Neurotrophin - Revision history

Alexander Berchansky at 14:26, 1 January 2019

2019-01-01T14:26:12Z

←Older revision		Revision as of 14:26, 1 January 2019
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	The complex between NT3 and p75 neurotrophin receptor (p75NTR) shows a <scene name='80/805035/Cv/2'>homodimer of NT3 with two symmetrically arranged p75NTR molecules</scene>. There are 3 sites of interactions between NT3 and p75NTR - site 1, site 2 and site 3<ref>PMID:18596692</ref>.		The complex between NT3 and p75 neurotrophin receptor (p75NTR) shows a <scene name='80/805035/Cv/2'>homodimer of NT3 with two symmetrically arranged p75NTR molecules</scene>. There are 3 sites of interactions between NT3 and p75NTR - site 1, site 2 and site 3<ref>PMID:18596692</ref>.
	*<scene name='80/805035/Cv/3'>Site 1</scene>.		*<scene name='80/805035/Cv/3'>Site 1</scene>.
		+	*<scene name='80/805035/Cv/4'>Site 2</scene>.
		+	*<scene name='80/805035/Cv/5'>Site 3</scene>.
	</StructureSection>		</StructureSection>

Alexander Berchansky at 14:09, 1 January 2019

2019-01-01T14:09:21Z

←Older revision		Revision as of 14:09, 1 January 2019
Line 12:		Line 12:
	== Structural highlights ==		== Structural highlights ==

-	The complex between NT3 and p75 neurotrophin receptor (p75NTR) shows a <scene name='80/805035/Cv/2'>homodimer of NT3 with two symmetrically arranged p75NTR molecules</scene>. There are 3 sites of interactions between NT3 and p75NTR - site 1, site 2 and site 3<ref>PMID:18596692</ref>.	+	The complex between NT3 and p75 neurotrophin receptor (p75NTR) shows a <scene name='80/805035/Cv/2'>homodimer of NT3 with two symmetrically arranged p75NTR molecules</scene>. There are 3 sites of interactions between NT3 and p75NTR - site 1, site 2 and site 3<ref>PMID:18596692</ref>.
		+	*<scene name='80/805035/Cv/3'>Site 1</scene>.
	</StructureSection>		</StructureSection>

Alexander Berchansky at 13:55, 1 January 2019

2019-01-01T13:55:38Z

←Older revision		Revision as of 13:55, 1 January 2019
Line 12:		Line 12:
	== Structural highlights ==		== Structural highlights ==

-	The complex between NT3 and p75 neurotrophin receptor (p75NTR) shows a homodimer of NT3 with two symmetrically arranged p75NTR molecules. There are 3 sites of interactions between NT3 and p75NTR - site 1, site 2 and site 3<ref>PMID:18596692</ref>.	+	The complex between NT3 and p75 neurotrophin receptor (p75NTR) shows a <scene name='80/805035/Cv/2'>homodimer of NT3 with two symmetrically arranged p75NTR molecules</scene>. There are 3 sites of interactions between NT3 and p75NTR - site 1, site 2 and site 3<ref>PMID:18596692</ref>.
	</StructureSection>		</StructureSection>

Alexander Berchansky at 13:51, 1 January 2019

2019-01-01T13:51:55Z

←Older revision		Revision as of 13:51, 1 January 2019
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-	<StructureSection load='3buk' size='400' side='right' caption='Glycosylated human NT3 homodimer (~~grey~~ and green) complex with p75NTR (pink and yellow) (PDB code [[3buk]])' scene=''>	+	<StructureSection load='3buk' size='400' side='right' caption='Glycosylated human NT3 homodimer (cyan and green) complex with p75NTR (pink and yellow) (PDB code [[3buk]])' scene='80/805035/Cv/1'>

