Phosphoserine phosphatase - Revision history

Michal Harel at 07:11, 29 August 2023

2023-08-29T07:11:23Z

←Older revision		Revision as of 07:11, 29 August 2023
Line 21:		Line 21:
	**[[4ij5]] – HtPSP – ''Hydrogenobacter thermophilus''<br />		**[[4ij5]] – HtPSP – ''Hydrogenobacter thermophilus''<br />
	**[[3n28]] – PSP – ''Vibrio cholerae''<br />		**[[3n28]] – PSP – ''Vibrio cholerae''<br />
		+	**[[5zkk]] – EhPSP – ''Entamoeba histolitica''<br />

	*Phosphoserine phosphatase binary complex		*Phosphoserine phosphatase binary complex
Line 35:		Line 36:
	**[[4ap9]] – ToPSP + pyridine derivative <br />		**[[4ap9]] – ToPSP + pyridine derivative <br />
	**[[4ij6]] – HtPSP (mutant) + phosphoserine<br />		**[[4ij6]] – HtPSP (mutant) + phosphoserine<br />
		+	**[[5zr2]] – EhPSP (mutant) + phosphoserine <br />

	*Phosphoserine phosphatase ternary complex		*Phosphoserine phosphatase ternary complex
Line 45:		Line 47:
	**[[1l7p]] – MjPSP (mutant) + phosphoserine + PO4<br />		**[[1l7p]] – MjPSP (mutant) + phosphoserine + PO4<br />
	**[[5jlp]], [[5jlr]], [[5jma]] – MaPSP (mutant) + Mg + serine<br />		**[[5jlp]], [[5jlr]], [[5jma]] – MaPSP (mutant) + Mg + serine<br />
		+	**[[8a1z]] – MaPSP + Mg + urea derivative<br />
		+	**[[8a21]] – MaPSP + Mg + phenylimidazole<br />
		+	**[[6m1x]] – EhPSP + PO4 + 3-phosphoglycerate<br />
		+	**[[7qpl]] – PSP + PO4 + Mg – ''Brucella melitensis''<br />
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 09:13, 21 November 2019

2019-11-21T09:13:18Z

←Older revision		Revision as of 09:13, 21 November 2019
Line 24:		Line 24:
	*Phosphoserine phosphatase binary complex		*Phosphoserine phosphatase binary complex

		+	**[[1l8l]] – hPSP (mutant) + phosphono-propionic acid – human<br />
		+	**[[1nnl]], [[6hyj]] – hPSP + Ca<br />
	**[[3p96]], [[5is2]] – MaPSP + Mg – ''Mycobacterium avium''<br />		**[[3p96]], [[5is2]] – MaPSP + Mg – ''Mycobacterium avium''<br />
	**[[5it0]], [[5it4]], [[5jjb]], [[5t41]] – MaPSP (mutant) + Mg<br />		**[[5it0]], [[5it4]], [[5jjb]], [[5t41]] – MaPSP (mutant) + Mg<br />
	**[[3m1y]] – PSP + Mg – ''Helicobacter pylori''<br />		**[[3m1y]] – PSP + Mg – ''Helicobacter pylori''<br />
	**[[1l7o]] – MjPSP (mutant) + Zn – ''Methanocaldococcus jannaschi''i<br />		**[[1l7o]] – MjPSP (mutant) + Zn – ''Methanocaldococcus jannaschi''i<br />
-	**[[1l8l]] – hPSP (mutant) + phosphono-propionic acid – human<br />
-	**[[1nnl]] – hPSP + Ca<br />
	**[[3w40]], [[3w41]] – BsPSP + Mg<br />		**[[3w40]], [[3w41]] – BsPSP + Mg<br />
	**[[3w42]], [[3w43]], [[3w44]] – BsPSP + Mn<br />		**[[3w42]], [[3w43]], [[3w44]] – BsPSP + Mn<br />
Line 38:		Line 38:
	*Phosphoserine phosphatase ternary complex		*Phosphoserine phosphatase ternary complex

		+	**[[6q6j]] – hPSP + Ca + substrate analog<br />
		+	**[[6hyy]] – hPSP + PO4 + serine + <br />
	**[[1l8o]] – hPSP (mutant) + serine + PO4<br />		**[[1l8o]] – hPSP (mutant) + serine + PO4<br />
	**[[1f5s]], [[1j97]], [[1l7m]] – MjPSP + PO4 + Mg<br />		**[[1f5s]], [[1j97]], [[1l7m]] – MjPSP + PO4 + Mg<br />

