] – TtPTH domain II <br />

	*NAD(P) transhydrogenase domain III		*NAD(P) transhydrogenase domain III

		+	**[[1djl]], [[1u31]] – hPTH domain III + NADP - human<br />
		+	**[[1pt9]] – hPTH domain III + NADP analog<br />
	**[[1e3t]] – RrPTH domain III + NADP - NMR<br />		**[[1e3t]] – RrPTH domain III + NADP - NMR<br />
	**[[1pno]] – RrPTH domain III + NADP <br />		**[[1pno]] – RrPTH domain III + NADP <br />
	**[[1pnq]] – RrPTH domain III + NADPH <br />		**[[1pnq]] – RrPTH domain III + NADPH <br />
	**[[1d4o]] – bPTH domain III + NADP - bovine<br />		**[[1d4o]] – bPTH domain III + NADP - bovine<br />
-	**[[1djl]], [[1u31]] – hPTH domain III + NADP - human<br />
-	**[[1pt9]] – hPTH domain III + NADP analog<br />

	*NAD(P) transhydrogenase domain I+III		*NAD(P) transhydrogenase domain I+III
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	**[[4j16]], [[4j1t]] – TtPTH domain I+III + NADP + NAD <br />		**[[4j16]], [[4j1t]] – TtPTH domain I+III + NADP + NAD <br />

-	*PTH domain I+II+III
-
-	**[[5uni]] – TtPTH<br />
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Alexander Berchansky at 12:18, 21 July 2019

2019-07-21T12:18:17Z

←Older revision		Revision as of 12:18, 21 July 2019
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	* Domain II is a membrane-spanning domain.<br />		* Domain II is a membrane-spanning domain.<br />
	* Domain III binds NADP(+)/NADPH.<br />		* Domain III binds NADP(+)/NADPH.<br />
-	PTH is composed of 2 subunits. Subunit β contains domain III and part of II. The active site of PTH contains <scene name='57/571286/Cv/3'>NAD in domain I</scene> and <scene name='57/571286/Cv/5'>NADP in domain III</scene><ref>PMID:15323555</ref>. Water molecules shown as red spheres.	+	PTH is composed of 2 subunits. Subunit β contains domain III and part of II. The active site of PTH contains <scene name='57/571286/Cv/6'>NAD in domain I</scene> and <scene name='57/571286/Cv/7'>NADP in domain III</scene><ref>PMID:15323555</ref>. Water molecules are shown as red spheres.
	</StructureSection>		</StructureSection>

Joel L. Sussman at 15:45, 17 August 2017

2017-08-17T15:45:53Z

←Older revision		Revision as of 15:45, 17 August 2017
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-	<StructureSection load='~~1u2d~~' size='450' side='right' caption='Structure of PTH domains I (cyan and green) and III (pink) complex with NAD, NADP and glycerol (PDB entry [[1u2d]])' scene='57/571286/Cv/1'>	+	<StructureSection load='' size='450' side='right' caption='Structure of PTH domains I (cyan and green) and III (pink) complex with NAD, NADP and glycerol (PDB entry [[1u2d]])' scene='57/571286/Cv/1'>

	'''NAD(P) transhydrogenase''' (PTH) catalyzes the conversion of NADP and NADH to NADPH and NAD. See [[NAD]] and [[NAD(P)H]]. The reaction is coupled with proton translocation across the cell membrane while the enzyme undergoes conformational change<ref>PMID:12788487</ref>. PTH uses FAD as cofactor.		'''NAD(P) transhydrogenase''' (PTH) catalyzes the conversion of NADP and NADH to NADPH and NAD. See [[NAD]] and [[NAD(P)H]]. The reaction is coupled with proton translocation across the cell membrane while the enzyme undergoes conformational change<ref>PMID:12788487</ref>. PTH uses FAD as cofactor.

Michal Harel at 09:17, 17 August 2017

2017-08-17T09:17:29Z

←Older revision		Revision as of 09:17, 17 August 2017
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	**[[2bru]] – EcPTH domain I+III + NADP + NAD - NMR<br />		**[[2bru]] – EcPTH domain I+III + NADP + NAD - NMR<br />
	**[[4j16]], [[4j1t]] – TtPTH domain I+III + NADP + NAD <br />		**[[4j16]], [[4j1t]] – TtPTH domain I+III + NADP + NAD <br />
		+
		+	*PTH domain I+II+III
		+
		+	**[[5uni]] – TtPTH<br />
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Alexander Berchansky at 09:57, 30 May 2016

2016-05-30T09:57:05Z

←Older revision		Revision as of 09:57, 30 May 2016
Line 1:		Line 1:
-	<StructureSection load='1u2d' size='~~350~~' side='right' caption='Structure of PTH domains I (cyan and green) and III (pink) complex with NAD, NADP and glycerol (PDB entry [[1u2d]])' scene='57/571286/Cv/1'>	+	<StructureSection load='1u2d' size='450' side='right' caption='Structure of PTH domains I (cyan and green) and III (pink) complex with NAD, NADP and glycerol (PDB entry [[1u2d]])' scene='57/571286/Cv/1'>

