Neuraminidase - Revision history

Alexander Berchansky at 10:45, 22 July 2021

2021-07-22T10:45:15Z

←Older revision		Revision as of 10:45, 22 July 2021
Line 10:		Line 10:
	See also<br />		See also<br />
	*[[Avian Influenza Neuraminidase, Tamiflu and Relenza]]<br />		*[[Avian Influenza Neuraminidase, Tamiflu and Relenza]]<br />
		+	*[[Journal:Acta Cryst D:S2059798320011869\|Lattice-translocation defects in some specific crystals of the catalytic head domain of influenza neuraminidase]]
	*[[Zanamivir]] (Relenza)<br />		*[[Zanamivir]] (Relenza)<br />
	*[[Molecular Playground/Relenza]]<br />		*[[Molecular Playground/Relenza]]<br />

Michal Harel at 09:34, 5 February 2020

2020-02-05T09:34:45Z

←Older revision		Revision as of 09:34, 5 February 2020
Line 6:		Line 6:
	*'''Pseudaminidase''' is a ''Pseudomonas aeruginosa'' neuraminidase. <br />		*'''Pseudaminidase''' is a ''Pseudomonas aeruginosa'' neuraminidase. <br />
	*'''Trans-sialidase''' transfers sialic acid from ''Trypanosoma cruzi'' to a host cell<ref>PMID:8405811</ref>. This enzyme is a modified sialidase which has transglycosidase activity and transfers sialic acid from host glycoconjugates to β-galactose on a parasite surface<ref>PMID:15588836</ref>.<br />		*'''Trans-sialidase''' transfers sialic acid from ''Trypanosoma cruzi'' to a host cell<ref>PMID:8405811</ref>. This enzyme is a modified sialidase which has transglycosidase activity and transfers sialic acid from host glycoconjugates to β-galactose on a parasite surface<ref>PMID:15588836</ref>.<br />
-	*	+	* '''Anhydrosialidase''' catalyzes the elimination of sialyl group in N-acetylneuraminic acid glycosides to yield 2,7-anhydro-α-N-acetylneuraminate<ref>PMID:2254319</ref>.
-	*For '''~~Sialidase~~''' ~~see [[Sialidase]].~~ <br />	+
	See also<br />		See also<br />
	*[[Avian Influenza Neuraminidase, Tamiflu and Relenza]]<br />		*[[Avian Influenza Neuraminidase, Tamiflu and Relenza]]<br />

Michal Harel at 09:31, 5 February 2020

2020-02-05T09:31:51Z

←Older revision		Revision as of 09:31, 5 February 2020
Line 6:		Line 6:
	*'''Pseudaminidase''' is a ''Pseudomonas aeruginosa'' neuraminidase. <br />		*'''Pseudaminidase''' is a ''Pseudomonas aeruginosa'' neuraminidase. <br />
	*'''Trans-sialidase''' transfers sialic acid from ''Trypanosoma cruzi'' to a host cell<ref>PMID:8405811</ref>. This enzyme is a modified sialidase which has transglycosidase activity and transfers sialic acid from host glycoconjugates to β-galactose on a parasite surface<ref>PMID:15588836</ref>.<br />		*'''Trans-sialidase''' transfers sialic acid from ''Trypanosoma cruzi'' to a host cell<ref>PMID:8405811</ref>. This enzyme is a modified sialidase which has transglycosidase activity and transfers sialic acid from host glycoconjugates to β-galactose on a parasite surface<ref>PMID:15588836</ref>.<br />
		+	*
	*For '''Sialidase''' see [[Sialidase]]. <br />		*For '''Sialidase''' see [[Sialidase]]. <br />
	See also<br />		See also<br />

