Phosphotriesterase - Revision history

Michal Harel at 08:50, 29 August 2023

2023-08-29T08:50:20Z

←Older revision		Revision as of 08:50, 29 August 2023
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	== Function ==		== Function ==
-	'''Phosphotriesterase''' or '''aryldialkylphosphatase''' (PTE) catalyzes the conversion of aryl dialkyl phosphate to dialkyl phosphate and aryl alcohol<ref name="Rood">PMID: 15790580 </ref>.<br />	+	'''Phosphotriesterase''' or '''aryldialkylphosphatase''' or '''haloalkylphosphorus hydrolase''' or '''organophosphorus hydrolase''' or '''parathion hydrolase''' (PTE) catalyzes the conversion of aryl dialkyl phosphate to dialkyl phosphate and aryl alcohol<ref name="Rood">PMID: 15790580 </ref>.<br />
	For more details see [[SsoPox: a natural lactonase with promiscuous phosphotriesterase activities]].		For more details see [[SsoPox: a natural lactonase with promiscuous phosphotriesterase activities]].

Joel L. Sussman at 06:59, 11 June 2023

2023-06-11T06:59:09Z

←Older revision		Revision as of 06:59, 11 June 2023
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	<StructureSection load='' size='350' side='right' scene='48/489268/Cv/1' caption='Phosphotriesterase dimer complex with reaction product ethyl phosphate and Co+2 ion (pink), [[3cak]]'>		<StructureSection load='' size='350' side='right' scene='48/489268/Cv/1' caption='Phosphotriesterase dimer complex with reaction product ethyl phosphate and Co+2 ion (pink), [[3cak]]'>
	__TOC__		__TOC__
		+	== Introduction ==
		+
		+	Phosphotriesterase (PTE) is an enzyme that plays a significant role in the detoxification and degradation of organophosphorus compounds, specifically phosphotriester pesticides and nerve agents. These compounds are highly toxic and can have detrimental effects on the environment and living organisms. Phosphotriesterase acts by catalyzing the hydrolysis of the phosphorus-oxygen bond in these compounds, converting them into non-toxic products.

	== Function ==		== Function ==
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	== Structural highlights ==		== Structural highlights ==
		+	The structure of phosphotriesterase typically consists of a single polypeptide chain folded into a globular shape. It contains an active site that can accommodate and bind phosphotriester substrates. The active site usually consists of a metal ion, such as zinc, that assists in the catalytic process.
		+
		+	The catalytic mechanism of phosphotriesterase involves the nucleophilic attack of a water molecule on the phosphorus atom of the phosphotriester substrate. This attack results in the cleavage of the phosphorus-oxygen bond and the formation of a phosphorylated enzyme intermediate. Subsequently, a second water molecule hydrolyzes the phosphorylated enzyme intermediate, leading to the release of the hydrolyzed product and the regenerated enzyme.
		+
	The <scene name='48/489268/Cv/4'>reaction product of PTE is located in the binuclear metal center</scene><ref>PMID:18702530</ref>.Water molecules are shown as red spheres.		The <scene name='48/489268/Cv/4'>reaction product of PTE is located in the binuclear metal center</scene><ref>PMID:18702530</ref>.Water molecules are shown as red spheres.
	Phosphotriesterases have been extensively studied in order to increase their catalytic efficiency by directed evolution and structure based design<ref>PMID:12505981</ref><ref name="Rood" /><ref>PMID:19966226</ref><ref>PMID:26612364</ref><ref>PMID:28159998</ref><ref>PMID:29035814</ref><ref>PMID:29990481</ref>.		Phosphotriesterases have been extensively studied in order to increase their catalytic efficiency by directed evolution and structure based design<ref>PMID:12505981</ref><ref name="Rood" /><ref>PMID:19966226</ref><ref>PMID:26612364</ref><ref>PMID:28159998</ref><ref>PMID:29035814</ref><ref>PMID:29990481</ref>.