Alexander Berchansky at 13:26, 5 August 2019

2019-08-05T13:26:19Z

←Older revision		Revision as of 13:26, 5 August 2019
Line 7:		Line 7:

	== Structural highlights ==		== Structural highlights ==
-	The human PSP overall structure contains a <scene name='48/488517/Cv/2'>large core domain and a smaller 4-helix bundle domain</scene>. The <scene name='48/488517/Cv/5'>active site</scene> is located in a <scene name='48/488517/Cv/6'>cleft between the 2 domains</scene><ref>PMID:12213811</ref>.	+	The human PSP overall structure contains a <scene name='48/488517/Cv/7'>large core domain and a smaller 4-helix bundle domain</scene>. The <scene name='48/488517/Cv/8'>active site</scene> is located in a <scene name='48/488517/Cv/9'>cleft between the 2 domains</scene><ref>PMID:12213811</ref>.
	</StructureSection>		</StructureSection>
	==3D structures of phosphoserine phosphatase==		==3D structures of phosphoserine phosphatase==

Joel L. Sussman at 06:22, 7 September 2017

2017-09-07T06:22:13Z

←Older revision		Revision as of 06:22, 7 September 2017
Line 1:		Line 1:
	<StructureSection load='' size='450' side='right' scene='48/488517/Cv/1' caption='Human phosphoserine phosphatase dimer complex with serine and phosphate [[1l8o]]'>		<StructureSection load='' size='450' side='right' scene='48/488517/Cv/1' caption='Human phosphoserine phosphatase dimer complex with serine and phosphate [[1l8o]]'>
	== Function ==		== Function ==
-	'''Phosphoserine phosphatase''' (PSP) catalyzes the dephosphorylation of phosphoserine to produce serine and phosphate. This is the last reaction in serine biosynthesis. PSP is part of the glycine, serine and threonine metabolism<ref>PMID:13610904</ref>. Mg+2 ion is a cofactor of PSP.	+	'''Phosphoserine phosphatase''' (PSP) catalyzes the dephosphorylation of phosphoserine to produce serine and phosphate. This is the last reaction in serine biosynthesis. PSP is part of the glycine, serine and threonine metabolism<ref>PMID:13610904</ref>. Mg<sup>+2</sup> ion is a cofactor of PSP.

	== Disease ==		== Disease ==

Joel L. Sussman at 06:20, 7 September 2017

2017-09-07T06:20:08Z

←Older revision		Revision as of 06:20, 7 September 2017
Line 1:		Line 1:
-	<StructureSection load='~~1l8o~~' size='450' side='right' scene='48/488517/Cv/1' caption='Human phosphoserine phosphatase dimer complex with serine and phosphate [[1l8o]]'>	+	<StructureSection load='' size='450' side='right' scene='48/488517/Cv/1' caption='Human phosphoserine phosphatase dimer complex with serine and phosphate [[1l8o]]'>
	== Function ==		== Function ==
	'''Phosphoserine phosphatase''' (PSP) catalyzes the dephosphorylation of phosphoserine to produce serine and phosphate. This is the last reaction in serine biosynthesis. PSP is part of the glycine, serine and threonine metabolism<ref>PMID:13610904</ref>. Mg+2 ion is a cofactor of PSP.		'''Phosphoserine phosphatase''' (PSP) catalyzes the dephosphorylation of phosphoserine to produce serine and phosphate. This is the last reaction in serine biosynthesis. PSP is part of the glycine, serine and threonine metabolism<ref>PMID:13610904</ref>. Mg+2 ion is a cofactor of PSP.

Michal Harel at 09:02, 6 September 2017

2017-09-06T09:02:20Z

←Older revision		Revision as of 09:02, 6 September 2017
Line 24:		Line 24:
	*Phosphoserine phosphatase binary complex		*Phosphoserine phosphatase binary complex

-	**[[3p96]] – ~~PSP~~ + Mg – ''Mycobacterium avium''<br />	+	**[[3p96]], [[5is2]] – MaPSP + Mg – ''Mycobacterium avium''<br />
		+	**[[5it0]], [[5it4]], [[5jjb]], [[5t41]] – MaPSP (mutant) + Mg<br />
	**[[3m1y]] – PSP + Mg – ''Helicobacter pylori''<br />		**[[3m1y]] – PSP + Mg – ''Helicobacter pylori''<br />
	**[[1l7o]] – MjPSP (mutant) + Zn – ''Methanocaldococcus jannaschi''i<br />		**[[1l7o]] – MjPSP (mutant) + Zn – ''Methanocaldococcus jannaschi''i<br />
Line 40:		Line 41:
	**[[1f5s]], [[1j97]], [[1l7m]] – MjPSP + PO4 + Mg<br />		**[[1f5s]], [[1j97]], [[1l7m]] – MjPSP + PO4 + Mg<br />
	**[[1l7n]] – MjPSP + AlF4 + Mg<br />		**[[1l7n]] – MjPSP + AlF4 + Mg<br />
-	**[[1l7p]] – MjPSP (mutant) + phosphoserine + PO4	+	**[[1l7p]] – MjPSP (mutant) + phosphoserine + PO4<br />
		+	**[[5jlp]], [[5jlr]], [[5jma]] – MaPSP (mutant) + Mg + serine<br />
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Alexander Berchansky at 14:41, 29 August 2016