Michal Harel at 09:29, 5 February 2020

2020-02-05T09:29:05Z

←Older revision		Revision as of 09:29, 5 February 2020
Line 2:		Line 2:
	__TOC__		__TOC__
	== Function ==		== Function ==
-	'''Neuraminidase''' (NAN) is a viral neuraminidase which cleaves the glycosidic bonds of neuraminic acid<ref>PMID:15507653</ref>. The non-viral neuraminidase is called [[Sialidase]].<br />	+	'''Neuraminidase''' or '''sialidase''' (NAN) is a viral neuraminidase which cleaves the glycosidic bonds of neuraminic acid<ref>PMID:15507653</ref>. The non-viral neuraminidase is called [[Sialidase]].<br />
	*'''endo-neuraminidase''' is a phage neuraminidase which cleaves α-2,8-polysialic acid<ref>PMID:4055897</ref>. <br />		*'''endo-neuraminidase''' is a phage neuraminidase which cleaves α-2,8-polysialic acid<ref>PMID:4055897</ref>. <br />
	*'''Pseudaminidase''' is a ''Pseudomonas aeruginosa'' neuraminidase. <br />		*'''Pseudaminidase''' is a ''Pseudomonas aeruginosa'' neuraminidase. <br />

Michal Harel at 11:19, 6 November 2019

2019-11-06T11:19:34Z

←Older revision		Revision as of 11:19, 6 November 2019
Line 31:		Line 31:

