Profilin - Revision history

Michal Harel at 10:43, 27 November 2019

2019-11-27T10:43:36Z

←Older revision		Revision as of 10:43, 27 November 2019
Line 12:		Line 12:
	</StructureSection>		</StructureSection>

-	== 3D Structures of profilin ==
-
-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*Profilin I
-
-	**[[1fik]], [[1fil]], [[4x1l]] – hPFN – human <br />
-	**[[1pfl]] – hPFN - NMR <br />
-	**[[4x25]], [[4x1m]] – hPFN (mutant) <br />
-	**[[1pne]] – bPFN – bovine <br />
-	**[[1cqa]] – biPFN - birch <br />
-	**[[3nul]], [[1a0k]] – AtPFN – ''Arabidopsis thaliana'' <br />
-	**[[4esp]] – PFN – peanut <br />
-	**[[5fef]] - PFN - maize<br />
-	**[[5em0]] - PFN - mugwort<br />
-	**[[5em1]] - rPFN - ragweed<br />
-	**[[6b6j]] – PFN – mugwort<br />
-	**[[6mbx]] – PFN – muskmelon<br />
-	**[[1ypr]], [[1k0k]] – PFN - yeast <br />
-	**[[3d9y]], [[3dav]] – PFN – fission yeast <br />
-	**[[1g5u]] – PFN – ''Hevea brasiliensis'' <br />
-	**[[2jkf]], [[4d60]] – PfPFN – ''Plasmodium falciparum'' <br />
-	**[[4qwo]] – PFN – monkeypox virus <br />
-	**[[2prf]] – AcPFN – ''Acanthamoeba castellanii'' - NMR<br />
-	**[[1prq]] – AcPFN <br />
-	**[[3nec]] – PFN – ''Toxoplasma gondii''<br />
-
-	*Profilin I complex
-
-	**[[1awi]], [[1cf0]], [[1cjf]] – hPFN + poly-Pro peptide <br />
-	**[[2pav]], [[2pbd]], [[3chw]] – hPFN + α-actin + VASP poly-Pro peptide + ATP <br />
-	**[[2btf]], [[3u4l]], [[3ub5]] – bPFN + β-actin <br />
-	**[[1hlu]] – bPFN + β-actin + ATP <br />
-	**[[2jkg]] – PfPFN + poly-Pro peptide <br />
-	**[[5ev0]], [[5eve]] - rPFN + poly-Pro peptide<br />
-
-	*Profilin II
-
-	**[[1d1j]] – hPFN <br />
-	**[[1acf]], [[2acg]], [[1f2k]] – AcPFN <br />
-	**[[2vk3]] – PFN - rat <br />
-	**[[2v8c]] – mPFN + VASP poly-Pro peptide - mouse <br />
-	**[[2v8f]] – mPFN + MDIA1 poly-Pro peptide <br />
-	**[[5fds]], [[5feg]] - PFN - rubber tree<br />
-	**[[5nzb]], [[5nzc]] – biPFN <br />
-	**[[6iqi]] – AtPFN <br />
-	**[[6iqj]] – AtPFN + formin1 <br />
-	**[[1acf]], [[2acg]], [[1f2k]] – AcPFN <br />
-
-	*Profilin III
-
-	**[[6iqf]] – AtPFN <br />
-
-	*Profilin V
-
-	**[[6iqk]] – AtPFN + ATPRF3 <br />
-
-	}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 10:42, 27 November 2019

2019-11-27T10:42:35Z

←Older revision		Revision as of 10:42, 27 November 2019
Line 6:		Line 6:

	PFN from birch, peanut and other plants is a major allergen<ref>PMID:25123397</ref>.		PFN from birch, peanut and other plants is a major allergen<ref>PMID:25123397</ref>.
		+
		+	== 3D Structures of profilin ==
		+	[[Profilin 3D Structures]]