2016-08-29T14:41:03Z

←Older revision		Revision as of 14:41, 29 August 2016
Line 7:		Line 7:

	== Structural highlights ==		== Structural highlights ==
-	The human PSP overall structure contains a <scene name='48/488517/Cv/2'>large core domain and a smaller 4-helix bundle domain</scene>. The <scene name='48/488517/Cv/5'>active site</scene> is located in a cleft between the 2 domains<ref>PMID:12213811</ref>.	+	The human PSP overall structure contains a <scene name='48/488517/Cv/2'>large core domain and a smaller 4-helix bundle domain</scene>. The <scene name='48/488517/Cv/5'>active site</scene> is located in a <scene name='48/488517/Cv/6'>cleft between the 2 domains</scene><ref>PMID:12213811</ref>.
	</StructureSection>		</StructureSection>
	==3D structures of phosphoserine phosphatase==		==3D structures of phosphoserine phosphatase==

Alexander Berchansky at 14:38, 29 August 2016

2016-08-29T14:38:50Z

←Older revision		Revision as of 14:38, 29 August 2016
Line 7:		Line 7:

	== Structural highlights ==		== Structural highlights ==
-	The human PSP overall structure contains a <scene name='48/488517/Cv/2'>large core domain and a smaller 4-helix bundle domain</scene>. The active site is located in a cleft between the 2 domains<ref>PMID:12213811</ref>.	+	The human PSP overall structure contains a <scene name='48/488517/Cv/2'>large core domain and a smaller 4-helix bundle domain</scene>. The <scene name='48/488517/Cv/5'>active site</scene> is located in a cleft between the 2 domains<ref>PMID:12213811</ref>.
	</StructureSection>		</StructureSection>
	==3D structures of phosphoserine phosphatase==		==3D structures of phosphoserine phosphatase==

Alexander Berchansky at 14:27, 29 August 2016

2016-08-29T14:27:41Z

←Older revision		Revision as of 14:27, 29 August 2016
Line 7:		Line 7:

	== Structural highlights ==		== Structural highlights ==
-	The human PSP overall structure contains a large core domain and a smaller 4-helix bundle domain. The active site is located in a cleft between the 2 domains<ref>PMID:12213811</ref>.	+	The human PSP overall structure contains a <scene name='48/488517/Cv/2'>large core domain and a smaller 4-helix bundle domain</scene>. The active site is located in a cleft between the 2 domains<ref>PMID:12213811</ref>.
	</StructureSection>		</StructureSection>
	==3D structures of phosphoserine phosphatase==		==3D structures of phosphoserine phosphatase==

Alexander Berchansky at 14:14, 29 August 2016

2016-08-29T14:14:28Z

←Older revision		Revision as of 14:14, 29 August 2016
Line 1:		Line 1:
-	<StructureSection load='1l8o' size='450' side='right' scene='' caption='Human phosphoserine phosphatase dimer complex with serine and phosphate [[1l8o]]'>	+	<StructureSection load='1l8o' size='450' side='right' scene='48/488517/Cv/1' caption='Human phosphoserine phosphatase dimer complex with serine and phosphate [[1l8o]]'>
	== Function ==		== Function ==
	'''Phosphoserine phosphatase''' (PSP) catalyzes the dephosphorylation of phosphoserine to produce serine and phosphate. This is the last reaction in serine biosynthesis. PSP is part of the glycine, serine and threonine metabolism<ref>PMID:13610904</ref>. Mg+2 ion is a cofactor of PSP.		'''Phosphoserine phosphatase''' (PSP) catalyzes the dephosphorylation of phosphoserine to produce serine and phosphate. This is the last reaction in serine biosynthesis. PSP is part of the glycine, serine and threonine metabolism<ref>PMID:13610904</ref>. Mg+2 ion is a cofactor of PSP.