	</StructureSection>		</StructureSection>
-	==3D structures of Neuraminidase==

-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*'''Influenza virus neuraminidase'''
-
-	**[[3nss]], [[3k36]], [[3beq]], [[3cye]], [[2cml]], [[2b8h]], [[2ht5]], [[1v0z]], [[1nn2]], [[4hzv]], [[4fvk]], [[4gez]] – IvNANA residues 82-469 – Influenza virus<br />
-	**[[4fvk]], [[4gez]] - IvNANA residues 76-442<br />
-	**[[3k38]], [[4hzy]] – IvNANA (mutant) <br />
-	**[[4b7m]], [[6d96]] - IvNAN H1n1<br />
-	**[[6n4d]] – IvNAN H3n2<br />
-	**[[4qn4]] – IvNAN H3n6<br />
-	**[[4wa3]] – IvNAN H3n8<br />
-	**[[5hug]], [[2ht5]], [[2htv]], [[2hty]] – IvNAN H5n1<br />
-	**[[5huk]] – IvNAN H5n2<br />
-	**[[5hun]], [[5hum]] – IvNAN H5n6<br />
-	**[[5l14]], [[3nn9]], [[4nn9]], [[5nn9]], [[6nn9]], [[4mwj]], [[4mwl]] – IvNAN H7n9<br />
-	**[[4qn3]] – IvNAN H10n7<br />
-	**[[7nn9]], [[6mcx]] - IvNAN H11n9 Tern<br />
-	**[[3sal]] - IvNAN H12n5 residues 82-469<br />
-	**[[4gdi]], [[4gdj]] - IvNAN H17n10<br />
-	**[[4mc7]] – IvNAN H18n11<br />
-	**[[2hty]] - IvNAN N1 residues 82-469<br />
-	**[[4gzo]], [[4k1h]], [[4k1i]], [[4k1k]] - IvNAN N2 residues 77-469<br />
-	**[[4gzs]], [[4k1j]] - IvNAN N2 residues 77-469 (mutant)<br />
-	**[[2htv]] - IvNAN N4 residues 82-469<br />
-	**[[6hgb]] – IvNAN N6<br />
-	**[[2ht5]] – IvNAN N8 residues 82-469<br />
-	**[[2qwa]] - IvNAN N9 Tern (mutant)<br />
-
-	*Binary complexes of Influenza virus neuraminidase
-
-	**[[3o9j]], [[3o9k]], [[2c4a]], [[2c4l]], [[1w1x]], [[1w20]], [[1w21]], [[1nsb]], [[1nsc]], [[1nsd]] – IvNANA + sialic derivative<br />
-	**[[3k37]], [[3b7e]], [[1vcj]], [[1l7f]], [[1f8c]], [[1f8d]], [[1f8e]], [[1a4g]], [[1a4q]], [[1b9t]], [[1b9v]], [[1b9s]], [[1inf]], [[1ing]], [[1inh]], [[1ivb]], [[1ivc]], [[1ivd]], [[1ive]], [[1ivf]], [[1ivg]], [[4d8s]], [[4ks1]], [[4ks2]], [[4ks3]], [[4ks4]], [[4ks5]], [[4m3m]], [[4mju]], [[4mjv]] – IvNANA + inhibitor<br />
-	**[[3k39]], [[3k3a]], [[3ckz]], [[3cl0]], [[3cl2]], [[1l7g]], [[1l7h]] - IvNANA (mutant) + inhibitor<br />
-	**[[1f8b]], [[1inv]], [[1inw]], [[1inx]], [[1iny]], [[4gb1]] – IvNANA + sialic acid analog<br />
-	**[[3ti3]], [[3ti4]], [[3ti5]], [[3ti6]], [[6g02]], [[6g01]] - IvNAN H1n1 + inhibitor<br />
-	**[[4qnp]], [[6q23]] - IvNAN H1n1 + antibody<br />
-	**[[3tia]], [[3tib]], [[3tic]] – IvNAN H2n2 + inhibitor<br />
-	**[[6q20]] - IvNAN H2n2 + antibody<br />
-	**[[6n6b]] - IvNAN H3n2 + antibody<br />
-	**[[2bat]], [[4gzw]], [[4gzx]], [[4gzq]] – IvNAN H3n2 + sialic acid<br />
-	**[[2ht7]], [[2ht8]], [[2htq]], [[2htu]] – IvNAN H5n1 + inhibitor<br />
-	**[[2htr]], [[2htw]] – IvNAN H5n1 + sialic acid analog<br /
-	**[[5l18]] - IvNAN H7n9 + sialic acid<br />
-	**[[6q1z]] - IvNAN H7n9 + antibody<br />
-	**[[1nna]], [[1nnb]], [[5w2y]], [[5w2w]], [[5w2u]], [[5w26]] - IvNAN H11n9 + neuraminic acid derivative<br />