	</StructureSection>		</StructureSection>
Line 21:		Line 24:
	**[[1pne]] – bPFN – bovine <br />		**[[1pne]] – bPFN – bovine <br />
	**[[1cqa]] – biPFN - birch <br />		**[[1cqa]] – biPFN - birch <br />
-	**[[3nul]], [[1a0k]] – ~~PFN~~ – ''Arabidopsis thaliana'' <br />	+	**[[3nul]], [[1a0k]] – AtPFN – ''Arabidopsis thaliana'' <br />
		+	**[[4esp]] – PFN – peanut <br />
		+	**[[5fef]] - PFN - maize<br />
		+	**[[5em0]] - PFN - mugwort<br />
		+	**[[5em1]] - rPFN - ragweed<br />
		+	**[[6b6j]] – PFN – mugwort<br />
		+	**[[6mbx]] – PFN – muskmelon<br />
	**[[1ypr]], [[1k0k]] – PFN - yeast <br />		**[[1ypr]], [[1k0k]] – PFN - yeast <br />
	**[[3d9y]], [[3dav]] – PFN – fission yeast <br />		**[[3d9y]], [[3dav]] – PFN – fission yeast <br />
	**[[1g5u]] – PFN – ''Hevea brasiliensis'' <br />		**[[1g5u]] – PFN – ''Hevea brasiliensis'' <br />
	**[[2jkf]], [[4d60]] – PfPFN – ''Plasmodium falciparum'' <br />		**[[2jkf]], [[4d60]] – PfPFN – ''Plasmodium falciparum'' <br />
-	**[[4esp]] – PFN – peanut <br />
	**[[4qwo]] – PFN – monkeypox virus <br />		**[[4qwo]] – PFN – monkeypox virus <br />
	**[[2prf]] – AcPFN – ''Acanthamoeba castellanii'' - NMR<br />		**[[2prf]] – AcPFN – ''Acanthamoeba castellanii'' - NMR<br />
	**[[1prq]] – AcPFN <br />		**[[1prq]] – AcPFN <br />
	**[[3nec]] – PFN – ''Toxoplasma gondii''<br />		**[[3nec]] – PFN – ''Toxoplasma gondii''<br />
-	**[[5fef]] - PFN - maize<br />
-	**[[5em0]] - PFN - mugwort<br />
-	**[[5em1]] - rPFN - ragweed<br />

	*Profilin I complex		*Profilin I complex

		+	**[[1awi]], [[1cf0]], [[1cjf]] – hPFN + poly-Pro peptide <br />
		+	**[[2pav]], [[2pbd]], [[3chw]] – hPFN + α-actin + VASP poly-Pro peptide + ATP <br />
	**[[2btf]], [[3u4l]], [[3ub5]] – bPFN + β-actin <br />		**[[2btf]], [[3u4l]], [[3ub5]] – bPFN + β-actin <br />
	**[[1hlu]] – bPFN + β-actin + ATP <br />		**[[1hlu]] – bPFN + β-actin + ATP <br />
	**[[2jkg]] – PfPFN + poly-Pro peptide <br />		**[[2jkg]] – PfPFN + poly-Pro peptide <br />
	**[[5ev0]], [[5eve]] - rPFN + poly-Pro peptide<br />		**[[5ev0]], [[5eve]] - rPFN + poly-Pro peptide<br />
-	**[[1awi]], [[1cf0]], [[1cjf]] – hPFN + poly-Pro peptide <br />
-	**[[2pav]], [[2pbd]], [[3chw]] – hPFN + α-actin + VASP poly-Pro peptide + ATP <br />