Michal Harel at 10:31, 21 November 2019

2019-11-21T10:31:32Z

←Older revision		Revision as of 10:31, 21 November 2019
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	</StructureSection>		</StructureSection>
-	==3D structures of phosphotriesterase==

-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*'''Phosphotriesterase'''
-
-	**[[1pta]] – BdPTE – ''Brevundimonas diminuta''<br />
-
-	*Phosphotriesterase complex with metal ion
-
-	**[[1hzy]], [[4pbe]], [[4pbf]], [[4pcn]], [[4pcp]], [[4xaf]], [[4xag]], [[4xay]], [[4xaz]], [[4xd3]], [[4xd4]], [[4xd5]], [[4xd6]], [[5wcq]], [[6aml]], [[6fev]], [[6ffw]], [[6for]], [[6fqe]], [[6frz]], [[6fs3]], [[6fu0]], [[6fu6]], [[6fvk]], [[6fvp]], [[6fw1]], [[6fwe]], [[6g0m]], [[6g1j]], [[6g23]], [[6g3l]], [[6g3m]], [[6gbj]], [[6gbk]], [[6gbl]], [[6fee]], [[6fef]] - BdPTE + Zn<br />
-	**[[2ob3]], [[2o4m]], [[2o4q]], [[2oql]], [[6bh7]], [[6bhk]], [[6bhl]], [[5wiz]], [[5wj0]], [[5wms]], [[5wcp]], [[5wcr]], [[5wcw]], [[5w6b]] - BdPTE (mutant) + Zn<br />
-	**[[3cs2]], [[3upm]], [[3ur2]], [[3ur5]], [[3ura]], [[3urb]], [[3urn]], [[3urq]], [[4zsu]], [[4zst]] - BdPTE (mutant) + Co<br />
-	**[[1i0b]] - BdPTE + Mn<br />
-	**[[1i0d]] - BdPTE + Cd + Zn<br />
-	**[[1jgm]] - BdPTE + Cd<br />
-	**[[1p6b]] - FlPTE (mutant) + Zn – ''Flavobacterium''<br />
-	**[[2d2j]], [[3a3x]], [[3a4j]], [[3oqe]] - AtPTE (mutant) + Co – ''Agrobacterium tumefaciens''<br />
-	**[[3wml]] - AtPTE (mutant) + Co + Fe <br />
-	**[[2gvu]] - LvPTE (mutant) + Ca – ''Loligo vulgaris''<br />
-	**[[2gvw]] - LvPTE + Ca<br />
-	**[[2zc1]] - DrPTE + Co – ''Deinococcus radiodurans''<br />
-	**[[3fdk]] - DrPTE + Zn<br />
-	**[[3gtf]], [[3gth]], [[3gti]], [[3gtx]], [[3gu1]], [[3gu2]], [[3gu9]] - DrPTE (mutant) + Co<br />
-	**[[3htw]] - DrPTE + Mg + Co<br />
-	**[[3orw]], [[3tn3]], [[4wvx]] - GkPTE + Co – ''Geobacillus kaustophilus''<br />
-	**[[3tn4]], [[3tn5]], [[3tn6]], [[3tnb]], [[5ch9]] - GkPTE (mutant) + Co<br />
-	**[[4h9u]] - GkPTE + Fe + Zn<br />
-	**[[4h9v]], [[4h9y]], [[4ha0]] - GkPTE (mutant) + Fe + Zn<br />
-	**[[4h9z]] - GkPTE (mutant) + Fe + Mn<br />
-	**[[4gy0]], [[4gy1]] – PTE arylesterase variant + Zn – synthetic<br />
-	**[[2vc5]] - SsPTE + Co + Fe – ''Sulfolobus solfataricus''<br />
-	**[[4ker]], [[4kes]], [[4ket]], [[4keu]], [[4kev]], [[4kez]], [[5vri]], [[5vrk]], [[5vsa]], [[5w3u]], [[5w3z]] - SsPTE (mutant) + Co + Fe <br />
-	**[[5w7h]] - RrPTE (mutant) + Zn – ''Rhizobium radiobacter''<br />
-
-	*Phosphotriesterase ternary complex with metal ion
-
-	**[[1psc]] - BdPTE + substrate analog + Cd<br />
-	**[[1eyw]], [[1dpm]], [[1ez2]] - BdPTE + substrate analog + Zn<br />
-	**[[3cak]] - BdPTE + product + Co<br />
-	**[[1qw7]], [[3e3h]] - BdPTE (mutant) + substrate analog + Co<br />
-	**[[4e3t]], [[6b2f]] – BdPTE arylesterase variant + transition state analog + Zn <br />
-	**[[1p6c]] - FlPTE (mutant) + substrate analog + Zn<br />
-	**[[2gvv]] - LvPTE + substrate analog + Ca<br />
-	**[[2d2g]], [[2r1k]], [[2r1l]], [[2r1m]], [[2r1p]], [[3c86]] - AtPTE (mutant) + product + Co<br />
-	**[[2d2h]] - AtPTE (mutant) + inhibitor + Co<br />
-	**[[2r1n]] - AtPTE (mutant) + substrate + Co<br />
-	**[[3so7]] - AtPTE + phosphate + Co<br />
-	**[[3a3w]], [[3ood]] - AtPTE (mutant) + substrate analog + Co<br />
-	**[[4np7]] - AtPTE (mutant) + Co + Fe + thiophosphate<br />
-	**[[3ojg]] - GkPTE + lactone + Fe + Zn<br />
-	**[[4h9t]] - GkPTE (mutant) + lactone derivative + Fe + Mn<br />
-	**[[4h9x]] - GkPTE (mutant) + lactone derivative + Fe + Zn<br />
-	**[[3uf9]] - SsPTE + Co + Fe + fensulfothion<br />
-	**[[2vc7]] - SsPTE + Co + Fe + thiophenium derivative<br />
-	**[[4kf1]] - SsPTE (mutant) + Co + Fe + thiophenium derivative<br />
-	**[[5vej]] - RrPTE + Co + F <br />
-
-	}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 10:30, 21 November 2019