-	**[[4dgr]] - IvNAN H11n9 + benzoic acid derivative<br />
-	**[[4weg]] - IvNAN H11n9 + sialic acid derivative <br />
-	**[[1bji]], [[1nnc]] - IvNAN H11n9 Tern + sialic acid analog<br />
-	**[[1xoe]], [[1xog]], [[3w09]] - IvNAN H11n9 Tern + inhibitor<br />
-	**[[4qn5]] - IvNAN H12n5 + sialic acid<br />
-	**[[4h52]], [[4h53]] – IvNAN N2 + inhibitor<br />
-	**[[2qwb]] - IvNAN N9 Tern (mutant) + sialic derivative<br />
-	**[[2qwc]], [[2qwd]], [[2qwe]] - IvNAN N9 Tern (mutant) + sialic acid analog<br />
-	**[[1mwe]] - IvNAN N9 Tern + sialic acid<br />
-	**[[2qwf]], [[2qwg]], [[2qwh]], [[2qwi]], [[2qwj]], [[2qwk]] - IvNAN N9 Tern (mutant) + inhibitor<br />
-	**[[1nma]], [[1nmb]], [[1a14]], [[1nca]], [[1ncb]], [[1ncc]], [[1ncd]], [[2aep]], [[2aeq]], [[1nmc]] - IvNAN N9 Tern + antibody – mouse<br />
-
-	*Binary complexes of Influenza virus neuraminidase with drugs
-
-	**[[4b7j]], [[4b7n]], [[4b7q]], [[4b7r]], [[5nzn]], [[6hp0]] - IvNAN H1n1 + drug<br />
-	**[[5nzf]], [[5nze]], [[5nz4]], [[5nwe]] - IvNAN H1n1 (mutant) + drug<br />
-	**[[4gzp]], [[4gzt]], [[6br6]], [[6br5]] - IvNAN H3n2 + drug<br />
-	**[[4qn6]] - IvNAN H3n6 + drug<br />
-	**[[4wa5]], [[4wa4]] - IvNAN H3n8 + drug<br />
-	**[[5l15]], [[5l17]], [[5jyy]], [[4mwq]], [[4mwr]], [[4mwu]], [[4mwv]], [[4mww]], [[4mwx]], [[4mwy]], [[4mx0]] - IvNAN H7n9 + drug<br />
-	**[[4mwq]], [[4mwr]], [[4mwu]], [[4mwv]], [[4mww]], [[4mwx]], [[4mwy]], [[4mx0]] - IvNAN H7n9 + flu drug<br />
-	**[[4qn7]]- IvNAN H10n7 + drug<br />
-	**[[3san]], [[3ti8]] - IvNAN H12N5 + flu drug<br />
-	**[[4hzw]], [[4hzx]] - IvNAN N3 + flu drug<br />
-	**[[4hzz]], [[4i00]] - IvNAN N3 (mutant) + flu drug<br />
-	**[[6hg5]] - IvNAN N6 + flu drug<br />
-	**[[6hfy]] - IvNAN N6 + DANA<br />
-	**[[6heb]], [[6hcx]] - IvNAN N9 + flu drug<br />
-	**[[6hg0]] - IvNAN N9 Tern + NANA<br />
-
-	*'''Endo-neuraminidase'''
-
-	**[[3gvf]], [[3gvk]], [[3gvj]] – ENANA (mutant) residues 246-910 – Enterobacteria phage K1F<br />
-	**[[3gvl]], [[3ju4]] – ENANA residues 246-910<br />
-	**[[3gw6]] – ENANA residues 790-1064<br />
-
-	*'''Pseudaminidase'''
-
-	**[[2w38]], [[3h6j]] – PNANA – ''Pseudomonas aeruginosa''
-
-	*'''Trans-sialidase'''
-
-	**[[2sli]], [[1sli]], [[3sli]] – lTS + inhibitor – leech<br />
-	**[[1mr5]], [[1ms3]], [[1ms4]] - TcTS (mutant) – ''Trypanosoma cruzi''<br />
-	**[[1ms0]] - TcTS (mutant) + DANA + lactose<br />
-	**[[1ms1]], [[1ms8]] - TcTS (mutant) + DANA <br />
-	**[[3b69]] - TcTS (mutant) + NANA derivative<br />
-	**[[1ms5]] - TcTS (mutant) + Na-S-Gal<br />
-	**[[1ms9]], [[3pjq]] - TcTS (mutant) + lactose<br />
-	**[[1s0i]] - TcTS (mutant) + sialyl-lactose<br />
-	**[[1s0j]] - TcTS (mutant) + MUNANA<br />
-	**[[3opz]] - TcTS (mutant) + antibody<br />
-	**[[2ah2]] - TcTS (mutant) + difluorosialic acid<br />
-
-	}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 11:18, 6 November 2019