	*Profilin II		*Profilin II

-	**[[1acf]], [[2acg]], [[1f2k]] – AcPFN <br />
	**[[1d1j]] – hPFN <br />		**[[1d1j]] – hPFN <br />
		+	**[[1acf]], [[2acg]], [[1f2k]] – AcPFN <br />
	**[[2vk3]] – PFN - rat <br />		**[[2vk3]] – PFN - rat <br />
-	**[[5fds]], [[5feg]] - PFN - rubber tree<br />
	**[[2v8c]] – mPFN + VASP poly-Pro peptide - mouse <br />		**[[2v8c]] – mPFN + VASP poly-Pro peptide - mouse <br />
	**[[2v8f]] – mPFN + MDIA1 poly-Pro peptide <br />		**[[2v8f]] – mPFN + MDIA1 poly-Pro peptide <br />
		+	**[[5fds]], [[5feg]] - PFN - rubber tree<br />
	**[[5nzb]], [[5nzc]] – biPFN <br />		**[[5nzb]], [[5nzc]] – biPFN <br />
		+	**[[6iqi]] – AtPFN <br />
		+	**[[6iqj]] – AtPFN + formin1 <br />
		+	**[[1acf]], [[2acg]], [[1f2k]] – AcPFN <br />
		+
		+	*Profilin III
		+
		+	**[[6iqf]] – AtPFN <br />
		+
		+	*Profilin V
		+
		+	**[[6iqk]] – AtPFN + ATPRF3 <br />
		+
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 10:18, 26 August 2018

2018-08-26T10:18:15Z

←Older revision		Revision as of 10:18, 26 August 2018
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	**[[4x25]], [[4x1m]] – hPFN (mutant) <br />		**[[4x25]], [[4x1m]] – hPFN (mutant) <br />
	**[[1pne]] – bPFN – bovine <br />		**[[1pne]] – bPFN – bovine <br />
-	**[[1cqa]] – ~~PFN~~ - birch <br />	+	**[[1cqa]] – biPFN - birch <br />
	**[[3nul]], [[1a0k]] – PFN – ''Arabidopsis thaliana'' <br />		**[[3nul]], [[1a0k]] – PFN – ''Arabidopsis thaliana'' <br />
	**[[1ypr]], [[1k0k]] – PFN - yeast <br />		**[[1ypr]], [[1k0k]] – PFN - yeast <br />
	**[[3d9y]], [[3dav]] – PFN – fission yeast <br />		**[[3d9y]], [[3dav]] – PFN – fission yeast <br />
	**[[1g5u]] – PFN – ''Hevea brasiliensis'' <br />		**[[1g5u]] – PFN – ''Hevea brasiliensis'' <br />
-	**[[2jkf]] – PfPFN – ''Plasmodium falciparum'' <br />	+	**[[2jkf]], [[4d60]] – PfPFN – ''Plasmodium falciparum'' <br />
	**[[4esp]] – PFN – peanut <br />		**[[4esp]] – PFN – peanut <br />
	**[[4qwo]] – PFN – monkeypox virus <br />		**[[4qwo]] – PFN – monkeypox virus <br />
Line 52:		Line 52:
	**[[2v8c]] – mPFN + VASP poly-Pro peptide - mouse <br />		**[[2v8c]] – mPFN + VASP poly-Pro peptide - mouse <br />
	**[[2v8f]] – mPFN + MDIA1 poly-Pro peptide <br />		**[[2v8f]] – mPFN + MDIA1 poly-Pro peptide <br />
-		+	**[[5nzb]], [[5nzc]] – biPFN <br />
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 13:16, 23 October 2017

2017-10-23T13:16:10Z

←Older revision		Revision as of 13:16, 23 October 2017
Line 56:		Line 56:
	== References ==		== References ==
	<references/>		<references/>
		+	[[Category:Topic Page]]

Michal Harel at 13:15, 23 October 2017

2017-10-23T13:15:34Z

←Older revision		Revision as of 13:15, 23 October 2017
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-	<StructureSection load='2pbd' size='340' side='right' caption='Human profilin I (green) complex with α-actin (~~pale green~~), VASP protein poly-Pro peptide (olive), ATP and Ca+2 ion (PDB code [[2pbd]])' scene=''>	+	<StructureSection load='2pbd' size='340' side='right' caption='Human profilin I (green) complex with α-actin (grey), VASP protein poly-Pro peptide (olive), ATP and Ca+2 ion (PDB code [[2pbd]])' scene=''>
	== Function ==		== Function ==
	'''Profilin''' (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin. PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin<ref>PMID:27307590</ref>. PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers. '''PFN-I''' is expressed in most tissues while '''PFN-II''' is expressed in brain and kidney. PFN was found in all eukaryotes.		'''Profilin''' (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin. PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin<ref>PMID:27307590</ref>. PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers. '''PFN-I''' is expressed in most tissues while '''PFN-II''' is expressed in brain and kidney. PFN was found in all eukaryotes.