2019-11-21T10:30:35Z

←Older revision		Revision as of 10:30, 21 November 2019
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	<StructureSection load='' size='350' side='right' scene='48/489268/Cv/1' caption='Phosphotriesterase dimer complex with reaction product ethyl phosphate and Co+2 ion (pink), [[3cak]]'>		<StructureSection load='' size='350' side='right' scene='48/489268/Cv/1' caption='Phosphotriesterase dimer complex with reaction product ethyl phosphate and Co+2 ion (pink), [[3cak]]'>
		+	__TOC__

	== Function ==		== Function ==
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	Phosphotriesterases have been extensively studied in order to increase their catalytic efficiency by directed evolution and structure based design<ref>PMID:12505981</ref><ref name="Rood" /><ref>PMID:19966226</ref><ref>PMID:26612364</ref><ref>PMID:28159998</ref><ref>PMID:29035814</ref><ref>PMID:29990481</ref>.		Phosphotriesterases have been extensively studied in order to increase their catalytic efficiency by directed evolution and structure based design<ref>PMID:12505981</ref><ref name="Rood" /><ref>PMID:19966226</ref><ref>PMID:26612364</ref><ref>PMID:28159998</ref><ref>PMID:29035814</ref><ref>PMID:29990481</ref>.

		+	==3D structures of phosphotriesterase==
		+	[[Phosphotriesterase 3D structures]]

	</StructureSection>		</StructureSection>
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	*Phosphotriesterase complex with metal ion		*Phosphotriesterase complex with metal ion

-	**[[1hzy]], [[4pbe]], [[4pbf]], [[4pcn]], [[4pcp]], [[4xaf]], [[4xag]], [[4xay]], [[4xaz]], [[4xd3]], [[4xd4]], [[4xd5]], [[4xd6]], [[5wcq]], [[6aml]] - BdPTE + Zn<br />	+	**[[1hzy]], [[4pbe]], [[4pbf]], [[4pcn]], [[4pcp]], [[4xaf]], [[4xag]], [[4xay]], [[4xaz]], [[4xd3]], [[4xd4]], [[4xd5]], [[4xd6]], [[5wcq]], [[6aml]], [[6fev]], [[6ffw]], [[6for]], [[6fqe]], [[6frz]], [[6fs3]], [[6fu0]], [[6fu6]], [[6fvk]], [[6fvp]], [[6fw1]], [[6fwe]], [[6g0m]], [[6g1j]], [[6g23]], [[6g3l]], [[6g3m]], [[6gbj]], [[6gbk]], [[6gbl]], [[6fee]], [[6fef]] - BdPTE + Zn<br />
-	**[[2ob3]], [[2o4m]], [[2o4q]], [[2oql]] - BdPTE (mutant) + Zn<br />	+	**[[2ob3]], [[2o4m]], [[2o4q]], [[2oql]], [[6bh7]], [[6bhk]], [[6bhl]], [[5wiz]], [[5wj0]], [[5wms]], [[5wcp]], [[5wcr]], [[5wcw]], [[5w6b]] - BdPTE (mutant) + Zn<br />
-	**[[3cs2]], [[3upm]], [[3ur2]], [[3ur5]], [[3ura]], [[3urb]], [[3urn]] - BdPTE (mutant) + Co<br />	+	**[[3cs2]], [[3upm]], [[3ur2]], [[3ur5]], [[3ura]], [[3urb]], [[3urn]], [[3urq]], [[4zsu]], [[4zst]] - BdPTE (mutant) + Co<br />
	**[[1i0b]] - BdPTE + Mn<br />		**[[1i0b]] - BdPTE + Mn<br />
	**[[1i0d]] - BdPTE + Cd + Zn<br />		**[[1i0d]] - BdPTE + Cd + Zn<br />
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	**[[2vc5]] - SsPTE + Co + Fe – ''Sulfolobus solfataricus''<br />		**[[2vc5]] - SsPTE + Co + Fe – ''Sulfolobus solfataricus''<br />
	**[[4ker]], [[4kes]], [[4ket]], [[4keu]], [[4kev]], [[4kez]], [[5vri]], [[5vrk]], [[5vsa]], [[5w3u]], [[5w3z]] - SsPTE (mutant) + Co + Fe <br />		**[[4ker]], [[4kes]], [[4ket]], [[4keu]], [[4kev]], [[4kez]], [[5vri]], [[5vrk]], [[5vsa]], [[5w3u]], [[5w3z]] - SsPTE (mutant) + Co + Fe <br />
		+	**[[5w7h]] - RrPTE (mutant) + Zn – ''Rhizobium radiobacter''<br />