2019-11-06T11:18:29Z

←Older revision		Revision as of 11:18, 6 November 2019
Line 26:		Line 26:
	== Structural highlights ==		== Structural highlights ==
	The biological assembly of H5N1 avian influenza virus neuraminidase is <scene name='35/352656/Cv/5'>homotetramer</scene>. The <scene name='35/352656/Cv/6'>active site of NAN contains the influenza drug Tamiflu</scene><ref>PMID:16915235</ref>.		The biological assembly of H5N1 avian influenza virus neuraminidase is <scene name='35/352656/Cv/5'>homotetramer</scene>. The <scene name='35/352656/Cv/6'>active site of NAN contains the influenza drug Tamiflu</scene><ref>PMID:16915235</ref>.
		+
		+	==3D structures of Neuraminidase==
		+	[[Neuraminidase 3D structures]]
		+
	</StructureSection>		</StructureSection>
	==3D structures of Neuraminidase==		==3D structures of Neuraminidase==
Line 37:		Line 41:
	**[[4fvk]], [[4gez]] - IvNANA residues 76-442<br />		**[[4fvk]], [[4gez]] - IvNANA residues 76-442<br />
	**[[3k38]], [[4hzy]] – IvNANA (mutant) <br />		**[[3k38]], [[4hzy]] – IvNANA (mutant) <br />
-	**[[~~4gzo~~]], [[~~4k1h]], [[4k1i]], [[4k1k~~]] - IvNAN ~~N2 residues 77-469~~<br />	+	**[[4b7m]], [[6d96]] - IvNAN H1n1<br />
-	**[[~~4gzs]], [[4k1j]] - IvNAN N2 residues 77-469 (mutant)<br />~~	+	**[[6n4d]] – IvNAN H3n2<br />
-	**[[2ht5]] – IvNAN ~~N8 residues 82-469<br />~~	+
-	**[[2htv]] - IvNAN N4 residues 82-469<br />	+
-	**[[2hty]] - IvNAN N1 residues 82-469<br />	+
-	**[[2qwa]] - IvNAN N9 Tern (mutant)<br />	+
-	**[[4b7m]] - IvNAN H1n1<br />	+
	**[[4qn4]] – IvNAN H3n6<br />		**[[4qn4]] – IvNAN H3n6<br />
	**[[4wa3]] – IvNAN H3n8<br />		**[[4wa3]] – IvNAN H3n8<br />
Line 51:		Line 50:
	**[[5l14]], [[3nn9]], [[4nn9]], [[5nn9]], [[6nn9]], [[4mwj]], [[4mwl]] – IvNAN H7n9<br />		**[[5l14]], [[3nn9]], [[4nn9]], [[5nn9]], [[6nn9]], [[4mwj]], [[4mwl]] – IvNAN H7n9<br />
	**[[4qn3]] – IvNAN H10n7<br />		**[[4qn3]] – IvNAN H10n7<br />
-	**[[7nn9]] - IvNAN H11n9 Tern<br />	+	**[[7nn9]], [[6mcx]] - IvNAN H11n9 Tern<br />
	**[[3sal]] - IvNAN H12n5 residues 82-469<br />		**[[3sal]] - IvNAN H12n5 residues 82-469<br />
	**[[4gdi]], [[4gdj]] - IvNAN H17n10<br />		**[[4gdi]], [[4gdj]] - IvNAN H17n10<br />
	**[[4mc7]] – IvNAN H18n11<br />		**[[4mc7]] – IvNAN H18n11<br />
		+	**[[2hty]] - IvNAN N1 residues 82-469<br />
		+	**[[4gzo]], [[4k1h]], [[4k1i]], [[4k1k]] - IvNAN N2 residues 77-469<br />
		+	**[[4gzs]], [[4k1j]] - IvNAN N2 residues 77-469 (mutant)<br />
		+	**[[2htv]] - IvNAN N4 residues 82-469<br />
		+	**[[6hgb]] – IvNAN N6<br />
		+	**[[2ht5]] – IvNAN N8 residues 82-469<br />
		+	**[[2qwa]] - IvNAN N9 Tern (mutant)<br />