Michal Harel at 21:44, 18 September 2017

2017-09-18T21:44:59Z

←Older revision		Revision as of 21:44, 18 September 2017
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	**[[1prq]] – AcPFN <br />		**[[1prq]] – AcPFN <br />
	**[[3nec]] – PFN – ''Toxoplasma gondii''<br />		**[[3nec]] – PFN – ''Toxoplasma gondii''<br />
		+	**[[5fef]] - PFN - maize<br />
		+	**[[5em0]] - PFN - mugwort<br />
		+	**[[5em1]] - rPFN - ragweed<br />

	*Profilin I complex		*Profilin I complex
Line 37:		Line 40:
	**[[1hlu]] – bPFN + β-actin + ATP <br />		**[[1hlu]] – bPFN + β-actin + ATP <br />
	**[[2jkg]] – PfPFN + poly-Pro peptide <br />		**[[2jkg]] – PfPFN + poly-Pro peptide <br />
		+	**[[5ev0]], [[5eve]] - rPFN + poly-Pro peptide<br />
	**[[1awi]], [[1cf0]], [[1cjf]] – hPFN + poly-Pro peptide <br />		**[[1awi]], [[1cf0]], [[1cjf]] – hPFN + poly-Pro peptide <br />
	**[[2pav]], [[2pbd]], [[3chw]] – hPFN + α-actin + VASP poly-Pro peptide + ATP <br />		**[[2pav]], [[2pbd]], [[3chw]] – hPFN + α-actin + VASP poly-Pro peptide + ATP <br />
Line 45:		Line 49:
	**[[1d1j]] – hPFN <br />		**[[1d1j]] – hPFN <br />
	**[[2vk3]] – PFN - rat <br />		**[[2vk3]] – PFN - rat <br />
		+	**[[5fds]], [[5feg]] - PFN - rubber tree<br />
	**[[2v8c]] – mPFN + VASP poly-Pro peptide - mouse <br />		**[[2v8c]] – mPFN + VASP poly-Pro peptide - mouse <br />
	**[[2v8f]] – mPFN + MDIA1 poly-Pro peptide <br />		**[[2v8f]] – mPFN + MDIA1 poly-Pro peptide <br />

Michal Harel at 21:11, 18 September 2017

2017-09-18T21:11:42Z

←Older revision		Revision as of 21:11, 18 September 2017
Line 1:		Line 1:
-	<StructureSection load='2pbd' size='340' side='right' caption='Human profilin I (green) complex with α-actin (pale green), VASP protein poly-Pro peptide (olive), ATP ~~(stick model)~~ and Ca+2 ion (PDB code [[2pbd]])' scene=''>	+	<StructureSection load='2pbd' size='340' side='right' caption='Human profilin I (green) complex with α-actin (pale green), VASP protein poly-Pro peptide (olive), ATP and Ca+2 ion (PDB code [[2pbd]])' scene=''>
	== Function ==		== Function ==
	'''Profilin''' (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin. PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin<ref>PMID:27307590</ref>. PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers. '''PFN-I''' is expressed in most tissues while '''PFN-II''' is expressed in brain and kidney. PFN was found in all eukaryotes.		'''Profilin''' (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin. PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin<ref>PMID:27307590</ref>. PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers. '''PFN-I''' is expressed in most tissues while '''PFN-II''' is expressed in brain and kidney. PFN was found in all eukaryotes.