	*Phosphotriesterase ternary complex with metal ion		*Phosphotriesterase ternary complex with metal ion
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	**[[3cak]] - BdPTE + product + Co<br />		**[[3cak]] - BdPTE + product + Co<br />
	**[[1qw7]], [[3e3h]] - BdPTE (mutant) + substrate analog + Co<br />		**[[1qw7]], [[3e3h]] - BdPTE (mutant) + substrate analog + Co<br />
		+	**[[4e3t]], [[6b2f]] – BdPTE arylesterase variant + transition state analog + Zn <br />
	**[[1p6c]] - FlPTE (mutant) + substrate analog + Zn<br />		**[[1p6c]] - FlPTE (mutant) + substrate analog + Zn<br />
	**[[2gvv]] - LvPTE + substrate analog + Ca<br />		**[[2gvv]] - LvPTE + substrate analog + Ca<br />
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	**[[3so7]] - AtPTE + phosphate + Co<br />		**[[3so7]] - AtPTE + phosphate + Co<br />
	**[[3a3w]], [[3ood]] - AtPTE (mutant) + substrate analog + Co<br />		**[[3a3w]], [[3ood]] - AtPTE (mutant) + substrate analog + Co<br />
		+	**[[4np7]] - AtPTE (mutant) + Co + Fe + thiophosphate<br />
	**[[3ojg]] - GkPTE + lactone + Fe + Zn<br />		**[[3ojg]] - GkPTE + lactone + Fe + Zn<br />
	**[[4h9t]] - GkPTE (mutant) + lactone derivative + Fe + Mn<br />		**[[4h9t]] - GkPTE (mutant) + lactone derivative + Fe + Mn<br />
	**[[4h9x]] - GkPTE (mutant) + lactone derivative + Fe + Zn<br />		**[[4h9x]] - GkPTE (mutant) + lactone derivative + Fe + Zn<br />
-	**[[4e3t]] – BdPTE arylesterase variant + transition state analog + Zn <br />
	**[[3uf9]] - SsPTE + Co + Fe + fensulfothion<br />		**[[3uf9]] - SsPTE + Co + Fe + fensulfothion<br />
	**[[2vc7]] - SsPTE + Co + Fe + thiophenium derivative<br />		**[[2vc7]] - SsPTE + Co + Fe + thiophenium derivative<br />
	**[[4kf1]] - SsPTE (mutant) + Co + Fe + thiophenium derivative<br />		**[[4kf1]] - SsPTE (mutant) + Co + Fe + thiophenium derivative<br />
-	**[[4np7]] - AtPTE (mutant) + Co + Fe + thiophosphate<br />	+	**[[5vej]] - RrPTE + Co + F <br />
-	**[[5vej]] - ~~PTE~~ + Co + F ~~– ''Rhizobium radiobacter''~~<br />	+