	*Binary complexes of Influenza virus neuraminidase		*Binary complexes of Influenza virus neuraminidase
Line 62:		Line 68:
	**[[3k39]], [[3k3a]], [[3ckz]], [[3cl0]], [[3cl2]], [[1l7g]], [[1l7h]] - IvNANA (mutant) + inhibitor<br />		**[[3k39]], [[3k3a]], [[3ckz]], [[3cl0]], [[3cl2]], [[1l7g]], [[1l7h]] - IvNANA (mutant) + inhibitor<br />
	**[[1f8b]], [[1inv]], [[1inw]], [[1inx]], [[1iny]], [[4gb1]] – IvNANA + sialic acid analog<br />		**[[1f8b]], [[1inv]], [[1inw]], [[1inx]], [[1iny]], [[4gb1]] – IvNANA + sialic acid analog<br />
-	**[[3ti3]], [[3ti4]], [[3ti5]], [[3ti6~~]] – IvNAN H1n1 + inhibitor<br />~~	+	**[[3ti3]], [[3ti4]], [[3ti5]], [[3ti6]], [[6g02]], [[6g01]] - IvNAN H1n1 + inhibitor<br />
-	**[[4b7j]], [[~~4b7n~~]], [[~~4b7q]], [[4b7r]], [[5nzn~~]] - IvNAN H1n1 + ~~drug~~<br />	+	**[[4qnp]], [[6q23]] - IvNAN H1n1 + antibody<br />
-	**[[4qnp~~]] - IvNAN H1n1 + antibody<br />~~	+
-	**[[5nzf]], [[~~5nze]], [[5nz4]], [[5nwe~~]] - IvNAN H1n1 ~~(mutant)~~ + ~~drug~~<br />	+
	**[[3tia]], [[3tib]], [[3tic]] – IvNAN H2n2 + inhibitor<br />		**[[3tia]], [[3tib]], [[3tic]] – IvNAN H2n2 + inhibitor<br />
		+	**[[6q20]] - IvNAN H2n2 + antibody<br />
		+	**[[6n6b]] - IvNAN H3n2 + antibody<br />
	**[[2bat]], [[4gzw]], [[4gzx]], [[4gzq]] – IvNAN H3n2 + sialic acid<br />		**[[2bat]], [[4gzw]], [[4gzx]], [[4gzq]] – IvNAN H3n2 + sialic acid<br />
-	**[[4gzp]], [[4gzt]], [[6br6]], [[6br5]] - IvNAN H3n2 + drug<br />
-	**[[4qn6]] - IvNAN H3n6 + drug<br />
-	**[[4wa5]], [[4wa4]] - IvNAN H3n8 + drug<br />
	**[[2ht7]], [[2ht8]], [[2htq]], [[2htu]] – IvNAN H5n1 + inhibitor<br />		**[[2ht7]], [[2ht8]], [[2htq]], [[2htu]] – IvNAN H5n1 + inhibitor<br />
-	**[[2htr]], [[2htw]] – IvNAN H5n1 + sialic acid analog<br />	+	**[[2htr]], [[2htw]] – IvNAN H5n1 + sialic acid analog<br /
-	**[[5l15]], [[5l17]], [[5jyy]], [[4mwq]], [[4mwr]], [[4mwu]], [[4mwv]], [[4mww]], [[4mwx]], [[4mwy]], [[4mx0]] - IvNAN H7n9 + drug<br />	+
	**[[5l18]] - IvNAN H7n9 + sialic acid<br />		**[[5l18]] - IvNAN H7n9 + sialic acid<br />
-	**[[~~4mwq~~]]~~, [[4mwr]], [[4mwu]], [[4mwv]], [[4mww]], [[4mwx]], [[4mwy]], [[4mx0]]~~ - IvNAN H7n9 + ~~flu drug<br />~~	+	**[[6q1z]] - IvNAN H7n9 + antibody<br />
-	**[[4qn7]]- IvNAN H10n7 + drug<br />	+
	**[[1nna]], [[1nnb]], [[5w2y]], [[5w2w]], [[5w2u]], [[5w26]] - IvNAN H11n9 + neuraminic acid derivative<br />		**[[1nna]], [[1nnb]], [[5w2y]], [[5w2w]], [[5w2u]], [[5w26]] - IvNAN H11n9 + neuraminic acid derivative<br />