Michal Harel at 10:29, 11 July 2016

2016-07-11T10:29:18Z

←Older revision		Revision as of 10:29, 11 July 2016
Line 1:		Line 1:
	<StructureSection load='2pbd' size='340' side='right' caption='Human profilin I (green) complex with α-actin (pale green), VASP protein poly-Pro peptide (olive), ATP (stick model) and Ca+2 ion (PDB code [[2pbd]])' scene=''>		<StructureSection load='2pbd' size='340' side='right' caption='Human profilin I (green) complex with α-actin (pale green), VASP protein poly-Pro peptide (olive), ATP (stick model) and Ca+2 ion (PDB code [[2pbd]])' scene=''>
	== Function ==		== Function ==
-	'''Profilin''' (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin. PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin<ref>PMID:27307590</ref>. PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers. PFN-I is expressed in most tissues while PFN-II is expressed in brain and kidney. PFN was found in all eukaryotes.	+	'''Profilin''' (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin. PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin<ref>PMID:27307590</ref>. PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers. '''PFN-I''' is expressed in most tissues while '''PFN-II''' is expressed in brain and kidney. PFN was found in all eukaryotes.

	== Disease ==		== Disease ==

	PFN from birch, peanut and other plants is a major allergen<ref>PMID:25123397</ref>.		PFN from birch, peanut and other plants is a major allergen<ref>PMID:25123397</ref>.
-
-	== Relevance ==
-
-	== Structural highlights ==

	</StructureSection>		</StructureSection>

Michal Harel at 10:22, 11 July 2016

2016-07-11T10:22:35Z

←Older revision		Revision as of 10:22, 11 July 2016
Line 1:		Line 1:
	<StructureSection load='2pbd' size='340' side='right' caption='Human profilin I (green) complex with α-actin (pale green), VASP protein poly-Pro peptide (olive), ATP (stick model) and Ca+2 ion (PDB code [[2pbd]])' scene=''>		<StructureSection load='2pbd' size='340' side='right' caption='Human profilin I (green) complex with α-actin (pale green), VASP protein poly-Pro peptide (olive), ATP (stick model) and Ca+2 ion (PDB code [[2pbd]])' scene=''>
-	'''Profilin''' (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin. PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin. PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers. PFN-I is expressed in most tissues while PFN-II is expressed in brain and kidney. PFN was found in all eukaryotes.
-
	== Function ==		== Function ==
		+	'''Profilin''' (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin. PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin<ref>PMID:27307590</ref>. PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers. PFN-I is expressed in most tissues while PFN-II is expressed in brain and kidney. PFN was found in all eukaryotes.

	== Disease ==		== Disease ==

-	PFN from birch, peanut and other plants is a major allergen.	+	PFN from birch, peanut and other plants is a major allergen<ref>PMID:25123397</ref>.

	== Relevance ==		== Relevance ==

Michal Harel at 08:20, 15 July 2015

2015-07-15T08:20:56Z

←Older revision		Revision as of 08:20, 15 July 2015
Line 1:		Line 1:
-		+	<StructureSection load='2pbd' size='340' side='right' caption='Human profilin I (green) complex with α-actin (pale green), VASP protein poly-Pro peptide (olive), ATP (stick model) and Ca+2 ion (PDB code [[2pbd]])' scene=''>
-	<StructureSection load='2pbd' size='340' side='right' caption='Human profilin I complex with α-actin ~~and~~ VASP protein poly-Pro peptide (PDB code [[2pbd]])' scene=''>	+
	'''Profilin''' (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin. PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin. PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers. PFN-I is expressed in most tissues while PFN-II is expressed in brain and kidney. PFN was found in all eukaryotes.		'''Profilin''' (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin. PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin. PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers. PFN-I is expressed in most tissues while PFN-II is expressed in brain and kidney. PFN was found in all eukaryotes.

Line 44:		Line 43:
	**[[2jkg]] – PfPFN + poly-Pro peptide <br />		**[[2jkg]] – PfPFN + poly-Pro peptide <br />
	**[[1awi]], [[1cf0]], [[1cjf]] – hPFN + poly-Pro peptide <br />		**[[1awi]], [[1cf0]], [[1cjf]] – hPFN + poly-Pro peptide <br />
-	**[[2pav]], [[2pbd]], [[3chw]] – hPFN + α-actin + VASP poly-Pro peptide <br />	+	**[[2pav]], [[2pbd]], [[3chw]] – hPFN + α-actin + VASP poly-Pro peptide + ATP <br />

	*Profilin II		*Profilin II