Alexander Berchansky at 13:49, 1 January 2019

2019-01-01T13:49:53Z

←Older revision		Revision as of 13:49, 1 January 2019
Line 1:		Line 1:
-	<StructureSection load='3buk' size='~~340~~' side='right' caption='Glycosylated human NT3 homodimer (grey and green) complex with p75NTR (pink and yellow) (PDB code [[3buk]])' scene=''>	+	<StructureSection load='3buk' size='400' side='right' caption='Glycosylated human NT3 homodimer (grey and green) complex with p75NTR (pink and yellow) (PDB code [[3buk]])' scene=''>


Line 12:		Line 12:
	== Structural highlights ==		== Structural highlights ==

-	The complex between NT3 and p75 neurotrophin receptor (p75NTR) shows A homodimer of NT3 with two symmetrically arranged p75NTR molecules. There are 3 sites of interactions between NT3 and p75NTR - site 1, site 2 and site 3<ref>PMID:18596692</ref>.	+	The complex between NT3 and p75 neurotrophin receptor (p75NTR) shows a homodimer of NT3 with two symmetrically arranged p75NTR molecules. There are 3 sites of interactions between NT3 and p75NTR - site 1, site 2 and site 3<ref>PMID:18596692</ref>.
	</StructureSection>		</StructureSection>

Michal Harel at 09:38, 1 January 2019

2019-01-01T09:38:37Z

←Older revision		Revision as of 09:38, 1 January 2019
Line 4:		Line 4:
	== Function ==		== Function ==

-	'''Neurotrophins''' (NT) are survival factors for sympathetic and sensory neurons and control a number of aspects of survival, development and function of neurons in the central and peripheral nervous systems<ref>PMID:22367798</ref>. There are 4 mammalian NTs and they are activated by the family of the receptor tyrosine kinases TrkA (see [[High affinity nerve growth factor receptor]]), TrkB (see [[TrkB tyrosine kinase receptor]]), TrkC. NTs activate the p75 neurotrophin receptor which is a member of the tumor necrosis factor receptor superfamily.	+	'''Neurotrophins''' (NT) are survival factors for sympathetic and sensory neurons and control a number of aspects of survival, development and function of neurons in the central and peripheral nervous systems<ref>PMID:22367798</ref>. There are 4 mammalian NTs and they are activated by the family of the receptor tyrosine kinases TrkA (see [[High affinity nerve growth factor receptor]]), TrkB (see [[TrkB tyrosine kinase receptor]]), TrkC. NTs activate the p75 neurotrophin receptor (BDNF) which is a member of the tumor necrosis factor receptor superfamily.

	== Relevance ==		== Relevance ==

Michal Harel at 09:36, 1 January 2019

2019-01-01T09:36:17Z

←Older revision		Revision as of 09:36, 1 January 2019
Line 1:		Line 1:
-	<StructureSection load='3buk' size='340' side='right' caption='~~Caption for this structure~~' scene=''>	+	<StructureSection load='3buk' size='340' side='right' caption='Glycosylated human NT3 homodimer (grey and green) complex with p75NTR (pink and yellow) (PDB code [[3buk]])' scene=''>


Line 12:		Line 12:
	== Structural highlights ==		== Structural highlights ==

-		+	The complex between NT3 and p75 neurotrophin receptor (p75NTR) shows A homodimer of NT3 with two symmetrically arranged p75NTR molecules. There are 3 sites of interactions between NT3 and p75NTR - site 1, site 2 and site 3<ref>PMID:18596692</ref>.
	</StructureSection>		</StructureSection>

Michal Harel at 09:28, 1 January 2019

2019-01-01T09:28:18Z

←Older revision		Revision as of 09:28, 1 January 2019
Line 1:		Line 1:
-	<StructureSection load='~~1stp~~' size='340' side='right' caption='Caption for this structure' scene=''>	+	<StructureSection load='3buk' size='340' side='right' caption='Caption for this structure' scene=''>