	'''NAD(P) transhydrogenase''' (PTH) catalyzes the conversion of NADP and NADH to NADPH and NAD. See [[NAD]] and [[NAD(P)H]]. The reaction is coupled with proton translocation across the cell membrane while the enzyme undergoes conformational change<ref>PMID:12788487</ref>. PTH uses FAD as cofactor.		'''NAD(P) transhydrogenase''' (PTH) catalyzes the conversion of NADP and NADH to NADPH and NAD. See [[NAD]] and [[NAD(P)H]]. The reaction is coupled with proton translocation across the cell membrane while the enzyme undergoes conformational change<ref>PMID:12788487</ref>. PTH uses FAD as cofactor.
Line 8:		Line 8:
	* Domain II is a membrane-spanning domain.<br />		* Domain II is a membrane-spanning domain.<br />
	* Domain III binds NADP(+)/NADPH.<br />		* Domain III binds NADP(+)/NADPH.<br />
-	PTH is composed of 2 subunits. Subunit β contains domain III and part of II. The active site of PTH contains NAD in domain I and NADP in domain III<ref>PMID:15323555</ref>.	+	PTH is composed of 2 subunits. Subunit β contains domain III and part of II. The active site of PTH contains <scene name='57/571286/Cv/3'>NAD in domain I</scene> and <scene name='57/571286/Cv/5'>NADP in domain III</scene><ref>PMID:15323555</ref>. Water molecules shown as red spheres.
	</StructureSection>		</StructureSection>

Alexander Berchansky at 08:48, 30 May 2016

2016-05-30T08:48:30Z

←Older revision		Revision as of 08:48, 30 May 2016
Line 1:		Line 1:
-	<StructureSection load='1u2d' size='350' side='right' caption='Structure of PTH domains I (~~grey~~ and green) and III (pink) complex with NAD, NADP and glycerol (PDB entry [[1u2d]])' scene=''>	+	<StructureSection load='1u2d' size='350' side='right' caption='Structure of PTH domains I (cyan and green) and III (pink) complex with NAD, NADP and glycerol (PDB entry [[1u2d]])' scene='57/571286/Cv/1'>

	'''NAD(P) transhydrogenase''' (PTH) catalyzes the conversion of NADP and NADH to NADPH and NAD. See [[NAD]] and [[NAD(P)H]]. The reaction is coupled with proton translocation across the cell membrane while the enzyme undergoes conformational change<ref>PMID:12788487</ref>. PTH uses FAD as cofactor.		'''NAD(P) transhydrogenase''' (PTH) catalyzes the conversion of NADP and NADH to NADPH and NAD. See [[NAD]] and [[NAD(P)H]]. The reaction is coupled with proton translocation across the cell membrane while the enzyme undergoes conformational change<ref>PMID:12788487</ref>. PTH uses FAD as cofactor.

Michal Harel at 08:31, 5 May 2016

2016-05-05T08:31:01Z

←Older revision		Revision as of 08:31, 5 May 2016
Line 1:		Line 1:
-	<StructureSection load='1u2d' size='350' side='right' caption='Structure of PTH domains I (grey and green) and III (pink) complex with NAD ~~and~~ NADP (PDB entry [[1u2d]])' scene=''>	+	<StructureSection load='1u2d' size='350' side='right' caption='Structure of PTH domains I (grey and green) and III (pink) complex with NAD, NADP and glycerol (PDB entry [[1u2d]])' scene=''>

	'''NAD(P) transhydrogenase''' (PTH) catalyzes the conversion of NADP and NADH to NADPH and NAD. See [[NAD]] and [[NAD(P)H]]. The reaction is coupled with proton translocation across the cell membrane while the enzyme undergoes conformational change<ref>PMID:12788487</ref>. PTH uses FAD as cofactor.		'''NAD(P) transhydrogenase''' (PTH) catalyzes the conversion of NADP and NADH to NADPH and NAD. See [[NAD]] and [[NAD(P)H]]. The reaction is coupled with proton translocation across the cell membrane while the enzyme undergoes conformational change<ref>PMID:12788487</ref>. PTH uses FAD as cofactor.

Michal Harel at 08:29, 5 May 2016

2016-05-05T08:29:49Z

←Older revision		Revision as of 08:29, 5 May 2016
Line 1:		Line 1:
-	<StructureSection load='~~1u28~~' size='350' side='right' caption='Structure of PTH domains I (grey and green) and III (pink) complex with NAD and NADP (PDB entry [[~~1u28~~]])' scene=''>	+	<StructureSection load='1u2d' size='350' side='right' caption='Structure of PTH domains I (grey and green) and III (pink) complex with NAD and NADP (PDB entry [[1u2d]])' scene=''>

	'''NAD(P) transhydrogenase''' (PTH) catalyzes the conversion of NADP and NADH to NADPH and NAD. See [[NAD]] and [[NAD(P)H]]. The reaction is coupled with proton translocation across the cell membrane while the enzyme undergoes conformational change<ref>PMID:12788487</ref>. PTH uses FAD as cofactor.		'''NAD(P) transhydrogenase''' (PTH) catalyzes the conversion of NADP and NADH to NADPH and NAD. See [[NAD]] and [[NAD(P)H]]. The reaction is coupled with proton translocation across the cell membrane while the enzyme undergoes conformational change<ref>PMID:12788487</ref>. PTH uses FAD as cofactor.

Michal Harel at 08:28, 5 May 2016

2016-05-05T08:28:15Z

←Older revision		Revision as of 08:28, 5 May 2016
Line 8:		Line 8:
	* Domain II is a membrane-spanning domain.<br />		* Domain II is a membrane-spanning domain.<br />
	* Domain III binds NADP(+)/NADPH.<br />		* Domain III binds NADP(+)/NADPH.<br />
-	PTH is composed of 2 subunits. Subunit ~~beta~~ contains domain III and part of II.	+	PTH is composed of 2 subunits. Subunit β contains domain III and part of II. The active site of PTH contains NAD in domain I and NADP in domain III<ref>PMID:15323555</ref>.
	</StructureSection>		</StructureSection>