	**[[4dgr]] - IvNAN H11n9 + benzoic acid derivative<br />		**[[4dgr]] - IvNAN H11n9 + benzoic acid derivative<br />
Line 83:		Line 84:
	**[[1xoe]], [[1xog]], [[3w09]] - IvNAN H11n9 Tern + inhibitor<br />		**[[1xoe]], [[1xog]], [[3w09]] - IvNAN H11n9 Tern + inhibitor<br />
	**[[4qn5]] - IvNAN H12n5 + sialic acid<br />		**[[4qn5]] - IvNAN H12n5 + sialic acid<br />
-	**[[3san]], [[3ti8]] - IvNAN H12N5 + flu drug<br />
-	**[[3san]], [[3ti8]] - IvNAN N5 + flu drug<br />
-	**[[4hzw]], [[4hzx]] - IvNAN N3 + flu drug<br />
-	**[[4hzz]], [[4i00]] - IvNAN N3 (mutant) + flu drug<br />
	**[[4h52]], [[4h53]] – IvNAN N2 + inhibitor<br />		**[[4h52]], [[4h53]] – IvNAN N2 + inhibitor<br />
	**[[2qwb]] - IvNAN N9 Tern (mutant) + sialic derivative<br />		**[[2qwb]] - IvNAN N9 Tern (mutant) + sialic derivative<br />
Line 93:		Line 90:
	**[[2qwf]], [[2qwg]], [[2qwh]], [[2qwi]], [[2qwj]], [[2qwk]] - IvNAN N9 Tern (mutant) + inhibitor<br />		**[[2qwf]], [[2qwg]], [[2qwh]], [[2qwi]], [[2qwj]], [[2qwk]] - IvNAN N9 Tern (mutant) + inhibitor<br />
	**[[1nma]], [[1nmb]], [[1a14]], [[1nca]], [[1ncb]], [[1ncc]], [[1ncd]], [[2aep]], [[2aeq]], [[1nmc]] - IvNAN N9 Tern + antibody – mouse<br />		**[[1nma]], [[1nmb]], [[1a14]], [[1nca]], [[1ncb]], [[1ncc]], [[1ncd]], [[2aep]], [[2aeq]], [[1nmc]] - IvNAN N9 Tern + antibody – mouse<br />
		+
		+	*Binary complexes of Influenza virus neuraminidase with drugs
		+
		+	**[[4b7j]], [[4b7n]], [[4b7q]], [[4b7r]], [[5nzn]], [[6hp0]] - IvNAN H1n1 + drug<br />
		+	**[[5nzf]], [[5nze]], [[5nz4]], [[5nwe]] - IvNAN H1n1 (mutant) + drug<br />
		+	**[[4gzp]], [[4gzt]], [[6br6]], [[6br5]] - IvNAN H3n2 + drug<br />
		+	**[[4qn6]] - IvNAN H3n6 + drug<br />
		+	**[[4wa5]], [[4wa4]] - IvNAN H3n8 + drug<br />
		+	**[[5l15]], [[5l17]], [[5jyy]], [[4mwq]], [[4mwr]], [[4mwu]], [[4mwv]], [[4mww]], [[4mwx]], [[4mwy]], [[4mx0]] - IvNAN H7n9 + drug<br />
		+	**[[4mwq]], [[4mwr]], [[4mwu]], [[4mwv]], [[4mww]], [[4mwx]], [[4mwy]], [[4mx0]] - IvNAN H7n9 + flu drug<br />
		+	**[[4qn7]]- IvNAN H10n7 + drug<br />
		+	**[[3san]], [[3ti8]] - IvNAN H12N5 + flu drug<br />
		+	**[[4hzw]], [[4hzx]] - IvNAN N3 + flu drug<br />
		+	**[[4hzz]], [[4i00]] - IvNAN N3 (mutant) + flu drug<br />
		+	**[[6hg5]] - IvNAN N6 + flu drug<br />
		+	**[[6hfy]] - IvNAN N6 + DANA<br />
		+	**[[6heb]], [[6hcx]] - IvNAN N9 + flu drug<br />
		+	**[[6hg0]] - IvNAN N9 Tern + NANA<br />