	}}		}}

Alexander Berchansky at 13:30, 5 August 2019

2019-08-05T13:30:13Z

←Older revision		Revision as of 13:30, 5 August 2019
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	== Structural highlights ==		== Structural highlights ==
-	The <scene name='48/489268/Cv/3'>reaction product of PTE is located in the binuclear metal center</scene><ref>PMID:18702530</ref>.Water molecules shown as red spheres.	+	The <scene name='48/489268/Cv/4'>reaction product of PTE is located in the binuclear metal center</scene><ref>PMID:18702530</ref>.Water molecules are shown as red spheres.
	Phosphotriesterases have been extensively studied in order to increase their catalytic efficiency by directed evolution and structure based design<ref>PMID:12505981</ref><ref name="Rood" /><ref>PMID:19966226</ref><ref>PMID:26612364</ref><ref>PMID:28159998</ref><ref>PMID:29035814</ref><ref>PMID:29990481</ref>.		Phosphotriesterases have been extensively studied in order to increase their catalytic efficiency by directed evolution and structure based design<ref>PMID:12505981</ref><ref name="Rood" /><ref>PMID:19966226</ref><ref>PMID:26612364</ref><ref>PMID:28159998</ref><ref>PMID:29035814</ref><ref>PMID:29990481</ref>.

Joel L. Sussman at 09:36, 24 August 2018

2018-08-24T09:36:28Z

←Older revision		Revision as of 09:36, 24 August 2018
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	== Function ==		== Function ==
-	'''Phosphotriesterase''' or '''aryldialkylphosphatase''' (PTE) catalyzes the conversion of aryl dialkyl phosphate to dialkyl phosphate and aryl alcohol<ref>PMID:15790580</ref>. <br />	+	'''Phosphotriesterase''' or '''aryldialkylphosphatase''' (PTE) catalyzes the conversion of aryl dialkyl phosphate to dialkyl phosphate and aryl alcohol<ref name="Rood">PMID: 15790580 </ref>.<br />
	For more details see [[SsoPox: a natural lactonase with promiscuous phosphotriesterase activities]].		For more details see [[SsoPox: a natural lactonase with promiscuous phosphotriesterase activities]].

Line 10:		Line 10:
	== Structural highlights ==		== Structural highlights ==
	The <scene name='48/489268/Cv/3'>reaction product of PTE is located in the binuclear metal center</scene><ref>PMID:18702530</ref>.Water molecules shown as red spheres.		The <scene name='48/489268/Cv/3'>reaction product of PTE is located in the binuclear metal center</scene><ref>PMID:18702530</ref>.Water molecules shown as red spheres.
-	Phosphotriesterases have been extensively studied in order to increase their catalytic efficiency by directed evolution and structure based design<ref>PMID:12505981</ref><ref~~>PMID:15790580<~~/~~ref~~><ref>PMID:19966226</ref><ref>PMID:26612364</ref><ref>PMID:28159998</ref><ref>PMID:29035814</ref><ref>PMID:29990481</ref>.	+	Phosphotriesterases have been extensively studied in order to increase their catalytic efficiency by directed evolution and structure based design<ref>PMID:12505981</ref><ref name="Rood" /><ref>PMID:19966226</ref><ref>PMID:26612364</ref><ref>PMID:28159998</ref><ref>PMID:29035814</ref><ref>PMID:29990481</ref>.

Joel L. Sussman at 10:20, 21 August 2018

2018-08-21T10:20:50Z

←Older revision		Revision as of 10:20, 21 August 2018
Line 10:		Line 10:
	== Structural highlights ==		== Structural highlights ==
	The <scene name='48/489268/Cv/3'>reaction product of PTE is located in the binuclear metal center</scene><ref>PMID:18702530</ref>.Water molecules shown as red spheres.		The <scene name='48/489268/Cv/3'>reaction product of PTE is located in the binuclear metal center</scene><ref>PMID:18702530</ref>.Water molecules shown as red spheres.
-	Phosphotriesterases have been extensively studied in order to increase their catalytic efficiency by directed evolution and structure based design<ref>PMID:12505981</ref><ref>PMID:15790580</ref>.	+	Phosphotriesterases have been extensively studied in order to increase their catalytic efficiency by directed evolution and structure based design<ref>PMID:12505981</ref><ref>PMID:15790580</ref><ref>PMID:19966226</ref><ref>PMID:26612364</ref><ref>PMID:28159998</ref><ref>PMID:29035814</ref><ref>PMID:29990481</ref>.