	== Function ==		== Function ==

-	'''Neurotrophins''' (NT) are survival factors for sympathetic and sensory neurons and control a number of aspects of survival, development and function of neurons in the central and peripheral nervous systems<ref>PMID:22367798</ref>. There are 4 mammalian NTs and they are activated by the family of the receptor tyrosine kinases TrkA (see [[High affinity nerve growth factor]]), TrkB (see [[TrkB tyrosine kinase receptor]]), TrkC. NTs activate the p75 neurotrophin receptor which is a member of the tumor necrosis factor receptor superfamily.	+	'''Neurotrophins''' (NT) are survival factors for sympathetic and sensory neurons and control a number of aspects of survival, development and function of neurons in the central and peripheral nervous systems<ref>PMID:22367798</ref>. There are 4 mammalian NTs and they are activated by the family of the receptor tyrosine kinases TrkA (see [[High affinity nerve growth factor receptor]]), TrkB (see [[TrkB tyrosine kinase receptor]]), TrkC. NTs activate the p75 neurotrophin receptor which is a member of the tumor necrosis factor receptor superfamily.
-		+
-	~~== Disease ==~~	+

	== Relevance ==		== Relevance ==

Michal Harel at 09:17, 1 January 2019

2019-01-01T09:17:55Z

←Older revision		Revision as of 09:17, 1 January 2019
Line 1:		Line 1:
-
	<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>		<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>

Line 5:		Line 4:
	== Function ==		== Function ==

-	'''Neurotrophins''' (NT) are survival factors for sympathetic and sensory neurons and control a number of aspects of survival, development and function of neurons in the central and peripheral nervous systems<ref>PMID:22367798</ref>. There are 4 mammalian NTs and they are activated by the family of the receptor tyrosine kinases TrkA, TrkB, TrkC. NTs activate the p75 neurotrophin receptor which is a member of the tumor necrosis factor receptor superfamily.	+	'''Neurotrophins''' (NT) are survival factors for sympathetic and sensory neurons and control a number of aspects of survival, development and function of neurons in the central and peripheral nervous systems<ref>PMID:22367798</ref>. There are 4 mammalian NTs and they are activated by the family of the receptor tyrosine kinases TrkA (see [[High affinity nerve growth factor]]), TrkB (see [[TrkB tyrosine kinase receptor]]), TrkC. NTs activate the p75 neurotrophin receptor which is a member of the tumor necrosis factor receptor superfamily.

	== Disease ==		== Disease ==

	== Relevance ==		== Relevance ==
		+
		+	Alterations in NTs levels were implicated in neurodegenerative disorders such as Alzheimer disease and Huntington disease as well as psychiatric disorders including depression and substance abuse<ref>PMID:16411893</ref>.

	== Structural highlights ==		== Structural highlights ==

Michal Harel: New page: == Function == '''Neurotrophins''' (NT) are survival factors for sympathetic and se...

2019-01-01T07:46:41Z

New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Neurotrophins''' (NT) are survival factors for sympathetic and se...

New page

<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>

== Function ==

'''Neurotrophins''' (NT) are survival factors for sympathetic and sensory neurons and control a number of aspects of survival, development and function of neurons in the central and peripheral nervous systems<ref>PMID:22367798</ref>. There are 4 mammalian NTs and they are activated by the family of the receptor tyrosine kinases TrkA, TrkB, TrkC. NTs activate the p75 neurotrophin receptor which is a member of the tumor necrosis factor receptor superfamily.

== Disease ==

== Relevance ==

== Structural highlights ==

</StructureSection>

==3D structures of neurotrophin==

Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

[[1b8k]], [[1nt3]] – hNT3 – human 
[[3buk]] – hNT3 + P75NTR 
[[1bnd]] – hNT3 139-257 + BDNF 
[[1b98]] – hNT4 81-210 
[[1b8m]], [[1hcf]] – hNT4 81-210 + BDNF 

== References ==
<references/>

[[Category:Topic Page]]