	*'''Endo-neuraminidase'''		*'''Endo-neuraminidase'''

Alexander Berchansky at 13:07, 22 July 2019

2019-07-22T13:07:35Z

←Older revision		Revision as of 13:07, 22 July 2019
Line 25:		Line 25:

	== Structural highlights ==		== Structural highlights ==
-	The biological assembly of H5N1 avian influenza virus neuraminidase is <scene name='35/352656/Cv/2'>homotetramer</scene>. The <scene name='35/352656/Cv/4'>active site of NAN contains the influenza drug Tamiflu</scene><ref>PMID:16915235</ref>.	+	The biological assembly of H5N1 avian influenza virus neuraminidase is <scene name='35/352656/Cv/5'>homotetramer</scene>. The <scene name='35/352656/Cv/6'>active site of NAN contains the influenza drug Tamiflu</scene><ref>PMID:16915235</ref>.
	</StructureSection>		</StructureSection>
	==3D structures of Neuraminidase==		==3D structures of Neuraminidase==

Michal Harel at 09:32, 11 November 2018

2018-11-11T09:32:00Z

←Older revision		Revision as of 09:32, 11 November 2018
Line 6:		Line 6:
	*'''Pseudaminidase''' is a ''Pseudomonas aeruginosa'' neuraminidase. <br />		*'''Pseudaminidase''' is a ''Pseudomonas aeruginosa'' neuraminidase. <br />
	*'''Trans-sialidase''' transfers sialic acid from ''Trypanosoma cruzi'' to a host cell<ref>PMID:8405811</ref>. This enzyme is a modified sialidase which has transglycosidase activity and transfers sialic acid from host glycoconjugates to β-galactose on a parasite surface<ref>PMID:15588836</ref>.<br />		*'''Trans-sialidase''' transfers sialic acid from ''Trypanosoma cruzi'' to a host cell<ref>PMID:8405811</ref>. This enzyme is a modified sialidase which has transglycosidase activity and transfers sialic acid from host glycoconjugates to β-galactose on a parasite surface<ref>PMID:15588836</ref>.<br />
		+	*For '''Sialidase''' see [[Sialidase]]. <br />
	See also<br />		See also<br />
	*[[Avian Influenza Neuraminidase, Tamiflu and Relenza]]<br />		*[[Avian Influenza Neuraminidase, Tamiflu and Relenza]]<br />

Michal Harel at 07:44, 7 November 2018

2018-11-07T07:44:01Z

←Older revision		Revision as of 07:44, 7 November 2018
Line 5:		Line 5:
	*'''endo-neuraminidase''' is a phage neuraminidase which cleaves α-2,8-polysialic acid<ref>PMID:4055897</ref>. <br />		*'''endo-neuraminidase''' is a phage neuraminidase which cleaves α-2,8-polysialic acid<ref>PMID:4055897</ref>. <br />
	*'''Pseudaminidase''' is a ''Pseudomonas aeruginosa'' neuraminidase. <br />		*'''Pseudaminidase''' is a ''Pseudomonas aeruginosa'' neuraminidase. <br />
-	*'''Trans-sialidase''' transfers sialic acid from ''Trypanosoma cruzi'' to a host cell<ref>PMID:8405811</ref>. This enzyme is a modified sialidase which has transglycosidase activity and transfers sialic acid from host glycoconjugates to β-galactose on a parasite surface<ref>PMID:~~8405811~~</ref>.<br />	+	*'''Trans-sialidase''' transfers sialic acid from ''Trypanosoma cruzi'' to a host cell<ref>PMID:8405811</ref>. This enzyme is a modified sialidase which has transglycosidase activity and transfers sialic acid from host glycoconjugates to β-galactose on a parasite surface<ref>PMID:15588836</ref>.<br />
	See also<br />		See also<br />
	*[[Avian Influenza Neuraminidase, Tamiflu and Relenza]]<br />		*[[Avian Influenza Neuraminidase, Tamiflu and Relenza]]<br />

Michal Harel at 07:39, 7 November 2018

2018-11-07T07:39:12Z

←Older revision		Revision as of 07:39, 7 November 2018
Line 5:		Line 5:
	*'''endo-neuraminidase''' is a phage neuraminidase which cleaves α-2,8-polysialic acid<ref>PMID:4055897</ref>. <br />		*'''endo-neuraminidase''' is a phage neuraminidase which cleaves α-2,8-polysialic acid<ref>PMID:4055897</ref>. <br />
	*'''Pseudaminidase''' is a ''Pseudomonas aeruginosa'' neuraminidase. <br />		*'''Pseudaminidase''' is a ''Pseudomonas aeruginosa'' neuraminidase. <br />
-	*'''Trans-sialidase''' transfers sialic acid from ''Trypanosoma cruzi'' to a host cell<ref>PMID:8405811</ref>. <br />	+	*'''Trans-sialidase''' transfers sialic acid from ''Trypanosoma cruzi'' to a host cell<ref>PMID:8405811</ref>. This enzyme is a modified sialidase which has transglycosidase activity and transfers sialic acid from host glycoconjugates to β-galactose on a parasite surface<ref>PMID:8405811</ref>.<br />
	See also<br />		See also<br />
	*[[Avian Influenza Neuraminidase, Tamiflu and Relenza]]<br />		*[[Avian Influenza Neuraminidase, Tamiflu and Relenza]]<br />