Joel L. Sussman at 10:19, 21 August 2018

2018-08-21T10:19:00Z

←Older revision		Revision as of 10:19, 21 August 2018
Line 10:		Line 10:
	== Structural highlights ==		== Structural highlights ==
	The <scene name='48/489268/Cv/3'>reaction product of PTE is located in the binuclear metal center</scene><ref>PMID:18702530</ref>.Water molecules shown as red spheres.		The <scene name='48/489268/Cv/3'>reaction product of PTE is located in the binuclear metal center</scene><ref>PMID:18702530</ref>.Water molecules shown as red spheres.
-	Phosphotriesterases have been extensively studied in order to increase their catalytic efficiency by directed evolution and structure based design<ref>PMID:12505981</ref> <ref>PMID:~~12505981~~</ref>.	+	Phosphotriesterases have been extensively studied in order to increase their catalytic efficiency by directed evolution and structure based design<ref>PMID:12505981</ref><ref>PMID:15790580</ref>.

Joel L. Sussman at 10:18, 21 August 2018

2018-08-21T10:18:17Z

←Older revision		Revision as of 10:18, 21 August 2018
Line 10:		Line 10:
	== Structural highlights ==		== Structural highlights ==
	The <scene name='48/489268/Cv/3'>reaction product of PTE is located in the binuclear metal center</scene><ref>PMID:18702530</ref>.Water molecules shown as red spheres.		The <scene name='48/489268/Cv/3'>reaction product of PTE is located in the binuclear metal center</scene><ref>PMID:18702530</ref>.Water molecules shown as red spheres.
		+	Phosphotriesterases have been extensively studied in order to increase their catalytic efficiency by directed evolution and structure based design<ref>PMID:12505981</ref> <ref>PMID:12505981</ref>.
		+
		+
	</StructureSection>		</StructureSection>
	==3D structures of phosphotriesterase==		==3D structures of phosphotriesterase==

Michal Harel at 09:40, 20 August 2018

2018-08-20T09:40:43Z

←Older revision		Revision as of 09:40, 20 August 2018
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-	<StructureSection load='' size='~~450~~' side='right' scene='48/489268/Cv/1' caption='Phosphotriesterase dimer complex with reaction product ethyl phosphate and Co+2 ion (pink), [[3cak]]'>	+	<StructureSection load='' size='350' side='right' scene='48/489268/Cv/1' caption='Phosphotriesterase dimer complex with reaction product ethyl phosphate and Co+2 ion (pink), [[3cak]]'>

	== Function ==		== Function ==
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	*Phosphotriesterase complex with metal ion		*Phosphotriesterase complex with metal ion

-	**[[1hzy]], [[4pbe]], [[4pbf]], [[4pcn]], [[4pcp]], [[4xaf]], [[4xag]], [[4xay]], [[4xaz]], [[4xd3]], [[4xd4]], [[4xd5]], [[4xd6]] - BdPTE + Zn<br />	+	**[[1hzy]], [[4pbe]], [[4pbf]], [[4pcn]], [[4pcp]], [[4xaf]], [[4xag]], [[4xay]], [[4xaz]], [[4xd3]], [[4xd4]], [[4xd5]], [[4xd6]], [[5wcq]], [[6aml]] - BdPTE + Zn<br />
	**[[2ob3]], [[2o4m]], [[2o4q]], [[2oql]] - BdPTE (mutant) + Zn<br />		**[[2ob3]], [[2o4m]], [[2o4q]], [[2oql]] - BdPTE (mutant) + Zn<br />
	**[[3cs2]], [[3upm]], [[3ur2]], [[3ur5]], [[3ura]], [[3urb]], [[3urn]] - BdPTE (mutant) + Co<br />		**[[3cs2]], [[3upm]], [[3ur2]], [[3ur5]], [[3ura]], [[3urb]], [[3urn]] - BdPTE (mutant) + Co<br />
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	**[[4gy0]], [[4gy1]] – PTE arylesterase variant + Zn – synthetic<br />		**[[4gy0]], [[4gy1]] – PTE arylesterase variant + Zn – synthetic<br />
	**[[2vc5]] - SsPTE + Co + Fe – ''Sulfolobus solfataricus''<br />		**[[2vc5]] - SsPTE + Co + Fe – ''Sulfolobus solfataricus''<br />
-	**[[4ker]], [[4kes]], [[4ket]], [[4keu]], [[4kev]], [[4kez]] - SsPTE (mutant) + Co + Fe <br />	+	**[[4ker]], [[4kes]], [[4ket]], [[4keu]], [[4kev]], [[4kez]], [[5vri]], [[5vrk]], [[5vsa]], [[5w3u]], [[5w3z]] - SsPTE (mutant) + Co + Fe <br />

	*Phosphotriesterase ternary complex with metal ion		*Phosphotriesterase ternary complex with metal ion